Sex/gender differences in the brain and cognition in schizophrenia

Neuroscience and Biobehavioral Reviews

Volumn 67, Issue , 2016, Pages 57-78

  Mendrek, Adrianna ^a,b,c   Mancini Marïe, Adham ^b,c,d  

^a BISHOP'S UNIVERSITY   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE MONTRÉAL   (Canada)

^d Department of Psychiatry   (Canada)

Author keywords

Brain morphology; Gender; Neurocognitive function; Schizophrenia; Sex differences; Sex steroid hormones

Indexed keywords

SEX HORMONE;

BRAIN FUNCTION; COGNITION; COGNITIVE DEFECT; FUNCTIONAL ANATOMY; HUMAN; LIMBIC SYSTEM; NEUROANATOMY; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SEX DIFFERENCE; SOCIALIZATION; SYMPTOMATOLOGY; BRAIN; FEMALE; MALE; PSYCHOLOGY; SEXUAL DEVELOPMENT;

BRAIN; COGNITION; FEMALE; HUMANS; MALE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEX CHARACTERISTICS;

EID: 84953438893     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2015.10.013     Document Type: Review

References (240)

1. Abbs, B., Liang, L., Makris, N., Tsuang, M., Seidman, L.J., Goldstein, J.M., Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: sex differences are critical. NeuroImage 56:Jun (4) (2011), 1865–1874.
2. Abel, K.M., Drake, R., Goldstein, J.M., Sex differences in schizophrenia. Int. Rev. Psychiatry 22:5 (2010), 417–428.
3. Abu-Akel, A., Bo, S., Superior mentalizing abilities of female patients with schizophrenia. Psychiatry Res. 210:Dec (3) (2013), 794–799.
4. Addington, J., Addington, D., Premorbid functioning, cognitive functioning, symptoms and outcome in schizophrenia. J. Psychiatry Neurosci. 18:1 (1993), 18–23.
5. Addington, D., Addington, J., Patten, S., Gender and affect in schizophrenia. Can. J. Psychiatry (Trans.) Rev. Can. Psychiatrie, 41(Jun (5)), 1996, 265–268.
6. Albus, M., Scherer, J., Hueber, S., Lechleuthner, T., Kraus, G., Zausinger, S., Burkes, S., The impact of familial loading on gender differences in age at onset of schizophrenia. Acta Psychiatr. Scand. 89:2 (1994), 132–134.
7. Albus, M., Hubmann, W., Mohr, F., et al. Are there gender differences in neuropsychological performance in patients with first-episode schizophrenia?. Schizophr. Res. 28:Nov (1) (1997), 39–50.
8. Allen, D.N., Strauss, G.P., Barchard, K.A., Vertinski, M., Carpenter, W.T., Buchanan, R.W., Differences in developmental changes in academic and social premorbid adjustment between males and females with schizophrenia. Schizophr. Res. 146:1–3 May (2013), 132–137.
9. Andia, A.M., Zisook, S., Heaton, R.K., Hesselink, J., Jernigan, T., Kuck, J., Morganville, J., Braff, D.L., Gender differences in schizophrenia. J. Nerv. Ment. Dis. 183:8 (1995), 522–528.
10. Andreasen, N.C., Carpenter, W.T. Jr., Diagnosis and classification of schizophrenia. Schizophr. Bull. 19:2 (1993), 199–214.
11. Andreasen, N.C., Flaum, M., Swayze, V.W. 2nd, Tyrrell, G., Arndt, S., Positive and negative symptoms in schizophrenia. A critical reappraisal. Arch. Gen. Psychiatry 47:7 (1990), 615–621.
12. Andreasen, N.C., Ehrhardt, J.C., Swayze, V.W. 2nd, Alliger, R.J., Yuh, W.T., Cohen, G., Ziebell, S., Magnetic resonance imaging of the brain in schizophrenia. The pathophysiologic significance of structural abnormalities. Arch. Gen. Psychiatry 47:1 (1990), 35–44.
13. Andreasen, N.C., Flashman, L., Flaum, M., Arndt, S., Swayze, V. 2nd, O'Leary, D.S., Ehrhardt, J.C., Yuh, W.T., Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging. JAMA 272:Dec (22) (1994), 1763–1769.
14. Angermeyer, M.C., Kuhn, L., Gender differences in age at onset of schizophrenia. An overview. Eur. Arch. Psychiatry Neurol. Sci. 237:Sep (6) (1988), 351–364.
15. Arato, M., Frecska, E., Beck, C., An, M., Kiss, H., Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization. Prog. Neuropsychopharmacol. Biol. Psychiatry 28:1 (2004), 191–194.
16. Arnold, A.P., The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm. Behav. 55:5 (2009), 570–578.
17. Ayesa-Arriola, R., Rodriguez-Sanchez, J.M., Gomez-Ruiz, E., Roiz-Santianez, R., Reeves, L.L., Crespo-Facorro, B., No sex differences in neuropsychological performance in first episode psychosis patients. Prog. Neuropsychopharmacol. Biol. Psychiatry 48:Jan (2014), 149–154.
18. Bailer, J., Brauer, W., Rey, E.R., Premorbid adjustment as predictor of outcome in schizophrenia: results of a prospective study. Acta Psychiatr. Scand. 93:5 (1996), 368–377.
19. Bergemann, N., Parzer, P., Kaiser, D., Maier-Braunleder, S., Mundt, C., Klier, C., Testosterone and gonadotropins but not estrogen associated with spatial ability in women suffering from schizophrenia: a double-blind, placebo-controlled study. Psychoneuroendocrinology 33:May (4) (2008), 507–516.
20. Bergen, S.E., O'Dushlaine, C.T., Lee, P.H., et al. Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history. Schizophr. Res. 154:Apr (1–3) (2014), 48–53.
21. Berlim, M.T., Mattevi, B.S., Belmonte-de-Abreu, P., Crow, T.J., The etiology of schizophrenia and the origin of language: overview of a theory. Compr. Psychiatry 44:1 (2003), 7–14.
22. Bertelsen, M., Jeppesen, P., Petersen, L., et al. Suicidal behaviour and mortality in first-episode psychosis: the OPUS trial. Br. J. Psychiatry 51:Dec (Supplement) (2007), s140–s146.
