메뉴 건너뛰기




Volumn 35, Issue 1, 2016, Pages

Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells

Author keywords

Lung cancer; miR 208a; p21; Proliferation; Radioresistance; Serum exosomes

Indexed keywords

MICRORNA; MICRORNA 126 3P; MICRORNA 200A 3P; MICRORNA 208A; MICRORNA 29B 3P; PROTEIN P21; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; MIRN208 MICRORNA, HUMAN;

EID: 84954149839     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/s13046-016-0285-3     Document Type: Article
Times cited : (171)

References (47)
  • 3
    • 84861694666 scopus 로고    scopus 로고
    • Targeted agents in non-small cell lung cancer (NSCLC): Clinical developments and rationale for the combination with thoracic radiotherapy
    • 22196919
    • Koh PK, Faivre-Finn C, Blackhall FH, De Ruysscher D. Targeted agents in non-small cell lung cancer (NSCLC): clinical developments and rationale for the combination with thoracic radiotherapy. Cancer Treat Rev. 2012;38:626-40.
    • (2012) Cancer Treat Rev , vol.38 , pp. 626-640
    • Koh, P.K.1    Faivre-Finn, C.2    Blackhall, F.H.3    De Ruysscher, D.4
  • 4
    • 84930272308 scopus 로고    scopus 로고
    • Stereotactic ablative radiotherapy versus lobectomy for operable stage i non-small-cell lung cancer: A pooled analysis of two randomised trials
    • 25981812
    • Chang JY, Senan S, Paul MA, Mehran RJ, Louie AV, Balter P, et al. Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials. Lancet Oncol. 2015;16:630-7.
    • (2015) Lancet Oncol , vol.16 , pp. 630-637
    • Chang, J.Y.1    Senan, S.2    Paul, M.A.3    Mehran, R.J.4    Louie, A.V.5    Balter, P.6
  • 5
    • 84948716716 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation
    • Toulany M, Rodemann HP. Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation. Semin Cancer Biol. 2015;3:180-90.
    • (2015) Semin Cancer Biol , vol.3 , pp. 180-190
    • Toulany, M.1    Rodemann, H.P.2
  • 6
    • 84899409082 scopus 로고    scopus 로고
    • Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1alpha-mediated VEGF-dependent angiogenesis
    • 23728336 1:CAS:528:DC%2BC3sXosFKqtbo%3D
    • Raja R, Kale S, Thorat D, Soundararajan G, Lohite K, Mane A, et al. Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1alpha-mediated VEGF-dependent angiogenesis. Oncogene. 2014;33:2053-64.
    • (2014) Oncogene , vol.33 , pp. 2053-2064
    • Raja, R.1    Kale, S.2    Thorat, D.3    Soundararajan, G.4    Lohite, K.5    Mane, A.6
  • 7
    • 84929623982 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells
    • 25843954 4484427
    • Gu Q, He Y, Ji J, Yao Y, Shen W, Luo J, et al. Hypoxia-inducible factor 1alpha (HIF-1alpha) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1alpha/CXCR4 pathway in non-small cell lung carcinoma cells. Oncotarget. 2015;6:10893-907.
    • (2015) Oncotarget , vol.6 , pp. 10893-10907
    • Gu, Q.1    He, Y.2    Ji, J.3    Yao, Y.4    Shen, W.5    Luo, J.6
  • 8
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • 15372042 1:CAS:528:DC%2BD2cXnsFaiu7g%3D
    • Ambros V. The functions of animal microRNAs. Nature. 2004;431:350-5.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 9
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • 16557279 1:CAS:528:DC%2BD28XivVyqtrs%3D
    • Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 2006;6:259-69.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 10
    • 2542626605 scopus 로고    scopus 로고
    • Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    • 15172979 1:CAS:528:DC%2BD2cXksVKgurs%3D
    • Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 2004;64:3753-56.
    • (2004) Cancer Res , vol.64 , pp. 3753-3756
    • Takamizawa, J.1    Konishi, H.2    Yanagisawa, K.3    Tomida, S.4    Osada, H.5    Endoh, H.6
  • 11
    • 27544495514 scopus 로고    scopus 로고
    • A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
    • 16266980 1:CAS:528:DC%2BD2MXhtFKkt7jE
    • Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 2005;65:9628-32.
