-
1
-
-
77955350443
-
Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development
-
Ahnfelt-Rønne J, Ravassard P, Pardanaud-Glavieux C, Scharfmann R, Serup P. 2010. Mesenchymal bone morphogenetic protein signaling is required for normal pancreas development. Diabetes 59:1948-1956.
-
(2010)
Diabetes
, vol.59
, pp. 1948-1956
-
-
Ahnfelt-Rønne, J.1
Ravassard, P.2
Pardanaud-Glavieux, C.3
Scharfmann, R.4
Serup, P.5
-
2
-
-
80053430193
-
Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance
-
Akerfeldt MC, Laybutt DR. 2011. Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance. Diabetes 60:2506-2514.
-
(2011)
Diabetes
, vol.60
, pp. 2506-2514
-
-
Akerfeldt, M.C.1
Laybutt, D.R.2
-
3
-
-
71949118923
-
Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor i
-
Böni-Schnetzler M, Boller S, Debray S, Bouzakri K, Meier DT, Prazak R, Kerr-Conte J, Pattou F, Ehses JA, Schuit FC, Donath MY. 2009. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I. Endocrinology 150:5218-5229.
-
(2009)
Endocrinology
, vol.150
, pp. 5218-5229
-
-
Böni-Schnetzler, M.1
Boller, S.2
Debray, S.3
Bouzakri, K.4
Meier, D.T.5
Prazak, R.6
Kerr-Conte, J.7
Pattou, F.8
Ehses, J.A.9
Schuit, F.C.10
Donath, M.Y.11
-
4
-
-
79952071106
-
Activation of vascular bone morphogenetic protein signaling in diabetes mellitus
-
Boström KI, Jumabay M, Matveyenko A, Nicholas SB, Yao Y. 2010. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res 108(4):446-457.
-
(2010)
Circ Res
, vol.108
, Issue.4
, pp. 446-457
-
-
Boström, K.I.1
Jumabay, M.2
Matveyenko, A.3
Nicholas, S.B.4
Yao, Y.5
-
5
-
-
70349145860
-
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity
-
Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, Tönjes A, Enigk B, Wolf S, Dietrich K, Koriath M, Scholz GH, Tseng Y-H, Dietrich A, Schön MR, Kiess W, Stumvoll M, Blüher M, Kovacs P. 2009. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes 58:2119-2128.
-
(2009)
Diabetes
, vol.58
, pp. 2119-2128
-
-
Böttcher, Y.1
Unbehauen, H.2
Klöting, N.3
Ruschke, K.4
Körner, A.5
Schleinitz, D.6
Tönjes, A.7
Enigk, B.8
Wolf, S.9
Dietrich, K.10
Koriath, M.11
Scholz, G.H.12
Tseng, Y.-H.13
Dietrich, A.14
Schön, M.R.15
Kiess, W.16
Stumvoll, M.17
Blüher, M.18
Kovacs, P.19
-
6
-
-
84926633380
-
Inhibition of beta cell growth and function by bone morphogenetic proteins
-
Bruun C, Christensen GL, Jacobsen MLB, Kanstrup MB, Jensen PR, Fjordvang H, Mandrup-Poulsen T, Billestrup N. 2014. Inhibition of beta cell growth and function by bone morphogenetic proteins. Diabetologia 57(12):2546-2554.
-
(2014)
Diabetologia
, vol.57
, Issue.12
, pp. 2546-2554
-
-
Bruun, C.1
Christensen, G.L.2
Jacobsen, M.L.B.3
Kanstrup, M.B.4
Jensen, P.R.5
Fjordvang, H.6
Mandrup-Poulsen, T.7
Billestrup, N.8
-
7
-
-
84892938274
-
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and b-cell protection
-
Christensen DP, Gysemans C, Lundh M, Dahllö f MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T. 2014. Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and b-cell protection. Proc Natl Acad Sci U S A 111:1055-1059.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 1055-1059
-
-
Christensen, D.P.1
Gysemans, C.2
Lundh, M.3
Dahllö, F.M.S.4
Noesgaard, D.5
Schmidt, S.F.6
Mandrup, S.7
Birkbak, N.8
Workman, C.T.9
Piemonti, L.10
Blaabjerg, L.11
Monzani, V.12
Fossati, G.13
Mascagni, P.14
Paraskevas, S.15
Aikin, R.A.16
Billestrup, N.17
Grunnet, L.G.18
Dinarello, C.A.19
Mathieu, C.20
Mandrup-Poulsen, T.21
more..