23. Bogerts, B., Ashtari, M., Degreef, G., Alvir, J.M., Bilder, R.M., Lieberman, J.A., Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Res. 35:Apr (1) (1990), 1–13.
24. Bozikas, V.P., Kosmidis, M.H., Peltekis, A., Giannakou, M., Nimatoudis, I., Karavatos, A., Fokas, K., Garyfallos, G., Sex differences in neuropsychological functioning among schizophrenia patients. Aust. N.Z. J. Psychiatry 44:4 (2010), 333–341.
25. Brebion, G., Villalta-Gil, V., Autonell, J., et al. Cognitive correlates of verbal memory and verbal fluency in schizophrenia, and differential effects of various clinical symptoms between male and female patients. Schizophr. Res. 147:Jun (1) (2013), 81–85.
26. Bryant, N.L., Buchanan, R.W., Vladar, K., Breier, A., Rothman, M., Gender differences in temporal lobe structures of patients with schizophrenia: a volumetric MRI study. Am. J. Psychiatry 156:4 (1999), 603–609.
27. Bullmore, E., Brammer, M., Harvey, I., Murray, R., Ron, M., Cerebral hemispheric asymmetry revisited: effects of handedness, gender and schizophrenia measured by radius of gyration in magnetic resonance images. Psychol. Med. 25:Mar (2) (1995), 349–363.
28. Burton, S., Symptom domains of schizophrenia: the role of atypical antipsychotic agents. J. Psychopharmacol. 20:Nov (Suppl. 6) (2006), 6–19.
29. Cahill, L., Gorski, L., Belcher, A., Huynh, Q., The influence of sex versus sex-related traits on long-term memory for gist and detail from an emotional story. Conscious Cogn. 13:Jun (2) (2004), 391–400.
30. Castle, D.J., Murray, R.M., The neurodevelopmental basis of sex differences in schizophrenia. Psychol. Med. 21:Aug (3) (1991), 565–575.
31. Castle, D.J., Wessely, S., Murray, R.M., Sex and schizophrenia: effects of diagnostic stringency, and associations with and premorbid variables. Br. J. Psychiatry: J. Ment. Sci. 162:May (1993), 658–664.
32. Champagne, J., Lakis, N., Bourque, J., Stip, E., Lipp, O., Mendrek, A., Progesterone and cerebral function during emotion processing in men and women with schizophrenia. Schizophr. Res. Treat., 2012, 2012, 917901.
33. Chang, W.C., Hui, C.L., Tang, J.Y., Wong, G.H., Lam, M.M., Chan, S.K., Chen, E.Y., Persistent negative symptoms in first-episode schizophrenia: a prospective three-year follow-up study. Schizophr. Res. 133:Dec (1–3) (2011), 22–28.
34. Cheek, F.E., A serendipitous finding: sex roles and schizophrenia. J. Abnormal Psychol. 69:Oct (1964), 392–400.
35. Childers, S.E., Harding, C.M., Gender, premorbid social functioning, and long-term outcome in DSM-III schizophrenia. Schizophr. Bull. 16:2 (1990), 309–318.
36. Collinson, S.L., Mackay, C.E., James, A.C., Quested, D.J., Phillips, T., Roberts, N., Crow, T.J., Brain volume, asymmetry and intellectual impairment in relation to sex in early-onset schizophrenia. Br. J. Psychiatry: J. Ment. Sci. 183:Aug (2003), 114–120.
37. Collinson, S.L., Lim, M., Chaw, J.H., Verma, S., Sim, K., Rapisarda, A., Chong, S.A., Increased ratio of 2nd to 4th digit (2D:4D) in schizophrenia. Psychiatry Res. 176:Mar (1) (2010), 8–12.
38. Crow, T.J., Brain changes and negative symptoms in schizophrenia. Psychopathology 28:1 (1995), 18–21.
39. Crow, T.J., Schizophrenia as the price that homo sapiens pays for language: a resolution of the central paradox in the origin of the species. Brain Res. Brain Res. Rev. 31:Mar (2–3) (2000), 118–129.
40. Crow, T., Genetic hypotheses for schizophrenia. Br. J. Psychiatry: J. Ment. Sci., 191(Aug), 2007, 180 author reply 180–181.
41. Dalman, C., Allebeck, P., Cullberg, J., Grunewald, C., Koster, M., Obstetric complications and the risk of schizophrenia: a longitudinal study of a national birth cohort. Arch. Gen. Psychiatry 56:3 (1999), 234–240.
42. Daly, M.P., Gooding, D.C., Jessen, H.M., Auger, A.P., Indicators of developmental deviance in individuals at risk for schizophrenia. Schizophr. Res. 101:Apr (1–3) (2008), 152–160.
43. Dassa, D., Sham, P.C., Van Os, J., Abel, K., Jones, P., Murray, R.M., Season of birth, obstetric complications and schizophrenia. L'Encephale 22:Oct (Spec No. 3) (1996), 9–12.
44. DeLisi, L.E., Maurizio, A.M., Svetina, C., Ardekani, B., Szulc, K., Nierenberg, J., Leonard, J., Harvey, P.D., Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 135B:May (1) (2005), 15–23.
45. Duggal, H.S., Muddasani, S., Keshavan, M.S., Insular volumes in first-episode schizophrenia: gender effect. Schizophr. Res. 73:Feb (1) (2005), 113–120.
46. Ecker, J., Levine, J., Zigler, E., Impaired sex-role identification in schizophrenia expressed in the comprehension of humor stimuli. J. Psychol. 83:Jan (1st Half) (1973), 67–77.
47. Fatemi, S.H., Folsom, T.D., The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr. Bull. 35:May (3) (2009), 528–548.
48. Fennig, S., Putnam, K., Bromet, E.J., Galambos, N., Gender, premorbid characteristics and negative symptoms in schizophrenia. Acta Psychiatr. Scand. 92:Sep (3) (1995), 173–177.
49. Fenton, W.S., McGlashan, T.H., Natural history of schizophrenia subtypes. II. Positive and negative symptoms and long-term course. Arch. Gen. Psychiatry 48:11 (1991), 978–986.
