Human GRK4γ 142V Variant Promotes Angiotensin II Type i Receptor-Mediated Hypertension via Renal Histone Deacetylase Type 1 Inhibition

Hypertension

Volumn 67, Issue 2, 2016, Pages 325-334

  Wang, Zheng ^a   Zeng, Chunyu ^b   Villar, Van Anthony M ^c,d   Chen, Shi You ^f   Konkalmatt, Prasad ^a   Wang, Xiaoyan ^c,d   Asico, Laureano D ^c,d   Jones, John E ^c,d   Yang, Yu ^c,d   Sanada, Hironobu ^g   Felder, Robin A ^h   Eisner, Gilbert M ^a   Weir, Matthew R ^c,d   Armando, Ines ^c,d   Jose, Pedro A ^c,d,e,i  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c Chongqing Institute of Cardiology   (China)

^d Division of Nephrology   (United Kingdom)

^e UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF GEORGIA   (United States)

^g NATIONAL VETERINARY ASSAY LABORATORY   (Japan)

^h UNIVERSITY OF VIRGINIA   (United States)

ⁱ GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

Angiotensin II type 1 receptor; dopamine D1 receptors; G protein coupled receptor kinase 4; histone deacetylase; hypertension; knockout mice

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; DOPAMINE 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 4; HISTONE DEACETYLASE 1; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BENZIMIDAZOLE DERIVATIVE; CANDESARTAN; GRK4 PROTEIN, HUMAN; RNA; TETRAZOLE DERIVATIVE;

AGTR1A GENE; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CYTOPLASM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE; GENE DELETION; GRK4 GAMMA GENE; HYPERTENSION; MOUSE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM URINE LEVEL; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOBLOTTING; KIDNEY; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BENZIMIDAZOLES; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 4; GENE EXPRESSION REGULATION; HEK293 CELLS; HISTONE DEACETYLASE 1; HUMANS; HYPERTENSION; IMMUNOBLOTTING; KIDNEY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, ANGIOTENSIN, TYPE 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TETRAZOLES;

EID: 84954314653     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05962     Document Type: Article

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