메뉴 건너뛰기




Volumn 15, Issue 9, 2015, Pages 1159-1169

The clinical relevance of circulating, exosomal miRNAs as biomarkers for cancer

Author keywords

cell to cell communication; diagnosis; exosomes; miRNAs; prognosis; signal pathways

Indexed keywords

MICRORNA; MICRORNA 100; MICRORNA 101; MICRORNA 125B; MICRORNA 141; MICRORNA 146A; MICRORNA 200A; MICRORNA 200B; MICRORNA 200C; MICRORNA 223; MICRORNA 29A; MICRORNA 375; TUMOR MARKER;

EID: 84940532964     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2015.1069183     Document Type: Review
Times cited : (79)

References (77)
  • 1
    • 84905122848 scopus 로고    scopus 로고
    • MicroRNAs in cancer: Biomarkers, functions and therapy
    • Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med 2014;20(8):460-9
    • (2014) Trends Mol Med , vol.20 , Issue.8 , pp. 460-469
    • Hayes, J.1    Peruzzi, P.P.2    Lawler, S.3
  • 2
    • 80053946666 scopus 로고    scopus 로고
    • Circulating microRNAs: Association with disease and potential use as biomarkers
    • Reid G, Kirschner MB, van Zandwijk N. Circulating microRNAs: Association with disease and potential use as biomarkers. Crit Rev Oncol Hematol 2011;80(2):193-208
    • (2011) Crit Rev Oncol Hematol , vol.80 , Issue.2 , pp. 193-208
    • Reid, G.1    Kirschner, M.B.2    Van Zandwijk, N.3
  • 3
    • 84911893001 scopus 로고    scopus 로고
    • Non-coding RNAs as clinical biomarkers for cancer diagnosis and prognosis
    • Mishra PJ. Non-coding RNAs as clinical biomarkers for cancer diagnosis and prognosis. Expert Rev Mol Diagn 2014; 14(8):917-19
    • (2014) Expert Rev Mol Diagn , vol.14 , Issue.8 , pp. 917-919
    • Mishra, P.J.1
  • 4
  • 5
    • 84863906869 scopus 로고    scopus 로고
    • MicroRNAs as therapeutic targets and their potential applications in cancer therapy
    • Cho WC. MicroRNAs as therapeutic targets and their potential applications in cancer therapy. Expert Opin Ther Targets 2012; 16(8):747-59
    • (2012) Expert Opin Ther Targets , vol.16 , Issue.8 , pp. 747-759
    • Cho, W.C.1
  • 6
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009;136(2): 215-33
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 79953202200 scopus 로고    scopus 로고
    • Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    • Arroyo JD, Chevillet JR, Kroh EM, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011;108(12):5003-8
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.12 , pp. 5003-5008
    • Arroyo, J.D.1    Chevillet, J.R.2    Kroh, E.M.3
  • 9
    • 84857968441 scopus 로고    scopus 로고
    • The majority of microRNAs detectable in serum and saliva is concentrated in exosomes
    • Gallo A, Tandon M, Alevizos I, Illei GG. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PloS One 2012;7(3), e30679
    • (2012) PloS One , vol.7 , Issue.3 , pp. e30679
    • Gallo, A.1    Tandon, M.2    Alevizos, I.3    Illei, G.G.4
  • 10
    • 84856812332 scopus 로고    scopus 로고
    • Changes in circulating microRNA levels associated with prostate cancer
    • Bryant RJ, Pawlowski T, Catto JW, et al. Changes in circulating microRNA levels associated with prostate cancer. Br J Cancer 2012;106(4):768-74
    • (2012) Br J Cancer , vol.106 , Issue.4 , pp. 768-774
    • Bryant, R.J.1    Pawlowski, T.2    Catto, J.W.3
  • 11
    • 84923699297 scopus 로고    scopus 로고
    • Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients
    • Eichelser C, Stuckrath I, Muller V, et al. Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. Oncotarget 2014;5(20):9650-63
    • (2014) Oncotarget , vol.5 , Issue.20 , pp. 9650-9663
    • Eichelser, C.1    Stuckrath, I.2    Muller, V.3
  • 12
