메뉴 건너뛰기




Volumn 103, Issue 1, 2016, Pages 128-143

Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: A systematic review and meta-analysis of observational studies and randomized controlled trials

Author keywords

Allergic disease; Asthma; Eczema; Fatty acids; Hayfever; N 3 LC PUFA; Pregnancy allergy prevention; Prenatal supplementation; Randomized controlled trial

Indexed keywords

IMMUNOGLOBULIN E; OMEGA 3 FATTY ACID;

EID: 84953855155     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.111104     Document Type: Article
Times cited : (131)

References (58)
  • 1
    • 84882511664 scopus 로고    scopus 로고
    • Fatty acis omega-3 polyunsaturated
    • Benjamin C, editor Oxford (United Kingdom): Elsevier
    • Simopoulos AP. Fatty acis omega-3 polyunsaturated. In: Benjamin C, editor. Encyclopedia of human nutrition. 2nd ed. Oxford (United Kingdom): Elsevier, 2005:205-19.
    • (2005) Encyclopedia of Human Nutrition. 2nd Ed , pp. 205-219
    • Simopoulos, A.P.1
  • 4
    • 0033866604 scopus 로고    scopus 로고
    • The development of the immune system during pregnancy and early life
    • Holt PG, Jones CA. The development of the immune system during pregnancy and early life. Allergy 2000;55:688-97.
    • (2000) Allergy , vol.55 , pp. 688-697
    • Holt, P.G.1    Jones, C.A.2
  • 5
    • 65549097263 scopus 로고    scopus 로고
    • Omega 3 and 6 oils for primary prevention of allergic disease: Systematic review and meta-analysis
    • Anandan C, Nurmatov U, Sheikh A. Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis. Allergy 2009;64:840-8.
    • (2009) Allergy , vol.64 , pp. 840-848
    • Anandan, C.1    Nurmatov, U.2    Sheikh, A.3
  • 6
    • 84894537039 scopus 로고    scopus 로고
    • Effect of maternal n-3 fatty acid supplementation on infant allergy
    • Ciaccio CE. Effect of maternal n-3 fatty acid supplementation on infant allergy. Ann Allergy Asthma Immunol 2014;112:191-4.
    • (2014) Ann Allergy Asthma Immunol , vol.112 , pp. 191-194
    • Ciaccio, C.E.1
  • 7
    • 79959832020 scopus 로고    scopus 로고
    • The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: A systematic review
    • Klemens CM, Berman DR, Mozurkewich EL. The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review. BJOG 2011;118:916-25.
    • (2011) BJOG , vol.118 , pp. 916-925
    • Klemens, C.M.1    Berman, D.R.2    Mozurkewich, E.L.3
  • 8
    • 82255191477 scopus 로고    scopus 로고
    • Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: A systematic review
    • Kremmyda L-S, Vlachava M, Noakes PS, Diaper ND, Miles EA, Calder PC. Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review. Clin Rev Allergy Immunol 2011;41:36-66.
    • (2011) Clin Rev Allergy Immunol , vol.41 , pp. 36-66
    • Kremmyda, L.-S.1    Vlachava, M.2    Noakes, P.S.3    Diaper, N.D.4    Miles, E.A.5    Calder, P.C.6
  • 9
    • 84893097134 scopus 로고    scopus 로고
    • Fish and fish oil intake in relation to risk of asthma: A systematic review and meta-analysis
    • Yang H, Xun P, He K. Fish and fish oil intake in relation to risk of asthma: a systematic review and meta-analysis. PLoS One 2013;8(11): e80048.
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e80048
    • Yang, H.1    Xun, P.2    He, K.3
  • 10
    • 0030567721 scopus 로고    scopus 로고
    • Fiber and breast cancer: Another piece of the puzzle-but still an incomplete picture
    • Gerber M. Fiber and breast cancer: another piece of the puzzle-but still an incomplete picture. J Natl Cancer Inst 1996;88:857-8.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 857-858
    • Gerber, M.1
  • 11
    • 68049137869 scopus 로고    scopus 로고
    • The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of studies that evaluate health care interventions: Explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med 2009;6:e1000100.
    • (2009) PLoS Med , vol.6 , pp. e1000100
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gøtzsche, P.C.5    Jpa, I.6    Clarke, M.7    Devereaux, P.J.8    Kleijnen, J.9    Moher, D.10
