Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells

Experimental Hematology

Volumn 39, Issue 6, 2011, Pages

  Konuma, Takaaki ^a,b   Nakamura, Shunsuke ^a,b   Miyagi, Satoru ^a,b   Negishi, Masamitsu ^a,b   Chiba, Tetsuhiro ^a,b   Oguro, Hideyuki ^a,b   Yuan, Jin ^a,b   Mochizuki Kashio, Makiko ^a,b   Ichikawa, Hitoshi ^c   Miyoshi, Hiroyuki ^d   Vidal, Miguel ^e   Iwama, Atsushi ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d RIKEN BIORESOURCE CENTER   (Japan)

^e CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CD34 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; F BOX AND LEUCINE RICH REPEAT PROTEIN 10; HISTONE DEMETHYLASE; HISTONE H3; LYSINE; METHYLCELLULOSE; POLYCOMB GROUP PROTEIN; PROTEIN INK4A; PROTEIN INK4B; PROTEIN INK4C; RETROVIRUS VECTOR; STEM CELL FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL REGENERATION; COLONY FORMING CELL; CONTROLLED STUDY; DEMETHYLATION; GENE EXPRESSION PROFILING; GENE REPRESSION; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HISTONE DEMETHYLASE GENE; HISTONE METHYLATION; HISTONE UBIQUITINATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION;

EID: 79956268072     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2011.03.008     Document Type: Article

References (44)

1. He S., Nakada D., Morrison S.J. Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol 2009, 25:377-406.
2. Zon L.I. Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal. Nature 2008, 453:306-313.
3. Blank U., Karlsson G., Karlsson S. Signaling pathways governing stem-cell fate. Blood 2008, 111:492-503.
4. Sauvageau M., Sauvageau G. Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 2010, 7:299-313.
5. Konuma T., Oguro H., Iwama A. Role of the polycomb group proteins in hematopoietic stem cells. Dev Growth Differ 2010, 52:505-516.
6. Kouzarides T. Chromatin modifications and their function. Cell 2007, 128:693-705.
7. Spivakov M., Fisher A.G. Epigenetic signatures of stem-cell identity. Nat Rev Genet 2007, 8:263-271.
8. Weishaupt H., Sigvardsson M., Attema J.L. Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells. Blood 2010, 115:247-256.
9. Cui K., Zang C., Roh T.Y., et al. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 2009, 4:80-93.
10. Oguro H., Yuan J., Ichikawa H., et al. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell 2010, 6:279-286.
11. Shi Y., Lan F., Matson C., et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004, 119:941-953.
12. Tsukada Y., Fang J., Erdjument-Bromage H., et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature 2006, 439:811-816.
13. Cloos P.A., Christensen J., Agger K., Helin K. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev 2008, 22:1115-1140.
14. Nottke A., Colaiácovo M.P., Shi Y. Developmental roles of the histone lysine demethylases. Development 2009, 136:879-889.
15. Jepsen K., Solum D., Zhou T., et al. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007, 450:415-419.
16. Sen G.L., Webster D.E., Barragan D.I., Chang H.Y., Khavari P.A. Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev 2008, 22:1865-1870.
17. Sun G., Alzayady K., Stewart R., et al. Histone demethylase LSD1 regulates neural stem cell proliferation. Mol Cell Biol 2010, 30:1997-2005.
18. Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., Harper J.W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 2004, 18:2573-2580.
19. Koyama-Nasu R., David G., Tanese N. The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun. Nat Cell Biol 2007, 9:1074-1080.
20. He J., Kallin E.M., Tsukada Y., Zhang Y. The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b). Nat Struct Mol Biol 2008, 15:1169-1175.
21. Tzatsos A., Pfau R., Kampranis S.C., Tsichlis P.N. Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus. Proc Natl Acad Sci U S A 2009, 106:2641-2646.
22. Pfau R., Tzatsos A., Kampranis S.C., Serebrennikova O.B., Bear S.E., Tsichlis P.N. Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci U S A 2008, 105:1907-1912.
23. Frescas D., Guardavaccaro D., Bassermann F., Koyama-Nasu R., Pagano M. JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature 2007, 450:309-313.
24. Lagarou A., Mohd-Sarip A., Moshkin Y.M., et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev 2008, 22:2799-2810.
25. Sánchez C., Sánchez I., Demmers J.A., Rodriguez P., Strouboulis J., Vidal M. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. Mol Cell Proteomics 2007, 6:820-834.
26. Gearhart M.D., Corcoran C.M., Wamstad J.A., Bardwell V.J. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol 2006, 26:6880-6889.
27. Noda S., Horiguchi K., Ichikawa H., Miyoshi H. Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. Stem Cells 2008, 26:646-655.
28. Ory D.S., Neugeboren B.A., Mulligan R.C. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A 1996, 93:11400-11406.
29. Iwama A., Oguro H., Negishi M., et al. Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity 2004, 21:843-851.
30. Oguro H., Iwama A., Morita Y., Kamijo T., van Lohuizen M., Nakauchi H. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med 2006, 203:2247-2253.
31. Kato Y., Iwama A., Tadokoro Y., et al. Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis. J Exp Med 2005, 202:169-179.
32. Takano H., Ema H., Sudo K., Nakauchi H. Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs. J Exp Med 2004, 199:295-302.
33. McMahon K.A., Hiew S.Y., Hadjur S., et al. Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal. Cell Stem Cell 2007, 1:338-345.
34. Kamminga L.M., Bystrykh L.V., de Boer A., et al. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood 2006, 107:2170-2179.
35. Osawa M., Hanada K., Hamada H., Nakauchi H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996, 273:242-245.
36. Orford K.W., Scadden D.T. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet 2008, 9:115-128.
37. Boyer M.J., Cheng T. The CDK inhibitors: potential targets for therapeutic stem cell manipulations?. Gene Ther 2008, 15:117-125.
38. Yuan Y., Shen H., Franklin D.S., Scadden D.T., Cheng T. In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nat Cell Biol 2004, 6:436-442.
39. Park I.K., Qian D., Kiel M., et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003, 423:302-305.
40. Stepanova L., Sorrentino B.P. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood 2005, 106:827-832.
41. Janzen V., Forkert R., Fleming H.E., et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 2006, 443:421-426.
42. Passegué E., Wagers A.J., Giuriato S., Anderson W.C., Weissman I.L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med 2005, 202:1599-1611.
43. Ko R.M., Kim H.G., Wolff L., Klug C.A. Roles of p15Ink4b and p16Ink4a in myeloid differentiation and RUNX1-ETO-associated acute myeloid leukemia. Leuk Res 2008, 32:1101-1111.
44. Drexler H.G. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia 1998, 12:845-859.