메뉴 건너뛰기




Volumn 31, Issue 9, 2012, Pages 2222-2234

Crystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding protein

Author keywords

RRM; spliceosome; Torus domain; X ray crystallography; zinc finger

Indexed keywords

PROTEIN CWC2; RNA BINDING PROTEIN; SMALL NUCLEAR RNA; UNCLASSIFIED DRUG;

EID: 84860540204     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.58     Document Type: Article
Times cited : (24)

References (34)
  • 1
    • 24744465409 scopus 로고    scopus 로고
    • The Prp19-associated complex is required for specifying interactions of U5 and U6 with pre-mRNA during spliceosome activation
    • Chan SP, Cheng SC (2005) The Prp19-associated complex is required for specifying interactions of U5 and U6 with pre-mRNA during spliceosome activation. J Biol Chem 280: 31190-31199
    • (2005) J Biol Chem , vol.280 , pp. 31190-31199
    • Chan, S.P.1    Cheng, S.C.2
  • 2
    • 0141924550 scopus 로고    scopus 로고
    • The Prp19p-associated complex in spliceosome activation
    • Chan SP, Kao DI, Tsai WY, Cheng SC (2003) The Prp19p-associated complex in spliceosome activation. Science 302: 279-282
    • (2003) Science , vol.302 , pp. 279-282
    • Chan, S.P.1    Kao, D.I.2    Tsai, W.Y.3    Cheng, S.C.4
  • 4
    • 0025001918 scopus 로고
    • Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing
    • Fabrizio P, Abelson J (1990) Two domains of yeast U6 small nuclear RNA required for both steps of nuclear precursor messenger RNA splicing. Science 250: 404-409
    • (1990) Science , vol.250 , pp. 404-409
    • Fabrizio, P.1    Abelson, J.2
  • 5
    • 70449625597 scopus 로고    scopus 로고
    • The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome
    • Fabrizio P, Dannenberg J, Dube P, Kastner B, Stark H, Urlaub H, Lührmann R (2009) The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell 36: 593-608
    • (2009) Mol Cell , vol.36 , pp. 593-608
    • Fabrizio, P.1    Dannenberg, J.2    Dube, P.3    Kastner, B.4    Stark, H.5    Urlaub, H.6    Lührmann, R.7
  • 6
    • 0028144641 scopus 로고
    • A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing
    • Fortner DM, Troy RG, Brow DA (1994) A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing. Genes Dev 8: 221-233
    • (1994) Genes Dev , vol.8 , pp. 221-233
    • Fortner, D.M.1    Troy, R.G.2    Brow, D.A.3
  • 7
    • 2442661481 scopus 로고    scopus 로고
    • Multiple functions for the invariant AGC triad of U6 snRNA
    • DOI 10.1261/rna.7310704
    • Hilliker AK, Staley JP (2004) Multiple functions for the invariant AGC triad of U6 snRNA. RNA 10: 921-928 (Pubitemid 38669765)
    • (2004) RNA , vol.10 , Issue.6 , pp. 921-928
    • Hilliker, A.K.1    Staley, J.P.2
  • 8
    • 77955929156 scopus 로고    scopus 로고
    • The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing
    • Hogg R, McGrail JC, O'Keefe RT (2010) The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing. Biochem Soc Trans 38: 1110-1115
    • (2010) Biochem Soc Trans , vol.38 , pp. 1110-1115
    • Hogg, R.1    McGrail, J.C.2    O'Keefe, R.T.3
  • 10
    • 0027923620 scopus 로고
    • Involvement of U6 snRNA in 50 splice site selection
    • Kandels-Lewis S, Seraphin B (1993) Involvement of U6 snRNA in 50 splice site selection. Science 262: 2035-2039
    • (1993) Science , vol.262 , pp. 2035-2039
    • Kandels-Lewis, S.1    Seraphin, B.2
  • 11
    • 79959756726 scopus 로고    scopus 로고
    • Mass-spectrometric analysis of proteins cross-linked to 4-thiouracil-and 5-bromo-uracil-substituted RNA
    • Kramer K, Hummel P, Hsiao H, Luo X, Wahl M, Urlaub H (2011) Mass-spectrometric analysis of proteins cross-linked to 4-thiouracil-and 5-bromo-uracil-substituted RNA. Int J Mass Spectrom 304: 184-194
    • (2011) Int J Mass Spectrom , vol.304 , pp. 184-194
    • Kramer, K.1    Hummel, P.2    Hsiao, H.3    Luo, X.4    Wahl, M.5    Urlaub, H.6
  • 12
    • 34547155595 scopus 로고    scopus 로고