  • 16
    • 69749092967 scopus 로고    scopus 로고
    • Maternal fat con-sumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study
    • Miyake Y, Sasaki S, Tanaka K, Ohfuji S, Hirota Y. Maternal fat con-sumption during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study. Thorax 2009;64:815-21.
    • (2009) Thorax , vol.64 , pp. 815-821
    • Miyake, Y.1    Sasaki, S.2    Tanaka, K.3    Ohfuji, S.4    Hirota, Y.5
  • 18
    • 84885959624 scopus 로고    scopus 로고
    • Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: The Kyushu Okinawa Maternal and Child Health Study
    • Miyake Y, Tanaka K, Okubo H, Sasaki S, Arakawa M. Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: the Kyushu Okinawa Maternal and Child Health Study. Ann Epidemiol 2013;23:674-80.
    • (2013) Ann Epidemiol , vol.23 , pp. 674-680
    • Miyake, Y.1    Tanaka, K.2    Okubo, H.3    Sasaki, S.4    Arakawa, M.5
  • 20
    • 84884619145 scopus 로고    scopus 로고
    • Fish intake during pregnancy and the risk of child asthma and allergic rhinitis-longitudinal evidence from the Danish National Birth Cohort
    • Maslova E, Strøm M, Oken E, Campos H, Lange C, Gold D, Olsen SF. Fish intake during pregnancy and the risk of child asthma and allergic rhinitis-longitudinal evidence from the Danish National Birth Cohort. Br J Nutr 2013;110:1313-25.
    • (2013) Br J Nutr , vol.110 , pp. 1313-1325
    • Maslova, E.1    Strøm, M.2    Oken, E.3    Campos, H.4    Lange, C.5    Gold, D.6    Olsen, S.F.7
  • 25
    • 79960520649 scopus 로고    scopus 로고
    • Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation
    • Furuhjelm C, Warstedt K, Fageras M, Falth-Magnusson K, Larsson J, Fredriksson M, Duchen K. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatr Allergy Immunol 2011;22:505-14.
    • (2011) Pediatr Allergy Immunol , vol.22 , pp. 505-514
    • Furuhjelm, C.1    Warstedt, K.2    Fageras, M.3    Falth-Magnusson, K.4    Larsson, J.5    Fredriksson, M.6    Duchen, K.7
  • 29
    • 84857529200 scopus 로고    scopus 로고
    • Effect of n-3 long chain polyunsaturated fatty acid sup-plementation in pregnancy on infants' allergies in first year of life: Randomised controlled trial
    • Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M. Effect of n-3 long chain polyunsaturated fatty acid sup-plementation in pregnancy on infants' allergies in first year of life: randomised controlled trial. BMJ 2012;344:e184.
    • (2012) BMJ , vol.344 , pp. e184
    • Palmer, D.J.1    Sullivan, T.2    Gold, M.S.3    Prescott, S.L.4    Heddle, R.5    Gibson, R.A.6    Makrides, M.7
  • 30
    • 0345734187 scopus 로고    scopus 로고
    • Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: A randomized, controlled trial
    • Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, Prescott SL. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Im-munol 2003;112:1178-84.
    • (2003) J Allergy Clin Im-munol , vol.112 , pp. 1178-1184
    • Dunstan, J.A.1    Mori, T.A.2    Barden, A.3    Beilin, L.J.4    Taylor, A.L.5    Holt, P.G.6    Prescott, S.L.7
  • 31
    • 47249092403 scopus 로고    scopus 로고
    • Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial
    • Olsen SF, Osterdal ML, Salvig JD, Mortensen LM, Rytter D, Secher NJ, Henriksen TB. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial. Am J Clin Nutr 2008;88:167-75.
    • (2008) Am J Clin Nutr , vol.88 , pp. 167-175
    • Olsen, S.F.1    Osterdal, M.L.2    Salvig, J.D.3    Mortensen, L.M.4    Rytter, D.5    Secher, N.J.6    Henriksen, T.B.7
  • 35
    • 0033996399 scopus 로고    scopus 로고
    • Lack of efficacy of a food-frequency questionnaire in assessing dietary macronutrient intakes in subjects consuming diets of known composition
    • Schaefer EJ, Augustin JL, Schaefer MM, Rasmussen H, Ordovas JM, Dallal GE, Dwyer JT. Lack of efficacy of a food-frequency questionnaire in assessing dietary macronutrient intakes in subjects consuming diets of known composition. Am J Clin Nutr 2000;71:746-51.
