Quaternary ammonium compounds as water channel blockers: Specificity, potency, and site of action

Journal of Biological Chemistry

Volumn 281, Issue 20, 2006, Pages 14207-14214

  Detmers, Frank J M ^a   De Groot, Bert L ^b   Müller, E Matthias ^b   Hinton, Andrew ^c   Konings, Irene B M ^a   Sze, Mozes ^a   Flitsch, Sabine L ^c,d   Grubmüller, Helmut ^b   Deen, Peter M T ^a,e  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d Michael Barber Centre for Mass Spectrometry   (United Kingdom)

^e RUNMC Nijmegen ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; COMPUTER SIMULATION; LEAD COMPOUNDS; MECHANICAL PERMEABILITY; MOLECULAR BIOLOGY; WATER;

AQUAPORINS; MOLECULAR INTERACTIONS; OOCYTES; TETRAETHYLAMMONIUM; WATER PERMEABILITY;

AMMONIUM COMPOUNDS;

AQUAPORIN; AQUAPORIN 1; AQUAPORIN 2; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 5; MONOMER; PHENYLALANINE; POTASSIUM CHANNEL; PROTEIN INHIBITOR; QUATERNARY AMMONIUM DERIVATIVE; TETRAMETHYLAMMONIUM; TETRYLAMMONIUM; TYROSINE; WATER;

AMINO ACID SUBSTITUTION; ARTICLE; COMPUTER SIMULATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG BINDING SITE; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; IC 50; MOLECULAR DYNAMICS; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WATER PERMEABILITY;

AMINO ACID SEQUENCE; AQUAPORINS; BINDING SITES; INHIBITORY CONCENTRATION 50; ION CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PERMEABILITY; QUATERNARY AMMONIUM COMPOUNDS; SEQUENCE HOMOLOGY, AMINO ACID; TETRAETHYLAMMONIUM; THERMODYNAMICS; TYROSINE;

EID: 33744923211     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513072200     Document Type: Article

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