50. Flaum, M., O'Leary, D.S., Swayze, V.W. 2nd, Miller, D.D., Arndt, S., Andreasen, N.C., Symptom dimensions and brain morphology in schizophrenia and related psychotic disorders. J. Psychiatr. Res. 29:4 (1995), 261–276.
51. Flaum, M., Swayze, V.W. 2nd, O'Leary, D.S., Yuh, W.T., Ehrhardt, J.C., Arndt, S.V., Andreasen, N.C., Effects of diagnosis, laterality, and gender on brain morphology in schizophrenia. Am. J. Psychiatry 152:5 (1995), 704–714.
52. Franzek, E., Beckmann, H., Sex differences and distinct subgroups in schizophrenia. A study of 54 chronic hospitalized schizophrenics. Psychopathology 25:2 (1992), 90–99.
53. Frederikse, M., Lu, A., Aylward, E., Barta, P., Sharma, T., Pearlson, G., Sex differences in inferior parietal lobule volume in schizophrenia. Am. J. Psychiatry 157:3 (2000), 422–427.
54. Funahashi, T., Ibuki, Y., Domon, Y., Nishimura, T., Akehashi, D., Sugiura, H., A clinical study on suicide among schizophrenics. Psychiatry Clin. Neurosci. 54:Apr (2) (2000), 173–179.
55. Ginovart, N., Kapur, S., Role of dopamine D(2) receptors for antipsychotic activity. Handb. Exp. Pharmacol.(212), 2012, 27–52.
56. Goldberg, T.E., Gold, J.M., Torrey, E.F., Weinberger, D.R., Lack of sex differences in the neuropsychological performance of patients with schizophrenia. Am. J. Psychiatry 152:6 (1995), 883–888.
57. Goldstein, J.M., Link, B.G., Gender and the expression of schizophrenia. J. Psychiatr. Res. 22:2 (1988), 141–155.
58. Goldstein, J.M., Tsuang, M.T., Faraone, S.V., Gender and schizophrenia: implications for understanding the heterogeneity of the illness. Psychiatry Res. 28:Jun (3) (1989), 243–253.
59. Goldstein, J.M., Seidman, L.J., Goodman, J.M., Koren, D., Lee, H., Weintraub, S., Tsuang, M.T., Are there sex differences in neuropsychological functions among patients with schizophrenia?. Am. J. Psychiatry 155:10 (1998), 1358–1364.
60. Goldstein, J.M., Seidman, L.J., O'Brien, L.M., et al. Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Arch. Gen. Psychiatry 59:2 (2002), 154–164.
61. Goldstein, J.M., Seidman, L.J., Makris, N., et al. Hypothalamic abnormalities in schizophrenia: sex effects and genetic vulnerability. Biol. Psychiatry 61:Apr (8) (2007), 935–945.
62. Gootjes, L., Bruggeling, E.C., Magnee, T., Van Strien, J.W., Sex differences in the latency of the late event-related potential mental rotation effect. NeuroReport 19:Feb (3) (2008), 349–353.
63. Green, M.F., Kern, R.S., Heaton, R.K., Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr. Res. 72:Dec (1) (2004), 41–51.
64. Green, M.F., Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J. Clin. Psychiatry 67:Suppl. 9 (2006), 3–8 discussion 36–42.
65. Grigoriadis, S., Seeman, M.V., The role of estrogen in schizophrenia: implications for schizophrenia practice guidelines for women. Can. J. Psychiatry (Trans.) Rev. Can. Psychiatrie, 47(Jun (5)), 2002, 437–442.
66. Guillem, F., Mendrek, A., Lavoie, M.E., Pampoulova, T., Stip, E., Sex differences in memory processing in schizophrenia: an event-related potential (ERP) study. Prog. Neuropsychopharmacol. Biol. Psychiatry 33:Feb (1) (2009), 1–10.
67. Gur, R.E., Petty, R.G., Turetsky, B.I., Gur, R.C., Schizophrenia throughout life: sex differences in severity and profile of symptoms. Schizophr. Res. 21:Jul (1) (1996), 1–12.
68. Gur, R.E., Cowell, P.E., Latshaw, A., Turetsky, B.I., Grossman, R.I., Arnold, S.E., Bilker, W.B., Gur, R.C., Reduced dorsal and orbital prefrontal gray matter volumes in schizophrenia. Arch. Gen. Psychiatry 57:8 (2000), 761–768.
69. Gur, R.E., Turetsky, B.I., Cowell, P.E., et al. Temporolimbic volume reductions in schizophrenia. Arch. Gen. Psychiatry 57:8 (2000), 769–775.
70. Gur, R.C., Gunning-Dixon, F.M., Turetsky, B.I., Bilker, W.B., Gur, R.E., Brain region and sex differences in age association with brain volume: a quantitative MRI study of healthy young adults. Am. J. Geriatr. Psychiatry 10:1 (2002), 72–80.
71. Gur, R.E., Kohler, C., Turetsky, B.I., Siegel, S.J., Kanes, S.J., Bilker, W.B., Brennan, A.R., Gur, R.C., A sexually dimorphic ratio of orbitofrontal to amygdala volume is altered in schizophrenia. Biol. Psychiatry 55:Mar (5) (2004), 512–517.
72. Hafner, H., Riecher, A., Maurer, K., Loffler, W., Munk-Jorgensen, P., Stromgren, E., How does gender influence age at first hospitalization for schizophrenia? A transnational case register study. Psychol. Med. 19:Nov (4) (1989), 903–918.
73. Hafner, H., Fatkenheuer, B., an der Heiden, W., Loffler, W., Maurer, K., Munk-Jorgensen, P., Riecher, A., Sex differences in age of onset, symptomatology and evolution of schizophrenia. Sante mentale au Quebec 16:Jun (1) (1991), 77–98.
74. Hafner, H., Maurer, K., Loffler, W., Riecher-Rossler, A., The influence of age and sex on the onset and early course of schizophrenia. Br. J. Psychiatry: J. Ment. Sci. 162:Jan (1993), 80–86.
75. Hafner, H., Riecher-Rossler, A., An Der Heiden, W., Maurer, K., Fatkenheuer, B., Loffler, W., Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia. Psychol. Med. 23:Nov (4) (1993), 925–940.
