메뉴 건너뛰기




Volumn 36, Issue , 2016, Pages 48-57

CryoEM structures of two spliceosomal complexes: Starter and dessert at the spliceosome feast

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ELONGATION FACTOR 2; RECA PROTEIN; SMALL NUCLEAR RIBONUCLEOPROTEIN; MACROMOLECULE; PROTEIN BINDING; SMALL NUCLEAR RNA; U4 SMALL NUCLEAR RNA; U5 SMALL NUCLEAR RNA; U6 SMALL NUCLEAR RNA;

EID: 84954550544     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2015.12.005     Document Type: Review
Times cited : (41)

References (72)
  • 2
    • 0001468848 scopus 로고    scopus 로고
    • Splicing of precursors to mRNAs by the spliceosome
    • Cold Spring Harbor Laboratory Press, R.F. Gesteland, T.R. Cech, J.F. Atkins (Eds.)
    • Burge C.B., Tuschl T., Sharp P.A. Splicing of precursors to mRNAs by the spliceosome. The RNA World II 1999, 525-560. Cold Spring Harbor Laboratory Press. R.F. Gesteland, T.R. Cech, J.F. Atkins (Eds.).
    • (1999) The RNA World II , pp. 525-560
    • Burge, C.B.1    Tuschl, T.2    Sharp, P.A.3
  • 3
    • 0000996356 scopus 로고    scopus 로고
    • The growing world of small nuclear ribonucleoproteins
    • Cold Spring Harbor Laboratory Press, R.F. Gesteland, T.R. Cech, J.F. Atkins (Eds.)
    • Yu Y.-T., Scharl E.C., Smith C.M., Steitz J.A. The growing world of small nuclear ribonucleoproteins. The RNA World II 1999, 487-524. Cold Spring Harbor Laboratory Press. R.F. Gesteland, T.R. Cech, J.F. Atkins (Eds.).
    • (1999) The RNA World II , pp. 487-524
    • Yu, Y.-T.1    Scharl, E.C.2    Smith, C.M.3    Steitz, J.A.4
  • 5
    • 0028365538 scopus 로고
    • Functional association of essential splicing factor(s) with PRP19 in a protein complex
    • Tarn W.Y., Hsu C.H., Huang K.T., Chen H.R., Kao H.Y., Lee K.R., Cheng S.C. Functional association of essential splicing factor(s) with PRP19 in a protein complex. EMBO J 1994, 13:2421-2431.
    • (1994) EMBO J , vol.13 , pp. 2421-2431
    • Tarn, W.Y.1    Hsu, C.H.2    Huang, K.T.3    Chen, H.R.4    Kao, H.Y.5    Lee, K.R.6    Cheng, S.C.7
  • 6
    • 0026486883 scopus 로고
    • A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for catalytic activation of the spliceosome
    • Madhani H.D., Guthrie C. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for catalytic activation of the spliceosome. Cell 1992, 71:803-817.
    • (1992) Cell , vol.71 , pp. 803-817
    • Madhani, H.D.1    Guthrie, C.2
  • 8
    • 84901929739 scopus 로고    scopus 로고
    • Evidence for a group II intron-like catalytic triplex in the spliceosome
    • Fica S.M., Mefford M.A., Piccirilli J.A., Staley J.P. Evidence for a group II intron-like catalytic triplex in the spliceosome. Nat Struct Mol Biol 2014, 21:464-471.
    • (2014) Nat Struct Mol Biol , vol.21 , pp. 464-471
    • Fica, S.M.1    Mefford, M.A.2    Piccirilli, J.A.3    Staley, J.P.4
  • 9
    • 41749109563 scopus 로고    scopus 로고
    • Crystal structure of a self-spliced group II intron
    • Toor N., Keating K.S., Taylor S.D., Pyle A.M. Crystal structure of a self-spliced group II intron. Science 2008, 320:77-82.
