Inhibition of Id1 augments insulin secretion and protects against high-fat diet-induced glucose intolerance

Diabetes

Volumn 60, Issue 10, 2011, Pages 2506-2514

  Åkerfeldt, Mia C ^a   Laybutt, D Ross ^a  

^a ST VINCENT S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INHIBITOR OF DIFFERENTIATION 1; INSULIN; PALMITIC ACID; SMALL INTERFERING RNA; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC INTAKE; CELL DIFFERENTIATION; GENE EXPRESSION; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN TOLERANCE TEST; LIPID DIET; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; BLOOD GLUCOSE; CELL LINE; DIETARY FATS; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; PALMITIC ACID; RNA, SMALL INTERFERING;

EID: 80053430193     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0083     Document Type: Article

References (51)

1. Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia 2009;52:1003-1012
2. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-1812 (Pubitemid 44033300)
3. Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir S. Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab 2009;11(Suppl. 4):82-90
4. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Betacell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-110 (Pubitemid 36042113)
5. Rahier J, Guiot Y, Goebbels RM, Sempoux C, Henquin JC. Pancreatic betacell mass in European subjects with type 2 diabetes. Diabetes Obes Metab 2008;10(Suppl. 4):32-42
6. Jonas JC, Sharma A, Hasenkamp W, et al. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999;274:14112-14121
7. Tokuyama Y, Sturis J, DePaoli AM, et al. Evolution of beta-cell dysfunction in the male Zucker diabetic fatty rat. Diabetes 1995;44:1447-1457
8. Kjørholt C, Åkerfeldt MC, Biden TJ, Laybutt DR. Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. Diabetes 2005;54:2755-2763 (Pubitemid 41233599)
9. Laybutt DR, Glandt M, Xu G, et al. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem 2003;278:2997-3005 (Pubitemid 36801207)
10. Laybutt DR, Hawkins YC, Lock J, et al. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia 2007;50:2117-2125 (Pubitemid 47373842)
11. Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 2005;5:603-614 (Pubitemid 41081386)
12. Ruzinova MB, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol 2003;13:410-418 (Pubitemid 36897645)
13. Yokota Y, Mori S. Role of Id family proteins in growth control. J Cell Physiol 2002;190:21-28
14. Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000;113:3897-3905 (Pubitemid 32194515)
15. Sikder HA, Devlin MK, Dunlap S, Ryu B, Alani RM. Id proteins in cell growth and tumorigenesis. Cancer Cell 2003;3:525-530 (Pubitemid 36808647)
16. Benezra R, Davis RL, Lockshon D, Turner DL, Weintraub H. The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell 1990;61:49-59
17. Yan W, Young AZ, Soares VC, Kelley R, Benezra R, Zhuang Y. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol Cell Biol 1997;17:7317-7327 (Pubitemid 27505961)
18. Busch AK, Cordery D, Denyer GS, Biden TJ. Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function. Diabetes 2002;51:977-987 (Pubitemid 34438339)
19. Webb GC, Akbar MS, Zhao C, Steiner DF. Expression profiling of pancreatic beta cells: glucose regulation of secretory and metabolic pathway genes. Proc Natl Acad Sci USA 2000;97:5773-5778 (Pubitemid 30367474)
20. Wice BM, Bernal-Mizrachi E, Permutt MA. Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells. Diabetologia 2001;44:453-463 (Pubitemid 32324356)
21. Lyden D, Young AZ, Zagzag D, et al. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature 1999;401:670-677
22. Åkerfeldt MC, Howes J, Chan JY, et al. Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling. Diabetes 2008;57:3034-3044
23. Pan L, Sato S, Frederick JP, Sun XH, Zhuang Y. Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene. Mol Cell Biol 1999;19:5969-5980 (Pubitemid 29399302)