-
8
-
-
55549098894
-
Bmp2 signaling regulates the hepatic vs pancreatic fate decision
-
Chung W-S, Shin CH, Stainier DYR. 2008. Bmp2 signaling regulates the hepatic vs pancreatic fate decision. Dev Cell 15:738-748.
-
(2008)
Dev Cell
, vol.15
, pp. 738-748
-
-
Chung, W.-S.1
Shin, C.H.2
Stainier, D.Y.R.3
-
9
-
-
33144469523
-
Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype
-
Csiszar A, Ahmad M, Smith K, ELabinskyy N, Gao Q, Kaley G, Edwards JG, Wolin MS, Ungvari Z. 2006. Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Am J Pathol 168:629-638.
-
(2006)
Am J Pathol
, vol.168
, pp. 629-638
-
-
Csiszar, A.1
Ahmad, M.2
Smith, K.3
Elabinskyy, N.4
Gao, Q.5
Kaley, G.6
Edwards, J.G.7
Wolin, M.S.8
Ungvari, Z.9
-
10
-
-
79151478555
-
Type 2 diabetes as an inflammatory disease
-
Donath MY, Shoelson SE. 2011. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98-107.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 98-107
-
-
Donath, M.Y.1
Shoelson, S.E.2
-
11
-
-
34548431826
-
Increased number of islet-associated macrophages in type 2 diabetes
-
Ehses JA, Perren A, Eppler E, Ribaux P, Pospisilik JA, Maor-Cahn R, Gueripel X, Ellingsgaard H, Schneider MKJ, Biollaz G, Fontana A, Reinecke M, Homo-Delarche F, Donath MY. 2007. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56:2356-2370.
-
(2007)
Diabetes
, vol.56
, pp. 2356-2370
-
-
Ehses, J.A.1
Perren, A.2
Eppler, E.3
Ribaux, P.4
Pospisilik, J.A.5
Maor-Cahn, R.6
Gueripel, X.7
Ellingsgaard, H.8
Schneider, M.K.J.9
Biollaz, G.10
Fontana, A.11
Reinecke, M.12
Homo-Delarche, F.13
Donath, M.Y.14
-
12
-
-
67649364114
-
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
-
Eizirik DL, Colli ML, Ortis F. 2009. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5:219-226.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 219-226
-
-
Eizirik, D.L.1
Colli, M.L.2
Ortis, F.3
-
13
-
-
0035668779
-
A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
-
Eizirik DL, Mandrup-Poulsen T. 2001. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133.
-
(2001)
Diabetologia
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
14
-
-
84859254586
-
The human pancreatic islet transcriptome: Expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines
-
Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M. 2012. The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet 8:e1002552.
-
(2012)
PLoS Genet
, vol.8
, pp. e1002552
-
-
Eizirik, D.L.1
Sammeth, M.2
Bouckenooghe, T.3
Bottu, G.4
Sisino, G.5
Igoillo-Esteve, M.6
Ortis, F.7
Santin, I.8
Colli, M.L.9
Barthson, J.10
Bouwens, L.11
Hughes, L.12
Gregory, L.13
Lunter, G.14
Marselli, L.15
Marchetti, P.16
McCarthy, M.I.17
Cnop, M.18
-
15
-
-
84907222786
-
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
-
Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, Hansson KB, Finotello F, Uvebrant K, Ofori JK, Di Camillo B, Krus U, Cilio CM, Hansson O, Eliasson L, Rosengren AH, Renström E, Wollheim CB, Groop L. 2014. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A 111:13924-13929.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 13924-13929
-
-
Fadista, J.1
Vikman, P.2
Laakso, E.O.3
Mollet, I.G.4
Esguerra, J.L.5
Taneera, J.6
Storm, P.7
Osmark, P.8
Ladenvall, C.9
Prasad, R.B.10
Hansson, K.B.11
Finotello, F.12
Uvebrant, K.13
Ofori, J.K.14
Di Camillo, B.15
Krus, U.16
Cilio, C.M.17
Hansson, O.18
Eliasson, L.19
Rosengren, A.H.20
Renström, E.21
Wollheim, C.B.22
Groop, L.23
more..
-
16
-
-
0028242526
-
Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): Comparison of the structures and promoter regions of BMP-2 and BMP-4 genes
-
Feng JQ, Harris MA, Ghosh-Choudhury N, Feng M, Mundy GR, Harris SE. 1994. Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. Biochim Biophys Acta 1218:221-224.
-
(1994)
Biochim Biophys Acta
, vol.1218
, pp. 221-224
-
-
Feng, J.Q.1
Harris, M.A.2
Ghosh-Choudhury, N.3
Feng, M.4
Mundy, G.R.5
Harris, S.E.6
-
17
-
-
0043237419
-
NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro
-
Feng JQ, Xing L, Zhang J-H, Zhao M, Horn D, Chan J, Boyce BF, Harris SE, Mundy GR, Chen D. 2003. NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro. J Biol Chem 278:29130-29135.
