Notch1 signaling controls cell proliferation, apoptosis and differentiation in lung carcinoma

Lung Cancer

Volumn 85, Issue 2, 2014, Pages 131-140

  Wael, Hassan ^a,b   Yoshida, Ryoji ^a   Kudoh, Shinji ^a   Hasegawa, Kohki ^a   Niimori Kita, Kanako ^a   Ito, Takaaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b Suez Canal University Faculty of Medicine   (Egypt)

Author keywords

Apoptosis; Cell proliferation; Epithelial phenotype; Human lung carcinoma; Neuro endocrine differentiation; Notch1 signaling

Indexed keywords

ALCIAN BLUE; CASPASE 3; NOTCH1 RECEPTOR; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNTING; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING; ANIMAL; CANCER GRADING; CARCINOMA; DISEASE MODEL; GENE EXPRESSION; GENE SILENCING; GENETICS; KNOCKOUT MOUSE; LUNG TUMOR; METABOLISM; NON SMALL CELL LUNG CANCER; PATHOLOGY; SMALL CELL LUNG CANCER; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; APOPTOSIS; CARCINOMA, NEUROENDOCRINE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HETEROGRAFTS; HUMANS; LUNG NEOPLASMS; MICE; MICE, KNOCKOUT; NEOPLASM GRADING; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; SMALL CELL LUNG CARCINOMA;

EID: 84904115667     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2014.05.001     Document Type: Article

References (30)

1. Méndez M., Custodio A., Provencio M. New molecular targeted therapies for advanced non-small-cell lung cancer. J Thorac Dis 2011, 3:30-56.
2. Rizzo P., Osipo C., Foreman K., Golde T., Osborne B., Miele L. Rational targeting of Notch signaling in cancer. Oncogene 2008, 27:5124-5131.
3. Roy M., Pear W., Aster J. The multifaceted role of Notch in cancer. Curr Opin Genet Dev 2007, 17:52-59.
4. Li Y., Burns J.A., Cheney C.A., Zhang N., Vitelli S., Wang F., et al. Distinct expression profiles of Notch-1 protein in human solid tumors: implications for development of targeted therapeutic monoclonal antibodies. Biologics 2010, 4:163-171.
5. Kunnimalaiyaan M.M., Chen H.H. Tumor suppressor role of Notch1 signaling in neuroendocrine tumors. Oncologist 2007, 12:535-542.
6. Sriuranpong V., Borges M.W., Ravi R.K., Arnold D.R., Nelkin B.D., Baylin S.B., et al. Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 2001, 6:3200-3205.
7. Zheng Q., Qin H., Zhang H., Li J., Hou L., Wang H., et al. Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol Rep 2007, 17:847-852.
8. Zhang S., Long H., Yang Y.L., Wang Y., Hsieh D., Li W., et al. Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med 2013, 17:854-862.
9. Talora C., Sgroi D.C., Crum C.P., Dotto G.P. Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev 2002, 16:2252-2263.
10. Yao J., Duan L., Fan M., Yuan J., Wu X. Notch1 induces cell cycle arrest and apoptosis in human cervical cancer cells: involvement of nuclear factor kappa B inhibition. Int J Gynecol Cancer 2007, 17:502-510.
11. Sullivan J.P., Spinola M., Dodge M., Raso M.G., Behrens C., Gao B., et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Res 2010, 23:9937-9948.
12. Ji X., Wang Z., Geamanu A., Sarkar F.H., Gupta S.V. Inhibition of cell growth and induction of apoptosis in non-small cell lung cancer cells by delta-tocotrienol is associated with notch-1 down-regulation. J Cell Biochem 2011, 10:2773-2783.
13. Artavanis-Tsakonas S., Rand D., Lake R. Notch signaling: cell fate control and signal integration in development. Science 1999, 284:770-776.
14. Yoshida R., Nagata M., Nakayama H., Niimori-Kita K., Hassan W., Tanaka T., et al. The pathological significance of Notch1 in oral squamous cell carcinoma. Lab Invest 2013, 93:1068-1081.
15. Haskell C., Sullivan A. Comparative survival in tissue culture of normal and neoplastic human cells exposed to adriamycin. Cancer Res 1974, 34:2991-2994.
16. Wu L., Griffin J.D. Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis. Semin Cancer Biol 2004, 14:348-356.
17. Zagouras P., Stifani S., Blaumueller C.M., Carcangiu M.L., Artavanis-Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci USA 1995, 92:6414-6418.
18. Platta C.S., Greenblatt D.Y., Kunnimalaiyaan M., Chen H. The HDAC inhibitor trichostatin A inhibits growth of small cell lung cancer cells. J Surg Res 2007, 142:219-226.
19. Platta C.S., Greenblatt D.Y., Kunnimalaiyaan M., Chen H. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res 2008, 148:31-37.
20. Gutierrez A., Look A. NOTCH and PI3K-AKT pathways intertwined. Cancer Cell 2007, 12:411-413.
21. Bedogni B., Warneke J.A., Nickoloff B.J., Giaccia A.J., Powel M.B. Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest 2008, 118:3660-3670.
22. Meurette O., Stylianou S., Rock R., Collu G.M., Gilmore A.P., Brennan K. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res 2009, 69:5015-5022.
23. Rangarajan A., Syal R., Selvarajah S., Chakrabarti O., Sarin A., Krishna S. Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology 2001, 286:23-30.
24. Yang X., Klein R., Tian X., Cheng H.T., Kopan R., Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 2004, 269:81-94.
25. Sriuranpong V., Borges M.W., Strock C.L., Nakakura E.K., Watkins D.N., Blaumueller C.M., et al. Notch signaling induces rapid degradation of achaete-scute homolog 1. Mol Cell Biol 2002, 22:3129-3139.
26. Shan L., Aster J.C., Sklar J., Sunday M.E. Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice. Am J Physiol Lung Cell Mol Physiol 2007, 292:L500-L509.
27. Ito T., Udaka N., Yazawa T., Okudela K., Hayashi H., Sudo T., et al. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development 2000, 127:3913-3921.
28. Cho E., Ha S., Park S., Lee J., Park J., Jung S., et al. Notch 1 and Notch 3 and prognosis of resected non-small cell lung cancer. J Clin Oncol 2010, 28:e21089.
29. Donnem T., Andersen S., Al-Shibli K., Al-Saad S., Busund L.T., Bremnes R.M. Prognostic impact of Notch ligands and receptors in Non small cell lung cancer. Cancer 2010, 116:5676-5685.
30. Wang N.J., Sanborn Z., Arnett K.L., Bayston L.J., Liao W., Proby C.M., et al. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci USA 2011, 198:17761-17766.