24. Schmitz-Peiffer C, Laybutt DR, Burchfield JG, et al. Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 2007;6:320-328 (Pubitemid 47450184)
25. Bernardo AS, Hay CW, Docherty K. Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell. Mol Cell Endocrinol 2008;294:1-9
26. Kebede M, Alquier T, Latour MG, Semache M, Tremblay C, Poitout V. The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. Diabetes 2008;57:2432-2437
27. Kebede MA, Alquier T, Latour MG, Poitout V. Lipid receptors and islet function: therapeutic implications? Diabetes Obes Metab 2009;11(Suppl. 4):10-20
28. Alquier T, Peyot ML, Latour MG, et al. Deletion of GPR40 impairs glucoseinduced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. Diabetes 2009;58:2607-2615
29. Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev 2008;29:351-366 (Pubitemid 351679704)
30. Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008;29:42-61 (Pubitemid 351252746)
31. Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat Cell Biol 2000;2:326-332
32. Wang XZ, Lawson B, Brewer JW, et al. Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol Cell Biol 1996;16:4273-4280 (Pubitemid 26251229)
33. Laybutt DR, Kaneto H, Hasenkamp W, et al. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes 2002;51:413-423
34. Miyazaki J, Araki K, Yamato E, et al. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 1990;127:126-132 (Pubitemid 20228111)
35. Bollheimer LC, Skelly RH, Chester MW, McGarry JD, Rhodes CJ. Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 1998;101:1094-1101 (Pubitemid 28125288)
36. Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994;93:870-876 (Pubitemid 24072831)
37. Mathews CE, Leiter EH. Constitutive differences in antioxidant defense status distinguish alloxan-resistant and alloxan-susceptible mice. Free Radic Biol Med 1999;27:449-455 (Pubitemid 29395440)
38. Tanaka K, Pracyk JB, Takeda K, et al. Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism. J Biol Chem 1998;273:25922-25928 (Pubitemid 28475823)
39. Cordle SR, Henderson E, Masuoka H, Weil PA, Stein R. Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Mol Cell Biol 1991;11:1734-1738 (Pubitemid 21895535)
40. Swarbrick A, Åkerfeldt MC, Lee CS, et al. Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix-loop-helix protein Id1. Oncogene 2005;24:381-389 (Pubitemid 40188586)
41. Hua H, Sarvetnick N. ID2 promotes the expansion and survival of growth-arrested pancreatic beta cells. Endocrine 2007;32:329-337
42. Hua H, Zhang YQ, Dabernat S, et al. BMP4 regulates pancreatic progenitor cell expansion through Id2. J Biol Chem 2006;281:13574-13580 (Pubitemid 43855271)
43. Garnett KE, Chapman P, Chambers JA, Waddell ID, Boam DS. Differential gene expression between Zucker fatty rats and Zucker diabetic fatty rats: a potential role for the immediate-early gene Egr-1 in regulation of beta cell proliferation. J Mol Endocrinol 2005;35:13-25 (Pubitemid 41167622)
44. Georgia S, Hinault C, Kawamori D, et al. Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 2010;59:987-996
45. Kushner JA, Ciemerych MA, Sicinska E, et al. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Mol Cell Biol 2005;25:3752-3762 (Pubitemid 40559580)
46. Cozar-Castellano I, Harb G, Selk K, et al. Lessons from the first comprehensive molecular characterization of cell cycle control in rodent insulinoma cell lines. Diabetes 2008;57:3056-3068
47. Pelengaris S, Khan M, Evan GI. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002;109:321-334 (Pubitemid 34606875)
48. Laybutt DR, Weir GC, Kaneto H, et al. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes 2002;51:1793-1804 (Pubitemid 34564292)
49. Gu C, Stein GH, Pan N, et al. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab 2010;11:298-310
50. Naya FJ, Huang HP, Qiu Y, et al. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroDdeficient mice. Genes Dev 1997;11:2323-2334 (Pubitemid 27408530)
51. Kaneto H, Sharma A, Suzuma K, et al. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem 2002;277:12998-13006 (Pubitemid 34952668)