-
(2003)
J Biol Chem
, vol.278
, pp. 29130-29135
-
-
Feng, J.Q.1
Xing, L.2
Zhang, J.-H.3
Zhao, M.4
Horn, D.5
Chan, J.6
Boyce, B.F.7
Harris, S.E.8
Mundy, G.R.9
Chen, D.10
-
18
-
-
0043136513
-
Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes
-
Fukui N, Zhu Y, Maloney WJ, Clohisy J, Sandell LJ. 2003. Stimulation of BMP-2 expression by pro-inflammatory cytokines IL-1 and TNF-alpha in normal and osteoarthritic chondrocytes. J Bone Joint Surg Am 85-A (Suppl. 3): 59-66.
-
(2003)
J Bone Joint Surg Am
, vol.85 A
, pp. 59-66
-
-
Fukui, N.1
Zhu, Y.2
Maloney, W.J.3
Clohisy, J.4
Sandell, L.J.5
-
20
-
-
33847256507
-
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion
-
Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H. 2007. BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion. Cell Metab 5:207-219.
-
(2007)
Cell Metab
, vol.5
, pp. 207-219
-
-
Goulley, J.1
Dahl, U.2
Baeza, N.3
Mishina, Y.4
Edlund, H.5
-
21
-
-
0034652287
-
Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
-
Gradwohl G, Dierich A, LeMeur M, Guillemot F. 2000. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 97:1607-1611.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1607-1611
-
-
Gradwohl, G.1
Dierich, A.2
LeMeur, M.3
Guillemot, F.4
-
22
-
-
0034601692
-
Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genes
-
Helvering LM, Sharp RL, Ou X, Geiser AG. 2000. Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genes. Gene 256:123-138.
-
(2000)
Gene
, vol.256
, pp. 123-138
-
-
Helvering, L.M.1
Sharp, R.L.2
Ou, X.3
Geiser, A.G.4
-
23
-
-
33744962512
-
BMP4 regulates pancreatic progenitor cell expansion through Id2
-
Hua H, Zhang Y-Q, Dabernat S, Kritzik M, Dietz D, Sterling L, Sarvetnick N. 2006. BMP4 regulates pancreatic progenitor cell expansion through Id2. J Biol Chem 281:13574-13580.
-
(2006)
J Biol Chem
, vol.281
, pp. 13574-13580
-
-
Hua, H.1
Zhang, Y.-Q.2
Dabernat, S.3
Kritzik, M.4
Dietz, D.5
Sterling, L.6
Sarvetnick, N.7
-
24
-
-
75749108893
-
Repressive BMP2 gene regulatory elements near the BMP2 promoter
-
Jiang S, Chandler RL, Fritz DT, Mortlock DP, Rogers MB. 2010. Repressive BMP2 gene regulatory elements near the BMP2 promoter. Biochem Biophys Res Commun 392:124-128.
-
(2010)
Biochem Biophys Res Commun
, vol.392
, pp. 124-128
-
-
Jiang, S.1
Chandler, R.L.2
Fritz, D.T.3
Mortlock, D.P.4
Rogers, M.B.5
-
25
-
-
84883427930
-
The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice
-
Koga M, Engberding N, Dikalova AE, Chang KH, Seidel-Rogol B, Long JS, Lassegue B, Jo H, Griendling KK. 2013. The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice. AJP Heart Circ Physiol 305:H747-H755.
-
(2013)
AJP Heart Circ Physiol
, vol.305
, pp. H747-H755
-
-
Koga, M.1
Engberding, N.2
Dikalova, A.E.3
Chang, K.H.4
Seidel-Rogol, B.5
Long, J.S.6
Lassegue, B.7
Jo, H.8
Griendling, K.K.9
-
26
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
Larsen CM, Faulenbach M, Vaag A, Vølund A, Ehses JA, Seifert B, Mandrup-Poulsen T, Donath MY. 2007. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356:1517-1526.
-
(2007)
N Engl J Med
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Vølund, A.4
Ehses, J.A.5
Seifert, B.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
27
-
-
0142072322
-
Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis
-
Lories RJU, Derese I, Ceuppens JL, Luyten FP. 2003. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum 48:2807-2818.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2807-2818
-
-
Lories, R.J.U.1
Derese, I.2
Ceuppens, J.L.3
Luyten, F.P.4
-
28
-
-
0036738398
-
Glucose-induced beta-cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY. 2002. Glucose-induced beta-cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 110:851-860.
