Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease

Cell

Volumn 164, Issue 1-2, 2016, Pages 141-155

  Yang, Chiao Wen ^a   Hojer, Caroline D ^a   Zhou, Meijuan ^a   Wu, Xiumin ^a   Wuster, Arthur ^a   Lee, Wyne P ^a   Yaspan, Brian L ^a   Chan, Andrew C ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CLATHRIN; DENND1B PROTEIN; PROTEIN; RAB PROTEIN; RAB35 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR AP 2; UNCLASSIFIED DRUG; CYTOKINE; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DENND1B PROTEIN, HUMAN; DENND1B PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LYMPHOCYTE ANTIGEN RECEPTOR; RAB35 PROTEIN, MOUSE;

ALLERGIC DISEASE; ALLERGIC REACTION; ANIMAL CELL; ARTICLE; ASTHMA; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE RESPONSE; EFFECTOR CELL; GENE SILENCING; HUMAN; HUMAN CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TH2 CELL; ANIMAL; DENDRITIC CELL; FEMALE; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ASTHMA; CYTOKINES; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; DENDRITIC CELLS; FEMALE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; HYPERSENSITIVITY; LYMPHOCYTE ACTIVATION; MICE; POLYMORPHISM, SINGLE NUCLEOTIDE; RAB GTP-BINDING PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 84954218765     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.11.052     Document Type: Article

References (54)