    • (2005) Cancer Res , vol.65 , pp. 9628-9632
    • Hayashita, Y.1    Osada, H.2    Tatematsu, Y.3    Yamada, H.4    Yanagisawa, K.5    Tomida, S.6
  • 12
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: Tumour resistance to apoptosis
    • 12001989 1:CAS:528:DC%2BD38XivFGqt7s%3D
    • Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2002;2:277-88.
    • (2002) Nat Rev Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 13
    • 84949788726 scopus 로고    scopus 로고
    • Role of miR-100 in the radioresistance of colorectal cancer cells
    • 25973296 4396051
    • Yang XD, Xu XH, Zhang SY, Wu Y, Xing CG, Ru G, et al. Role of miR-100 in the radioresistance of colorectal cancer cells. Am J Cancer Res. 2015;5:545-59.
    • (2015) Am J Cancer Res , vol.5 , pp. 545-559
    • Yang, X.D.1    Xu, X.H.2    Zhang, S.Y.3    Wu, Y.4    Xing, C.G.5    Ru, G.6
  • 14
    • 72449142765 scopus 로고    scopus 로고
    • MicroRNAs: Predictors and modifiers of chemo- and radiotherapy in different tumour types
    • 19948396 1:CAS:528:DC%2BD1MXhs1WgtLfO
    • Hummel R, Hussey DJ, Haier J. MicroRNAs: predictors and modifiers of chemo- and radiotherapy in different tumour types. Eur J Cancer. 2010;46:298-311.
    • (2010) Eur J Cancer , vol.46 , pp. 298-311
    • Hummel, R.1    Hussey, D.J.2    Haier, J.3
  • 15
    • 84875911885 scopus 로고    scopus 로고
    • MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines
    • 23492775 1:CAS:528:DC%2BC3sXhtVyktb7N 3615727
    • Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, et al. MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines. Cell Death Dis. 2013;4:e544.
    • (2013) Cell Death Dis , vol.4 , pp. e544
    • Grosso, S.1    Doyen, J.2    Parks, S.K.3    Bertero, T.4    Paye, A.5    Cardinaud, B.6
  • 16
    • 84870469858 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN
    • 22956424 1:CAS:528:DC%2BC38XhslantLjO
    • Liu ZL, Wang H, Liu J, Wang ZX. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem. 2013;372:35-45.
    • (2013) Mol Cell Biochem , vol.372 , pp. 35-45
    • Liu, Z.L.1    Wang, H.2    Liu, J.3    Wang, Z.X.4
  • 17
    • 0035874498 scopus 로고    scopus 로고
    • Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner
    • 11342433 1:CAS:528:DC%2BD3MXjsl2rur8%3D
    • Majka M, Janowska-Wieczorek A, Ratajczak J, Ehrenman K, Pietrzkowski Z, Kowalska MA, et al. Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood. 2001;97:3075-85.
    • (2001) Blood , vol.97 , pp. 3075-3085
    • Majka, M.1    Janowska-Wieczorek, A.2    Ratajczak, J.3    Ehrenman, K.4    Pietrzkowski, Z.5    Kowalska, M.A.6
  • 18
    • 3242667696 scopus 로고    scopus 로고
    • Cellular microparticles: A disseminated storage pool of bioactive vascular effectors
    • 15257014 1:CAS:528:DC%2BD2cXmvFKmtLY%3D
    • Morel O, Toti F, Hugel B, Freyssinet JM. Cellular microparticles: a disseminated storage pool of bioactive vascular effectors. Curr Opin Hematol. 2004;11:156-64.
    • (2004) Curr Opin Hematol , vol.11 , pp. 156-164
    • Morel, O.1    Toti, F.2    Hugel, B.3    Freyssinet, J.M.4
  • 19
    • 1142286348 scopus 로고    scopus 로고
    • Nanotubular highways for intercellular organelle transport
    • 14963329 1:CAS:528:DC%2BD2cXhtlWnu7w%3D
    • Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH. Nanotubular highways for intercellular organelle transport. Science. 2004;303:1007-10.
