Antenatal hypoxia induces epigenetic repression of glucocorticoid receptor and promotes ischemic-sensitive phenotype in the developing heart

Journal of Molecular and Cellular Cardiology

Volumn 91, Issue , 2016, Pages 160-171

  Xiong, Fuxia ^a,b   Lin, Thant ^b   Song, Minwoo ^b   Ma, Qingyi ^b   Martinez, Shannalee R ^b   Lv, Juanxiu ^a,b   MataGreenwood, Eugenia ^b   Xiao, Daliao ^b   Xu, Zhice ^a,b   Zhang, Lubo ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA methylation; Fetal programming; Glucocorticoid receptor; Hypoxia

Indexed keywords

DECITABINE; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; TRANSCRIPTION FACTOR SP1; AZACITIDINE; OXYGEN; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CPG ISLAND; CYCLIC AMP RESPONSIVE ELEMENT; DNA METHYLATION; DOWN REGULATION; DRUG EFFECT; EPIGENETIC REPRESSION; EXON; FEMALE; FETUS; FETUS HYPOXIA; GENE REPRESSION; GENETIC TRANSCRIPTION; GESTATION PERIOD; GR GENE; HEART DEVELOPMENT; HEART MUSCLE ISCHEMIA; IN VIVO STUDY; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPERFUSION INJURY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; HYPOXIA; MALE; MATERNAL EXPOSURE; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; AZACITIDINE; BINDING SITES; DNA METHYLATION; EPIGENESIS, GENETIC; EXONS; FEMALE; HYPOXIA; MALE; MATERNAL EXPOSURE; MYOCARDIAL REPERFUSION INJURY; OXYGEN; PHENOTYPE; PREGNANCY; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR;

EID: 84954289842     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.01.003     Document Type: Article

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