    • (2008) Science , vol.320 , pp. 77-82
    • Toor, N.1    Keating, K.S.2    Taylor, S.D.3    Pyle, A.M.4
  • 10
    • 0026605043 scopus 로고
    • U5 snRNA interacts with exon sequences at 5' and 3' splice sites
    • Newman A.J., Norman C. U5 snRNA interacts with exon sequences at 5' and 3' splice sites. Cell 1992, 68:743-754.
    • (1992) Cell , vol.68 , pp. 743-754
    • Newman, A.J.1    Norman, C.2
  • 11
    • 0027739853 scopus 로고
    • The U5 and U6 small nuclear RNAs as active site components of the spliceosome
    • Sontheimer E.J., Steitz J.A. The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science 1993, 262:1989-1996.
    • (1993) Science , vol.262 , pp. 1989-1996
    • Sontheimer, E.J.1    Steitz, J.A.2
  • 12
    • 84874268195 scopus 로고    scopus 로고
    • Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system
    • Fourmann J.B., Schmitzová J., Christian H., Urlaub H., Ficner R., Boon K.L., Fabrizio P., Lührmann R. Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes Dev 2013, 27:413-428.
    • (2013) Genes Dev , vol.27 , pp. 413-428
    • Fourmann, J.B.1    Schmitzová, J.2    Christian, H.3    Urlaub, H.4    Ficner, R.5    Boon, K.L.6    Fabrizio, P.7    Lührmann, R.8
  • 15
    • 84861984263 scopus 로고    scopus 로고
    • Structure, function and regulation of spliceosomal RNA helicases
    • Cordin O., Hahn D., Beggs J.D. Structure, function and regulation of spliceosomal RNA helicases. Curr Opin Cell Biol 2012, 24:431-438.
    • (2012) Curr Opin Cell Biol , vol.24 , pp. 431-438
    • Cordin, O.1    Hahn, D.2    Beggs, J.D.3
  • 16
    • 63649099704 scopus 로고    scopus 로고
    • Crystal structure of human spliceosomal U1 snRNP at 5.5Å resolution
    • Pomeranz Krummel D.A., Oubridge C., Leung A.K., Li J., Nagai K. Crystal structure of human spliceosomal U1 snRNP at 5.5Å resolution. Nature 2009, 458:475-480.
    • (2009) Nature , vol.458 , pp. 475-480
    • Pomeranz Krummel, D.A.1    Oubridge, C.2    Leung, A.K.3    Li, J.4    Nagai, K.5
  • 17
    • 84922041769 scopus 로고    scopus 로고
    • Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition
    • Kondo Y., Oubridge C., van Roon A.M., Nagai K. Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. eLife 2015, 10.7554/eLife.04986.
    • (2015) eLife
    • Kondo, Y.1    Oubridge, C.2    van Roon, A.M.3    Nagai, K.4
  • 18
    • 33745050151 scopus 로고    scopus 로고
    • Cryo-electron microscopy of spliceosomal components
    • Stark H., Lührmann R. Cryo-electron microscopy of spliceosomal components. Annu Rev Biophys Biomol Struct 2006, 35:435-457.
    • (2006) Annu Rev Biophys Biomol Struct , vol.35 , pp. 435-457
    • Stark, H.1    Lührmann, R.2
  • 20
    • 38849192403 scopus 로고    scopus 로고
    • A protein-based EM label for RNA identifies the location of exons in spliceosomes
    • Alcid E.A., Jurica M.S. A protein-based EM label for RNA identifies the location of exons in spliceosomes. Nat Struct Mol Biol 2008, 15:213-215.
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 213-215
    • Alcid, E.A.1    Jurica, M.S.2
  • 21
    • 68249149579 scopus 로고    scopus 로고
    • Exon, intron and splice site locations in the spliceosomal B complex
    • Wolf E., Kastner B., Deckert J., Merz C., Stark H., Lührmann R. Exon, intron and splice site locations in the spliceosomal B complex. EMBO J 2009, 28:2283-2292.