    • A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing
    • Liu YC, Chen HC, Wu NY, Cheng SC (2007) A novel splicing factor, Yju2, is associated with NTC and acts after Prp2 in promoting the first catalytic reaction of pre-mRNA splicing. Mol Cell Biol 27: 5403-5413
    • (2007) Mol Cell Biol , vol.27 , pp. 5403-5413
    • Liu, Y.C.1    Chen, H.C.2    Wu, N.Y.3    Cheng, S.C.4
  • 13
    • 84555189176 scopus 로고    scopus 로고
    • Structure of the mRNA splicing complex component Cwc2: Insights into RNA recognition
    • Lu P, Lu G, Yan C, Wang L, Li W, Yin P (2012) Structure of the mRNA splicing complex component Cwc2: insights into RNA recognition. Biochem J 441: 591-597
    • (2012) Biochem J , vol.441 , pp. 591-597
    • Lu, P.1    Lu, G.2    Yan, C.3    Wang, L.4    Li, W.5    Yin, P.6
  • 15
    • 0028556367 scopus 로고
    • Dynamic RNA-RNA interactions in the spliceosome
    • Madhani HD, Guthrie C (1994) Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet 28: 1-26
    • (1994) Annu Rev Genet , vol.28 , pp. 1-26
    • Madhani, H.D.1    Guthrie, C.2
  • 16
    • 18544377013 scopus 로고    scopus 로고
    • The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression
    • DOI 10.1111/j.1742-4658.2005.04653.x
    • Maris C, Dominguez C, Allain FH (2005) The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression. FEBS J 272: 2118-2131 (Pubitemid 40655326)
    • (2005) FEBS Journal , vol.272 , Issue.9 , pp. 2118-2131
    • Maris, C.1    Dominguez, C.2    Allain, F.H.-T.3
  • 17
    • 0037107401 scopus 로고    scopus 로고
    • 7GpppG cap analogue by the human nuclear cap-binding complex
    • DOI 10.1093/emboj/cdf538
    • Mazza C, Segref A, Mattaj IW, Cusack S (2002) Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. EMBO J 21: 5548-5557 (Pubitemid 35231034)
    • (2002) EMBO Journal , vol.21 , Issue.20 , pp. 5548-5557
    • Mazza, C.1    Segref, A.2    Mattaj, I.W.3    Cusack, S.4
  • 18
    • 67949106544 scopus 로고    scopus 로고
    • The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing
    • McGrail JC, Krause A, O'Keefe RT (2009) The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing. Nucleic Acids Res 37: 4205-4217
    • (2009) Nucleic Acids Res , vol.37 , pp. 4205-4217
    • McGrail, J.C.1    Krause, A.2    O'Keefe, R.T.3
  • 19
    • 0030598839 scopus 로고    scopus 로고
    • The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of pre-mRNA splicing in yeast
    • DOI 10.1016/S0092-8674(00)80140-3
    • O'Keefe RT, Norman C, Newman AJ (1996) The invariant U5 snRNA loop 1 sequence is dispensable for the first catalytic step of premRNA splicing in yeast. Cell 86: 679-689 (Pubitemid 26299498)
    • (1996) Cell , vol.86 , Issue.4 , pp. 679-689
    • O'Keefe, R.T.1    Norman, C.2    Newman, A.J.3
  • 20
    • 0036269649 scopus 로고    scopus 로고
    • Characterization of interactions among the Cef1p-Prp19p-associated splicing complex
    • DOI 10.1017/S1355838202025050
    • Ohi MD, Gould KL (2002) Characterization of interactions among the Cef1p-Prp19p-associated splicing complex. RNA 8: 798-815 (Pubitemid 34620456)
    • (2002) RNA , vol.8 , Issue.6 , pp. 798-815
    • Ohi, M.D.1    Gould, K.L.2
  • 21
    • 0028004607 scopus 로고
    • Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin
    • Oubridge C, Ito N, Evans PR, Teo CH, Nagai K (1994) Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. Nature 372: 432-438
    • (1994) Nature , vol.372 , pp. 432-438
    • Oubridge, C.1    Ito, N.2    Evans, P.R.3    Teo, C.H.4    Nagai, K.5
  • 22
    • 33847053558 scopus 로고    scopus 로고
    • Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa
    • DOI 10.1016/j.molcel.2007.01.023, PII S1097276507000469
    • Pena V, Liu S, Bujnicki JM, Lührmann R, Wahl MC (2007) Structure of a multipartite protein-protein interaction domain in splicing factor prp8 and its link to retinitis pigmentosa. Mol Cell 25: 615-624 (Pubitemid 46274448)
