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Volumn 109, Issue 43, 2012, Pages 17418-17423

Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosome

Author keywords

pre mRNA splicing; RNA helicase Brr2; X ray crystallography

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; BRR2 ENZYME; HELICASE; SINGLE STRANDED RNA; SMALL NUCLEAR RNA; UNCLASSIFIED DRUG;

EID: 84867913431     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208098109     Document Type: Article
Times cited : (81)

References (26)
  • 1
    • 0032489021 scopus 로고    scopus 로고
    • Mechanical devices of the spliceosome: Motors, clocks, springs, and things
    • DOI 10.1016/S0092-8674(00)80925-3
    • Staley JP, Guthrie C (1998) Mechanical devices of the spliceosome: Motors, clocks, springs, and things. Cell 92:315-326. (Pubitemid 28093010)
    • (1998) Cell , vol.92 , Issue.3 , pp. 315-326
    • Staley, J.P.1    Guthrie, C.2
  • 2
    • 60349104299 scopus 로고    scopus 로고
    • The spliceosome: Design principles of a dynamic RNP machine
    • Wahl MC,Will CL, Lührmann R (2009) The spliceosome: Design principles of a dynamic RNP machine. Cell 136:701-718.
    • (2009) Cell , vol.136 , pp. 701-718
    • Wahl, M.C.1    Will, C.L.2    Lührmann, R.3
  • 4
    • 0032537739 scopus 로고    scopus 로고
    • RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2
    • Raghunathan PL, Guthrie C (1998) RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol 8:847-855. (Pubitemid 28356043)
    • (1998) Current Biology , vol.8 , Issue.15 , pp. 847-855
    • Raghunathan, P.L.1    Guthrie, C.2
  • 5
    • 0029871680 scopus 로고    scopus 로고
    • Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations
    • Noble SM, Guthrie C (1996) Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 143:67-80. (Pubitemid 26136973)
    • (1996) Genetics , vol.143 , Issue.1 , pp. 67-80
    • Noble, S.M.1    Guthrie, C.2
  • 6
    • 0033056712 scopus 로고    scopus 로고
    • The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex
    • Kim DH, Rossi JJ (1999) The first ATPase domain of the yeast 246-kDa protein is required for in vivo unwinding of the U4/U6 duplex. RNA 5:959-971.
    • (1999) RNA , vol.5 , pp. 959-971
    • Kim, D.H.1    Rossi, J.J.2
  • 7
    • 71849087061 scopus 로고    scopus 로고
    • Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs
    • Zhao C, et al. (2009) Autosomal-dominant retinitis pigmentosa caused by a mutation in SNRNP200, a gene required for unwinding of U4/U6 snRNAs. AmJHumGenet 85:617-627.
    • (2009) AmJHumGenet , vol.85 , pp. 617-627
    • Zhao, C.1
  • 8
    • 33746441457 scopus 로고    scopus 로고
    • The EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H Box ATPase
    • DOI 10.1016/j.molcel.2006.05.043, PII S1097276506004138
    • Small EC, Leggett SR, Winans AA, Staley JP (2006) The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase. Mol Cell 23:389-399. (Pubitemid 44128846)
    • (2006) Molecular Cell , vol.23 , Issue.3 , pp. 389-399
    • Small, E.C.1    Leggett, S.R.2    Winans, A.A.3    Staley, J.P.4
  • 9
    • 0033569743 scopus 로고    scopus 로고
    • A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro
    • DOI 10.1093/emboj/18.20.5789
    • Achsel T, et al. (1999) A doughnut-shaped heteromer of human Sm-like proteins binds to the 3?-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. EMBO J 18:5789-5802. (Pubitemid 29486396)
    • (1999) EMBO Journal , vol.18 , Issue.20 , pp. 5789-5802
    • Achsel, T.1    Brahms, H.2    Kastner, B.3    Bachi, A.4    Wilm, M.5    Luhrmann, R.6
  • 10
    • 79957601559 scopus 로고    scopus 로고
    • Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis
    • Leung AK, Nagai K, Li J (2011) Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis. Nature 473:536-539.
    • (2011) Nature , vol.473 , pp. 536-539
    • Leung, A.K.1    Nagai, K.2    Li, J.3
  • 11
    • 77449121298 scopus 로고    scopus 로고
    • Mutations in ASCC3L1 on 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese family
    • Li N, Mei H, MacDonald IM, Jiao X, Hejtmancik JF (2010) Mutations in ASCC3L1 on 2q11.2 are associated with autosomal dominant retinitis pigmentosa in a Chinese family. Invest Ophthalmol Vis Sci 51:1036-1043.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 1036-1043
    • Li, N.1    Mei, H.2    MacDonald, I.M.3    Jiao, X.4    Hejtmancik, J.F.5
  • 12
    • 79957582993 scopus 로고    scopus 로고
    • Next generation sequencing of pooled samples reveals new SNRNP200 mutations associated with retinitis pigmentosa
    • Benaglio P, et al. (2011) Next generation sequencing of pooled samples reveals new SNRNP200 mutations associated with retinitis pigmentosa. Hum Mutat 32: E2246-E2258.
    • (2011) Hum Mutat , vol.32
    • Benaglio, P.1
  • 13
    • 0030981863 scopus 로고    scopus 로고
    • Identification of gene encoding a putative RNA-helicase, homologous to SKI2, in chromosome VII of Saccharomyces cerevisiae
    • DOI 10.1002/(SICI)1097-0061(19970330)13:4<391::AID-YEA92>3.0.CO;2-Q
    • Martegani E, et al. (1997) Identification of gene encoding a putative RNA-helicase, homologous to SKI2, in chromosome VII of Saccharomyces cerevisiae. Yeast 13:391-397. (Pubitemid 27192251)
