Bone Morphogenetic Proteins 2 and 6, Expressed in Arthritic Synovium, are Regulated by Proinflammatory Cytokines and Differentially Modulate Fibroblast-Like Synoviocyte Apoptosis

Arthritis and Rheumatism

Volumn 48, Issue 10, 2003, Pages 2807-2818

  Lories, Rik J U ^a   Derese, Inge ^a   Ceuppens, Jan L ^a   Luyten, Frank P ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Lab for Skeletal Devmt/Jt Disord   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 6; COMPLEMENTARY DNA; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTHRITIS; ARTICLE; CLINICAL ARTICLE; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM;

ADULT; AGED; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARTHRITIS, RHEUMATOID; BONE MORPHOGENETIC PROTEINS; CELL DIVISION; CELLS, CULTURED; FEMALE; FIBROBLASTS; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; MALE; MIDDLE AGED; NITRIC OXIDE; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0142072322     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11389     Document Type: Article

References (43)

1. Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, Macfarlane JD, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor α monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41:1552-63.
2. Braun J, Brandt J, Listing J, Zink A, Alten R, Golder W, et al. Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial. Lancet 2002;359:1187-93.
3. Panayi GS, Corrigall VM, Pitzalis C. Pathogenesis of rheumatoid arthritis. The role of T cells and other beasts. Rheum Dis Clin North Am 2001;27:317-34.
4. Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM. T cell activation in rheumatoid synovium is B cell dependent. J Immunol 2001;167:4710-8.
5. Firestein GS, Zvaifler NJ. How important are T cells in chronic rheumatoid synovitis? II. T cell-independent mechanisms from beginning to end. Arthritis Rheum 2002;46:298-308.
6. Firestein GS. Invasive fibroblast-like synoviocytes in rheumatoid arthritis: passive responders or transformed aggressors? Arthritis Rheum 1996;39:1781-90.
7. Kinne RW, Liehr T, Beensen V, Kunisch E, Zimmermann T, Holland H, et al. Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases. Arthritis Res 2001;3:319-30.
8. Marinova-Mutafchieva L, Taylor P, Funa K, Maini RN, Zvaifler NJ. Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint. Arthritis Rheum 2000;43:2046-55.
9. De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 2001;44:1928-42.
10. Luyten FP, Dell'Accio F, De Bari C. Skeletal tissue engineering: opportunities and challenges. Best Pract Res Clin Rheumatol 2001;15:759-69.
11. Luyten FP, Lories RJ, De Bari C, Devalck D, Dell'Accio F. Bone morphogenetic proteins and the synovial joint. In: Vukicevic S, Sampath KT, editors. Progress in inflammation research. Basel (Switzerland): Birckhauser Verlag; 2002. p. 223-48.
12. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753-91.
13. Urist MR. Bone: formation by autoinduction. Science 1965;150:893-9.
14. Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-34.
15. Hogan BL. Bone morphogenetic proteins in development. Curr Opin Genet Dev 1996;6:432-8.
16. Wozney JM, Rosen V. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop 1998;26-37.
17. Nakase T, Nomura S, Yoshikawa H, Hashimoto J, Hirota S, Kitamura Y, et al. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing. J Bone Miner Res 1994;9:651-9.
18. Yang X, Chen L, Xu X, Li C, Huang C, Deng CX. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J Cell Biol 2001;153:35-46.
19. Van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB. Differential effects of local application of BMP-2 or TGF-beta 1 on both articular cartilage composition and osteophyte formation. Osteoarthritis Cartilage 1998;6:306-17.
20. Scharstuhl A, Glansbeek HL, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB. Inhibition of endogenous TGF-β during experimental osteoarthritis prevents osteophyte formation and impairs cartilage repair. J Immunol 2002;169:507-14.
21. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
22. Dougados M, van der Linden S, Juhlin R, Huitfeldt B, Amor B, Calin A, et al, and the European Spondylarthropathy Study Group. The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 1991;34:1218-30.
23. Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986;29:1039-49.
24. Baeten D, van Den Bosch F, Elewaut D, Stuer A, Veys EM, de Keyser F. Needle arthroscopy of the knee with synovial biopsy sampling: technical experience in 150 patients. Clin Rheumatol 1999;18:434-41.
25. Zimmermann T, Kunisch E, Pfeiffer R, Hirth A, Stahl H, Sack U, et al. Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture-primary culture cells markedly differ from fourth-passage cells. Arthritis Res 2001;3:72-6.
26. Chen S, Guttridge DC, Tang E, Shi S, Guan K, Wang CY. Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling. J Biol Chem 2001;276:39259-63.
27. Bhatia M, Bonnet D, Wu D, Murdoch B, Wrana J, Gallacher L, et al. Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J Exp Med 1999;189:1139-48.
28. Fowler MJ Jr, Neff MS, Borghaei RC, Pease EA, Mochan E, Thornton RD. Induction of bone morphogenetic protein-2 by interleukin-1 in human fibroblasts. Biochem Biophys Res Commun 1998;248:450-3.
29. Ferguson CM, Miclau T, Hu D, Alpern E, Helms JA. Common molecular pathways in skeletal morphogenesis and repair. Ann N Y Acad Sci 1998;857:33-42.
30. Erlacher L, Ng C-K, Ullrich R, Krieger S, Luyten FP. Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro. Arthritis Rheum 1998;41:263-73.
31. Wan M, Shi X, Feng X, Cao X. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegerin gene expression. J Biol Chem 2001;276:10119-25.
32. Hofbauer LC, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S. Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines. Biochem Biophys Res Commun 1998;250:776-81.
33. Koide M, Murase Y, Yamato K, Noguchi T, Okahashi N, Nishihara T. Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2. Biochem Biophys Res Commun 1999;259:97-102.
34. Cunningham NS, Paralkar V, Reddi AH. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta 1 mRNA expression. Proc Natl Acad Sci U S A 1992;89:11740-4.
35. Massague J. How cells read TGF-beta signals. Nat Rev Mol Cell Biol 2000;1:169-78.
36. Graham A, Francis-West P, Brickell P, Lumsden A. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 1994;372:684-6.
37. Macias D, Ganan Y, Sampath TK, Piedra ME, Ros MA, Hurle JM. Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development. Development 1997;124:1109-17.
38. Hay E, Lemonnier J, Fromigue O, Marie PJ. Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway. J Biol Chem 2001;276:29028-36.
39. Kawamura C, Kizaki M, Yamato K, Uchida H, Fukuchi Y, Hattori Y, et al. Bone morphogenetic protein-2 induces apoptosis in human myeloma cells with modulation of STAT3. Blood 2000;96:2005-11.
40. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T. BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 2000;275:17647-52.
41. Izumi M, Fujio Y, Kunisada K, Negoro S, Tone E, Funamoto M, et al. Bone morphogenetic protein-2 inhibits serum deprivation-induced apoptosis of neonatal cardiac myocytes through activation of the Smad1 pathway. J Biol Chem 2001;276:31133-41.
42. Wang Y, Chang CF, Morales M, Chou J, Chen HL, Chiang YH, et al. Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats. Stroke 2001;32:2170-8.
43. Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, et al. Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. J Cell Sci 1999;112(Pt 20):3519-27.