76. Hafner, H., an der Heiden, W., Behrens, S., et al. Causes and consequences of the gender difference in age at onset of schizophrenia. Schizophr. Bull. 24:1 (1998), 99–113.
77. Hafner, H., Maurer, K., Loffler, W., an der Heiden, W., Munk-Jorgensen, P., Hambrecht, M., Riecher-Rossler, A., The ABC Schizophrenia Study: a preliminary overview of the results. Soc. Psychiatry Psychiatr. Epidemiol. 33:8 (1998), 380–386.
78. Hafner, H., Gender differences in schizophrenia. Psychoneuroendocrinology 28:Apr (Suppl. 2) (2003), 17–54.
79. Haijma, S.V., Van Haren, N., Cahn, W., Koolschijn, P.C., Hulshoff Pol, H.E., Kahn, R.S., Brain volumes in schizophrenia: a meta-analysis in over 18,000 subjects. Schizophr. Bull. 39:Sep (5) (2013), 1129–1138.
80. Halari, R., Kumari, V., Mehrotra, R., Wheeler, M., Hines, M., Sharma, T., The relationship of sex hormones and cortisol with cognitive functioning in Schizophrenia. J. Psychopharmacol. 18:Sep (3) (2004), 366–374.
81. Halari, R., Mehrotra, R., Sharma, T., Ng, V., Kumari, V., Cognitive impairment but preservation of sexual dimorphism in cognitive abilities in chronic schizophrenia. Psychiatry Res. 141:2 (2006), 129–139.
82. Halari, R., Sharma, T., Hines, M., Andrew, C., Simmons, A., Kumari, V., Comparable fMRI activity with differential behavioural performance on mental rotation and overt verbal fluency tasks in healthy men and women. Exp. Brain Res. 169:Feb (1) (2006), 1–14.
83. Hambrecht, M., Maurer, K., Hafner, H., Gender differences in schizophrenia in three cultures. Results of the WHO collaborative study on psychiatric disability. Soc. Psychiatry Psychiatr. Epidemiol. 27:May (3) (1992), 117–121.
84. Han, M., Huang, X.F., Chen da, C., Xiu, M.H., Hui, L., Liu, H., Kosten, T.R., Zhang, X.Y., Gender differences in cognitive function of patients with chronic schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 39:Dec (2) (2012), 358–363.
85. Harrison, P.J., Weinberger, D.R., Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 10:1 (2005), 40–68 image 45.
86. Hausmann, M., Slabbekoorn, D., Van Goozen, S.H., Cohen-Kettenis, P.T., Gunturkun, O., Sex hormones affect spatial abilities during the menstrual cycle. Behav. Neurosci. 114:Dec (6) (2000), 1245–1250.
87. Hausmann, M., Schoofs, D., Rosenthal, H.E., Jordan, K., Interactive effects of sex hormones and gender stereotypes on cognitive sex differences—a psychobiosocial approach. Psychoneuroendocrinology 34:Apr (3) (2009), 389–401.
88. Helle, S., Gjestad, R., Johnsen, E., Kroken, R.A., Jorgensen, H.A., Loberg, E.M., Cognitive changes in patients with acute phase psychosis—effects of illicit drug use. Psychiatry Res., 8(Sep), 2014.
89. Hines, M., Sex-related variation in human behavior and the brain. Trends Cogn. Sci. 14:10 (2010), 448–456.
90. Hoff, A.L., Wieneke, M., Faustman, W.O., Horon, R., Sakuma, M., Blankfeld, H., Espinoza, S., DeLisi, L.E., Sex differences in neuropsychological functioning of first-episode and chronically ill schizophrenic patients. Am. J. Psychiatry 155:10 (1998), 1437–1439.
91. Hoff, A.L., Kremen, W.S., Wieneke, M.H., Lauriello, J., Blankfeld, H.M., Faustman, W.O., Csernansky, J.G., Nordahl, T.E., Association of estrogen levels with neuropsychological performance in women with schizophrenia. Am. J. Psychiatry 158:7 (2001), 1134–1139.
92. Holdcroft, A., Gender bias in research: how does it affect evidence based medicine?. J. R. Soc. Med. 100:1 (2007), 2–3.
93. Hugdahl, K., Thomsen, T., Ersland, L., Sex differences in visuo-spatial processing: an fMRI study of mental rotation. Neuropsychologia 44:9 (2006), 1575–1583.
94. Irle, E., Lange, C., Ruhleder, M., Exner, C., Siemerkus, J., Weniger, G., Hippocampal size in women but not men with schizophrenia relates to disorder duration. Psychiatry Res. 192:Jun (3) (2011), 133–139.
95. Ittig, S., Studerus, E., Papmeyer, M., Uttinger, M., Koranyi, S., Ramyead, A., Riecher-Rossler, A., Sex differences in cognitive functioning in at-risk mental state for psychosis, first episode psychosis and healthy control subjects. Eur. Psychiatry 30:2 (2015), 242–250.
96. Jablensky, A., Sartorius, N., Ernberg, G., Anker, M., Korten, A., Cooper, J.E., Day, R., Bertelsen, A., Schizophrenia:, manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol. Med. Monogr. 20:Supplement (1992), 1–97.
97. Jayaswal, S.K., Adityanjee, Khandelwal, S.K., Age of onset of schizophrenia. Br. J. Psychiatry: J. Ment. Sci., 152(Mar), 1988, 428.
98. Jimenez, J., Mancini-Marie, A., Mendrek, A., The case for not combining men and women in neurocognitive studies for schizophrenia. Schizophr. Res. 108:Mar (1–3) (2009), 293–294.
99. Jimenez, J.A., Mancini-Marie, A., Lakis, N., Rinaldi, M., Mendrek, A., Disturbed sexual dimorphism of brain activation during mental rotation in schizophrenia. Schizophr. Res. 122:Sep (1–3) (2010), 53–62.
100. Jonsson, A.J., Birgisdottir, H., Sigurdsson, E., Does the use of cannabis increase the risk for psychosis and the development of schizophrenia?. Laeknabladid 100:9 (2014), 443–451.
