Variants of DENND1B associated with asthma in children

New England Journal of Medicine

Volumn 362, Issue 1, 2010, Pages 36-44

  Sleiman, Patrick M A ^a   Flory, James ^a   Imielinski, Marcin ^a   Bradfield, Jonathan P ^a   Annaiah, Kiran ^a   Willis Owen, Saffron A G ^d   Wang, Kai ^a   Rafaels, Nicholas M ^e   Michel, Sven ^h   Bonnelykke, Klaus ⁱ   Zhang, Haitao ^a   Kim, Cecilia E ^a   Frackelton, Edward C ^a   Glessner, Joseph T ^a   Hou, Cuiping ^a   Otieno, F George ^a   Santa, Erin ^a   Thomas, Kelly ^a   Smith, Ryan M ^a   Glaberson, Wendy R ^a   Garris, Maria ^a   Chiavacci, Rosetta M ^a   Beaty, Terri H ^e   Ruczinski, Ingo ^e   Orange, Jordan M ^b   Allen, Julian ^b   Spergel, Jonathan M ^b   Grundmeier, Robert ^b,c   Mathias, Rasika A ^f   Christie, Jason D ^b   Von Mutius, Erika ^g   Cookson, William O C ^d   Kabesch, Michael ^h   Moffatt, Miriam F ^d   Grunstein, Michael M ^b   Barnes, Kathleen C ^e   Devoto, Marcella ^b   Magnusson, Mark ^b   Li, Hongzhe ^b   Grant, Struan F A ^a,b   Bisgaard, Hans ⁱ   Hakonarson, Hakon ^a,b   more..

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^g UNIVERSITY OF MUNICH   (Germany)

^h HANNOVER MEDICAL SCHOOL   (Germany)

ⁱ UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DENN MADD DOMAIN CONTAINING 1B PROTEIN; IMMUNOLOGIC FACTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DENND1B PROTEIN, HUMAN; GUANINE NUCLEOTIDE EXCHANGE FACTOR;

AFRICAN AMERICAN; ARTICLE; ASTHMA; CHILD; CHROMOSOME 1Q; CONTROLLED STUDY; DENDRITIC CELL; EUROPEAN AMERICAN; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; GENE REPLICATION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CAUCASIAN; CHROMOSOME 1; CHROMOSOME 17; CLINICAL TRIAL; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; META ANALYSIS; MULTICENTER STUDY; NEGRO; NORTH AMERICA; RISK;

AFRICAN CONTINENTAL ANCESTRY GROUP; ASTHMA; CASE-CONTROL STUDIES; CHILD; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 17; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; META-ANALYSIS AS TOPIC; NORTH AMERICA; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 74049129976     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa0901867     Document Type: Article

References (24)

1. Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006;7:95-100.
2. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev 2008;8:169-82.
3. Halapi E, Hakonarson H. Recent development in genomic and proteomic research for asthma. Curr Opin Pulm Med 2004;10:22-30.
4. Moffatt MF, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007;448:470-3.
5. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ. Asthma and wheezing in the first six years of life. N Engl J Med 1995;332:133-8.
6. Sears MR, Greene JM, Willan AR, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med 2003;349:1414-22.
7. Bouzigon E, Corda E, Aschard H, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008;359:1985-94.
8. National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma - summary report 2007. J Allergy Clin Immunol 2007; 120:5 Suppl:S94-S138. [Erratum, J Allergy Clin Immunol 2008;121:1330.]
9. Luca D, Ringquist S, Klei L, et al. On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am J Hum Genet 2008;82:453-63.
10. Lin PI, Vance JM, Pericak-Vance MA, Martin ER. No gene is an island: the flip-flop phenomenon. Am J Hum Genet 2007; 80:531-8. [Erratum, Am J Hum Genet 2007; 80:1002.]
11. Gosens I, den Hollander AI, Cremers FP, Roepman R. Composition and function of the Crumbs protein complex in the mammalian retina. Exp Eye Res 2008;86:713-26.
12. den Hollander AI, ten Brink JB, de Kok YJ, et al. Mutations in a human homologue of Drosophila crumbs cause retinitis pigmentosa (RP12). Nat Genet 1999;23:217-21.
13. den Hollander AI, Johnson K, de Kok YJ, et al. CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila, Hum Mol Genet 2001;10:2767-73.
14. Del Villar K, Miller CA, Down-regulation of DENN/MADD, a TNF receptor binding protein, correlates with neuronal cell death in Alzheimer's disease brain and hippocampal neurons. Proc Natl Acad Sci U S A 2004;101:4210-5.
15. Miyoshi J, Takai Y. Dual role of DENN/MADD (Rab3GEP) in neurotransmission and neuroprotection. Trends Mol Med 2004;10:476-80.
16. Lindstedt M, Lundberg K, Borrebaeck CA. Gene family clustering identifies functionally associated subsets of human in vivo blood and tonsillar dendritic cells. J Immunol 2005;175:4839-46.
17. Su AI, Cooke MP, Ching KA, et al. Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A 2002;99:4465-70.
18. Liu YJ. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell 2001;106:259-62.
19. Willinger T, Freeman T, Hasegawa H, McMichael AJ, Callan MF. Molecular signatures distinguish human central memory from effector memory CD8 T cell subsets. J Immunol 2005;175:5895-903.
20. Bisgaard H, Hermansen M, Buchvald F, et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 2007;357:1487-95.
21. Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet 2004;5:376-87.
22. Galanter J, Choudhry S, Eng C, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med 2008;177:1194-200.
23. Tavendale R, Macgregor DF, Mukhopadhyay S, Palmer CN. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol 2008;121:860-3.
24. Sleiman PM, Annaiah K, Imielinski M, et al. ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. J Allergy Clin Immunol 2008;122:1225-7.