Innate lymphoid cells: Parallel checkpoints and coordinate interactions with T cells

Current Opinion in Immunology

Volumn 38, Issue , 2016, Pages 86-93

  Huntington, Nicholas D ^a   Carpentier, Sabrina ^b   Vivier, Eric ^c,d   Belz, Gabrielle T ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MI mAbs   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d HÔPITAL DE LA CONCEPTION   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNE RESPONSE; LYMPHOID CELL; MAMMAL; T LYMPHOCYTE; ADAPTIVE IMMUNITY; ANIMAL; CD8+ T LYMPHOCYTE; CELL COMMUNICATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MUCOSA; NATURAL KILLER CELL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION;

BCL6 PROTEIN, HUMAN; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; GATA3 PROTEIN, HUMAN; IL15 PROTEIN, HUMAN; INTERLEUKIN 15; PROTEIN BCL 6; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RORC PROTEIN, HUMAN; TRANSCRIPTION FACTOR GATA 3;

ADAPTIVE IMMUNITY; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-15; KILLER CELLS, NATURAL; MUCOUS MEMBRANE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PROTO-ONCOGENE PROTEINS C-BCL-6; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 84954168989     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2015.11.008     Document Type: Review

References (85)

1. Spits H., Artis D., Colonna M., Diefenbach A., Di Santo J.P., Eberl G., Koyasu S., Locksley R.M., McKenzie A.N., Mebius R.E., et al. Innate lymphoid cells - a proposal for uniform nomenclature. Nat Rev Immunol 2013, 13:145-149.
2. Robinette M.L., Fuchs A., Cortez V.S., Lee J.S., Wang Y., Durum S.K., Gilfillan S., Colonna M. Immunological Genome C: Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol 2015, 16:306-317.
3. Voskoboinik I., Whisstock J.C., Trapani J.A. Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol 2015, 15:388-400.
4. Huntington N.D., Puthalakath H., Gunn P., Naik E., Michalak E.M., Smyth M.J., Tabarias H., Degli-Esposti M.A., Dewson G., Willis S.N., et al. Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol 2007, 8:856-863.
5. Huntington N.D. The unconventional expression of IL-15 and its role in NK cell homeostasis. Immunol Cell Biol 2014, 92:210-213.
6. Verdeil G., Puthier D., Nguyen C., Schmitt-Verhulst A.M., Auphan-Anezin N. STAT5-mediated signals sustain a TCR-initiated gene expression program toward differentiation of CD8 T cell effectors. J Immunol 2006, 176:4834-4842.
7. Grange M., Verdeil G., Arnoux F., Griffon A., Spicuglia S., Maurizio J., Buferne M., Schmitt-Verhulst A.M., Auphan-Anezin N. Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-beta1 signaling. J Immunol 2013, 191:3712-3724.
8. Sathe P., Delconte R.B., Souza-Fonseca-Guimaraes F., Seillet C., Chopin M., Vandenberg C.J., Rankin L.C., Mielke L.A., Vikstrom I., Kolesnik T.B., et al. Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells. Nat Commun 2014, 5:4539.
9. Opferman J.T., Letai A., Beard C., Sorcinelli M.D., Ong C.C., Korsmeyer S.J. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003, 426:671-676.
10. Huntington N.D., Legrand N., Alves N.L., Jaron B., Weijer K., Plet A., Corcuff E., Mortier E., Jacques Y., Spits H., et al. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med 2009, 206:25-34.
11. Fehniger T.A., Suzuki K., Ponnappan A., VanDeusen J.B., Cooper M.A., Florea S.M., Freud A.G., Robinson M.L., Durbin J., Caligiuri M.A. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J Exp Med 2001, 193:219-231.
12. Rubinstein M.P., Lind N.A., Purton J.F., Filippou P., Best J.A., McGhee P.A., Surh C.D., Goldrath A.W. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood 2008, 112:3704-3712.
