DENND1B gene variants associate with elevated exhaled nitric oxide in healthy high-risk neonates

Pediatric Pulmonology

Volumn 50, Issue 2, 2015, Pages 109-117

  Chawes, Bo L K ^a   Bischoff, Anne Louise ^a   Kreiner Møller, Eskil ^a   Buchvald, Frederik ^a   Hakonarson, Hakon ^b   Bisgaard, Hans ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Asthma; Genetics; Infant; Nitric oxide

Indexed keywords

ANTIBIOTIC AGENT; FILAGGRIN; NITRIC OXIDE; PARACETAMOL; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DENND1B PROTEIN, HUMAN; GUANINE NUCLEOTIDE EXCHANGE FACTOR;

ALLELE; ARTICLE; BACTERIAL COLONIZATION; BREATHING; DEMOGRAPHY; DENND1B GENE; EXHALATION; FORCED EXPIRATORY VOLUME; GENE; GENETIC VARIABILITY; GENOTYPE; HAEMOPHILUS INFLUENZAE; HUMAN; LUNG MINUTE VOLUME; MATERNAL SMOKING; MORAXELLA CATARRHALIS; NEWBORN; ORMDL3 GENE; PRENATAL EXPOSURE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STREPTOCOCCUS PNEUMONIAE; THIRD TRIMESTER PREGNANCY; BREATH ANALYSIS; COHORT ANALYSIS; FATHER; FEMALE; GENETIC VARIATION; GENETICS; HYPERSENSITIVITY; MALE; METABOLISM;

ALLELES; BREATH TESTS; COHORT STUDIES; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; EXHALATION; FATHERS; FEMALE; GENETIC VARIATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; HYPERSENSITIVITY; INFANT, NEWBORN; MALE; NITRIC OXIDE; RISK FACTORS;

EID: 84920986763     PISSN: 87556863     EISSN: 10990496     Source Type: Journal    
DOI: 10.1002/ppul.22958     Document Type: Article

References (34)

1. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994;343:133-135.
2. Pijnenburg MW, Hofhuis W, Hop WC, de Jongste JC. Exhaled nitric oxide predicts asthma relapse in children with clinical asthma remission. Thorax 2005;60:215-218.
3. Zacharasiewicz A, Wilson N, Lex C, Erin EM, Li AM, Hansel T, Khan M, Bush A. Clinical use of noninvasive measurements of airway inflammation in steroid reduction in children. Am J Respir Crit Care Med 2005;171:1077-1082.
4. Buchvald F, Baraldi E, Carraro S, Gaston B, De JJ, Pijnenburg MW, Silkoff PE, Bisgaard H. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005;115:1130-1136.
5. Moeller A, Diefenbacher C, Lehmann A, Rochat M, Brooks-Wildhaber J, Hall GL, Wildhaber JH. Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms. J Allergy Clin Immunol 2008;121:705-709.
6. Gabriele C, Nieuwhof EM, Van Der Wiel EC, Hofhuis W, Moll HA, Merkus PJ, de Jongste JC. Exhaled nitric oxide differentiates airway diseases in the first two years of life. Pediatr Res 2006;60:461-465.
7. Latzin P, Kuehni CE, Baldwin DN, Roiha HL, Casaulta C, Frey U. Elevated exhaled nitric oxide in newborns of atopic mothers precedes respiratory symptoms. Am J Respir Crit Care Med 2006;174:1292-1298.
8. Bisgaard H. The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. Ann Allergy Asthma Immunol 2004;93:381-389.
9. Chawes BL, Buchvald F, Bischoff AL, Loland L, Hermansen M, Halkjaer LB, Bonnelykke K, Bisgaard H. Elevated exhaled nitric oxide in high-risk neonates precedes transient early but not persistent wheeze. Am J Respir Crit Care Med 2010;182:138-142.
10. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005. Am J Respir Crit Care Med 2005;171:912-930.
11. Frey U, Kuehni C, Roiha H, Cernelc M, Reinmann B, Wildhaber JH, Hall GL. Maternal atopic disease modifies effects of prenatal risk factors on exhaled nitric oxide in infants. Am J Respir Crit Care Med 2004;170:260-265.
12. Gabriele C, Asgarali R, Jaddoe VW, Hofman A, Moll HA, de Jongste JC. Smoke exposure, airway symptoms and exhaled nitric oxide in infants: the Generation R study. Eur Respir J 2008;32:307-313.
13. Bisgaard H, Hermansen MN, Buchvald F, Loland L, Halkjaer LB, Bonnelykke K, Brasholt M, Heltberg A, Vissing NH, Thorsen SV, Stage M, Pipper CB. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007;357:1487-1495.
14. Bisgaard H, Loland L, Holst KK, Pipper CB. Prenatal determinants of neonatal lung function in high-risk newborns. J Allergy Clin Immunol 2009;123:651-657, 657.
15. Kreiner-Moller E, Sevelsted A, Vissing NH, Schoos AM, Bisgaard H. Infant acetaminophen use associates with early asthmatic symptoms independently of respiratory tract infections: the Copenhagen Prospective Study on Asthma in Childhood 2000 (COPSAC (2000)) cohort. J Allergy Clin Immunol 2012;130: 1434-1436.
16. Stensballe LG, Simonsen J, Jensen SM, Bonnelykke K, Bisgaard H. Use of antibiotics during pregnancy increases the risk of asthma in early childhood. J Pediatr 2013;162:832-838.
17. Bonnelykke K, Pipper CB, Tavendale R, Palmer CN, Bisgaard H. Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth. Pediatr Allergy Immunol 2010;21:954-961.
18. Bisgaard H, Bonnelykke K, Sleiman PM, Brasholt M, Chawes B, Kreiner-Moller E, Stage M, Kim C, Tavendale R, Baty F, Pipper CB, Palmer CN, Hakonarsson H. Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am J Respir Crit Care Med 2009;179:179-185.
19. Sleiman PM, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SA, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JM, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von ME, Cookson WO, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SF, Bisgaard H, Hakonarson H. Variants of DENND1B associated with asthma in children. N Engl J Med 2010;362:36-44.
20. Bisgaard H, Hermansen MN, Loland L, Halkjaer LB, Buchvald F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 2006;354:1998-2005.
21. Hayden MJ, Devadason SG, Sly PD, Wildhaber JH, Lesouef PN. Methacholine responsiveness using the raised volume forced expiration technique in infants. Am J Respir Crit Care Med 1997;155:1670-1675.
22. Loland L, Buchvald FF, Halkjaer LB, Anhoj J, Hall GL, Persson T, Krause TG, Bisgaard H. Sensitivity of bronchial responsiveness measurements in young infants. Chest 2006;129:669-675.
23. Loland L, Bisgaard H. Feasibility of repetitive lung function measurements by raised volume rapid thoracoabdominal compression during methacholine challenge in young infants. Chest 2008;133:115-122.
24. Turner DJ, Stick SM, Lesouef KL, Sly PD, Lesouef PN. A new technique to generate and assess forced expiration from raised lung volume in infants. Am J Respir Crit Care Med 1995;151: 1441-1450.
25. Wildhaber JH, Hall GL, Stick SM. Measurements of exhaled nitric oxide with the single-breath technique and positive expiratory pressure in infants. Am J Respir Crit Care Med 1999;159:74-78.
26. Hall GL, Reinmann B, Wildhaber JH, Frey U. Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure. J Appl Physiol 2002;92:59-66.
27. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O'Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El HB, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH. Common loss-offunction variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38:441-446.
28. Kharitonov SA, Barnes PJ. Nasal contribution to exhaled nitric oxide during exhalation against resistance or during breath holding. Thorax 1997;52:540-544.
29. Silkoff PE, McClean PA, Slutsky AS, Furlott HG, Hoffstein E, Wakita S, Chapman KR, Szalai JP, Zamel N. Marked flowdependence of exhaled nitric oxide using a new technique to exclude nasal nitric oxide. Am J Respir Crit Care Med 1997;155:260-267.
30. Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De VM, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van GA, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panes J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42:1118-1125.
31. Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat Genet 2011;43:329-332.
32. Lindstedt M, Lundberg K, Borrebaeck CA. Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells. J Immunol 2005;175:4839-4846.
33. de Jongste JC, Alving K. Gas analysis. Am J Respir Crit Care Med 2000;162:S23-S27.
34. Jobsis Q, Schellekens SL, Kroesbergen A, Hop WC, de Jongste JC. Sampling of exhaled nitric oxide in children: end-expiratory plateau, balloon and tidal breathing methods compared. Eur Respir J 1999;13:1406-1410.