Phosphorylation of the exchange factor DENND3 by ULK in response to starvation activates Rab12 and induces autophagy

EMBO Reports

Volumn 16, Issue 6, 2015, Pages 709-718

  Xu, Jie ^a   Fotouhi, Maryam ^a   McPherson, Peter S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

14 3 3; DENN domain; GEF; guanine nucleotide exchange factor; LC3

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR DENND3; GUANOSINE TRIPHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN P62; RAB PROTEIN; RAB12 PROTEIN; UNC 51 LIKE KINASE; UNCLASSIFIED DRUG; DENND3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; RAB12 PROTEIN, HUMAN; SERINE THREONINE PROTEIN KINASE ULK1; SIGNAL PEPTIDE; SMALL INTERFERING RNA; ULK1 PROTEIN, HUMAN; ULK2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL MIGRATION; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STABLE EXPRESSION; STARVATION; UPREGULATION; GENE SILENCING; GENETICS; METABOLISM; PHAGOSOME; PHOSPHORYLATION; PROTEIN TRANSPORT;

AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN-1 HOMOLOG; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHAGOSOMES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RAB GTP-BINDING PROTEINS; RNA, SMALL INTERFERING;

EID: 84930383375     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201440006     Document Type: Article

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