13. Murali-Krishna K., Ahmed R. Cutting edge: naive T cells masquerading as memory cells. J Immunol 2000, 165:1733-1737.
14. Goldrath A.W., Bogatzki L.Y., Bevan M.J. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med 2000, 192:557-564.
15. Huntington N.D., Tabarias H., Fairfax K., Brady J., Hayakawa Y., Degli-Esposti M.A., Smyth M.J., Tarlinton D.M., Nutt S.L. NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J Immunol 2007, 178:4764-4770.
16. Sun J.C., Lanier L.L. NK cell development, homeostasis and function: parallels with CD8(+) T cells. Nat Rev Immunol 2011, 11:645-657.
17. Cho B.K., Rao V.P., Ge Q., Eisen H.N., Chen J. Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells. J Exp Med 2000, 192:549-556.
18. Marcais A., Cherfils-Vicini J., Viant C., Degouve S., Viel S., Fenis A., Rabilloud J., Mayol K., Tavares A., Bienvenu J., et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol 2014, 15:749-757.
19. Pollizzi K.N., Patel C.H., Sun I.H., Oh M.H., Waickman A.T., Wen J., Delgoffe G.M., Powell J.D. mTORC1 and mTORC2 selectively regulate CD8(+) T cell differentiation. J Clin Invest 2015, 125:2090-2108.
20. Fuchs A., Vermi W., Lee J.S., Lonardi S., Gilfillan S., Newberry R.D., Cella M., Colonna M. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-gamma-producing cells. Immunity 2013, 38:769-781.
21. Klose C.S., Flach M., Mohle L., Rogell L., Hoyler T., Ebert K., Fabiunke C., Pfeifer D., Sexl V., Fonseca-Pereira D., et al. Differentiation of Type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 2014, 157:340-356.
22. Constantinides M.G., McDonald B.D., Verhoef P.A., Bendelac A. A committed precursor to innate lymphoid cells. Nature 2014, 508:397-401.
23. Gangadharan D., Lambolez F., Attinger A., Wang-Zhu Y., Sullivan B.A., Cheroutre H. Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus. Immunity 2006, 25:631-641.
24. Pobezinsky L.A., Angelov G.S., Tai X., Jeurling S., Van Laethem F., Feigenbaum L., Park J.H., Singer A. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 2012, 13:569-578.
25. Klose C.S., Blatz K., d'Hargues Y., Hernandez P.P., Kofoed-Nielsen M., Ripka J.F., Ebert K., Arnold S.J., Diefenbach A., Palmer E., et al. The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8alphaalpha(+) intraepithelial lymphocyte development. Immunity 2014, 41:230-243.
26. Delconte R.B., Shi W., Sathe P., Ushiki T., Seillet C., Minnich M., Kolesnik T.B., Rankin L.C., Mielke L.A., Zhang J.-G., et al. Id2 governs natural killer cell fate by tuning their sensitivity to IL-15. Immunity 2015, (In press).
27. Yang C.Y., Best J.A., Knell J., Yang E., Sheridan A.D., Jesionek A.K., Li H.S., Rivera R.R., Lind K.C., D'Cruz L.M., et al. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol 2011, 12:1221-1229.
28. Masson F., Ghisi M., Groom J.R., Kallies A., Seillet C., Johnstone R.W., Nutt S.L., Belz G.T. Id2 represses E2A-mediated activation of IL-10 expression in T cells. Blood 2014, 123:3420-3428.
29. Masson F., Minnich M., Olshansky M., Bilic I., Mount A.M., Kallies A., Speed T.P., Busslinger M., Nutt S.L., Belz G.T. Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation. J Immunol 2013, 190:4585-4594.
30. Knell J., Best J.A., Lind N.A., Yang E., D'Cruz L.M., Goldrath A.W. Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells. J Immunol 2013, 190:1501-1509.
31. Walker J.A., Oliphant C.J., Englezakis A., Yu Y., Clare S., Rodewald H.R., Belz G., Liu P., Fallon P.G., McKenzie A.N. Bcl11b is essential for group 2 innate lymphoid cell development. J Exp Med 2015, 212:875-882.
32. Califano D., Cho J.J., Uddin M.N., Lorentsen K.J., Yang Q., Bhandoola A., Li H., Avram D. Transcription factor Bcl11b controls identity and function of mature Type 2 innate lymphoid cells. Immunity 2015, 43:354-368.
