The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA

Genes and Development

Volumn 26, Issue 21, 2012, Pages 2422-2434

  Mozaffari Jovin, Sina ^a   Santos, Karine F ^b   Hsiao, He Hsuan ^a,d   Will, Cindy L ^a   Urlaub, Henning ^a,c   Wahl, Markus C ^b   Lührmann, Reinhard ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Pre mRNA splicing; RNA helicase; RNA protein complex; RNA protein cross linking; Spliceosome catalytic activation

Indexed keywords

PROTEIN; PRP8 PROTEIN; RNA HELICASE; SINGLE STRANDED RNA; SMALL NUCLEAR RNA; SMALL NUCLEAR RNA U4; SMALL NUCLEAR RNA U6; UNCLASSIFIED DRUG;

ARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA SPLICING; SACCHAROMYCES CEREVISIAE;

MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RIBONUCLEOPROTEIN, U5 SMALL NUCLEAR; RNA HELICASES; RNA, SMALL NUCLEAR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84868583242     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.200949.112     Document Type: Article

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