1. A. Alcover, and B. Alarcón Internalization and intracellular fate of TCR-CD3 complexes Crit. Rev. Immunol. 20 2000 325 346
2. P.D. Allaire, B. Ritter, S. Thomas, J.L. Burman, A.Y. Denisov, V. Legendre-Guillemin, S.Q. Harper, B.L. Davidson, K. Gehring, and P.S. McPherson Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis J. Neurosci. 26 2006 13202 13212
3. P.D. Allaire, A.L. Marat, C. Dall'Armi, G. Di Paolo, P.S. McPherson, and B. Ritter The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes Mol. Cell 37 2010 370 382
4. h2 differentiation and Il4 locus accessibility Annu. Rev. Immunol. 24 2006 607 656
5. K. Bachmaier, C. Krawczyk, I. Kozieradzki, Y.Y. Kong, T. Sasaki, A. Oliveira-dos-Santos, S. Mariathasan, D. Bouchard, A. Wakeham, A. Itie, and et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b Nature 403 2000 211 216
6. L. Balagopalan, V.A. Barr, and L.E. Samelson Endocytic events in TCR signaling: focus on adapters in microclusters Immunol. Rev. 232 2009 84 98
7. G.T. Belz, and S.L. Nutt Transcriptional programming of the dendritic cell network Nat. Rev. Immunol. 12 2012 101 113
8. F.M. Brodsky Diversity of clathrin function: new tricks for an old protein Annu. Rev. Cell Dev. Biol. 28 2012 309 336
9. S.K. Bromley, W.R. Burack, K.G. Johnson, K. Somersalo, T.N. Sims, C. Sumen, M.M. Davis, A.S. Shaw, P.M. Allen, and M.L. Dustin The immunological synapse Annu. Rev. Immunol. 19 2001 375 396
10. R.J. Brownlie, and R. Zamoyska T cell receptor signalling networks: branched, diversified and bounded Nat. Rev. Immunol. 13 2013 257 269
11. B.L. Chawes, F. Buchvald, A.L. Bischoff, L. Loland, M. Hermansen, L.B. Halkjaer, K. Bønnelykke, and H. Bisgaard Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze Am. J. Respir. Crit. Care Med. 182 2010 138 142
12. B.L. Chawes, A.L. Bischoff, E. Kreiner-Møller, F. Buchvald, H. Hakonarson, and H. Bisgaard DENND1B gene variants associate with elevated exhaled nitric oxide in healthy high-risk neonates Pediatr. Pulmonol. 50 2015 109 117
13. + T cell responses: the alternative approaches Annu. Rev. Immunol. 15 1997 297 322
14. J. Dietrich, X.H. Hou, A.M.K. Wegener, and C. Geisler CD3γ contains a phosphoserine-dependent di-leucine motif involved in downregulation of the TCR EMBO J. 13 1994 2156 2166
15. J. Dietrich, J. Kastrup, B.L. Nielsen, N. Odum, and C. Geisler Regulation and function of the CD3γ DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro J. Cell Biol. 138 1997 271 281
16. T.G. Falbel, L.M. Koch, J.A. Nadeau, J.M. Segui-Simarro, F.D. Sack, and S.Y. Bednarek SCD1 is required for cytokinesis and polarized cell expansion in Arabidopsis thaliana [corrected] Development 130 2003 4011 4024
17. M.A.R. Ferreira, A.F. McRae, S.E. Medland, D.R. Nyholt, S.D. Gordon, M.J. Wright, A.K. Henders, P.A. Madden, P.M. Visscher, N.R. Wray, and et al. Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia Eur. J. Hum. Genet. 19 2011 458 464
18. A. Franke, D.P.B. McGovern, J.C. Barrett, K. Wang, G.L. Radford-Smith, T. Ahmad, C.W. Lees, T. Balschun, J. Lee, R. Roberts, and et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci Nat. Genet. 42 2010 1118 1125
19. C. Geisler TCR trafficking in resting and stimulated T cells Crit. Rev. Immunol. 24 2004 67 86
20. GTEx Consortium Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans Science 348 2015 648 660
21. +) T cells Immunity 39 2013 846 857
22. J.B. Huppa, M. Gleimer, C. Sumen, and M.M. Davis Continuous T cell receptor signaling required for synapse maintenance and full effector potential Nat. Immunol. 4 2003 749 755
23. L.M. Kingeter, S. Paul, S.K. Maynard, N.G. Cartwright, and B.C. Schaefer Cutting edge: TCR ligation triggers digital activation of NF-kappaB J. Immunol. 185 2010 4520 4524
24. D.A. Korasick, C. McMichael, K.A. Walker, J.C. Anderson, S.Y. Bednarek, and A. Heese Novel functions of Stomatal Cytokinesis-Defective 1 (SCD1) in innate immune responses against bacteria J. Biol. Chem. 285 2010 23342 23350
25. I. Kouranti, M. Sachse, N. Arouche, B. Goud, and A. Echard Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis Curr. Biol. 16 2006 1719 1725
26. K.H. Lee, A.R. Dinner, C. Tu, G. Campi, S. Raychaudhuri, R. Varma, T.N. Sims, W.R. Burack, H. Wu, J. Wang, and et al. The immunological synapse balances T cell receptor signaling and degradation Science 302 2003 1218 1222
27. E. Levivier, B. Goud, M. Souchet, T.P.G. Calmels, J.P. Mornon, and I. Callebaut uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways Biochem. Biophys. Res. Commun. 287 2001 688 695
28. M. Lindstedt, K. Lundberg, and C.A.K. Borrebaeck Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells J. Immunol. 175 2005 4839 4846