33. Yu Y., Wang C., Clare S., Wang J., Lee S.C., Brandt C., Burke S., Lu L., He D., Jenkins N.A., et al. The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development. J Exp Med 2015, 212:865-874.
34. Wong S.H., Walker J.A., Jolin H.E., Drynan L.F., Hams E., Camelo A., Barlow J.L., Neill D.R., Panova V., Koch U., et al. Transcription factor RORalpha is critical for nuocyte development. Nat Immunol 2012, 13:229-236.
35. Yagi R., Zhong C., Northrup D.L., Yu F., Bouladoux N., Spencer S., Hu G., Barron L., Sharma S., Nakayama T., et al. The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells. Immunity 2014, 40:378-388.
36. Mjosberg J., Bernink J., Golebski K., Karrich J.J., Peters C.P., Blom B., te Velde A.A., Fokkens W.J., van Drunen C.M., Spits H. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 2012, 37:649-659.
37. Walker J.A., McKenzie A.N. Development and function of group 2 innate lymphoid cells. Curr Opin Immunol 2013, 25:148-155.
38. Shimoda K., van Deursen J., Sangster M.Y., Sarawar S.R., Carson R.T., Tripp R.A., Chu C., Quelle F.W., Nosaka T., Vignali D.A., et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996, 380:630-633.
39. Bando J.K., Liang H.E., Locksley R.M. Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine. Nat Immunol 2015, 16:153-160.
40. Guo L., Huang Y., Chen X., Hu-Li J., Urban J.F., Paul W.E. Innate immunological function of TH2 cells in vivo. Nat Immunol 2015, 16:1051-1059.
41. Doherty T.A., Khorram N., Lund S., Mehta A.K., Croft M., Broide D.H. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol 2013, 132:205-213.
42. Molofsky A.B., Van Gool F., Liang H.E., Van Dyken S.J., Nussbaum J.C., Lee J., Bluestone J.A., Locksley R.M. Interleukin-33 and interferon-gamma counter-regulate Group 2 innate lymphoid cell activation during immune perturbation. Immunity 2015, 43:161-174.
43. Monticelli L.A., Osborne L.C., Noti M., Tran S.V., Zaiss D.M., Artis D. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions. Proc Natl Acad Sci U S A 2015, 112:10762-10767.
44. Oliphant C.J., Hwang Y.Y., Walker J.A., Salimi M., Wong S.H., Brewer J.M., Englezakis A., Barlow J.L., Hams E., Scanlon S.T., et al. MHCII-mediated dialog between Group 2 innate lymphoid cells and CD4(+) T cells potentiates Type 2 immunity and promotes parasitic helminth expulsion. Immunity 2014, 41:283-295.
45. Neill D.R., Wong S.H., Bellosi A., Flynn R.J., Daly M., Langford T.K., Bucks C., Kane C.M., Fallon P.G., Pannell R., et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 2010, 464:1367-1370.
46. Mebius R.E., Rennert R., Weissman I.L. Developing lymph nodes collect CD4+ CD3- LTb+ cells the can differentiate to APC, NK Cells, and follicular cells but not T or B cells. Immunity 1997, 7:493-504.
47. Mirchandani A.S., Besnard A.-G., Yip E., Scott C., Bain C.C., Cerovic V., Salmond R.J., Liew F.Y. Type 2 innate lymphoid cells drive CD4+ Th2 cell responses. J Immunol (Baltimore Md.: 1950) 2014.
48. Roediger B., Weninger W. Group 2 innate lymphoid cells in the regulation of immune responses. Adv Immunol 2015, 125:111-154.
49. Vallentin B., Barlogis V., Piperoglou C., Cypowyj S., Zucchini N., Chene M., Navarro F., Farnarier C., Vivier E., Vely F. Innate lymphoid cells in cancer. Cancer Immunol Res 2015, 3:1109-1114.
50. Rankin L.C., Groom J.R., Chopin M., Herold M.J., Walker J.A., Mielke L.A., McKenzie A.N., Carotta S., Nutt S.L., Belz G.T. The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway. Nat Immunol 2013, 14:389-395.
