Porcine glucocorticoid receptor (NR3C1) gene: Tissue-specificity of transcriptional strength and glucocorticoid responsiveness of alternative promoters

Journal of Steroid Biochemistry and Molecular Biology

Volumn 141, Issue , 2014, Pages 87-93

  Jiang, Zheng ^a   Qian, Lu ^b   Zou, Huafeng ^a   Jia, Yimin ^a   Ni, Yingdong ^a   Yang, Xiaojing ^a   Jiang, Zhihua ^c   Zhao, Ruqian ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

First exon variants; Glucocorticoid responsiveness; Porcine glucocorticoid receptor; Promoter activity; Tissue specificity

Indexed keywords

FIRST EXON VARIANTS; GLUCOCORTICOID RESPONSIVENESS; PORCINE GLUCOCORTICOID RECEPTOR; PROMOTER ACTIVITY; TISSUE-SPECIFICITY;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL SURVIVAL; DEXAMETHASONE; GLUCOCORTICOIDS; HIPPOCAMPUS; HUMANS; LIVER; MALE; MICE; MIFEPRISTONE; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SUS SCROFA; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84894288599     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.01.012     Document Type: Article

References (29)

1. S. Jitrapakdee Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis International Journal of Biochemistry & Cell Biology 44 1 2012 33 45
2. M. Joels Functional actions of corticosteroids in the hippocampus European Journal of Pharmacology 583 2-3 2008 312 321
3. J.P. Herman, P.D. Patel, H. Akil, and S.J. Watson Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat Molecular Endocrinology 3 11 1989 1886 1894
4. L. Cao-Lei, S.C. Leija, R. Kumsta, S. Wust, J. Meyer, J.D. Turner, and C.P. Muller Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions Human Genetics 129 5 2011 533 543
5. J.D. Turner, S.R. Alt, L. Cao, S. Vernocchi, S. Trifonova, N. Battello, and C.P. Muller Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more Biochemical Pharmacology 80 12 2010 1860 1868
6. J.D. Turner, A.B. Schote, J.A. Macedo, L.P. Pelascini, and C.P. Muller Tissue specific glucocorticoid receptor expression, a role for alternative first exon usage? Biochemical Pharmacology 72 11 2006 1529 1537
7. J. Zong, J. Ashraf, and E.B. Thompson The promoter and first, untranslated exon of the human glucocorticoid receptor gene are GC rich but lack consensus glucocorticoid receptor element sites Molecular and Cellular Biology 10 10 1990 5580 5585
8. Y. Nobukuni, C.L. Smith, G.L. Hager, and S.D. Detera-Wadleigh Characterization of the human glucocorticoid receptor promoter Biochemistry 34 25 1995 8207 8214
9. E. Presul, S. Schmidt, R. Kofler, and A. Helmberg Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor Journal of Molecular Endocrinology 38 1-2 2007 79 90
10. J.D. Turner, and C.P. Muller Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification, and tissue distribution of multiple new human exon 1 Journal of Molecular Endocrinology 35 2 2005 283 292
11. Y. Bockmuhl, C.A. Murgatroyd, A. Kuczynska, I.M. Adcock, O.F. Almeida, and D. Spengler Differential regulation and function of 5′-untranslated GR-exon 1 transcripts Molecular Endocrinology 25 7 2011 1100 1110
12. M.B. Breslin, C.D. Geng, and W.V. Vedeckis Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids Molecular Endocrinology 15 8 2001 1381 1395
13. T.J. Barrett, E. Vig, and W.V. Vedeckis Coordinate regulation of glucocorticoid receptor and c-jun gene expression is cell type-specific and exhibits differential hormonal sensitivity for down- and up-regulation Biochemistry 35 30 1996 9746 9753
14. B.S. Nunez, and W.V. Vedeckis Characterization of promoter 1B in the human glucocorticoid receptor gene Molecular and Cellular Endocrinology 189 1-2 2002 191 199
15. S. Wei, D. Xia, L. Li, J. Xiao, J. Bao, N. Parvizi, and R. Zhao Breed-specific expression of hippocampal 11β-hydroxysteroid dehydrogenases and glucocorticoid receptors in Erhualian and Pietrain pigs exhibiting distinct stress coping characteristics Livestock Science 131 2-3 2010 240 244
16. X. Yang, R. Liu, A. Elke, D. Xia, and R. Zhao Breed-specific patterns of hepatic gluconeogenesis and glucocorticoid action in pigs Archiv Tierzucht 2 2012 152 162
17. X. Li, X. Yang, B. Shan, J. Shi, D. Xia, J. Wegner, and R. Zhao Meat quality is associated with muscle metabolic status but not contractile myofiber type composition in premature pigs Meat Science 81 1 2009 218 223
18. R. Poletto, J.P. Steibel, J.M. Siegford, and A.J. Zanella Effects of early weaning and social isolation on the expression of glucocorticoid and mineralocorticoid receptor and 11β-hydroxysteroid dehydrogenase 1 and 2 mRNAs in the frontal cortex and hippocampus of piglets Brain Research 1067 1 2006 36 42
19. L.-A. Li, D. Xia, E.-D. Bao, S. Wei, J.-S. Xiao, J.-W. Bao, W.-H. Chen, J. Chen, J. Hartung, and R.-Q. Zhao Erhualian and Pietrain pigs exhibit distinct behavioral, endocrine and biochemical responses during transport Livestock Science 113 2-3 2008 169 177
20. H. Zou, R. Li, Y. Jia, X. Yang, Y. Ni, R. Cong, P.D. Soloway, and R. Zhao Breed-dependent transcriptional regulation of 5′-untranslated GR (NR3C1) exon 1 mRNA variants in the liver of newborn piglets PLoS One 7 7 2012 e40432
21. H. Reyer, S. Ponsuksili, K. Wimmers, and E. Murani Transcript variants of the porcine glucocorticoid receptor gene (NR3C1) General and Comparative Endocrinology 189 2013 127 133
22. J.A. McCormick, V. Lyons, M.D. Jacobson, J. Noble, J. Diorio, M. Nyirenda, S. Weaver, W. Ester, J.L. Yau, M.J. Meaney, J.R. Seckl, and K.E. Chapman 5′-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events Molecular Endocrinology 14 4 2000 506 517
23. C.D. Geng, J.R. Schwartz, and W.V. Vedeckis A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters Molecular Endocrinology 22 12 2008 2624 2642
24. M. Revel, and F. Gros The stimulation by ribosomes of DNA transcription: requirement for a translation factor Biochemical and Biophysical Research Communications 27 1 1967 12 19
25. K. Shimada, H. Ogasawara, K. Yamada, M. Shimura, A. Kori, T. Shimada, Y. Yamanaka, K. Yamamoto, and A. Ishihama Screening of promoter-specific transcription factors: multiple regulators for the sdiA gene involved in cell division control and quorum sensing Microbiology 159 Pt 12 2013 2501 2512
26. P.J. Barnes Glucocorticosteroids: current and future directions British Journal of Pharmacology 163 1 2011 29 43
27. C.D. Geng, and W.V. Vedeckis Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter Molecular Endocrinology 18 4 2004 912 924
28. M.V. Govindan Recruitment of cAMP-response element-binding protein and histone deacetylase has opposite effects on glucocorticoid receptor gene transcription Journal of Biological Chemistry 285 7 2010 4489 4510
29. A.I. Freeman, H.L. Munn, V. Lyons, A. Dammermann, J.R. Seckl, and K.E. Chapman Glucocorticoid down-regulation of rat glucocorticoid receptor does not involve differential promoter regulation Journal of Endocrinology 183 2 2004 365 374