    • 14844364472 scopus 로고    scopus 로고
    • Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
    • Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 2005;33(4):1290-7
    • (2005) Nucleic Acids Res , vol.33 , Issue.4 , pp. 1290-1297
    • Cheng, A.M.1    Byrom, M.W.2    Shelton, J.3    Ford, L.P.4
  • 13
    • 18344369543 scopus 로고    scopus 로고
    • MicroRNA biogenesis: Coordinated cropping and dicing
    • Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol 2005;6(5):376-85
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.5 , pp. 376-385
    • Kim, V.N.1
  • 14
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet 2010;11(9):597-610
    • (2010) Nat Rev Genet , vol.11 , Issue.9 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 15
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 2004;101(9):2999-3004
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 16
    • 84921358315 scopus 로고    scopus 로고
    • The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response
    • Schwarzenbach H. The potential of circulating nucleic acids as components of companion diagnostics for predicting and monitoring chemotherapy response. Expert Rev Mol Diagn 2015;15(2):267-75
    • (2015) Expert Rev Mol Diagn , vol.15 , Issue.2 , pp. 267-275
    • Schwarzenbach, H.1
  • 17
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011; 11(6):426-37
    • (2011) Nat Rev Cancer , vol.11 , Issue.6 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.2    Pantel, K.3
  • 18
    • 84925884485 scopus 로고    scopus 로고
    • MicroRNA profiling of exosomes isolated from biofluids and conditioned media
    • Rani S. MicroRNA profiling of exosomes isolated from biofluids and conditioned media. Methods Mol Biol 2014;1182: 131-44
    • (2014) Methods Mol Biol , vol.1182 , pp. 131-144
    • Rani, S.1
  • 20
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekstrom K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9(6):654-9
    • (2007) Nat Cell Biol , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3
  • 21
    • 84862169420 scopus 로고    scopus 로고
    • Horizontal transfer of microRNAs: Molecular mechanisms and clinical applications
    • Chen X, Liang H, Zhang J, et al. Horizontal transfer of microRNAs: molecular mechanisms and clinical applications. Protein & cell 2012;3(1):28-37
    • (2012) Protein & Cell , vol.3 , Issue.1 , pp. 28-37
    • Chen, X.1    Liang, H.2    Zhang, J.3
  • 22
    • 85028118470 scopus 로고    scopus 로고
    • Microvesicles as mediators of intercellular communication in cancer-The emerging science of cellular 'debris'
    • Lee TH, D'Asti E, Magnus N, et al. Microvesicles as mediators of intercellular communication in cancer-the emerging science of cellular 'debris'. Semin Immunopathol 2011;33(5):455-67
    • (2011) Semin Immunopathol , vol.33 , Issue.5 , pp. 455-467
    • Lee, T.H.1    D'Asti, E.2    Magnus, N.3
  • 23
    • 79961234482 scopus 로고    scopus 로고
    • Vesicle transfer and cell fusion: Emerging concepts of cell-cell communication in the tumor microenvironment
    • Howcroft TK, Zhang HG, Dhodapkar M, Mohla S. Vesicle transfer and cell fusion: Emerging concepts of cell-cell communication in the tumor microenvironment. Cancer Biol Ther 2011; 12(3):159-64
    • (2011) Cancer Biol Ther , vol.12 , Issue.3 , pp. 159-164
    • Howcroft, T.K.1    Zhang, H.G.2    Dhodapkar, M.3    Mohla, S.4
  • 24
    • 84890313522 scopus 로고    scopus 로고
    • Exosomes in cancer development, metastasis, and drug resistance: A comprehensive review
    • Azmi AS, Bao B, Sarkar FH. Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Rev 2013;32(3-4):623