101. Jordan, K., Wustenberg, T., Heinze, H.J., Peters, M., Jancke, L., Women and men exhibit different cortical activation patterns during mental rotation tasks. Neuropsychologia 40:13 (2002), 2397–2408.
102. Joseph, J., Bae, G., Silverstein, S.M., Sex, symptom, and premorbid social functioning associated with perceptual organization dysfunction in schizophrenia. Front. Psychol., 4, 2013, 547.
103. Kadri, N., Sartorius, N., The global fight against the stigma of schizophrenia. PLoS Med., 2(7), 2005, e136.
104. Kao, Y.C., Liu, Y.P., Lien, Y.J., Lin, S.J., Lu, C.W., Wang, T.S., Loh, C.H., The influence of sex on cognitive insight and neurocognitive functioning in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 1:Jul (44) (2013), 193–200.
105. Kay, S.R., Opler, L.A., Fiszbein, A., Significance of positive and negative syndromes in chronic schizophrenia. Br. J. Psychiatry 149:Oct (1986), 439–448.
106. Kelly, B.D., Feeney, L., O'Callaghan, E., et al. Obstetric adversity and age at first presentation with schizophrenia: evidence of a dose–response relationship. Am. J. Psychiatry 161:5 (2004), 920–922.
107. Kendler, K.S., Walsh, D., Gender and schizophrenia. Results of an epidemiologically-based family study. Br. J. Psychiatry: J. Ment. Sci. 167:Aug (2) (1995), 184–192.
108. Keshavan, M.S., Development, disease and degeneration in schizophrenia: a unitary pathophysiological model. J. Psychiatr. Res. 33:6 (1999), 513–521.
109. Keshavan, M.S., Hogarty, G.E., Brain maturational processes and delayed onset in schizophrenia. Dev. Psychopathol. 11:Summer (3) (1999), 525–543.
110. Kirov, G., Jones, P.B., Harvey, I., Lewis, S.W., Toone, B.K., Rifkin, L., Sham, P., Murray, R.M., Do obstetric complications cause the earlier age at onset in male than female schizophrenics?. Schizophr. Res. 20:May (1–2) (1996), 117–124.
111. Kozaki, T., Yasukouchi, A., Sex differences on components of mental rotation at different menstrual phases. Int. J. Neurosci. 119:1 (2009), 59–67.
112. Kraepelin, E., (eds.) Dementia Praecox and Paraphrenia, 1919/1971, Publishing Co. Inc, Huntington, NY.
113. Krysta, K., Murawiec, S., Klasik, A., Wiglusz, M.S., Krupka-Matuszczyk, I., Sex-specific differences in cognitive functioning among schizophrenic patients. Psychiatr. Danubina 25:Sep (Suppl. 2) (2013), S244–S246.
114. Kulkarni, J., Gavrilidis, E., Hayes, E., Heaton, V., Worsley, R., Special biological issues in the management of women with schizophrenia. Expert Rev. Neurother. 12:7 (2012), 823–833.
115. Kulkarni, J., Hayes, E., Gavrilidis, E., Hormones and schizophrenia. Curr. Opin. Psychiatry 25:Mar (2) (2012), 89–95.
116. Kulkarni, J., Gavrilidis, E., Worsley, R., Hayes, E., Role of estrogen treatment in the management of schizophrenia. CNS Drugs 26:7 (2012), 549–557.
117. Lakis, N., Jimenez, J.A., Mancini-Marie, A., Stip, E., Lavoie, M.E., Mendrek, A., Neural correlates of emotional recognition memory in schizophrenia: effects of valence and arousal. Psychiatry Res. 194:Dec (3) (2011), 245–256.
118. Lang, D.J., Khorram, B., Goghari, V.M., Kopala, L.C., Vandorpe, R.A., Rui, Q., Smith, G.N., Honer, W.G., Reduced anterior internal capsule and thalamic volumes in first-episode psychosis. Schizophr. Res. 87:Oct (1–3) (2006), 89–99.
119. Larsen, T.K., McGlashan, T.H., Johannessen, J.O., Vibe-Hansen, L., First-episode schizophrenia: II. Premorbid patterns by gender. Schizophr. Bull. 22:2 (1996), 257–269.
120. LaTorre, R.A., The psychological assessment of gender identity and gender role in schizophrenia. Schizophr. Bull. 2:2 (1976), 266–285.
121. Lauriello, J., Hoff, A., Wieneke, M.H., et al. Similar extent of brain dysmorphology in severely ill women and men with schizophrenia. Am. J. Psychiatry 154:6 (1997), 819–825.
122. Leung, A., Chue, P., Sex differences in schizophrenia, a review of the literature. Acta Psychiatr. Scand. 401:Supplementum (2000), 3–38.
123. Levine, M.E., Stern, R.M., Spatial task performance, sex differences, and motion sickness susceptibility. Percept. Mot. Skills 95:Oct (2) (2002), 425–431.
124. Lewine, R.R., Hudgins, P., Brown, F., Caudle, J., Risch, S.C., Differences in qualitative brain morphology findings in schizophrenia, major depression, bipolar disorder, and normal volunteers. Schizophr. Res. 15:May (3) (1995), 253–259.
125. Lewine, R.R., Walker, E.F., Shurett, R., Caudle, J., Haden, C., Sex differences in neuropsychological functioning among schizophrenic patients. Am. J. Psychiatry 153:9 (1996), 1178–1180.
126. Lewine, R., Haden, C., Caudle, J., Shurett, R., Sex-onset effects on neuropsychological function in schizophrenia. Schizophr. Bull. 23:1 (1997), 51–61.
127. Lewine, R.R., Thurston-Snoha, B.J., Ardery, R., Sex, gender, and neuropsychological functioning in schizophrenia. J. Clin. Exp. Neuropsychol. 28:Nov (8) (2006), 1362–1372.
128. Lewine, R.R., Sex differences in age of symptom onset and first hospitalization in schizophrenia. Am. J. Orthopsychiatry 50:Apr (2) (1980), 316–322.
129. Lewine, R., At issue: Sex and gender in schizophrenia. Schizophr. Bull. 30:4 (2004), 755–762.
130. Lewis, D.A., Lieberman, J.A., Catching up on schizophrenia: natural history and neurobiology. Neuron 28:Nov (2) (2000), 325–334.