    • (2004) Science , vol.303 , pp. 1007-1010
    • Rustom, A.1    Saffrich, R.2    Markovic, I.3    Walther, P.4    Gerdes, H.H.5
  • 20
    • 33747616431 scopus 로고    scopus 로고
    • Membrane-derived microvesicles: Important and underappreciated mediators of cell-to-cell communication
    • 16791265 1:CAS:528:DC%2BD28XosVSjsrk%3D
    • Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia. 2006;20:1487-95.
    • (2006) Leukemia , vol.20 , pp. 1487-1495
    • Ratajczak, J.1    Wysoczynski, M.2    Hayek, F.3    Janowska-Wieczorek, A.4    Ratajczak, M.Z.5
  • 21
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • 17486113 1:CAS:528:DC%2BD2sXmtVSmtb8%3D
    • Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654-9.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 22
    • 79961187284 scopus 로고    scopus 로고
    • Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development
    • 21665894 1:CAS:528:DC%2BC3MXhtVSitLbP
    • Zhang S, Hao J, Xie F, Hu X, Liu C, Tong J, et al. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis. 2011;32:1183-9.
    • (2011) Carcinogenesis , vol.32 , pp. 1183-1189
    • Zhang, S.1    Hao, J.2    Xie, F.3    Hu, X.4    Liu, C.5    Tong, J.6
  • 23
    • 84879414000 scopus 로고    scopus 로고
    • MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene
    • 22847611 1:CAS:528:DC%2BC38XhtFWmtL%2FF
    • Ke G, Liang L, Yang JM, Huang X, Han D, Huang S, et al. MiR-181a confers resistance of cervical cancer to radiation therapy through targeting the pro-apoptotic PRKCD gene. Oncogene. 2013;32:3019-27.
    • (2013) Oncogene , vol.32 , pp. 3019-3027
    • Ke, G.1    Liang, L.2    Yang, J.M.3    Huang, X.4    Han, D.5    Huang, S.6
  • 24
    • 84929378904 scopus 로고    scopus 로고
    • Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS
    • 25973575 1:CAS:528:DC%2BC2MXhtFOrtr%2FO 4650752
    • Momen-Heravi F, Bala S, Kodys K, Szabo G. Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Sci Rep. 2015;5:9991.
    • (2015) Sci Rep , vol.5 , pp. 9991
    • Momen-Heravi, F.1    Bala, S.2    Kodys, K.3    Szabo, G.4
  • 25
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • 18228490 3.22
    • Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol. 2006;Chapter 3:Unit 3.22.
    • (2006) Curr Protoc Cell Biol , vol.3 , pp. Unit
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 26
    • 84873324354 scopus 로고    scopus 로고
    • Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells
    • 23188828 1:CAS:528:DC%2BC3sXhvFehsrY%3D 3561521
    • Yang HJ, Youn H, Seong KM, Jin YW, Kim J, Youn B. Phosphorylation of ribosomal protein S3 and antiapoptotic TRAF2 protein mediates radioresistance in non-small cell lung cancer cells. J Biol Chem. 2013;288:2965-75.
    • (2013) J Biol Chem , vol.288 , pp. 2965-2975
    • Yang, H.J.1    Youn, H.2    Seong, K.M.3    Jin, Y.W.4    Kim, J.5    Youn, B.6
  • 27
    • 67650735457 scopus 로고    scopus 로고
    • DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment
    • 19522503 1:CAS:528:DC%2BD1MXnt1SisL4%3D
    • Skladanowski A, Bozko P, Sabisz M. DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment. Chem Rev. 2009;109:2951-73.
    • (2009) Chem Rev , vol.109 , pp. 2951-2973
    • Skladanowski, A.1    Bozko, P.2    Sabisz, M.3
  • 28
    • 84859131111 scopus 로고    scopus 로고
    • Radiation damage and radioprotectants: New concepts in the era of molecular medicine
    • 22294702 1:STN:280:DC%2BC38vhslSltQ%3D%3D 3486665
    • Koukourakis MI. Radiation damage and radioprotectants: new concepts in the era of molecular medicine. Br J Radiol. 2012;85:313-30.