29. H. Liu, M. Rhodes, D.L. Wiest, and D.A.A. Vignali On the dynamics of TCR:CD3 complex cell surface expression and downmodulation Immunity 13 2000 665 675
30. X. Liu, P. Invernizzi, Y. Lu, R. Kosoy, Y. Lu, I. Bianchi, M. Podda, C. Xu, G. Xie, F. Macciardi, and et al. Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis Nat. Genet. 42 2010 658 660
31. J.Z. Liu, M.A. Almarri, D.J. Gaffney, G.F. Mells, L. Jostins, H.J. Cordell, S.J. Ducker, D.B. Day, M.A. Heneghan, J.M. Neuberger, et al. UK Primary Biliary Cirrhosis (PBC) Consortium Wellcome Trust Case Control Consortium 3 Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis Nat. Genet. 44 2012 1137 1141
32. A.L. Marat, and P.S. McPherson The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery J. Biol. Chem. 285 2010 10627 10637
33. A.L. Marat, H. Dokainish, and P.S. McPherson DENN domain proteins: regulators of Rab GTPases J. Biol. Chem. 286 2011 13791 13800
34. A.L. Marat, M.S. Ioannou, and P.S. McPherson Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton Mol. Biol. Cell 23 2012 163 175
35. G.F. Mells, J.A.B. Floyd, K.I. Morley, H.J. Cordell, C.S. Franklin, S.-Y. Shin, M.A. Heneghan, J.M. Neuberger, P.T. Donaldson, D.B. Day, et al. UK PBC Consortium Wellcome Trust Case Control Consortium 3 Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis Nat. Genet. 43 2011 329 332
36. M.F. Moffatt, I.G. Gut, F. Demenais, D.P. Strachan, E. Bouzigon, S. Heath, E. von Mutius, M. Farrall, M. Lathrop, W.O. Cookson GABRIEL Consortium A large-scale, consortium-based genomewide association study of asthma N. Engl. J. Med. 363 2010 1211 1221
37. J.R. Morgan, K. Prasad, W. Hao, G.J. Augustine, and E.M. Lafer A conserved clathrin assembly motif essential for synaptic vesicle endocytosis J. Neurosci. 20 2000 8667 8676
38. M.A. Murphy, R.G. Schnall, D.J. Venter, L. Barnett, I. Bertoncello, C.B.F. Thien, W.Y. Langdon, and D.D.L. Bowtell Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice Mol. Cell. Biol. 18 1998 4872 4882
39. M. Naramura, H.K. Kole, R.J. Hu, and H. Gu Altered thymic positive selection and intracellular signals in Cbl-deficient mice Proc. Natl. Acad. Sci. USA 95 1998 15547 15552
40. + T cells Sci. Signal. 7 2014 1 12
41. G. Patino-Lopez, X. Dong, K. Ben-Aissa, K.M. Bernot, T. Itoh, M. Fukuda, M.J. Kruhlak, L.E. Samelson, and S. Shaw Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation J. Biol. Chem. 283 2008 18323 18330
42. M. Sato, K. Sato, W. Liou, S. Pant, A. Harada, and B.D. Grant Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein EMBO J. 27 2008 1183 1196
43. P.M.A. Sleiman, J. Flory, M. Imielinski, J.P. Bradfield, K. Annaiah, S.A.G. Willis-Owen, K. Wang, N.M. Rafaels, S. Michel, K. Bonnelykke, and et al. Variants of DENND1B associated with asthma in children N. Engl. J. Med. 362 2010 36 44
44. N.L.D. Smith, J. Hankinson, A. Simpson, D.W. Denning, and P. Bowyer Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in Chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT Clin. Microbiol. Infect. 20 2014 O960 O968
45. A.I. Su, M.P. Cooke, K.A. Ching, Y. Hakak, J.R. Walker, T. Wiltshire, A.P. Orth, R.G. Vega, L.M. Sapinoso, A. Moqrich, and et al. Large-scale analysis of the human and mouse transcriptomes Proc. Natl. Acad. Sci. USA 99 2002 4465 4470
46. A. Telerman, R.B. Amson, F. Romasco, J. Wybran, P. Galand, and R. Mosselmans Internalization of human T lymphocyte receptors Eur. J. Immunol. 17 1987 991 997
47. S. Valitutti, S. Muller, M. Cella, E. Padovan, and A. Lanzavecchia Serial triggering of many T-cell receptors by a few of pMHC complexes Nature 375 1995 148 151
48. S. Valitutti, S. Muller, M. Dessing, and A. Lanzavecchia Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates Eur. J. Immunol. 26 1996 2012 2016
49. S. Valitutti, S. Muller, M. Salio, and A. Lanzavecchia Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation J. Exp. Med. 185 1997 1859 1864
50. D.B. Wheeler, R. Zoncu, D.E. Root, D.M. Sabatini, and C.L. Sawyers Identification of an oncogenic RAB protein Science 350 2015 211 217
51. X. Wu, M.J. Bradley, Y. Cai, D. Kümmel, E.M. De La Cruz, F.A. Barr, and K.M. Reinisch Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate Proc. Natl. Acad. Sci. USA 108 2011 18672 18677
52. J. Xu, M. Fotouhi, and P.S. McPherson Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy EMBO Rep. 16 2015 709 718
53. S. Yoshimura, A. Gerondopoulos, A. Linford, D.J. Rigden, and F.A. Barr Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors J. Cell Biol. 191 2010 367 381
54. I.A. Yudushkin, and R.D. Vale Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment Proc. Natl. Acad. Sci. USA 107 2010 22128 22133