    • (2013) Cancer Metastasis Rev , vol.32 , Issue.3-4 , pp. 623
    • Azmi, A.S.1    Bao, B.2    Sarkar, F.H.3
  • 25
    • 77954385414 scopus 로고    scopus 로고
    • MicroRNAs in immune regulation-opportunities for cancer immunotherapy
    • Okada H, Kohanbash G, Lotze MT. MicroRNAs in immune regulation-opportunities for cancer immunotherapy. Int J Biochem Cell Biol 2010;42(8): 1256-61
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.8 , pp. 1256-1261
    • Okada, H.1    Kohanbash, G.2    Lotze, M.T.3
  • 26
    • 84901270033 scopus 로고    scopus 로고
    • MicroRNAs in the tumor microenvironment: Solving the riddle for a better diagnostics
    • Challagundla KB, Fanini F, Vannini I, et al. microRNAs in the tumor microenvironment: solving the riddle for a better diagnostics. Expert Rev Mol Diagn 2014;14(5):565-74
    • (2014) Expert Rev Mol Diagn , vol.14 , Issue.5 , pp. 565-574
    • Challagundla, K.B.1    Fanini, F.2    Vannini, I.3
  • 27
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor DD, Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 2008;110(1): 13-21
    • (2008) Gynecol Oncol , vol.110 , Issue.1 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 28
    • 84907090492 scopus 로고    scopus 로고
    • Isolation of biologically-active exosomes from human plasma
    • Muller L, Hong CS, Stolz DB, et al. Isolation of biologically-active exosomes from human plasma. J Immunol Methods 2014;411:55-65
    • (2014) J Immunol Methods , vol.411 , pp. 55-65
    • Muller, L.1    Hong, C.S.2    Stolz, D.B.3
  • 29
    • 84926661390 scopus 로고    scopus 로고
    • Methods for extracellular vesicles isolation in a hospital setting
    • Saenz-Cuesta M, Arbelaiz A, Oregi A, et al. Methods for extracellular vesicles isolation in a hospital setting. Front Immunol 2015;6:50
    • (2015) Front Immunol , vol.6 , pp. 50
    • Saenz-Cuesta, M.1    Arbelaiz, A.2    Oregi, A.3
  • 30
    • 22044446912 scopus 로고    scopus 로고
    • Exosomal-like vesicles are present in human blood plasma
    • Caby MP, Lankar D, Vincendeau-Scherrer C, et al. Exosomal-like vesicles are present in human blood plasma. Int Immunol 2005;17(7):879-87
    • (2005) Int Immunol , vol.17 , Issue.7 , pp. 879-887
    • Caby, M.P.1    Lankar, D.2    Vincendeau-Scherrer, C.3
  • 31
    • 84896910344 scopus 로고    scopus 로고
    • Emerging technologies in extracellular vesicle-based molecular diagnostics
    • Jia S, Zocco D, Samuels ML, et al. Emerging technologies in extracellular vesicle-based molecular diagnostics. Expert Rev Mol Diagn 2014;14(3):307-21
    • (2014) Expert Rev Mol Diagn , vol.14 , Issue.3 , pp. 307-321
    • Jia, S.1    Zocco, D.2    Samuels, M.L.3
  • 32
    • 29144470346 scopus 로고    scopus 로고
    • Real-time quantification of microRNAs by stem-loop RT-PCR
    • Chen C, Ridzon DA, Broomer AJ, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005;33(20):e179
    • (2005) Nucleic Acids Res , vol.33 , Issue.20 , pp. e179
    • Chen, C.1    Ridzon, D.A.2    Broomer, A.J.3
  • 33
    • 84859892863 scopus 로고    scopus 로고
    • MicroRNA profiling: Approaches and considerations
    • Pritchard CC, Cheng HH, Tewari M. MicroRNA profiling: approaches and considerations. Nat Rev Genet 2012;13(5): 358-69
    • (2012) Nat Rev Genet , vol.13 , Issue.5 , pp. 358-369
    • Pritchard, C.C.1    Cheng, H.H.2    Tewari, M.3
  • 34
    • 84883856321 scopus 로고    scopus 로고
    • MicroRNA: Function, detection, and bioanalysis
    • Dong H, Lei J, Ding L, et al. MicroRNA: Function, detection, and bioanalysis. Chem Rev 2013;113(8):6207-33
    • (2013) Chem Rev , vol.113 , Issue.8 , pp. 6207-6233