    • (2012) Br J Radiol , vol.85 , pp. 313-330
    • Koukourakis, M.I.1
  • 29
    • 54749113690 scopus 로고    scopus 로고
    • Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2
    • 18794145 1:CAS:528:DC%2BD1cXhtFWltb%2FL 2597026
    • Zheng M, Morgan-Lappe SE, Yang J, Bockbrader KM, Pamarthy D, Thomas D, et al. Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2. Cancer Res. 2008;68:7570-8.
    • (2008) Cancer Res , vol.68 , pp. 7570-7578
    • Zheng, M.1    Morgan-Lappe, S.E.2    Yang, J.3    Bockbrader, K.M.4    Pamarthy, D.5    Thomas, D.6
  • 30
    • 84915757181 scopus 로고    scopus 로고
    • Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer
    • 25466375 1:CAS:528:DC%2BC2cXhvFeisrjI
    • Xu T, Liao Z, O'Reilly MS, Levy LB, Welsh JW, Wang LE, et al. Serum inflammatory miRNAs predict radiation esophagitis in patients receiving definitive radiochemotherapy for non-small cell lung cancer. Radiother Oncol. 2014;113:379-84.
    • (2014) Radiother Oncol , vol.113 , pp. 379-384
    • Xu, T.1    Liao, Z.2    O'Reilly, M.S.3    Levy, L.B.4    Welsh, J.W.5    Wang, L.E.6
  • 31
    • 84901244024 scopus 로고    scopus 로고
    • MiR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion
    • 24604208 1:CAS:528:DC%2BC2cXjs1OgsLg%3D
    • Liu A, Shao C, Jin G, Liu R, Hao J, Song B, et al. miR-208-induced epithelial to mesenchymal transition of pancreatic cancer cells promotes cell metastasis and invasion. Cell Biochem Biophys. 2014;69:341-6.
    • (2014) Cell Biochem Biophys , vol.69 , pp. 341-346
    • Liu, A.1    Shao, C.2    Jin, G.3    Liu, R.4    Hao, J.5    Song, B.6
  • 32
    • 84904077771 scopus 로고    scopus 로고
    • Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma
    • 25023649 4107867
    • Li H, Zheng D, Zhang B, Liu L, Ou J, Chen W, et al. Mir-208 promotes cell proliferation by repressing SOX6 expression in human esophageal squamous cell carcinoma. J Transl Med. 2014;12:196.
    • (2014) J Transl Med , vol.12 , pp. 196
    • Li, H.1    Zheng, D.2    Zhang, B.3    Liu, L.4    Ou, J.5    Chen, W.6
  • 33
    • 84860340270 scopus 로고    scopus 로고
    • A cardiac microRNA governs systemic energy homeostasis by regulation of MED13
    • 22541436 1:CAS:528:DC%2BC38Xmt1Kjs7Y%3D 3340581
    • Grueter CE, van Rooij E, Johnson BA, DeLeon SM, Sutherland LB, Qi X, et al. A cardiac microRNA governs systemic energy homeostasis by regulation of MED13. Cell. 2012;149:671-83.
    • (2012) Cell , vol.149 , pp. 671-683
    • Grueter, C.E.1    Van Rooij, E.2    Johnson, B.A.3    DeLeon, S.M.4    Sutherland, L.B.5    Qi, X.6
  • 34
  • 35
    • 84928791848 scopus 로고    scopus 로고
    • MicroRNA-208a Increases Myocardial Endoglin Expression and Myocardial Fibrosis in Acute Myocardial Infarction
    • 25936493
    • Shyu KG, Wang BW, Cheng WP, Lo HM. MicroRNA-208a Increases Myocardial Endoglin Expression and Myocardial Fibrosis in Acute Myocardial Infarction. Can J Cardiol. 2015;31:679-90.
    • (2015) Can J Cardiol , vol.31 , pp. 679-690
    • Shyu, K.G.1    Wang, B.W.2    Cheng, W.P.3    Lo, H.M.4
  • 37
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • 10385618 1:CAS:528:DyaK1MXktlOhsLs%3D
    • Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501-12.
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.M.2
  • 38
    • 0033621560 scopus 로고    scopus 로고
    • P21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis
    • 10676653 1:CAS:528:DC%2BD3cXht1Gmtb0%3D
    • Tian H, Wittmack EK, Jorgensen TJ. p21WAF1/CIP1 antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. Cancer Res. 2000;60:679-84.