    • (1997) Yeast , vol.13 , Issue.4 , pp. 391-397
    • Martegani, E.1    Vanoni, M.2    Mauri, I.3    Rudoni, S.4    Saliola, M.5    Alberghina, L.6
  • 14
    • 80555127349 scopus 로고    scopus 로고
    • DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation
    • Dango S, et al. (2011) DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. Mol Cell 44:373-384.
    • (2011) Mol Cell , vol.44 , pp. 373-384
    • Dango, S.1
  • 15
    • 69149090973 scopus 로고    scopus 로고
    • Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase
    • Pena V, et al. (2009) Common design principles in the spliceosomal RNA helicase Brr2 and in the Hel308 DNA helicase. Mol Cell 35:454-466.
    • (2009) Mol Cell , vol.35 , pp. 454-466
    • Pena, V.1
  • 16
    • 67650296697 scopus 로고    scopus 로고
    • Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2
    • Zhang L, et al. (2009) Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol 16:731-739.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 731-739
    • Zhang, L.1
  • 17
    • 34447132375 scopus 로고    scopus 로고
    • Structural basis for DNA duplex separation by a superfamily-2 helicase
    • DOI 10.1038/nsmb1246, PII NSMB1246
    • Büttner K, Nehring S, Hopfner KP (2007) Structural basis for DNA duplex separation by a superfamily-2 helicase. Nat Struct Mol Biol 14:647-652. (Pubitemid 47037060)
    • (2007) Nature Structural and Molecular Biology , vol.14 , Issue.7 , pp. 647-652
    • Buttner, K.1    Nehring, S.2    Hopfner, K.-P.3
  • 18
    • 0029782402 scopus 로고    scopus 로고
    • The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases
    • Lauber J, et al. (1996) The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. EMBO J 15:4001-4015. (Pubitemid 26289810)
    • (1996) EMBO Journal , vol.15 , Issue.15 , pp. 4001-4015
    • Lauber, J.1    Fabrizio, P.2    Teigelkamp, S.3    Lane, W.S.4    Hartmann, E.5    Luhrmann, R.6
  • 19
    • 77954958169 scopus 로고    scopus 로고
    • Prp43p contains a processive helicase structural architecture with a specific regulatory domain
    • Walbott H, et al. (2010) Prp43p contains a processive helicase structural architecture with a specific regulatory domain. EMBO J 29:2194-2204.
    • (2010) EMBO J , vol.29 , pp. 2194-2204
    • Walbott, H.1
  • 20
    • 77955453339 scopus 로고    scopus 로고
    • Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance
    • Weir JR, Bonneau F, Hentschel J, Conti E (2010) Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nuclear RNA processing and surveillance. Proc Natl Acad Sci USA 107:12139-12144.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12139-12144
    • Weir, J.R.1    Bonneau, F.2    Hentschel, J.3    Conti, E.4
  • 21
    • 0035104772 scopus 로고    scopus 로고
    • Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome
    • DOI 10.1016/S1097-2765(01)00169-1
    • Frilander MJ, Steitz JA (2001) Dynamic exchanges of RNA interactions leading to catalytic core formation in the U12-dependent spliceosome. Mol Cell 7:217-226. (Pubitemid 32162914)
    • (2001) Molecular Cell , vol.7 , Issue.1 , pp. 217-226
    • Frilander, M.J.1    Steitz, J.A.2
  • 22
    • 84864279894 scopus 로고    scopus 로고
    • New lives for old: Evolution of pseudoenzyme function illustrated by iRhoms
    • Adrain C, Freeman M (2012) New lives for old: Evolution of pseudoenzyme function illustrated by iRhoms. Nat Rev Mol Cell Biol 13:489-498.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 489-498
    • Adrain, C.1    Freeman, M.2
  • 23
    • 36248999467 scopus 로고    scopus 로고
    • Archaeal Hel308 Domain V Couples DNA Binding to ATP Hydrolysis and Positions DNA for Unwinding Over the Helicase Ratchet
    • DOI 10.1016/j.jmb.2007.10.004, PII S0022283607013083
    • Woodman IL, Briggs GS, Bolt EL (2007) Archaeal Hel308 domain V couples DNA binding to ATP hydrolysis and positions DNA for unwinding over the helicase ratchet. J Mol Biol 374:1139-1144. (Pubitemid 350122543)
    • (2007) Journal of Molecular Biology , vol.374 , Issue.5 , pp. 1139-1144
    • Woodman, I.L.1    Briggs, G.S.2    Bolt, E.L.3
  • 24
    • 0035053295 scopus 로고    scopus 로고
    • Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae
    • van Nues RW, Beggs JD (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157:1451-1467.
    • (2001) Genetics , vol.157 , pp. 1451-1467
    • Van Nues, R.W.1    Beggs, J.D.2
  • 25
    • 33745613530 scopus 로고    scopus 로고
    • The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP
    • DOI 10.1261/rna.55406
    • Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006) The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. RNA 12:1418-1430. (Pubitemid 43990565)
    • (2006) RNA , vol.12 , Issue.7 , pp. 1418-1430
    • Liu, S.1    Rauhut, R.2    Vornlocher, H.-P.3    Luhrmann, R.4
  • 26
    • 57649231776 scopus 로고    scopus 로고
    • Dynamic regulation of alternative splicing by silencers that modulate 5′ splice site competition
    • Yu Y, et al. (2008) Dynamic regulation of alternative splicing by silencers that modulate 5′ splice site competition. Cell 135:1224-1236.
    • (2008) Cell , vol.135 , pp. 1224-1236
    • Yu, Y.1


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