Variable transcriptional regulation of the human aldosterone synthase gene causes salt-dependent high blood pressure in transgenic mice

Circulation: Cardiovascular Genetics

Volumn 8, Issue 1, 2015, Pages 30-39

  Mopidevi, Brahmaraju ^a   Kaw, Meenakshi K ^a   Puri, Nitin ^a   Ponnala, Madhusudan ^a   Jain, Sudhir ^a   Rana, Anita ^a   Keetha, Narsimha R ^a   Khuder, Sadik A ^a   Fiering, Steven N ^b   Kumar, Ashok ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Aldosterone; Gene expression regulation; Genetics; Renin angiotensin system

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; MESSENGER RNA; SALT INTAKE;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; CARDIOVASCULAR EFFECT; CAUCASIAN; CONTROLLED STUDY; DNA FLANKING REGION; EXON; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; HAPLOTYPE; HUMAN; HUMAN CELL; HYPERTENSION; INTRON; KIDNEY PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION; TRANSGENE; TRANSGENIC MOUSE; TRANSIENT TRANSFECTION; UPREGULATION; ADVERSE EFFECTS; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; PHARMACOLOGY; PROMOTER REGION; SALT INTAKE;

MUS; MUS MUSCULUS;

ANIMALS; CYTOCHROME P-450 CYP11B2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPERTENSION; MICE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SODIUM CHLORIDE, DIETARY;

EID: 84924613924     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.114.000694     Document Type: Article

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