51. van de Pavert S.A., Vivier E. Differentiation and function of group 3 innate lymphoid cells, from embryo to adult. Int Immunol 2015.
52. Satoh-Takayama N., Vosshenrich C.A., Lesjean-Pottier S., Sawa S., Lochner M., Rattis F., Mention J.J., Thiam K., Cerf-Bensussan N., Mandelboim O., et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 2008, 29:958-970.
53. Cella M., Fuchs A., Vermi W., Facchetti F., Otero K., Lennerz J.K., Doherty J.M., Mills J.C., Colonna M. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 2009, 457:722-725.
54. Satoh-Takayama N., Serafini N., Verrier T., Rekiki A., Renauld J.C., Frankel G., Di Santo J.P. The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity 2014, 41:776-788.
55. Song C., Lee J.S., Gilfillan S., Robinette M.L., Newberry R.D., Stappenbeck T.S., Mack M., Cella M., Colonna M. Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation. J Exp Med 2015, 212:1869-1882.
56. Rankin L.C., Girard-Madoux M.J.H., Seillet C., Mielke L.A., Kerdiles Y., Fenis A., Wieduwild E., Putoczki T., Mondot S., Lantz O., et al. Complementarity and redundancy of IL-22-producing innate lymphoid cells. Nat Immunol 2015, (In press).
57. Basu R., O'Quinn D.B., Silberger D.J., Schoeb T.R., Fouser L., Ouyang W., Hatton R.D., Weaver C.T. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity 2012, 37:1061-1075.
58. Zheng Y., Valdez P.A., Danilenko D.M., Hu Y., Sa S.M., Gong Q., Abbas A.R., Modrusan Z., Ghilardi N., de Sauvage F.J., et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 2008, 14:282-289.
59. Sonnenberg G.F., Monticelli L.A., Alenghat T., Fung T.C., Hutnick N.A., Kunisawa J., Shibata N., Grunberg S., Sinha R., Zahm A.M., et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 2012, 336:1321-1325.
60. Guo X., Qiu J., Tu T., Yang X., Deng L., Anders R.A., Zhou L., Fu Y.X. Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity 2014, 40:25-39.
61. Ahlfors H., Morrison P.J., Duarte J.H., Li Y., Biro J., Tolaini M., Di Meglio P., Potocnik A.J., Stockinger B. IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection. J Immunol 2014, 193:4602-4613.
62. Hepworth M.R., Fung T.C., Masur S.H., Kelsen J.R., McConnell F.M., Dubrot J., Withers D.R., Hugues S., Farrar M.A., Reith W., et al. Immune tolerance, Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4(+) T cells. Science 2015, 348:1031-1035.
63. Hepworth M.R., Monticelli L.A., Fung T.C., Ziegler C.G., Grunberg S., Sinha R., Mantegazza A.R., Ma H.L., Crawford A., Angelosanto J.M., et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature 2013, 498:113-117.
64. von Burg N., Chappaz S., Baerenwaldt A., Horvath E., Bose Dasgupta S., Ashok D., Pieters J., Tacchini-Cottier F., Rolink A., Acha-Orbea H., et al. Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses. Proc Natl Acad Sci U S A 2014, 111:12835-12840.
65. Sano T., Huang W., Hall J.A., Yang Y., Chen A., Gavzy S.J., Lee J.Y., Ziel J.W., Miraldi E.R., Domingos A.I. An IL-23R/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses. Cell 2015.
66. Aparicio-Domingo P., Romera-Hernandez M., Karrich J.J., Cornelissen F., Papazian N., Lindenbergh-Kortleve D.J., Butler J.A., Boon L., Coles M.C., Samsom J.N., et al. Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage. J Exp Med 2015, 212:1783-1791.
67. Goto Y., Obata T., Kunisawa J., Sato S., Ivanov I.I., Lamichhane A., Takeyama N., Kamioka M., Sakamoto M., Matsuki T., et al. Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science 2014, 345:1254009.
68. Chen L., He Z., Slinger E., Bongers G., Lapenda T.L., Pacer M.E., Jiao J., Beltrao M.F., Soto A.J., Harpaz N., et al. IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology. Mucosal Immunol 2015, 8:390-402.