    • (2007) Molecular Cell , vol.25 , Issue.4 , pp. 615-624
    • Pena, V.1    Liu, S.2    Bujnicki, J.M.3    Luhrmann, R.4    Wahl, M.C.5
  • 23
    • 55549143970 scopus 로고    scopus 로고
    • Structure and function of an RNase H domain at the heart of the spliceosome
    • Pena V, Rozov A, Fabrizio P, Lührmann R, Wahl MC (2008) Structure and function of an RNase H domain at the heart of the spliceosome. EMBO J 27: 2929-2940
    • (2008) EMBO J , vol.27 , pp. 2929-2940
    • Pena, V.1    Rozov, A.2    Fabrizio, P.3    Lührmann, R.4    Wahl, M.C.5
  • 24
    • 0034841844 scopus 로고    scopus 로고
    • The tandem affinity purification (TAP) method: A general procedure of protein complex purification
    • DOI 10.1006/meth.2001.1183
    • Puig O, Caspary F, Rigaut G, Rutz B, Bouveret E, Bragado-Nilsson E, Wilm M, Seraphin B (2001) The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods 24: 218-229 (Pubitemid 32846428)
    • (2001) Methods , vol.24 , Issue.3 , pp. 218-229
    • Puig, O.1    Caspary, F.2    Rigaut, G.3    Rutz, B.4    Bouveret, E.5    Bragado-Nilsson, E.6    Wilm, M.7    Seraphin, B.8
  • 25
    • 84858799296 scopus 로고    scopus 로고
    • Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre
    • Rasche N, Dybkov O, Schmitzová J, Akyildiz B, Fabrizio P, Lührmann R (2012) Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO J 31: 1591-1604
    • (2012) EMBO J , vol.31 , pp. 1591-1604
    • Rasche, N.1    Dybkov, O.2    Schmitzová, J.3    Akyildiz, B.4    Fabrizio, P.5    Lührmann, R.6
  • 27
    • 0028365538 scopus 로고
    • Functional association of essential splicing factor(s) with PRP19 in a protein complex
    • Tarn WY, Hsu CH, Huang KT, Chen HR, Kao HY, Lee KR, Cheng SC (1994) Functional association of essential splicing factor(s) with PRP19 in a protein complex. EMBO J 13: 2421-2431
    • (1994) EMBO J , vol.13 , pp. 2421-2431
    • Tarn, W.Y.1    Hsu, C.H.2    Huang, K.T.3    Chen, H.R.4    Kao, H.Y.5    Lee, K.R.6    Cheng, S.C.7
  • 28
    • 57149097433 scopus 로고    scopus 로고
    • Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1
    • Teplova M, Patel DJ (2008) Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol 15: 1343-1351
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 1343-1351
    • Teplova, M.1    Patel, D.J.2
  • 29
    • 77952666620 scopus 로고    scopus 로고
    • The Prp19 WD40 domain contains a conserved protein interaction region essential for its function
    • Vander Kooi CW, Ren L, Xu P, Ohi MD, Gould KL, Chazin WJ (2010) The Prp19 WD40 domain contains a conserved protein interaction region essential for its function. Structure 18: 584-593
    • (2010) Structure , vol.18 , pp. 584-593
    • Vander Kooi, C.W.1    Ren, L.2    Xu, P.3    Ohi, M.D.4    Gould, K.L.5    Chazin, W.J.6
  • 30
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC, Will CL, Lührmann R (2009) The spliceosome: design principles of a dynamic RNP machine. Cell 136: 701-718
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Lührmann, R.3
  • 33
    • 52949131890 scopus 로고    scopus 로고
    • Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins
    • Yang K, Zhang L, Xu T, Heroux A, Zhao R (2008) Crystal structure of the beta-finger domain of Prp8 reveals analogy to ribosomal proteins. Proc Natl Acad Sci USA 105: 13817-13822
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13817-13822
    • Yang, K.1    Zhang, L.2    Xu, T.3    Heroux, A.4    Zhao, R.5
  • 34
    • 0034649666 scopus 로고    scopus 로고
    • Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
    • DOI 10.1038/35048617
    • Yean SL, Wuenschell G, Termini J, Lin RJ (2000) Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. Nature 408: 881-884 (Pubitemid 32016101)
    • (2000) Nature , vol.408 , Issue.6814 , pp. 881-884
    • Yean, S.-L.1    Wuenschell, G.2    Termini, J.3    Lin, R.-J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.