131. Lewis, S.W., Murray, R.M., Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia. J. Psychiatr. Res. 21:4 (1987), 413–421.
132. Lewis, S., Sex and schizophrenia: vive la difference. Br. J. Psychiatry: J. Ment. Sci. 161:Oct (1992), 445–450.
133. Lichtermann, D., Karbe, E., Maier, W., The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders. Eur. Arch. Psychiatry Clin. Neurosci. 250:6 (2000), 304–310.
134. Limosin, F., Neurodevelopmental and environmental hypotheses of negative symptoms of schizophrenia. BMC Psychiatry, 14, 2014, 88.
135. Lindamer, L.A., Lohr, J.B., Harris, M.J., McAdams, L.A., Jeste, D.V., Gender-related clinical differences in older patients with schizophrenia. J. Clin. Psychiatry 60:1 (1999), 61–67 quiz 68-69.
136. Lindstrom, E., von Knorring, L., Symptoms in schizophrenic syndromes in relation to age, sex, duration of illness and number of previous hospitalizations. Acta Psychiatr. Scand. 89:4 (1994), 274–278.
137. Luine, V.N., Sex steroids and cognitive function. J. Neuroendocrinol. 20:6 (2008), 866–872.
138. Lutchmaya, S., Baron-Cohen, S., Raggatt, P., Knickmeyer, R., Manning, J.T., 2nd to 4th digit ratios, fetal testosterone and estradiol. Early Hum. Dev. 77:Apr (1–2) (2004), 23–28.
139. Maibing, C.F., Pedersen, C.B., Benros, M.E., Mortensen, P.B., Dalsgaard, S., Nordentoft, M., Risk of schizophrenia increases after all child and adolescent psychiatric disorders: a Nationwide Study. Schizophr. Bull. 41:Jul (4) (2015), 963–970.
140. Makinen, J., Miettunen, J., Isohanni, M., Koponen, H., Negative symptoms in schizophrenia: a review. Nordic J. Psychiatry 62:5 (2008), 334–341.
141. Malaspina, D., Goetz, R., Keller, A., et al. Olfactory processing, sex effects and heterogeneity in schizophrenia. Schizophr. Res. 135:Mar (1–3) (2012), 144–151.
142. Malaspina, D., Keller, A., Antonius, D., Messinger, J.W., Goetz, D.M., Harkavy-Friedman, J., Goetz, R.R., Harlap, S., Olfaction and cognition in schizophrenia: sex matters. J. Neuropsychiatry Clin. Neurosci. 24:Spring (2) (2012), 165–175.
143. Markham, J.A., Sex steroids and schizophrenia. Rev. Endocr. Metab. Disord. 13:Sep (3) (2012), 187–207.
144. Marneros, A., Frequency of occurrence of Schneider's first rank symptoms in Schizophrenia. Eur. Arch. Psychiatry Neurol. Sci. 234:1 (1984), 78–82.
145. McClelland, D.C., Watt, N.F., Sex-role alienation in schizophrenia. J. Abnormal Psychol. 73:Jun (3) (1968), 226–239.
146. McGrath, J., Saha, S., Chant, D., Welham, J., Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol. Rev. 30 (2008), 67–76.
147. Meisenzahl, E.M., Koutsouleris, N., Bottlender, R., et al. Structural brain alterations at different stages of schizophrenia: a voxel-based morphometric study. Schizophr. Res. 104:Sep (1–3) (2008), 44–60.
148. Mendrek, A., Stip, E., Sexual dimorphism in schizophrenia: is there a need for gender-based protocols?. Expert Rev. Neurother. 11:7 (2011), 951–959.
149. Mendrek, A., Mancini-Marie, A., Fahim, C., Stip, E., Sex differences in the cerebral function associated with processing of aversive stimuli by schizophrenia patients. Aust. N.Z. J. Psychiatry 41:2 (2007), 136–141.
150. Mendrek, A., Lakis, N., Jimenez, J., Associations of sex steroid hormones with cerebral activations during mental rotation in men and women with schizophrenia. Psychoneuroendocrinology 36:Oct (9) (2011), 1422–1426.
151. Mendrek, A., Bourque, J., Dube, A., Lakis, N., Champagne, J., Emotion processing in women with schizophrenia is menstrual cycle phase and affective valence dependent: an FMRI study. ISRN Psychiatry, 2012, 2012, 656274.
152. Mendrek, A., Reversal of normal cerebral sexual dimorphism in schizophrenia: evidence and speculations. Med. Hypotheses 69:4 (2007), 896–902.
153. Mendrek, A., Is it important to consider sex and gender in neurocognitive studies?. Front. Psychiatry, 6, 2015, 83.
154. Mesholam-Gately, R.I., Giuliano, A.J., Goff, K.P., Faraone, S.V., Seidman, L.J., Neurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology 23:May (3) (2009), 315–336.
155. Molina, V., Sanz, J., Sarramea, F., Misiego, J.M., Benito, C., Palomo, T., Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia. Eur. Psychiatry 20:Jun (4) (2005), 332–338.
156. Moore, L., Kyaw, M., Vercammen, A., et al. Serum testosterone levels are related to cognitive function in men with schizophrenia. Psychoneuroendocrinology 38:9 (2013), 1717–1728.
157. Morgan, V.A., Castle, D.J., Jablensky, A.V., Do women express and experience psychosis differently from men? Epidemiological evidence from the Australian National Study of Low Prevalence (Psychotic) Disorders. Aust. N.Z. J. Psychiatry 42:1 (2008), 74–82.
158. Narr, K.L., Thompson, P.M., Sharma, T., Moussai, J., Cannestra, A.F., Toga, A.W., Mapping morphology of the corpus callosum in schizophrenia. Cereb. Cortex 10:1 (2000), 40–49.
159. Narr, K., Thompson, P., Sharma, T., Moussai, J., Zoumalan, C., Rayman, J., Toga, A., Three-dimensional mapping of gyral shape and cortical surface asymmetries in schizophrenia: gender effects. Am. J. Psychiatry 158:2 (2001), 244–255.
160. Narr, K.L., Sharma, T., Woods, R.P., et al. Increases in regional subarachnoid CSF without apparent cortical gray matter deficits in schizophrenia: modulating effects of sex and age. Am. J. Psychiatry 160:12 (2003), 2169–2180.