    • Dong, H.1    Lei, J.2    Ding, L.3
  • 35
    • 82955189198 scopus 로고    scopus 로고
    • How novel molecular diagnostic technologies and biomarkers are revolutionizing genetic testing and patient care
    • Baudhuin LM, Donato LJ, Uphoff TS. How novel molecular diagnostic technologies and biomarkers are revolutionizing genetic testing and patient care. Expert Rev Mol Diagn 2012;12(1): 25-37
    • (2012) Expert Rev Mol Diagn , vol.12 , Issue.1 , pp. 25-37
    • Baudhuin, L.M.1    Donato, L.J.2    Uphoff, T.S.3
  • 36
    • 84964240625 scopus 로고    scopus 로고
    • Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation
    • Sugimachi K, Matsumura T, Hirata H, et al. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. Br J Cancer 2015;112(3):532-8
    • (2015) Br J Cancer , vol.112 , Issue.3 , pp. 532-538
    • Sugimachi, K.1    Matsumura, T.2    Hirata, H.3
  • 37
    • 84880634054 scopus 로고    scopus 로고
    • MicroRNA-21 gene and cancer
    • Huang Y, Yang YB, Zhang XH, et al. MicroRNA-21 gene and cancer. Med oncol 2013;30(1):376
    • (2013) Med Oncol , vol.30 , Issue.1 , pp. 376
    • Huang, Y.1    Yang, Y.B.2    Zhang, X.H.3
  • 38
    • 43449102192 scopus 로고    scopus 로고
    • Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
    • Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 2008;141(5):672-5
    • (2008) Br J Haematol , vol.141 , Issue.5 , pp. 672-675
    • Lawrie, C.H.1    Gal, S.2    Dunlop, H.M.3
  • 39
    • 84902176122 scopus 로고    scopus 로고
    • Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma
    • Wang H, Hou L, Li A, et al. Expression of serum exosomal microRNA-21 in human hepatocellular carcinoma. Biomed Res Int 2014;2014:864894
    • (2014) Biomed Res Int , vol.2014 , pp. 864894
    • Wang, H.1    Hou, L.2    Li, A.3
  • 40
    • 84906834990 scopus 로고    scopus 로고
    • Exosome-derived miRNAs and ovarian carcinoma progression
    • Vaksman O, Trope C, Davidson B, Reich R. Exosome-derived miRNAs and ovarian carcinoma progression. Carcinogenesis 2014;35(9):2113-20
    • (2014) Carcinogenesis , vol.35 , Issue.9 , pp. 2113-2120
    • Vaksman, O.1    Trope, C.2    Davidson, B.3    Reich, R.4
  • 41
    • 84874755851 scopus 로고    scopus 로고
    • Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma
    • Tanaka Y, Kamohara H, Kinoshita K, et al. Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer 2013;119(6):1159-67
    • (2013) Cancer , vol.119 , Issue.6 , pp. 1159-1167
    • Tanaka, Y.1    Kamohara, H.2    Kinoshita, K.3
  • 42
    • 84905318644 scopus 로고    scopus 로고
    • Combined detection of serum exosomal MIR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma
    • Wang J, Zhou Y, Lu J, et al. Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma. Med oncol 2014;31(9):148
    • (2014) Med Oncol , vol.31 , Issue.9 , pp. 148
    • Wang, J.1    Zhou, Y.2    Lu, J.3
  • 43
    • 84926686903 scopus 로고    scopus 로고
    • HOTAIR: An oncogenic long non-coding RNA in different cancers
    • Hajjari M, Salavaty A. HOTAIR: an oncogenic long non-coding RNA in different cancers. Cancer Biol Med 2015; 12(1):1-9
    • (2015) Cancer Biol Med , vol.12 , Issue.1 , pp. 1-9
    • Hajjari, M.1    Salavaty, A.2
  • 44
    • 84899431845 scopus 로고    scopus 로고
    • Circulating exosomal microRNAs as biomarkers of colon cancer
    • Ogata-Kawata H, Izumiya M, Kurioka D, et al. Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS ONE 2014;9(4):e92921
    • (2014) PLoS ONE , vol.9 , Issue.4 , pp. e92921
    • Ogata-Kawata, H.1    Izumiya, M.2    Kurioka, D.3
  • 45
    • 79952415252 scopus 로고    scopus 로고