    • (2000) Am J Clin Nutr , vol.71 , pp. 746-751
    • Schaefer, E.J.1    Augustin, J.L.2    Schaefer, M.M.3    Rasmussen, H.4    Ordovas, J.M.5    Dallal, G.E.6    Dwyer, J.T.7
  • 36
    • 84903548362 scopus 로고    scopus 로고
    • Limitations of observational evidence: Implications for evidence-based dietary rec-ommendations
    • Maki KC, Slavin JL, Rains TM, Kris-Etherton PM. Limitations of observational evidence: implications for evidence-based dietary rec-ommendations. Adv Nutr 2014;5:7-15.
    • (2014) Adv Nutr , vol.5 , pp. 7-15
    • Maki, K.C.1    Slavin, J.L.2    Rains, T.M.3    Kris-Etherton, P.M.4
  • 37
    • 33645966695 scopus 로고    scopus 로고
    • Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort
    • Mikkelsen TB, Osler M, Olsen SF. Validity of protein, retinol, folic acid and n-3 fatty acid intakes estimated from the food-frequency questionnaire used in the Danish National Birth Cohort. Public Health Nutr 2006;9:771-8.
    • (2006) Public Health Nutr , vol.9 , pp. 771-778
    • Mikkelsen, T.B.1    Osler, M.2    Olsen, S.F.3
  • 38
    • 0344837859 scopus 로고    scopus 로고
    • Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study
    • Welch AA, Lund E, Amiano P, Dorronsoro M, Brustad M, Kumle M, Rodriguez M, Lasheras C, Janzon L, Jansson J, et al. Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 2002;5(6b):1273-85.
    • (2002) Public Health Nutr , vol.5 , Issue.6 B , pp. 1273-1285
    • Welch, A.A.1    Lund, E.2    Amiano, P.3    Dorronsoro, M.4    Brustad, M.5    Kumle, M.6    Rodriguez, M.7    Lasheras, C.8    Janzon, L.9    Jansson, J.10
  • 41
    • 84904666273 scopus 로고    scopus 로고
    • Con-cordance between the findings of epidemiological studies and ran-domized trials in nutrition: An empirical evaluation and citation analysis
    • [Internet]. [cited 2014 Nov 26]
    • Moorthy D, Chung M, Lee J, Yu WW, Lau J, Trikalinos TA. Con-cordance between the findings of epidemiological studies and ran-domized trials in nutrition: an empirical evaluation and citation analysis. Nutritional Research Series, Vol. 6 [Internet]. 2013. [cited 2014 Nov 26]. Available from
    • (2013) Nutritional Research Series , vol.6
    • Moorthy, D.1    Chung, M.2    Lee, J.3    Yu, W.W.4    Lau, J.5    Trikalinos, T.A.6
  • 42
    • 0030945567 scopus 로고    scopus 로고
    • Sensitization to hen's egg at the age of twelve months is predictive for allergic sensitization to common indoor and outdoor allergens at the age of three years
    • Nickel R, Kulig M, Forster J, Bergmann R, Bauer CP, Lau S, Gug-genmoos-Holzmann I, Wahn U. Sensitization to hen's egg at the age of twelve months is predictive for allergic sensitization to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol 1997;99:613-7.
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 613-617
    • Nickel, R.1    Kulig, M.2    Forster, J.3    Bergmann, R.4    Bauer, C.P.5    Lau, S.6    Gug-Genmoos-Holzmann, I.7    Wahn, U.8
  • 43
    • 0033850049 scopus 로고    scopus 로고
    • Egg allergy in infancy predicts respiratory allergic disease by 4 years of age
    • Tariq SM, Matthews SM, Hakim EA, Arshad SH. Egg allergy in infancy predicts respiratory allergic disease by 4 years of age. Pediatr Allergy Immunol 2000;11(3):162-7.
    • (2000) Pediatr Allergy Immunol , vol.11 , Issue.3 , pp. 162-167
    • Tariq, S.M.1    Matthews, S.M.2    Hakim, E.A.3    Arshad, S.H.4
  • 44
    • 79953211122 scopus 로고    scopus 로고
    • The atopic March: Progression from atopic dermatitis to allergic rhinitis and asthma
    • Zheng T, Jinho Y, Oh MH, Zhu Z. The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma. Allergy Asthma Im-munol Res 2011;3:67-73.
    • (2011) Allergy Asthma Im-munol Res , vol.3 , pp. 67-73
    • Zheng, T.1    Jinho, Y.2    Oh, M.H.3    Zhu, Z.4
  • 46
    • 82255183130 scopus 로고    scopus 로고
    • Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations
