Common variants of the G protein-coupled receptor type 4 are associated with human essential hypertension and predict the blood pressure response to angiotensin receptor blockade

Pharmacogenomics Journal

Volumn 16, Issue 1, 2016, Pages 3-9

  Sanada, H ^a,b   Yoneda, M ^a,b   Yatabe, J ^a,b   Williams, S M ^c,d   Bartlett, J ^c,d   White, M J ^c,d   Gordon, L N ^c,d   Felder, R A ^e   Eisner, G M ^f   Armando, I ^g   Jose, P A ^g  

^a NATIONAL VETERINARY ASSAY LABORATORY   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^f GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ANGIOTENSIN RECEPTOR ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; CANDESARTAN; CYTOSINE; DIURETIC AGENT; GUANINE; LOSARTAN; TELMISARTAN; THYMINE; VALSARTAN; G PROTEIN COUPLED RECEPTOR; GENETIC MARKER; GPR4 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; CASE CONTROL STUDY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ESSENTIAL HYPERTENSION; FEMALE; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GRK4 GENE; HETEROZYGOTE; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; ASIAN CONTINENTAL ANCESTRY GROUP; DRUG EFFECTS; GENETIC ASSOCIATION STUDY; GENETIC MARKER; GENETICS; HAPLOTYPE; HYPERTENSION; MIDDLE AGED; PATHOPHYSIOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANGIOTENSIN RECEPTOR ANTAGONISTS; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC LOCI; GENETIC MARKERS; HAPLOTYPES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84956786846     PISSN: 1470269X     EISSN: 14731150     Source Type: Journal    
DOI: 10.1038/tpj.2015.6     Document Type: Article

