An F2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: Design and genetic parameters

Frontiers in Genetics

Volumn 4, Issue MAR, 2013, Pages

  Kogelman, Lisette J A ^a   Kadarmideen, Haja N ^a   Mark, Thomas ^a   Karlskov Mortensen, Peter ^a   Bruun, Camilla S ^a   Cirera, Susanna ^a   Jacobsen, Mette J ^a   Jørgensen, Claus B ^a   Fredholm, Merete ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Animal model; Diabetes; F2 design; Genetic correlations; Genetic predictions; Heritabilities; Obesity

Indexed keywords

ANIMALIA; SUIDAE;

EID: 84876187792     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00029     Document Type: Article

References (56)

1. Arabi, A., Nabulsi, M., Maalouf, J., Choucair, M., Khalife, H., Vieth, R., et al. (2004). Bone mineral density by age, gender, pubertal stages, and socioeconomic status in healthy. Lebanese children and adolescents. Bone 35, 1169-1179.
2. Arner, P. (2005). Resistin: yet another adipokine tells us that men are not mice. Diabetologia 48, 2203-2205.
3. Bahelka, I., Hanusová, E., Peškovicová, D., and Demo, P. (2007). The effect of sex and slaughter weight on intramuscular fat content and its relationship to carcass traits of pigs. Czech J. Anim. Sci. 52, 122-129.
4. Bellinger, D. A., Merricks, E. P., and Nichols, T. C. (2006). Swine models of type 2 diabetes mellitus: insulin resistance, glucose tolerance, and cardiovascular complications. ILAR J. 47, 243-258.
5. Bener, A., Zirie, M., and Al-Rikabi, A. (2005). Genetics, obesity, and environmental risk factors associated with type 2 diabetes. Croat. Med. J. 46, 302-307.
6. Bergman, R. N., Stefanovski, D., Buchanan, T. A., Sumner, A. E., Reynolds, J. C., Sebring, N. G., et al. (2011). A better index of body adiposity. Obesity 19, 1083-1089.
7. Bougnères, P. (2002). Genetics of obesity and type 2 diabetes. Diabetes 51, S295-S303.
8. Brandt, H., and Täubert, H. (1998). Parameter estimates for purebred and crossbred performances in pigs. J. Anim. Breed. Genet. 115, 97-104.
9. Brown, L. B., Streeten, E. A., Shuldiner, A. R., Almasy, L. A., Peyser, P. A., and Mitchell, B. D. (2004). Assessment of sex-specific genetic and environmental effects on bone mineral density. Genet. Epidemiol. 27, 153-161.
10. Fan, B., Onteru, S. K., Du, Z.-Q., Garrick, D. J., Stalder, K. J., and Rothschild, M. F. (2011). Genome-wide association study identifies loci for body composition and structural soundness traits in pigs. PLoS ONE 6:e14726. doi:10.1371/journal.pone.0014726
11. Farooqi, I. S., and O'Rahilly, S. (2007). Genetic factors in human obesity. Obes. Rev. 8, 37-40.
12. Felson, D. T., Zhang, Y., Hannan, M. T., and Anderson, J. J. (1993). Effects of weight and body mass index on bone mineral density in men and women: the framingham study. J. Bone Miner. Res. 8, 567-573.
13. Fontanesi, L., Scotti, E., Buttazzoni, L., Davoli, R., and Russo,V. (2009). The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian duroc pigs. Anim. Genet. 40, 90-93.
14. Gilmour, A. R., Gogel, B. J., Cullis, B. R., and Thompson, R. (2009). ASReml User Guide Release 3.0. Hemel Hempstead: VSN International.
15. Goossens, G. H. (2008). The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol. Behav. 94, 206-218.
16. Groenen, M. A. M., Archibald, A. L., Uenishi, H., Tuggle, C. K., Takeuchi, Y., Rothschild, M. F., et al. (2012). Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491, 393-398.
17. Hanotte, O., Ronin, Y., Agaba, M., Nilsson, P., Gelhaus, A., Horstmann, R., et al. (2003). Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible, East African Boran cattle. Proc. Natl. Acad. Sci. U.S.A. 100, 7443-7448.
18. Heber, D. (2010). An integrative view of obesity. Am. J. Clin. Nutr. 91, 280S-283S.