    • (2009) EMBO J , vol.28 , pp. 2283-2292
    • Wolf, E.1    Kastner, B.2    Deckert, J.3    Merz, C.4    Stark, H.5    Lührmann, R.6
  • 22
    • 84923368907 scopus 로고    scopus 로고
    • How cryo-EM is revolutionizing structural biology
    • Bai X.C., McMullan G., Scheres S.H. How cryo-EM is revolutionizing structural biology. Trends Biochem Sci 2015, 40:49-57.
    • (2015) Trends Biochem Sci , vol.40 , pp. 49-57
    • Bai, X.C.1    McMullan, G.2    Scheres, S.H.3
  • 24
    • 84942474131 scopus 로고    scopus 로고
    • Structure of a yeast spliceosome at 3.6-angstrom resolution
    • Yan C., Hang J., Wan R., Huang M., Wong C.C., Shi Y. Structure of a yeast spliceosome at 3.6-angstrom resolution. Science 2015, 349:1182-1191.
    • (2015) Science , vol.349 , pp. 1182-1191
    • Yan, C.1    Hang, J.2    Wan, R.3    Huang, M.4    Wong, C.C.5    Shi, Y.6
  • 25
    • 33847688429 scopus 로고    scopus 로고
    • Structural characterization of the fission yeast U5.U2/U6 spliceosome complex
    • Ohi M.D., Ren L., Wall J.S., Gould K.L., Walz T. Structural characterization of the fission yeast U5.U2/U6 spliceosome complex. Proc Natl Acad Sci U S A 2007, 104:3195-3200.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 3195-3200
    • Ohi, M.D.1    Ren, L.2    Wall, J.S.3    Gould, K.L.4    Walz, T.5
  • 26
    • 33749672830 scopus 로고    scopus 로고
    • Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy
    • Sander B., Golas M.M., Makarov E.M., Brahms H., Kastner B., Lührmann R., Stark H. Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy. Mol Cell 2006, 24:267-278.
    • (2006) Mol Cell , vol.24 , pp. 267-278
    • Sander, B.1    Golas, M.M.2    Makarov, E.M.3    Brahms, H.4    Kastner, B.5    Lührmann, R.6    Stark, H.7
  • 28
    • 33745860086 scopus 로고    scopus 로고
    • Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions
    • Deckert J., Hartmuth K., Boehringer D., Behzadnia N., Will C.L., Kastner B., Stark H., Urlaub H., Lührmann R. Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol Cell Biol 2006, 26:5528-5543.
    • (2006) Mol Cell Biol , vol.26 , pp. 5528-5543
    • Deckert, J.1    Hartmuth, K.2    Boehringer, D.3    Behzadnia, N.4    Will, C.L.5    Kastner, B.6    Stark, H.7    Urlaub, H.8    Lührmann, R.9
  • 29
    • 0035161567 scopus 로고    scopus 로고
    • Biochemical and genetic analyses of the U5 U6, and U4/U6×U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae
    • Stevens S.W., Barta I., Ge H.Y., Moore R.E., Young M.K., Lee T.D., Abelson J. Biochemical and genetic analyses of the U5 U6, and U4/U6×U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae. RNA 2001, 7:1543-1553.
    • (2001) RNA , vol.7 , pp. 1543-1553
    • Stevens, S.W.1    Barta, I.2    Ge, H.Y.3    Moore, R.E.4    Young, M.K.5    Lee, T.D.6    Abelson, J.7
  • 30
    • 0033575711 scopus 로고    scopus 로고
    • Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP
    • Gottschalk A., Neubauer G., Banroques J., Mann M., Lührmann R., Fabrizio P. Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP. EMBO J 1999, 18:4535-4548.