References (61)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 36: 217-223.
2. Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation 2011; 12: 933-944.
3. Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. JAMA 2010; 303: 2043-2050.
4. Roden DM, Johnson JA, Kimmel SE, Krauss RM, Medina MW, Shuldiner A et al. Cardiovascular pharmacogenomics. Circ Res 2011; 109: 807-820.
5. Harrap SB. Blood pressure genetics: time to focus. J Am Soc Hypertens 2009; 3: 231-237.
6. Aburto NJ, Ziolkovska A, Hooper L, Elliott P, Cappuccio FP, Meerpohl JJ. Effect of lower sodium intake on health: systematic review and meta-analyses. BMJ 2013; 346: f1326.
7. Brook RD, Appel LJ, Rubenfire M, Ogedegbe G, Bisognano JD, Elliot WJ et al. Beyond medications and diet: alternative approaches to lowering blood pressure: a scientific statement from the American Heart Association. Hypertension 2013; 61: 1360-1383.
8. Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H et al. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 2002; 99: 3872-3877.
9. Harris RC. Abnormalities in renal dopamine signaling and hypertension: the role of GRK4. Curr Opin Nephrol Hypertens. 2012; 21: 61-65.
10. Trivedi M, Lokhandwala MF. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Am J Physiol Renal Physiol 2005; 289: F298-F304.
11. Watanabe H, Xu J, Bengra C, Jose PA, Felder RA. Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4. Kidney Int 2002; 62: 790-798.
12. Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C et al. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. J Biol Chem 1996; 271: 6403-6410.
13. Bengra C, Mifflin TE, Khripin Y, Manunta P, Williams SM, Jose PA et al. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. Clin Chem 2002; 48: 2131-2140.
14. Speirs HJ, Katyk K, Kumar NN, Benjafield AV, Wang WY, Morris BJ. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. J Hypertens 2004; 22: 931-936.
15. Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN et al. Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension 2012; 60: 1359-1366.
16. Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Watanabe T, Moore JH et al. Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem 2006; 52: 352-360.
17. Gu D, Su S, Ge D, Chen S, Huang J, Li B et al. Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese. Hypertension 2006; 47: 1147-1154.
18. Wang Z, Asico LD, Escano CS, Felder RA, Jose PA. Human G protein-coupled receptor kinase type 4 (hGRK4γ) wild-type prevents salt sensitivity while its variant, hGRK4γ486V, promotes salt sensitivity in transgenic mice: Role of genetic background [Abstract]. Hypertension 2006; 48: e27.
19. Wang Z, Armando I, Asico LD, Escano C, Wang X, Lu Q et al. The elevated blood pressure of human GRK4γA142V transgenic mice is not associated with increased ROS production. Am J Physiol Heart Circ Physiol 2007; 292: H2083-H2092.
20. Jain S, Prater A, Pandey V, Rana A, Puri N, Kumar A. A haplotype of angiotensin receptor type 1 associated with human hypertension increases blood pressure in transgenic mice. J Biol Chem 2013; 288: 37048-37056.
21. Trudu M, Janas S, Lanzani C, Debaix H, Schaeffer C, Ikehata M. Common non-coding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression. Nat Med 2013; 19: 1655-1660.
22. Glazier AM, Nadeau JH, Aitman TJ. Finding genes that underlie complex traits. Science 2002; 298: 2345-2349.
23. Yatabe J, Sanada H, Midorikawa S, Hashimoto S, Watanabe T, Andrews PM et al. Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats. Hypertens Res 2008; 31: 1455-1464.
24. Jose PA, Wang Z, Sanada H, Yoneda M, Zeng C, Williams S et al. Human GRK4γ142V, via histone deacetylase 1, produces AT1R-dependent hypertension. Hypertension 2013; 62: A52.
25. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009; 53: 982-992.
26. Yokokawa H, Sanada H, Goto A, Watanabe T, Felder RA, Jose PA. Characteristics of antihypertensive medication and change of prescription over 1 year of follow up in Japan: Fukushima Research of Hypertension (FRESH). Am J Hypertens 2010; 23: 1299-1305.
27. Ogihara T, Kikuchi K, Matsuoka H, Fujita T, Higaki J, Horiuchi M et al. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res 2009; 32: 3-107.
28. Wirta MR, Hiltunen TP, Lehtimaki T. Rapid detection of angiotensinogen M/T235 polymorphism by fluorescence probe melting curves. Clin Chem 2000; 46: 880-881.
29. Wittke-Thompson JK, Pluzhnikov A, Cox NJ. Rational inferences about departures from Hardy-Weinberg equilibrium. Am J Hum Genet 2005; 76: 967-986.
30. Ryckman KK, Jiang L, Li C, Bartlett J, Haines JL, Williams SM. A prevalence-based association test for case-control studies. Genet Epidemiol 2008; 32: 600-605.
31. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
32. Dudbridge F. Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. Hum Hered 2008; 66: 87-98.
33. Ritchie MD, Hahn LW, Moore JH. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 2003; 24: 150-157.
34. Center for Human Genetics Research of Vanderbilt University, http://chgr.mc.vanderbilt.edu/wasp/.