    • Emerging molecular biomarkers-blood-based strategies to detect and monitor cancer
    • Hanash SM, Baik CS, Kallioniemi O. Emerging molecular biomarkers-blood-based strategies to detect and monitor cancer. Nat Rev Clin Oncol 2011;8(3): 142-50
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.3 , pp. 142-150
    • Hanash, S.M.1    Baik, C.S.2    Kallioniemi, O.3
  • 46
    • 84883296595 scopus 로고    scopus 로고
    • Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma
    • Que R, Ding G, Chen J, Cao L. Analysis of serum exosomal microRNAs and clinicopathologic features of patients with pancreatic adenocarcinoma. World J Surg Oncol 2013;11:219
    • (2013) World J Surg Oncol , vol.11 , pp. 219
    • Que, R.1    Ding, G.2    Chen, J.3    Cao, L.4
  • 47
    • 84924372715 scopus 로고    scopus 로고
    • Exosomal MIR-1290 and MIR-375 as prognostic markers in castration-resistant prostate cancer
    • Huang X, Yuan T, Liang M, et al. Exosomal miR-1290 and miR-375 as prognostic markers in castration-resistant prostate cancer. Eur Urol 2015;67(1):33-41
    • (2015) Eur Urol , vol.67 , Issue.1 , pp. 33-41
    • Huang, X.1    Yuan, T.2    Liang, M.3
  • 48
    • 84883373154 scopus 로고    scopus 로고
    • MicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer
    • Cazzoli R, Buttitta F, Di Nicola M, et al. microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J Thorac Oncol 2013;8(9):1156-62
    • (2013) J Thorac Oncol , vol.8 , Issue.9 , pp. 1156-1162
    • Cazzoli, R.1    Buttitta, F.2    Di Nicola, M.3
  • 49
    • 84904393091 scopus 로고    scopus 로고
    • Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer
    • Rodriguez M, Silva J, Lopez-Alfonso A, et al. Different exosome cargo from plasma/bronchoalveolar lavage in non-small-cell lung cancer. Genes Chromosomes Cancer 2014;53(9):713-24
    • (2014) Genes Chromosomes Cancer , vol.53 , Issue.9 , pp. 713-724
    • Rodriguez, M.1    Silva, J.2    Lopez-Alfonso, A.3
  • 50
    • 84892171579 scopus 로고    scopus 로고
    • Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer
    • Liu J, Sun H, Wang X, et al. Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer. Int J Mol Sci 2014;15(1):758-73
    • (2014) Int J Mol Sci , vol.15 , Issue.1 , pp. 758-773
    • Liu, J.1    Sun, H.2    Wang, X.3
  • 51
    • 84896971533 scopus 로고    scopus 로고
    • A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool
    • Manterola L, Guruceaga E, Gallego Perez-Larraya J, et al. A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. Neuro Oncol 2014;16(4): 520-7
    • (2014) Neuro Oncol , vol.16 , Issue.4 , pp. 520-527
    • Manterola, L.1    Guruceaga, E.2    Gallego Perez-Larraya, J.3
  • 52
    • 84902438436 scopus 로고    scopus 로고
    • Study of circulating microRNA-125b levels in serum exosomes in advanced melanoma
    • Alegre E, Sanmamed MF, Rodriguez C, et al. Study of circulating microRNA-125b levels in serum exosomes in advanced melanoma. Arch Pathol Lab Med 2014; 138(6):828-32
    • (2014) Arch Pathol Lab Med , vol.138 , Issue.6 , pp. 828-832
    • Alegre, E.1    Sanmamed, M.F.2    Rodriguez, C.3
  • 53
    • 84919414483 scopus 로고    scopus 로고
    • The role of exosomes and exosomal shuttle microRNA in tumorigenesis and drug resistance
    • Zhao L, Liu W, Xiao J, Cao B. The role of exosomes and exosomal shuttle microRNA in tumorigenesis and drug resistance. Cancer lett 2015;356(2 Pt B): 339-46
    • (2015) Cancer Lett , vol.356 , Issue.2 , pp. 339-346
    • Zhao, L.1    Liu, W.2    Xiao, J.3    Cao, B.4
  • 54
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • Montecalvo A, Larregina AT, Shufesky WJ, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 2012;119(3):756-66
