Lipophilic triphenylphosphonium cations inhibit mitochondrial electron transport chain and induce mitochondrial proton leak

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Trnka, Jan ^a   Elkalaf, Moustafa ^a   Andě, Michal ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CATION; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TRIPHENYLPHOSPHONIUM CATION; UNCLASSIFIED DRUG; HETEROCYCLIC COMPOUND; MULTIENZYME COMPLEX; ORGANOPHOSPHORUS COMPOUND; TRIS(O-PHENYLENEDIOXY)CYCLOTRIPHOSPHAZENE;

ACIDIFICATION; ALKYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; CELL FRACTIONATION; CELL RESPIRATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; EXTRACELLULAR ACIDIFICATION; HYDROPHOBICITY; INFANT; LIPOPHILICITY; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PROTON LEAK; MITOCHONDRIAL RESPIRATION; NONHUMAN; RAT; TOXICITY; ANIMAL; CELL LINE; DRUG EFFECTS; MALE; METABOLISM; MUSCLE MITOCHONDRION; OXYGEN CONSUMPTION; WISTAR RAT;

ANIMALS; CELL LINE; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; HETEROCYCLIC COMPOUNDS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, MUSCLE; ORGANOPHOSPHORUS COMPOUNDS; OXYGEN CONSUMPTION; RATS; RATS, WISTAR;

EID: 84928796672     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121837     Document Type: Article

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