-
(2002)
J Clin Invest
, vol.110
, pp. 851-860
-
-
Maedler, K.1
Sergeev, P.2
Ris, F.3
Oberholzer, J.4
Joller-Jemelka, H.I.5
Spinas, G.A.6
Kaiser, N.7
Halban, P.A.8
Donath, M.Y.9
-
29
-
-
0029817047
-
The role of interleukin-1 in the pathogenesis of IDDM
-
Mandrup-Poulsen DT. 1996. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 39:1005-1029.
-
(1996)
Diabetologia
, vol.39
, pp. 1005-1029
-
-
Mandrup-Poulsen, D.T.1
-
30
-
-
0030886674
-
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/ neuroD-deficient mice
-
Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. 1997. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/ neuroD-deficient mice. Genes Dev 11:2323-2334.
-
(1997)
Genes Dev
, vol.11
, pp. 2323-2334
-
-
Naya, F.J.1
Huang, H.P.2
Qiu, Y.3
Mutoh, H.4
DeMayo, F.J.5
Leiter, A.B.6
Tsai, M.J.7
-
31
-
-
0034622449
-
The interleukin-1 receptor/Toll-like receptor superfamily: Signal transduction during inflammation and host defense
-
O'Neill LA. 2000. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 2000:re1.
-
(2000)
Sci STKE
, vol.2000
, pp. re1
-
-
O'Neill, L.A.1
-
32
-
-
67650685521
-
Islet-associated macrophages in type 2 diabetes
-
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG. 2009. Islet-associated macrophages in type 2 diabetes. Diabetologia 52:1686-1688.
-
(2009)
Diabetologia
, vol.52
, pp. 1686-1688
-
-
Richardson, S.J.1
Willcox, A.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
33
-
-
18544371055
-
The effect of suppressor of cytokine signaling 3 on GH signaling in B-cells
-
Rønn SG, Hansen JA, Lindberg K, Karlsen AE, Billestrup N. 2002. The effect of suppressor of cytokine signaling 3 on GH signaling in B-cells. Mol Endocrinol 16:2124-2134.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2124-2134
-
-
Rønn, S.G.1
Hansen, J.A.2
Lindberg, K.3
Karlsen, A.E.4
Billestrup, N.5
-
34
-
-
70349167300
-
Abnormal glucose metabolism in heterozygous mutant mice for a type i receptor required for BMP signaling
-
Scott GJ, Ray MK, Ward T, McCann K, Peddada S, Jiang F-X, Mishina Y. 2009. Abnormal glucose metabolism in heterozygous mutant mice for a type I receptor required for BMP signaling. Genesis 47:385-391.
-
(2009)
Genesis
, vol.47
, pp. 385-391
-
-
Scott, G.J.1
Ray, M.K.2
Ward, T.3
McCann, K.4
Peddada, S.5
Jiang, F.-X.6
Mishina, Y.7
-
35
-
-
79551505124
-
Association of serum bone morphogenetic protein 4 levels with obesity and metabolic syndrome in non-diabetic individuals
-
Son J-W, Kim M-K, Park Y-M, Baek K-H, Yoo S-J, Song K-H, Son HS, Yoon K-H, Lee, WC, Cha B-Y, Son H-Y, Kwon, HS. 2011. Association of serum bone morphogenetic protein 4 levels with obesity and metabolic syndrome in non-diabetic individuals. Endocr J 58:39-46.
-
(2011)
Endocr J
, vol.58
, pp. 39-46
-
-
Son, J.-W.1
Kim, M.-K.2
Park, Y.-M.3
Baek, K.-H.4
Yoo, S.-J.5
Song, K.-H.6
Son, H.S.7
Yoon, K.-H.8
Lee, W.C.9
Cha, B.-Y.10
Son, H.-Y.11
Kwon, H.S.12
-
36
-
-
77951627143
-
BMPs: From bone to body morphogenetic proteins
-
Wagner DO, Sieber C, Bhushan R, Börgermann JH, Graf D, Knaus P. 2010. BMPs: from bone to body morphogenetic proteins. Sci Signal 3:mr1.
-
(2010)
Sci Signal
, vol.3
, pp. mr1
-
-
Wagner, D.O.1
Sieber, C.2
Bhushan, R.3
Börgermann, J.H.4
Graf, D.5
Knaus, P.6
-
37
-
-
18244370762
-
Inflammation, stress, and diabetes
-
Wellen KE, Hotamisligil GS. 2005. Inflammation, stress, and diabetes. J Clin Invest 115:1111-1119.
-
(2005)
J Clin Invest
, vol.115
, pp. 1111-1119
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
|