161. Narr, K.L., Bilder, R.M., Kim, S., Thompson, P.M., Szeszko, P., Robinson, D., Luders, E., Toga, A.W., Abnormal gyral complexity in first-episode schizophrenia. Biol. Psychiatry 55:Apr (8) (2004), 859–867.
162. Narr, K.L., Toga, A.W., Szeszko, P., et al. Cortical thinning in cingulate and occipital cortices in first episode schizophrenia. Biol. Psychiatry 58:Jul (1) (2005), 32–40.
163. Narr, K.L., Bilder, R.M., Woods, R.P., et al. Regional specificity of cerebrospinal fluid abnormalities in first episode schizophrenia. Psychiatry Res. 146:Jan (1) (2006), 21–33.
164. Narr, K.L., Woods, R.P., Lin, J., et al. Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorder. J. Am. Acad. Child. Adolesc. Psychiatry 48:10 (2009), 1014–1022.
165. Niu, L., Matsui, M., Zhou, S.Y., et al. Volume reduction of the amygdala in patients with schizophrenia: a magnetic resonance imaging study. Psychiatry Res. 132:Nov (1) (2004), 41–51.
166. Nopoulos, P., Flaum, M., Andreasen, N.C., Sex differences in brain morphology in schizophrenia. Am. J. Psychiatry 154:12 (1997), 1648–1654.
167. Notman, M.T., Nadelson, C.C., (eds.) Women and Men: New Perspectives on Gender Differences, 1991, American Psychiatric Press, Washington, DC.
168. Parrott, B., Lewine, R., Socioeconomic status of origin and the clinical expression of Schizophrenia. Schizophr. Res. 75:Jun (2–3) (2005), 417–424.
169. Paus, T., Otaky, N., Caramanos, Z., et al. In vivo morphometry of the intrasulcal gray matter in the human cingulate, paracingulate, and superior-rostral sulci: hemispheric asymmetries, gender differences and probability maps. J. Comp. Neurol. 376:Dec (4) (1996), 664–673.
170. Perala, J., Suvisaari, J., Saarni, S.I., et al. Lifetime prevalence of psychotic and bipolar I disorders in a general population. Arch. Gen. Psychiatry 64:1 (2007), 19–28.
171. Perlick, D., Mattis, S., Stastny, P., Teresi, J., Gender differences in cognition in schizophrenia. Schizophr. Res. 8:Oct (1) (1992), 69–73.
172. Peters, M., Manning, J.T., Reimers, S., The effects of sex, sexual orientation, and digit ratio (2D:4D) on mental rotation performance. Arch. Sex Behav. 36:Apr (2) (2007), 251–260.
173. Plocka, M., Rybakowski, J., Gender differences in schizophrenia. Psychiatria Polska 26:5 (1992), 327–336.
174. Potvin, S., Tikàsz, A., Lungu, O., Dumais, A., Stip, E., Mendrek, A., Emotion processing in treatment-resistant schizophrenia patients treated with clozapine: An fMRI study. Schizophr Res. 168:1-2 (2015), 377–380, 10.1016/j.schres.2015.07.046 Epub 2015 Aug 6.
175. Rector, N.A., Seeman, M.V., Auditory hallucinations in women and men. Schizophr. Res. 7:Sep (3) (1992), 233–236.
176. Reite, M., Sheeder, J., Teale, P., Adams, M., Richardson, D., Simon, J., Jones, R.H., Rojas, D.C., Magnetic source imaging evidence of sex differences in cerebral lateralization in schizophrenia. Arch. Gen. Psychiatry 54:5 (1997), 433–440.
177. Riecher-Rossler, A., Hafner, H., Dutsch-Strobel, A., Oster, M., Stumbaum, M., van Gulick-Bailer, M., Loffler, W., Further evidence for a specific role of estradiol in schizophrenia?. Biol. Psychiatry 36:Oct (7) (1994), 492–494.
178. Ring, N., Tantam, D., Montague, L., Newby, D., Black, D., Morris, J., Gender differences in the incidence of definite schizophrenia and atypical psychosis--focus on negative symptoms of schizophrenia. Acta Psychiatr. Scand. 84:Dec (6) (1991), 489–496.
179. Roesch-Ely, D., Hornberger, E., Weiland, S., Hornstein, C., Parzer, P., Thomas, C., Weisbrod, M., Do sex differences affect prefrontal cortex associated cognition in schizophrenia?. Schizophr. Res. 107:Feb (2–3) (2009), 255–261.
180. Rosenfield, P.J., Kleinhaus, K., Opler, M., et al. Later paternal age and sex differences in schizophrenia symptoms. Schizophr. Res. 116:Feb (2–3) (2010), 191–195.
181. Ruigrok, A.N., Salimi-Khorshidi, G., Lai, M.C., Baron-Cohen, S., Lombardo, M.V., Tait, R.J., Suckling, J., A meta-analysis of sex differences in human brain structure. Neurosci. Biobehav. Rev. 39:Feb (2014), 34–50.
182. Rund, B.R., Borg, N.E., Cognitive deficits and cognitive training in schizophrenic patients: a review. Acta Psychiatr. Scand. 100:Aug (2) (1999), 85–95.
183. Saha, S., Chant, D., Welham, J., McGrath, J., A systematic review of the prevalence of schizophrenia. PLoS Med., 2(5), 2005, e141.
184. Saha, S., Chant, D., McGrath, J., A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?. Arch. Gen. Psychiatry 64:10 (2007), 1123–1131.
185. Sajatovic, M., Jenkins, J.H., Strauss, M.E., Butt, Z.A., Carpenter, E., Gender identity and implications for recovery among men and women with schizophrenia. Psychiatr. Serv. 56:1 (2005), 96–98.
186. Salem, J.E., Kring, A.M., The role of gender differences in the reduction of etiologic heterogeneity in schizophrenia. Clin. Psychol. Rev. 18:Nov (7) (1998), 795–819.
187. Savadjiev, P., Whitford, T.J., Hough, M.E., et al. Sexually dimorphic white matter geometry abnormalities in adolescent onset schizophrenia. Cereb. Cortex 24:5 (2014), 1389–1396.