    • (1999) EMBO J , vol.18 , pp. 4535-4548
    • Gottschalk, A.1    Neubauer, G.2    Banroques, J.3    Mann, M.4    Lührmann, R.5    Fabrizio, P.6
  • 31
    • 0031741144 scopus 로고    scopus 로고
    • The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein
    • Achsel T., Ahrens K., Brahms H., Teigelkamp S., Lührmann R. The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein. Mol Cell Biol 1998, 18:6756-6766.
    • (1998) Mol Cell Biol , vol.18 , pp. 6756-6766
    • Achsel, T.1    Ahrens, K.2    Brahms, H.3    Teigelkamp, S.4    Lührmann, R.5
  • 32
    • 17844395704 scopus 로고    scopus 로고
    • Prp8 protein: at the heart of the spliceosome
    • Grainger R.J., Beggs J.D. Prp8 protein: at the heart of the spliceosome. RNA 2005, 11:533-557.
    • (2005) RNA , vol.11 , pp. 533-557
    • Grainger, R.J.1    Beggs, J.D.2
  • 33
    • 0032537739 scopus 로고    scopus 로고
    • RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2
    • Raghunathan P.L., Guthrie C. RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol 1998, 8:847-855.
    • (1998) Curr Biol , vol.8 , pp. 847-855
    • Raghunathan, P.L.1    Guthrie, C.2
  • 34
  • 36
    • 84867913431 scopus 로고    scopus 로고
    • Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome
    • Santos K.F., Jovin S.M., Weber G., Pena V., Lührmann R., Wahl M.C. Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome. Proc Natl Acad Sci U S A 2012, 109:17418-17423.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 17418-17423
    • Santos, K.F.1    Jovin, S.M.2    Weber, G.3    Pena, V.4    Lührmann, R.5    Wahl, M.C.6
  • 37
    • 84878849387 scopus 로고    scopus 로고
    • Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site
    • Nguyen T.H., Li J., Galej W.P., Oshikane H., Newman A.J., Nagai K. Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site. Structure 2013, 21:910-919.
    • (2013) Structure , vol.21 , pp. 910-919
    • Nguyen, T.H.1    Li, J.2    Galej, W.P.3    Oshikane, H.4    Newman, A.J.5    Nagai, K.6
  • 38
    • 0030976931 scopus 로고    scopus 로고
    • An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2
    • Fabrizio P., Laggerbauer B., Lauber J., Lane W.S., Lührmann R. An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2. EMBO J 1997, 16:4092-4106.
    • (1997) EMBO J , vol.16 , pp. 4092-4106
    • Fabrizio, P.1    Laggerbauer, B.2    Lauber, J.3    Lane, W.S.4    Lührmann, R.5
  • 39
    • 0242516080 scopus 로고    scopus 로고
    • Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase
    • Jørgensen R., Ortiz P.A., Carr-Schmid A., Nissen P., Kinzy T.G., Andersen G.R. Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase. Nat Struct Biol 2003, 10:379-385.
    • (2003) Nat Struct Biol , vol.10 , pp. 379-385
    • Jørgensen, R.1    Ortiz, P.A.2    Carr-Schmid, A.3    Nissen, P.4    Kinzy, T.G.5    Andersen, G.R.6
  • 40
    • 33746441457 scopus 로고    scopus 로고
    • The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase
    • Small E.C., Leggett S.R., Winans A.A., Staley J.P. The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase. Mol Cell 2006, 23:389-399.
    • (2006) Mol Cell , vol.23 , pp. 389-399
    • Small, E.C.1    Leggett, S.R.2    Winans, A.A.3    Staley, J.P.4
  • 41
    • 0041344523 scopus 로고    scopus 로고
    • Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing
    • Bartels C., Urlaub H., Lührmann R., Fabrizio P. Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing. J Biol Chem 2003, 278:28324-28334.
    • (2003) J Biol Chem , vol.278 , pp. 28324-28334
    • Bartels, C.1    Urlaub, H.2    Lührmann, R.3    Fabrizio, P.4
  • 42
    • 84873629024 scopus 로고    scopus 로고
    • Crystal structure of Prp8 reveals active site cavity of the spliceosome
    • Galej W.P., Oubridge C., Newman A.J., Nagai K. Crystal structure of Prp8 reveals active site cavity of the spliceosome. Nature 2013, 493:638-643.