35. Rosskopf D, Schürks M, Rimmbach C, Schäfers R. Genetics of arterial hypertension and hypotension. Naunyn Schmiedebergs Arch Pharmacol 2007; 374: 429-469.
36. Wang Y, Li B, Zhao W, Liu P, Zhao Q, Chen S et al. Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese. Ann Hum Genet 2006; 70: 778-783.
37. Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG et al. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension 2007; 49: 96-106.
38. Staessen JA, Kuznetsova T, Zhang H, Maillard M, Bochud M, Hasenkaml S et al. Blood pressure and renal sodium handling in relation to genetic variation in the DRD1 promoter and GRK4. Hypertension 2008; 51: 1643-1650.
39. Williams SM, Haines JL. Correcting away the hidden heritability. Ann Hum Genet 2011; 75: 348-350.
40. Jose PA, Soares-da-Silva P, Eisner GM, Felder RA. Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation. Biochim Biophys Acta 2010; 1802: 1259-1267.
41. Kimura L, Angeli CB, Auricchio MT, Fernandes GR, Pereira AC, Vicente JP et al. Multilocus family-based association analysis of seven candidate polymorphisms with essential hypertension in an African-derived semi-isolated Brazilian population. Int J Hypertens 2012; 2012: 859219.
42. Hiura Y, Tabara Y, Kokubo Y, Okamura T, Miki T, Tomoike H et al. A genome-wide association study of hypertension-related phenotypes in a Japanese population. Circ J 2010; 74: 2353-2359.
43. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ et al. Executive summary: heart disease and stroke statistics - 2014 update: a report from the American Heart Association. Circulation 2013; 127: e6-e245.
44. Arnett DK, Claas SA, Glasser SP. Pharmacogenetics of antihypertensive treatment. Vascul Pharmacol 2006; 44: 107-118.
45. Mellen PB, Herrington DM. Pharmacogenomics of blood pressure response to antihypertensive treatment. J Hypertens 2005; 23: 1311-1325.
46. Nordestgaard BG, Kontula K, Benn M, Dahlöf B, de Faire U, Edelman JM et al. Effect of ACE insertion/deletion and 12 other polymorphisms on clinical outcomes and response to treatment in the LIFE study. Pharmacogenet Genomics 2010; 20: 77-78.
47. Liljedahl U, Lind L, Kurland L, Berglund L, Kahan T. Single nucleotide polymorphisms in the apolipoprotein B and low density lipoprotein receptor genes affect response to antihypertensive treatment. BMC Cardiovasc Disord 2004; 4: 16.
48. Leineweber K, Rohe P, Beilfuss A, Wolf C, Sporkmann H, Bruck H et al. G-protein-coupled receptor kinase activity in human heart failure: effects of β-adrenoceptor blockade. Cardiovasc Res 2005; 66: 512-519.
49. Bhatnagar V, O'Connor DT, Brophy VH, Schork NJ, Richard E, Salem RM et al. G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. Am J Hypertens 2009; 22: 332-338.
50. Vandell AG, Lobmeyer MT, Gawronski BE, Langaee TY, Gong Y, Gums JG et al. G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension. Hypertension 2012; 60: 957-964.
51. Rayner B, Ramesar R, Steyn K, Levitt N, Lombard C, Charlton K. G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension. J Hum Hypertens 2012; 26: 334-339.
52. Wagner F, Malice MP, Wiegert E, McGrath HE, Gildea J, Mitta S. A comparison of the natriuretic and kaliuretic effects of cicletanine and hydrochlorothiazide in prehypertensive and hypertensive humans. J Hypertens 2012; 30: 819-827.
53. Wang Z, Asico LD, Escano CS, Felder RA, Jose PA. Human G protein-coupled receptor kinase type 4 γ (hGRK4γ) wild-type prevents salt sensitivity while its variant, hGRK4γ486V, promotes salt sensitivity in transgenic mice: role of genetic background. Hypertension 2006; 48: e27-e27.
54. Sanada H, Yatabe J, Yatabe MS, Yokokawa H, Williams S, Bartlett J et al. G protein-coupled receptor type 4 gene variants and response to antihypertensive medication. Circulation 2009; 120: S1087-S1087.
55. O'Donnell MJ, Yusuf S, Mente A, Gao P, Mann JF, Teo K et al. Urinary sodium and potassium excretion and risk of cardiovascular events. JAMA 2011; 306: 2229-2238.
56. Turner ST, Boerwinkle E, O'Connell JR, Bailey KR, Gong Y, Chapman AB et al. Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide. Hypertension 2013; 62: 391-397.
57. Lohmueller KE, Wong LJ, Mauney MM, Jiang L, Felder RA, Jose PA et al. Patterns of genetic variation in the hypertension candidate gene GRK4: ethnic variation and haplotype structure. Ann Hum Genet 2006; 70: 27-41.
58. Stolarz-Skrzypek K, Kuznetsova T, Thijs L, Tikhonoff V, Seidlerová J, Richart T et al. Fatal and nonfatal outcomes, incidence of hypertension, and blood pressure changes in relation to urinary sodium excretion. JAMA 2011; 305: 1777-1785.
59. Graudal N, Jürgens G, Baslund B, Alderman MH. Compared with usual sodium intake, low- and excessive-sodium diets are associated with increased mortality: a meta-analysis. Am J Hypertens 2014; 27: 1129-1137.
60. Oparil S. Low sodium intake - cardiovascular health benefit or risk? N Engl J Med 2014; 371: 677-679.
61. Reungjui S, Hu H, Mu W, Roncal CA, Croker BP, Patel JM et al. Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. Kidney Int 2007; 72: 1483-1492.