Expression studies of six human obesity-related genes in seven tissues from divergent pig breeds

Animal Genetics

Volumn 45, Issue 1, 2014, Pages 59-66

  Cirera, S ^a   Jensen, M S ^a   Elbrond V S ^a   Moesgaard, S G ^b   Christoffersen, B O ^b   Kadarmideen, H N ^a   Skovgaard, K ^c   Bruun, C V ^a   Karlskov Mortensen, P ^a   Jorgensen C B ^a   Fredholm, M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

ADIPOQ; FTO; G ttingen minipig; LEP; LEPR; MC4R; NEGR1; obesity; Production pig

Indexed keywords

ANIMALIA; RODENTIA; SUIDAE;

ADIPONECTIN; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; NERVE CELL ADHESION MOLECULE; TRANSCRIPTOME;

ADIPOSE TISSUE; ANIMAL; BREEDING; FEMALE; GENETICS; HUMAN; HYPOTHALAMUS; METABOLISM; MUSCLE; OBESITY; PANCREAS; SWINE;

ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; BREEDING; CELL ADHESION MOLECULES, NEURONAL; FEMALE; HUMANS; HYPOTHALAMUS; LEPTIN; MUSCLES; OBESITY; PANCREAS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, LEPTIN; SUS SCROFA; TRANSCRIPTOME;

EID: 84892434364     PISSN: 02689146     EISSN: 13652052     Source Type: Journal    
DOI: 10.1111/age.12082     Document Type: Article

References (26)

1. Bollen P.J., Madsen L.W., Meyer O., &, Ritskes-Hoitinga J., (2005) Growth differences of male and female Göttingen minipigs during ad libitum feeding: a pilot study. Laboratory Animals 39, 80-93.
2. Campfield L.A., Smith F.J., Guisez Y., Devos R., &, Burn P., (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-9.
3. Christoffersen B.O., Grand N., Golozoubova V., Svendsen O., &, Raun K., (2007) Gender-associated differences in metabolic syndrome-related parameters in Göttingen minipigs. Journal of Comparative Medicine 57, 493-504.
4. Cleveland E.R., Cunningham P.J., &, Peo E.R., (1982) Selection for lean growth in swine. Journal of Animal Science 54, 719-27.
5. Dougkas A., Yaqoob P., Givens D.I., Reynolds C.K., &, Minihane A.M., (2013) The impact of obesity related SNP on appetite and energy intake. British Journal of Nutrition 22, 1-6.
6. Gerken T., Girard C.A., Tung Y.C., et al,. (2007) The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 318, 1469-72.
7. Herrera B.M., &, Lindgren C.M., (2010) The genetics of obesity. Current Diabetes Reports 10, 498-505. Review.
8. Jacobi S.K., Ajuwon K.M., Weber T.E., Kuske J.L., Dyer C.J., &, Spurlock M.E., (2004) Cloning and expression of porcine adiponectin, and its relationship to adiposity, lipogenesis and the acute phase response. Journal of Endocrinology 182, 133-44.
9. Kanter R., &, Caballero B., (2012) Global gender disparities in obesity: a review. Advances in Nutrition 3, 491-8.
10. Kim K.S., Reecy J.M., Hsu W.H., Anderson L.L., &, Rothschild M.F., (2004) Functional and phylogenetic analyses of a melanocortin-4 receptor mutation in domestic pig. Domestic Animal Endocrinology 26, 75-86.
11. Lange J., Barz T., Ekkernkamp A., Wilke B., Klöting I., &, Follak N., (2012) Phenotypic and gene expression differences between DA, BN and WOKW rats. PLoS ONE 7, e38981.
12. Lubrano-Berthelier C., Cavazos M., Dubern B., et al,. (2003) Molecular genetics of human obesity-associated MC4R mutations. Annals of the New York Academy of Sciences 994, 49-57.
13. Madsen M.B., Birck M.M., Fredholm M., &, Cirera S., (2010) Expression studies of the obesity candidate gene FTO in pig. Animal Biotechnology 21, 51-63.
14. Maes H.H., Neale M.C., &, Eaves L.J., (1997) Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics 27, 325-51. Review.
15. Mårin P., Andersson B., Ottosson M., Olbe L., Chowdhury B., Kvist H., Holm G., Sjöström L., &, Björntorp P., (1992) The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism 41, 1242-8.
16. Matsuzawa Y., Funahashi T., &, Nakamura T., (2011) The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. Journal of Atherosclerosis and Thrombosis 18, 629-39. Review.
17. Nygard A.B., Jørgensen C.B., Cirera S., &, Fredholm M., (2007) Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR. BMC Molecular Biology 8, 67.
18. Schäfer M., Bräuer A.U., Savaskan N.E., &, Rathjen F.G., (2005) Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Molecular and Cellular Neuroscience 29, 580-90.
19. Singh A., Wirtz M., Parker N., et al,. (2009) Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proceedings of the National Academy of Sciences of the USA 106, 13100-5.
20. Speliotes E.K., Willer C.J., Berndt S.I, et al,. (2010) Association analyses of 249 796 individuals reveal 18 new loci associated with body mass index. Nature Genetics 42, 937-48.
21. Spurlock M.E., &, Gabler N.K., (2008) The development of porcine models of obesity and the metabolic syndrome. The Journal of Nutrition 138, 397-402.
22. Switonski M., Stachowiak M., Cieslak J., Bartz M., &, Grzes M., (2010) Genetics of fat tissue accumulation in pigs: a comparative approach. Journal of Applied Genetics 51, 153-68.
23. Terra X., Auguet T., Porras J.A., Quintero Y., Aguilar C., Luna A.M., Hernández M., Sabench F., del Castillo D., &, Richart C., (2010) Anti-inflammatory profile of FTO gene expression in adipose tissues from morbidly obese women. Cellular Physiology and Biochemistry 26, 1041-50.
24. Wajchenberg B.L., (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocrine Reviews 21, 697-738.
25. Walley A.J., Jacobson P., Falchi M., et al,. (2012) Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue. International Journal of Obesity (London) 36, 137-47.
26. Willer C.J., Speliotes E.K., Loos R.J., et al,. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 41, 25-34.