19. Heymsfield, S. B., and Shen, W. (2011). Obesity: BAI as a new measure of adiposity - throw away your scale? Nat. Rev. Endocrinol. 7, 321-322.
20. Hodgson, R. R., Davis, G. W., Smith, G. C., Savell, J. W., and Cross, H. R. (1991). Relationships between pork loin palatability traits and physical characteristics of cooked chops. J. Anim. Sci. 69, 4858-4865.
21. Hofer, A., Hagger, C., and Künzi, N. (1992). Genetic evaluation of onfarm tested pigs using an animal model I. Estimation of variance components with restricted maximum likelihood. Livest. Prod. Sci. 30, 69-82.
22. Huisman, A. E., Veerkamp, R. F., and Van Arendonk, J. A. M. (2002). Genetic parameters for various random regression models to describe the weight data of pigs. J. Anim. Sci. 80, 575-582.
23. Johansen, T., Hansen, H. S., Richelsen, B., and Malmlöf, K. (2001). The obese gottingen minipig as a model of the metabolic syndrome: dietary effects on obesity, insulin sensitivity, and growth hormone profile. Comp. Med. 51, 150-155.
24. Johnson,Z. B.,and Nugent,R.A. (2003). Heritability of body length and measures of body density and their relationship to backfat thickness and loin muscle area in swine. J. Anim. Sci. 81, 1943-1949.
25. Kadarmideen, H. N., Von Rohr, P., and Janss, L. (2006). From genetical genomics to systems genetics: potential applications in quantitative genomics and animal breeding. Mamm. Genome 17, 548-564.
26. Kadarmideen, H. N., Janss, L. L. G., and Dekkers, J. C. M. (2000). Power of quantitative trait locus mapping for polygenic binary traits using generalized and regression interval mapping in multi-family half-sib designs. Genet. Res. 76, 305-317.
27. Kadarmideen, H. N., Schwörer, D., Ilahi, H., Malek, M., and Hofer, M. (2004). Genetics of osteochondral disease and its relationship with meat quality and quantity, growth, and feed conversion traits in pigs. J. Anim. Sci. 82, 3118-3127.
28. Kadarmideen, H. N., Watson-Haigh, N. S., and Andronicos, N. M. (2011). Systems biology of ovine intestinal parasite resistance: disease gene modules and biomarkers. Mol. Biosyst. 7, 235-246.
29. Kim, C. W., Hong, Y. H., Yun, S. I., Lee, S. R., Kim, Y. H., Kim, M. S., et al. (2006). Use of microsatellite markers to detect quantitative trait loci in Yorkshire pigs. J. Reprod. Dev. 52, 229-237.
30. Kim, K. S., Larsen, N., Short, T., Plastow, G., and Rothschild, M. F. (2000). A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm. Genome 11, 131-135.
31. Kogelman, L. J. A., Byrne, K., Vuocolo, T., Watson-Haigh, N., Kadarmideen, H. N., Kijas, J., et al. (2011). Genetic architecture of gene expression in ovine skeletal muscle. BMC Genomics 12:607. doi:10.1186/1471-2164-12-607
32. Laenoi, W., Uddin, M., Cinar, M., Grosze-Brinkhaus, C., Tesfaye, D., Jonas, E., et al. (2011). Quantitative trait loci analysis for leg weakness related traits in a Duroc × Pietrain crossbred population. Genet. Sel. Evol. 43, 13.
33. Larsen, M., Gotfredsen, C., Wilken, M., Carr, R., Pørksen, N., and Rolin, B. (2003). Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs. Diabetologia 46, 195-202.
34. Larsen, M. O., and Rolin, B. (2004). Use of the gottingen minipig as a model of diabetes, with special focus on type 1 diabetes research. ILAR J. 45, 10.
35. Liu, G., Jennen, D. G. J., Tholen, E., Juengst, H., Kleinwächter, T., Hölker, M., et al. (2007). A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population. Anim. Genet. 38, 241-252.
36. Mitchell, A. D., Scholz, A. M., Pursel, V. G., and Evock-Clover, C. M. (1998). Composition analysis of pork carcasses by dual-energy x-ray absorptiometry. J. Anim. Sci. 76, 2104-2114.