    • (2000) Cancer Res , vol.60 , pp. 679-684
    • Tian, H.1    Wittmack, E.K.2    Jorgensen, T.J.3
  • 39
    • 84938382982 scopus 로고    scopus 로고
    • Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways
    • Zhao R, Chen M, Jiang Z, Zhao F, Xi B, Zhang X, et al. Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways. J Cancer Educ. 2015;6:623-31.
    • (2015) J Cancer Educ , vol.6 , pp. 623-631
    • Zhao, R.1    Chen, M.2    Jiang, Z.3    Zhao, F.4    Xi, B.5    Zhang, X.6
  • 40
    • 40349106029 scopus 로고    scopus 로고
    • The potential role of mTOR inhibitors in non-small cell lung cancer
    • 18305058 1:CAS:528:DC%2BD1cXktVSgs78%3D
    • Gridelli C, Maione P, Rossi A. The potential role of mTOR inhibitors in non-small cell lung cancer. Oncologist. 2008;13:139-47.
    • (2008) Oncologist , vol.13 , pp. 139-147
    • Gridelli, C.1    Maione, P.2    Rossi, A.3
  • 41
    • 38949200283 scopus 로고    scopus 로고
    • Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
    • 18054038 1:CAS:528:DC%2BD1cXitVehsbs%3D 2278035
    • Mao K, Kobayashi S, Jaffer ZM, Huang Y, Volden P, Chernoff J, et al. Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol. 2008;44:429-34.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 429-434
    • Mao, K.1    Kobayashi, S.2    Jaffer, Z.M.3    Huang, Y.4    Volden, P.5    Chernoff, J.6
  • 42
    • 84936855517 scopus 로고    scopus 로고
    • Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells
    • 26061184 4465694
    • Chen B, Xu X, Luo J, Wang H, Zhou S. Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells. PLoS One. 2015;10:e0129663.
    • (2015) PLoS One , vol.10 , pp. e0129663
    • Chen, B.1    Xu, X.2    Luo, J.3    Wang, H.4    Zhou, S.5
  • 43
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 21376230 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 44
    • 84931287779 scopus 로고    scopus 로고
    • Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML
    • 26067326 1:CAS:528:DC%2BC2MXhtFyiu77O 4650871
    • Hornick NI, Huan J, Doron B, Goloviznina NA, Lapidus J, Chang BH, et al. Serum Exosome MicroRNA as a Minimally-Invasive Early Biomarker of AML. Sci Rep. 2015;5:11295.
    • (2015) Sci Rep , vol.5 , pp. 11295
    • Hornick, N.I.1    Huan, J.2    Doron, B.3    Goloviznina, N.A.4    Lapidus, J.5    Chang, B.H.6
  • 45
    • 84898476721 scopus 로고    scopus 로고
    • Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
    • 24735924 1:CAS:528:DC%2BC2cXmt1ahtbc%3D 4016197
    • Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 2014;25:501-15.
    • (2014) Cancer Cell , vol.25 , pp. 501-515
    • Zhou, W.1    Fong, M.Y.2    Min, Y.3    Somlo, G.4    Liu, L.5    Palomares, M.R.6
  • 46
    • 84940532964 scopus 로고    scopus 로고
    • The clinical relevance of circulating, exosomal miRNAs as biomarkers for cancer
    • 26202667 1:CAS:528:DC%2BC2MXhslCms7vP
    • Schwarzenbach H. The clinical relevance of circulating, exosomal miRNAs as biomarkers for cancer. Expert Rev Mol Diagn. 2015;15:1159-69.
    • (2015) Expert Rev Mol Diagn , vol.15 , pp. 1159-1169
    • Schwarzenbach, H.1
  • 47
    • 84922527336 scopus 로고    scopus 로고
    • Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells
    • 25159140 1:CAS:528:DC%2BC2cXhsVarsb7L
    • Squadrito ML, Baer C, Burdet F, Maderna C, Gilfillan GD, Lyle R, et al. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep. 2014;8:1432-46.
    • (2014) Cell Rep , vol.8 , pp. 1432-1446
    • Squadrito, M.L.1    Baer, C.2    Burdet, F.3    Maderna, C.4    Gilfillan, G.D.5    Lyle, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.