Rapid Identification of Novel Inhibitors of the Human Aquaporin-1 Water Channel

Chemical Biology and Drug Design

Volumn 87, Issue 5, 2016, Pages 794-805

  Patil, Rajkumar V ^a,h   Xu, Shouxi ^a   Van Hoek, Alfred N ^b   Rusinko, Andrew ^a   Feng, Zixia ^a   May, Jesse ^a   Hellberg, Mark ^a   Sharif, Najam A ^a   Wax, Martin B ^c   Irigoyen, Macarena ^d   Carr, Grant ^d   Brittain, Tom ^e   Brown, Peter ^e,g   Colbert, Damon ^e   Kumari, Sindhu ^f   Varadaraj, Kulandaiappan ^f   Mitra, Alok K ^e  

^a Novartis Institutes of Biomedical Research Institute   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d ALBANY MOLECULAR RESEARCH INC   (United States)

^e UNIVERSITY OF AUCKLAND   (New Zealand)

^f STONY BROOK UNIVERSITY   (United States)

^g James and Wells Intellectual Property   (New Zealand)

^h SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

Author keywords

aquaporin; drug discovery; membrane transport; protein expression; water channel

Indexed keywords

AQUAPORIN 1; AQUAPORIN INHIBITOR; CALCEIN; DIHYDROBENZOFURAN DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; XENOPUS; ANIMAL; ANTAGONISTS AND INHIBITORS; CRICETULUS; HAMSTER;

ANIMALS; AQUAPORIN 1; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS;

EID: 84955083957     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12713     Document Type: Article

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