37. Nunez, N. P., Carpenter, C. L., Perkins, S. N., Berrigan, D., Jaque, S. V., Ingles, S. A., et al. (2007). Extreme obesity reduces bone mineral density: complementary evidence from mice and women. Obesity 15, 1980-1987.
38. Okumura, N., Matsumoto, T., Hayashi, T., Hirose, K., Fukawa, K., Itou, T., et al. (2012). Genomic regions affecting backfat thickness and cannon bone circumference identified by genome-wide association study in a Duroc pig population. Anim. Genet. 1365-2052.
39. O'Rahilly, S. (2009). Human genetics illuminates the paths to metabolic disease. Nature 462, 307-314.
40. Ovilo,C.,Clop,A.,Noguera,J. L.,Oliver, M. A., Barragán, C., Rodríguez, C., et al. (2002). Quantitative trait locus mapping for meat quality traits in an Iberian × Landrace F2 pig population. J. Anim. Sci. 80, 2801-2808.
41. Ponsuksili, S., Murani, E., Brand, B., Schwerin, M., and Wimmers, K. (2011). Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model. J. Lipid Res. 52, 668-678.
42. Rubin, C.-J., Megens, H.-J., Barrio, A. M., Maqbool, K., Sayyab, S., Schwochow, D., et al. (2012). Strong signatures of selection in the domestic pig genome. Proc. Natl. Acad. Sci. U.S.A. 109, 19529-19536.
43. Santos, R. L. P., Zillikens, M. C., Rivadeneira, F. R., Pols, H. A. P., Oostra, B. A., Duijn, C. M., et al. (2006). Heritability of fasting glucose levels in a young genetically isolated population. Diabetologia 49, 667-672.
44. Saunders, C. L., Chiodini, B. D., Sham, P., Lewis, C. M., Abkevich, V., Adeyemo, A. A., et al. (2007). Metaanalysis of genome-wide linkage studies in BMI and obesity. Obesity 15, 2263-2275.
45. Scott, L. J., Mohlke, K. L., Bonnycastle, L. L., Willer, C. J., Li, Y., Duren, W. L., et al. (2007). A genomewide association study of type 2 diabetes in finns detects multiple susceptibility variants. Science 316, 1341-1345.
46. Sen, S., Satagopan, J., Broman, K., and Churchill, G. (2007). R/qtlDesign: inbred line cross experimental design. Mamm. Genome 18, 87-93.
47. Singh, K. P., Mishra, R. R., Rajendra, S., and Chaudhary, A. P. (2001). Heritability estimates for growth and carcass traits in Landrace pigs. Indian J. Anim. Res. 35, 138-140.
48. Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., et al. (2007). A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445, 881-885.
49. Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948.
50. Spurlock, M. E., and Gabler, N. K. (2008). The development of porcine models of obesity and the metabolic syndrome. J. Nutr. 138, 397-402.
51. Suster, D., Leury, B. J., Hofmeyr, C. D., D'souza, D. N., and Dunshea, F. R. (2004). The accuracy of dual energy X-ray absorptiometry (DXA), weight, and P2 back fat to predict half-carcass and primalcut composiion in pigs within and across research experiments. Aust. J. Agric. Res. 55, 973-982.
52. Teslovich, T. M., Musunuru, K., Smith, A.V.,Edmondson,A. C.,Stylianou,I. M., Koseki, M., et al. (2010). Biological,clinical andpopulationrelevance of 95 loci for blood lipids. Nature 466, 707-713.
53. Uddin, M., Duy, D., Cinar, M., Tesfaye, D., Tholen, E., Juengst, H., et al. (2011). Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs. BMC Genet. 12:62. doi:10.1186/1471-2156-12-62
54. Van Der Waaij, E. H., Hanotte, O., Van Arendonk, J. A. M., Kemp, S. J., Kennedy, D., Gibson, J. P., et al. (2003). Population parameters for traits defining trypanotolerance in an F2 cross of N'Dama and Boran cattle. Livest. Prod. Sci. 84, 219-230.
55. Weiler, H. A., Janzen, L., Green, K., Grabowski, J., Seshia, M. M., and Yuen, K. C. (2000). Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age. Bone 27, 203-207.
56. World Health Organization, (2012). Obesity and overweight, Fact sheet No311, updated March 2013. Available at: http://www.who.int/mediacentre/factsheets/fs311/en/