    • (2013) Nature , vol.493 , pp. 638-643
    • Galej, W.P.1    Oubridge, C.2    Newman, A.J.3    Nagai, K.4
  • 45
    • 31044438832 scopus 로고    scopus 로고
    • Prp8p dissection reveals domain structure and protein interaction sites
    • Boon K.L., Norman C.M., Grainger R.J., Newman A.J., Beggs J.D. Prp8p dissection reveals domain structure and protein interaction sites. RNA 2006, 12:198-205.
    • (2006) RNA , vol.12 , pp. 198-205
    • Boon, K.L.1    Norman, C.M.2    Grainger, R.J.3    Newman, A.J.4    Beggs, J.D.5
  • 46
    • 73249134403 scopus 로고    scopus 로고
    • Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome
    • Grainger R.J., Barrass J.D., Jacquier A., Rain J.C., Beggs J.D. Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome. RNA 2009, 15:2161-2173.
    • (2009) RNA , vol.15 , pp. 2161-2173
    • Grainger, R.J.1    Barrass, J.D.2    Jacquier, A.3    Rain, J.C.4    Beggs, J.D.5
  • 47
    • 0037107418 scopus 로고    scopus 로고
    • Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins
    • Nottrott S., Urlaub H., Lührmann R. Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. EMBO J 2002, 21:5527-5538.
    • (2002) EMBO J , vol.21 , pp. 5527-5538
    • Nottrott, S.1    Urlaub, H.2    Lührmann, R.3
  • 50
    • 0032484029 scopus 로고    scopus 로고
    • Functional and structural characterization of the prp3 binding domain of the yeast prp4 splicing factor
    • Ayadi L., Callebaut I., Saguez C., Villa T., Mornon J.P., Banroques J. Functional and structural characterization of the prp3 binding domain of the yeast prp4 splicing factor. J Mol Biol 1998, 284:673-687.
    • (1998) J Mol Biol , vol.284 , pp. 673-687
    • Ayadi, L.1    Callebaut, I.2    Saguez, C.3    Villa, T.4    Mornon, J.P.5    Banroques, J.6
  • 52
    • 84868592766 scopus 로고    scopus 로고
    • Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning
    • Hahn D., Kudla G., Tollervey D., Beggs J.D. Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning. Genes Dev 2012, 26:2408-2421.
    • (2012) Genes Dev , vol.26 , pp. 2408-2421
    • Hahn, D.1    Kudla, G.2    Tollervey, D.3    Beggs, J.D.4
  • 53
    • 84868583242 scopus 로고    scopus 로고
    • The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA
    • Mozaffari-Jovin S., Santos K.F., Hsiao H.H., Will C.L., Urlaub H., Wahl M.C., Lührmann R. The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev 2012, 26:2422-2434.
    • (2012) Genes Dev , vol.26 , pp. 2422-2434
    • Mozaffari-Jovin, S.1    Santos, K.F.2    Hsiao, H.H.3    Will, C.L.4    Urlaub, H.5    Wahl, M.C.6    Lührmann, R.7
  • 54
    • 33344460290 scopus 로고    scopus 로고
    • Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome
    • Turner I.A., Norman C.M., Churcher M.J., Newman A.J. Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome. RNA 2006, 12:375-386.
    • (2006) RNA , vol.12 , pp. 375-386
    • Turner, I.A.1    Norman, C.M.2    Churcher, M.J.3    Newman, A.J.4
  • 55
    • 84942913896 scopus 로고    scopus 로고
    • Structural basis of pre-mRNA splicing
    • Hang J., Wan R., Yan C., Shi Y. Structural basis of pre-mRNA splicing. Science 2015, 349:1191-1198.