    • (2012) Blood , vol.119 , Issue.3 , pp. 756-766
    • Montecalvo, A.1    Larregina, A.T.2    Shufesky, W.J.3
  • 55
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado H, Aleckovic M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012;18(6):883-91
    • (2012) Nat Med , vol.18 , Issue.6 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3
  • 56
    • 84858783222 scopus 로고    scopus 로고
    • Lipid-based carriers of microRNAs and intercellular communication
    • Vickers KC, Remaley AT. Lipid-based carriers of microRNAs and intercellular communication. Curr Opin Lipidol 2012; 23(2):91-7
    • (2012) Curr Opin Lipidol , vol.23 , Issue.2 , pp. 91-97
    • Vickers, K.C.1    Remaley, A.T.2
  • 57
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10(12):1470-6
    • (2008) Nat Cell Biol , vol.10 , Issue.12 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3
  • 58
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M, Paone A, Calore F, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA 2012;109(31): E2110-16
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.31 , pp. E2110-E2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3
  • 59
    • 84860517282 scopus 로고    scopus 로고
    • Exosome-delivered microRNAs of chromosome 19 microRNA cluster as immunomodulators in pregnancy and tumorigenesis
    • Bullerdiek J, Flor I. Exosome-delivered microRNAs of chromosome 19 microRNA cluster as immunomodulators in pregnancy and tumorigenesis. Mol Cytogenet 2012;5(1):27
    • (2012) Mol Cytogenet , vol.5 , Issue.1 , pp. 27
    • Bullerdiek, J.1    Flor, I.2
  • 60
    • 84898776366 scopus 로고    scopus 로고
    • MicroRNAs delivered by extracellular vesicles: An emerging resistance mechanism for breast cancer
    • Chen WX, Zhong SL, Ji MH, et al. MicroRNAs delivered by extracellular vesicles: an emerging resistance mechanism for breast cancer. Tumour Biol 2014;35(4): 2883-92
    • (2014) Tumour Biol , vol.35 , Issue.4 , pp. 2883-2892
    • Chen, W.X.1    Zhong, S.L.2    Ji, M.H.3
  • 61
    • 84930172395 scopus 로고    scopus 로고
    • Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs
    • Chen WX, Liu XM, Lv MM, et al. Exosomes from drug-resistant breast cancer cells transmit chemoresistance by a horizontal transfer of microRNAs. PLoS One 2014;9(4):e95240
    • (2014) PLoS One , vol.9 , Issue.4 , pp. e95240
    • Chen, W.X.1    Liu, X.M.2    Lv, M.M.3
  • 62
    • 84896760337 scopus 로고    scopus 로고
    • Exosomes: Decreased sensitivity of lung cancer A549 cells to cisplatin
    • Xiao X, Yu S, Li S, et al. Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin. PLoS One 2014; 9(2):e89534
    • (2014) PLoS One , vol.9 , Issue.2 , pp. e89534
    • Xiao, X.1    Yu, S.2    Li, S.3
  • 63
    • 84899474348 scopus 로고    scopus 로고
    • MiRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization
    • Valencia K, Luis-Ravelo D, Bovy N, et al. miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization. Mol Oncol 2014;8(3):689-703
    • (2014) Mol Oncol , vol.8 , Issue.3 , pp. 689-703
    • Valencia, K.1    Luis-Ravelo, D.2    Bovy, N.3
  • 64
    • 84898476721 scopus 로고    scopus 로고
    • Cancer-secreted MIR-105 destroys vascular endothelial barriers to promote metastasis
    • Zhou W, Fong MY, Min Y, et al. Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell 2014;25(4):501-15
    • (2014) Cancer Cell , vol.25 , Issue.4 , pp. 501-515
    • Zhou, W.1    Fong, M.Y.2    Min, Y.3
  • 65
    • 80053175966 scopus 로고    scopus 로고
    • Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells
    • Yang M, Chen J, Su F, et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol Cancer 2011;10:117
    • (2011) Mol Cancer , vol.10 , pp. 117
    • Yang, M.1    Chen, J.2    Su, F.3
  • 66
    • 84879419464 scopus 로고    scopus 로고
    • Leukemia cell to endothelial cell communication via exosomal miRNAs
    • Umezu T, Ohyashiki K, Kuroda M, Ohyashiki JH. Leukemia cell to endothelial cell communication via exosomal miRNAs. Oncogene 2013;32(22):2747-55
    • (2013) Oncogene , vol.32 , Issue.22 , pp. 2747-2755
    • Umezu, T.1    Ohyashiki, K.2    Kuroda, M.3    Ohyashiki, J.H.4
  • 67
    • 84855519096 scopus 로고    scopus 로고
    • Competitive interactions of cancer cells and normal cells via secretory microRNAs
    • Kosaka N, Iguchi H, Yoshioka Y, et al. Competitive interactions of cancer cells and normal cells via secretory microRNAs. J Biol Chem 2012;287(2):1397-405
    • (2012) J Biol Chem , vol.287 , Issue.2 , pp. 1397-1405
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3
  • 68
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • Roccaro AM, Sacco A, Maiso P, et al. BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J Clin Invest 2013;123(4):1542-55
    • (2013) J Clin Invest , vol.123 , Issue.4 , pp. 1542-1555
    • Roccaro, A.M.1    Sacco, A.2    Maiso, P.3
  • 69
    • 84907906605 scopus 로고    scopus 로고
    • Quantitative and stoichiometric analysis of the microRNA content of exosomes
    • Chevillet JR, Kang Q, Ruf IK, et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc Natl Acad Sci USA 2014;111(41):14888-93
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.41 , pp. 14888-14893
    • Chevillet, J.R.1    Kang, Q.2    Ruf, I.K.3
  • 70
    • 84911966357 scopus 로고    scopus 로고
    • Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
    • Melo SA, Sugimoto H, O'Connell JT, et al. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 2014;26(5): 707-21
    • (2014) Cancer Cell , vol.26 , Issue.5 , pp. 707-721
    • Melo, S.A.1    Sugimoto, H.2    O'Connell, J.T.3
  • 71
    • 84936869846 scopus 로고    scopus 로고
    • Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines
    • Tosar JP, Gambaro F, Sanguinetti J, et al. Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines. Nucleic Acids Res 2015;43(11): 5601-16
    • (2015) Nucleic Acids Res , vol.43 , Issue.11 , pp. 5601-5616
    • Tosar, J.P.1    Gambaro, F.2    Sanguinetti, J.3
  • 72
    • 84908139770 scopus 로고    scopus 로고
    • Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties
    • Ostenfeld MS, Jeppesen DK, Laurberg JR, et al. Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties. Cancer res 2014;74(20):5758-71
    • (2014) Cancer Res , vol.74 , Issue.20 , pp. 5758-5771
    • Ostenfeld, M.S.1    Jeppesen, D.K.2    Laurberg, J.R.3
  • 73
    • 84922009394 scopus 로고    scopus 로고
    • Tumor surveillance by circulating microRNAs: A hypothesis
    • Igaz I, Igaz P. Tumor surveillance by circulating microRNAs: a hypothesis. Cell Mol Life Sci 2014;71(21):4081-7
    • (2014) Cell Mol Life Sci , vol.71 , Issue.21 , pp. 4081-4087
    • Igaz, I.1    Igaz, P.2
  • 75
    • 84887101163 scopus 로고    scopus 로고
    • MicroRNAs and other non-coding RNAs as targets for anticancer drug development
    • Ling H, Fabbri M, Calin GA. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat Rev Drug Discov 2013;12(11):847-65
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.11 , pp. 847-865
    • Ling, H.1    Fabbri, M.2    Calin, G.A.3
  • 77
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008;105(30): 10513-18
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.30 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.