69. Buonocore S., Ahern P.P., Uhlig H.H., Ivanov I.I., Littman D.R., Maloy K.J., Powrie F. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 2010, 464:1371-1375.
70. Mortha A., Chudnovskiy A., Hashimoto D., Bogunovic M., Spencer S.P., Belkaid Y., Merad M. Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science 2014, 343:1249288.
71. Powell N., Lo J.W., Biancheri P., Vossenkamper A., Pantazi E., Walker A.W., Stolarczyk E., Ammoscato F., Goldberg R., Scott P., et al. Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation. Gastroenterology 2015, 149. 456-467 e415.
72. Longman R.S., Diehl G.E., Victorio D.A., Huh J.R., Galan C., Miraldi E.R., Swaminath A., Bonneau R., Scherl E.J., Littman D.R. CX(3)CR1(+) mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med 2014, 211:1571-1583.
73. Seo S.U., Kuffa P., Kitamoto S., Nagao-Kitamoto H., Rousseau J., Kim Y.G., Nunez G., Kamada N. Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells. Nat Commun 2015, 6:8010.
74. Reynders A., Yessaad N., Vu Manh T.P., Dalod M., Fenis A., Aubry C., Nikitas G., Escaliere B., Renauld J.C., Dussurget O., et al. Identity, regulation and in vivo function of gut NKp46+RORgammat+ and NKp46+RORgammat- lymphoid cells. EMBO J 2011, 30:2934-2947.
75. Tan C., Wei L., Vistica B.P., Shi G., Wawrousek E.F., Gery I. Phenotypes of Th lineages generated by the commonly used activation with anti-CD3/CD28 antibodies differ from those generated by the physiological activation with the specific antigen. Cell Mol Immunol 2014, 11:305-313.
76. Monticelli L.A., Sonnenberg G.F., Abt M.C., Alenghat T., Ziegler C.G., Doering T.A., Angelosanto J.M., Laidlaw B.J., Yang C.Y., Sathaliyawala T., et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol 2011, 12:1045-1054.
77. Lotem J., Levanon D., Negreanu V., Leshkowitz D., Friedlander G., Groner Y. Runx3-mediated transcriptional program in cytotoxic lymphocytes. PLoS One 2013, 8:e80467.
78. Lattin J.E., Schroder K., Su A.I., Walker J.R., Zhang J., Wiltshire T., Saijo K., Glass C.K., Hume D.A., Kellie S., et al. Expression analysis of G protein-coupled receptors in mouse macrophages. Immunome Res 2008, 4:5.
79. Konuma T., Nakamura S., Miyagi S., Negishi M., Chiba T., Oguro H., Yuan J., Mochizuki-Kashio M., Ichikawa H., Miyoshi H., et al. Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells. Exp Hematol 2011, 39. 697-709 e695.
80. Robbins S.H., Walzer T., Dembele D., Thibault C., Defays A., Bessou G., Xu H., Vivier E., Sellars M., Pierre P., et al. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol 2008, 9:R17.
81. Moro K., Yamada T., Tanabe M., Takeuchi T., Ikawa T., Kawamoto H., Furusawa J., Ohtani M., Fujii H., Koyasu S. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2010, 463:540-544.
82. Lin C.C., Bradstreet T.R., Schwarzkopf E.A., Sim J., Carrero J.A., Chou C., Cook L.E., Egawa T., Taneja R., Murphy T.L., et al. Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation. Nat Commun 2014, 5:3551.
83. Fehniger T.A., Cai S.F., Cao X., Bredemeyer A.J., Presti R.M., French A.R., Ley T.J. Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs. Immunity 2007, 26:798-811.
84. Horiuchi S., Onodera A., Hosokawa H., Watanabe Y., Tanaka T., Sugano S., Suzuki Y., Nakayama T. Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J Immunol 2011, 186:6378-6389.
85. Lee Y., Kumagai Y., Jang M.S., Kim J.H., Yang B.G., Lee E.J., Kim Y.M., Akira S., Jang M.H. Intestinal Lin- c-Kit+ NKp46- CD4- population strongly produces IL-22 upon IL-1beta stimulation. J Immunol 2013, 190:5296-5305.