    • (2015) Science , vol.349 , pp. 1191-1198
    • Hang, J.1    Wan, R.2    Yan, C.3    Shi, Y.4
  • 56
    • 79952239719 scopus 로고    scopus 로고
    • Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19
    • Ren L., McLean J.R., Hazbun T.R., Fields S., Vander Kooi C., Ohi M.D., Gould K.L. Systematic two-hybrid and comparative proteomic analyses reveal novel yeast pre-mRNA splicing factors connected to Prp19. PLoS One 2011, 6:e16719.
    • (2011) PLoS One , vol.6 , pp. e16719
    • Ren, L.1    McLean, J.R.2    Hazbun, T.R.3    Fields, S.4    Vander Kooi, C.5    Ohi, M.D.6    Gould, K.L.7
  • 59
    • 0036269649 scopus 로고    scopus 로고
    • Characterization of interactions among the Cef1p-Prp19p-associated splicing complex
    • Ohi M.D., Gould K.L. Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. RNA 2002, 8:798-815.
    • (2002) RNA , vol.8 , pp. 798-815
    • Ohi, M.D.1    Gould, K.L.2
  • 61
    • 3242737496 scopus 로고    scopus 로고
    • A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing
    • Makarova O.V., Makarov E.M., Urlaub H., Will C.L., Gentzel M., Wilm M., Lührmann R. A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J 2004, 23:2381-2391.
    • (2004) EMBO J , vol.23 , pp. 2381-2391
    • Makarova, O.V.1    Makarov, E.M.2    Urlaub, H.3    Will, C.L.4    Gentzel, M.5    Wilm, M.6    Lührmann, R.7
  • 62
    • 77952666620 scopus 로고    scopus 로고
    • The Prp19 WD40 domain contains a conserved protein interaction region essential for its function
    • Vander Kooi C.W., Ren L., Xu P., Ohi M.D., Gould K.L., Chazin W.J. The Prp19 WD40 domain contains a conserved protein interaction region essential for its function. Structure 2010, 18:584-593.
    • (2010) Structure , vol.18 , pp. 584-593
    • Vander Kooi, C.W.1    Ren, L.2    Xu, P.3    Ohi, M.D.4    Gould, K.L.5    Chazin, W.J.6
  • 64
    • 0027184481 scopus 로고
    • A general two-metal-ion mechanism for catalytic RNA
    • Steitz T.A., Steitz J.A. A general two-metal-ion mechanism for catalytic RNA. Proc Natl Acad Sci USA 1993, 90:6498-6502.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6498-6502
    • Steitz, T.A.1    Steitz, J.A.2
  • 66
    • 84858799296 scopus 로고    scopus 로고
    • Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre
    • Rasche N., Dybkov O., Schmitzova J., Akyildiz B., Fabrizio P., Lührmann R. Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO J 2012, 31:1591-1604.
    • (2012) EMBO J , vol.31 , pp. 1591-1604
    • Rasche, N.1    Dybkov, O.2    Schmitzova, J.3    Akyildiz, B.4    Fabrizio, P.5    Lührmann, R.6
  • 68
    • 70449625597 scopus 로고    scopus 로고
    • The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome
    • Fabrizio P., Dannenberg J., Dube P., Kastner B., Stark H., Urlaub H., Lührmann R. The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell 2009, 36:593-608.
    • (2009) Mol Cell , vol.36 , pp. 593-608
    • Fabrizio, P.1    Dannenberg, J.2    Dube, P.3    Kastner, B.4    Stark, H.5    Urlaub, H.6    Lührmann, R.7
  • 71
    • 84868035651 scopus 로고    scopus 로고
    • Visualizing group II intron catalysis through the stages of splicing
    • Marcia M., Pyle A.M. Visualizing group II intron catalysis through the stages of splicing. Cell 2012, 151:497-507.
    • (2012) Cell , vol.151 , pp. 497-507
    • Marcia, M.1    Pyle, A.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.