Site-directed mutagenesis of glutamate 166 in two β-lactamases. Kinetic and molecular modeling studies

Journal of Biological Chemistry

Volumn 272, Issue 9, 1997, Pages 5438-5444

  Guillaume, Gilliane ^b   Vanhove, Marc ^c   Lamotte Brasseur, Josette ^c   Ledent, Philippe ^c   Jamin, Marc ^c   Joris, Bernard ^c   Frère, Jean Marie ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Fonds Pour Form Rech Dans l'I   (Belgium)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE; CEFALORIDINE; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFUROXIME; CEPHALOSPORIN C; GLUTAMIC ACID; IMIPENEM; LATAMOXEF; MUTANT PROTEIN; PENICILLIN G; TEMOCILLIN;

ACYLATION; ARTICLE; BACTERIUM MUTANT; DEACYLATION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME PURIFICATION; ESCHERICHIA COLI; MICHAELIS MENTEN KINETICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRAIN DIFFERENCE; STREPTOMYCES;

ACYLATION; BETA-LACTAMASES; CEFOXITIN; CEFUROXIME; CEPHALORIDINE; ENZYME STABILITY; GLUTAMIC ACID; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PENICILLIN G; STREPTOMYCES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STREPTOMYCES; STREPTOMYCES ALBUS G;

EID: 0031041590     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.9.5438     Document Type: Article

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