    • Trikalinos TA, Moorthy D, Chung M, Yu WW, Lee J, Lichtenstein AH, Lau J. Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. J Clin Epidemiol 2012;65:16-29.
    • (2012) J Clin Epidemiol , vol.65 , pp. 16-29
    • Trikalinos, T.A.1    Moorthy, D.2    Chung, M.3    Yu, W.W.4    Lee, J.5    Lichtenstein, A.H.6    Lau, J.7
  • 47
    • 0035892870 scopus 로고    scopus 로고
    • Food frequency dietary assessment: How bad is good enough?
    • Byers T. Food frequency dietary assessment: how bad is good enough? Am J Epidemiol 2001;154:1087-8.
    • (2001) Am J Epidemiol , vol.154 , pp. 1087-1088
    • Byers, T.1
  • 50
    • 51049107484 scopus 로고    scopus 로고
    • Long-chain polyunsaturated fatty acids influence the immune system of infants
    • Gottrand F. Long-chain polyunsaturated fatty acids influence the immune system of infants. J Nutr 2008;138(Suppl):1807S-12S.
    • (2008) J Nutr , vol.138 , pp. 1807S-1812S
    • Gottrand, F.1
  • 52
    • 33847145791 scopus 로고    scopus 로고
    • Consumption of omega3-fatty acids during perinatal life: Role in immuno-modulation and allergy prevention
    • Blumer N, Renz H. Consumption of omega3-fatty acids during perinatal life: role in immuno-modulation and allergy prevention. J Perinat Med 2007;35(Suppl 1):S12-8.
    • (2007) J Perinat Med , vol.35 , pp. S12-S18
    • Blumer, N.1    Renz, H.2
  • 53
    • 12844258662 scopus 로고    scopus 로고
    • Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy
    • Denburg JA, Hatfield HM, Cyr MM, Hayes L, Holt PG, Sehmi R. Fish oil supplementation in pregnancy modifies neonatal progenitors at birth in infants at risk of atopy. Pediatr Res 2005;57:276-81.
    • (2005) Pediatr Res , vol.57 , pp. 276-281
    • Denburg, J.A.1    Hatfield, H.M.2    Cyr, M.M.3    Hayes, L.4    Holt, P.G.5    Sehmi, R.6
  • 54
    • 36749092235 scopus 로고    scopus 로고
    • What's new in pediatric allergology in 2006-2007? Part 1: Epidemiology, early diagnosis and prevention
    • Ponvert C. What's new in pediatric allergology in 2006-2007? Part 1: epidemiology, early diagnosis and prevention. Rev Fr Allergol Immunol Clin 2007;47:515-34.
    • (2007) Rev Fr Allergol Immunol Clin , vol.47 , pp. 515-534
    • Ponvert, C.1
  • 55
    • 84883404365 scopus 로고    scopus 로고
    • Diet and allergic diseases among population aged 0 to 18 years: Myth or reality?
    • Saadeh D, Salameh P, Baldi I, Raherison C. Diet and allergic diseases among population aged 0 to 18 years: myth or reality? Nutrients 2013; 5:3399-423.
    • (2013) Nutrients , vol.5 , pp. 3399-3423
    • Saadeh, D.1    Salameh, P.2    Baldi, I.3    Raherison, C.4
  • 56
    • 84873947592 scopus 로고    scopus 로고
    • Timing of allergy-preventive and immu-nomodulatory dietary interventions-are prenatal, perinatal or postnatal strategies optimal?
    • Jenmalm MC, Duchén K. Timing of allergy-preventive and immu-nomodulatory dietary interventions-are prenatal, perinatal or postnatal strategies optimal? Clin Exp Allergy 2013;43:273-8.
    • (2013) Clin Exp Allergy , vol.43 , pp. 273-278
    • Jenmalm, M.C.1    Duchén, K.2
  • 57
    • 84905969073 scopus 로고    scopus 로고
    • N-3 LC-PUFA supplementation: Effects on infant and maternal outcomes
    • De Giuseppe R, Roggi C, Cena H. n-3 LC-PUFA supplementation: effects on infant and maternal outcomes. Eur J Nutr 2014;53:1147-54.
    • (2014) Eur J Nutr , vol.53 , pp. 1147-1154
    • De Giuseppe, R.1    Roggi, C.2    Cena, H.3
  • 58
    • 0031671302 scopus 로고    scopus 로고
    • Atopic sensitization during the first year of life in relation to long chain polyunsaturated fatty acid levels in human milk
    • Duchén K, Yu G, Bjorksten B. Atopic sensitization during the first year of life in relation to long chain polyunsaturated fatty acid levels in human milk. Pediatr Res 1998;44:478-84.
    • (1998) Pediatr Res , vol.44 , pp. 478-484
    • Duchén, K.1    Yu, G.2    Bjorksten, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.