188. Savic, I., Advances in research on the neurological and neuropsychiatric phenotype of Klinefelter syndrome. Curr. Opin. Neurol. 25:Apr (2) (2012), 138–143.
189. Schmael, C., Georgi, A., Krumm, B., Buerger, C., Deschner, M., Nothen, M.M., Schulze, T.G., Rietschel, M., Premorbid adjustment in schizophrenia—an important aspect of phenotype definition. Schizophr. Res. 92:May (1–3) (2007), 50–62.
190. Schoning, S., Engelien, A., Kugel, H., et al. Functional anatomy of visuo-spatial working memory during mental rotation is influenced by sex, menstrual cycle, and sex steroid hormones. Neuropsychologia 45:Nov (14) (2007), 3203–3214.
191. Schultz, S.K., Miller, D.D., Oliver, S.E., Arndt, S., Flaum, M., Andreasen, N.C., The life course of schizophrenia: age and symptom dimensions. Schizophr. Res. 23:1 (1997), 15–23.
192. Seeman, M.V., The role of sex hormones in psychopathology: focus on schizophrenia. Prim. Care 29:Mar (1) (2002), 171–182 viii.
193. Seeman, M.V., Menstrual exacerbation of schizophrenia symptoms. Acta Psychiatr. Scand. 125:5 (2012), 363–371.
194. Seidman, L.J., Goldstein, J.M., Goodman, J.M., Koren, D., Turner, W.M., Faraone, S.V., Tsuang, M.T., Sex differences in olfactory identification and Wisconsin Card Sorting performance in schizophrenia: relationship to attention and verbal ability. Biol. Psychiatry 42:Jul (2) (1997), 104–115.
195. Semaan, S.J., Kauffman, A.S., Sexual differentiation and development of forebrain reproductive circuits. Curr. Opin. Neurobiol. 20:Aug (4) (2010), 424–431.
196. Sham, P.C., MacLean, C.J., Kendler, K.S., Risk of schizophrenia and age difference with older siblings. Evidence for a maternal viral infection hypothesis?. Br. J. Psychiatry: J. Ment. Sci. 163:Nov (1993), 627–633.
197. Shepherd, A.M., Laurens, K.R., Matheson, S.L., Carr, V.J., Green, M.J., Systematic meta-review and quality assessment of the structural brain alterations in schizophreni. Neurosci. Biobehav. Rev. 36:4 (2012), 1342–1356.
198. Sherwin, B.B., Estrogen and cognitive functioning in women: lessons we have learned. Behav. Neurosci. 126:Feb (1) (2012), 123–127.
199. Shimizu, A., Kurachi, M., Noda, M., Yamaguchi, N., Torii, H., Isaki, K., Influence of sex on age at onset of schizophrenia. Jpn. J. Psychiatry Neurol. 42:Mar (1) (1988), 35–40.
200. Shipman, S.L., Baker, E.K., Pearlson, G., Astur, R.S., Absence of established sex differences in patients with schizophrenia on a two-dimensional object array task. Psychiatry Res. 166:Apr (2–3) (2009), 158–165.
201. Shtasel, D.L., Gur, R.E., Gallacher, F., Heimberg, C., Gur, R.C., Gender differences in the clinical expression of schizophrenia. Schizophr. Res. 7:Sep (3) (1992), 225–231.
202. Sota, T.L., Heinrichs, R.W., Sex differences in verbal memory in schizophrenia patients treated with “typical” neuroleptics. Schizophr. Res. 62:Jul (1–2) (2003), 175–182.
203. Steen, R.G., Mull, C., McClure, R., Hamer, R.M., Lieberman, J.A., Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. Br. J. Psychiatry 188:Jun (2006), 510–518.
204. Strauss, G.P., Horan, W.P., Kirkpatrick, B., et al. Deconstructing negative symptoms of schizophrenia: avolition-apathy and diminished expression clusters predict clinical presentation and functional outcome. J. Psychiatr. Res. 47:6 (2013), 783–790.
205. Strauss, G.P., Keller, W.R., Koenig, J.I., Sullivan, S.K., Gold, J.M., Buchanan, R.W., Endogenous oxytocin levels are associated with the perception of emotion in dynamic body expressions in schizophrenia. Schizophr. Res. 162:Mar (1–3) (2015), 52–56.
206. Stromgren, E., Changes in the incidence of schizophrenia?. Br. J. Psychiatry: J. Ment. Sci. 150:Jan (1987), 1–7.
207. Sun, D., Phillips, L., Velakoulis, D., et al. Progressive brain structural changes mapped as psychosis develops in ‘at risk’ individuals. Schizophr. Res. 108:Mar (1–3) (2009), 85–92.
208. Sun, J., Jia, P., Fanous, A.H., et al. Schizophrenia gene networks and pathways and their applications for novel candidate gene selection. PLoS ONE, 5(6), 2010, e11351.
209. Susser, E., Hoek, H.W., Brown, A., Neurodevelopmental disorders after prenatal famine: the story of the Dutch Famine Study. Am. J. Epidemiol. 147:Feb (3) (1998), 213–216.
210. Swaab, D.F., Garcia-Falgueras, A., Sexual differentiation of the human brain in relation to gender identity and sexual orientation. Funct. Neurol. 24:1 (2009), 17–28.
211. Szymanski, S., Lieberman, J.A., Alvir, J.M., et al. Gender differences in onset of illness, treatment response, course, and biologic indexes in first-episode schizophrenic patients. Am. J. Psychiatry 152:5 (1995), 698–703.
212. Takahashi, T., Kawasaki, Y., Kurokawa, K., et al. Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study. Schizophr. Res. 55:May (1–2) (2002), 69–81.
213. Takahashi, T., Suzuki, M., Kawasaki, Y., et al. Perigenual cingulate gyrus volume in patients with schizophrenia: a magnetic resonance imaging study. Biol. Psychiatry 53:Apr (7) (2003), 593–600.
214. Takahashi, T., Suzuki, M., Zhou, S.Y., et al. Lack of normal gender differences of the perigenual cingulate gyrus in schizophrenia spectrum disorders. A magnetic resonance imaging study. Eur. Arch. Psychiatry Clin. Neurosci. 254:Oct (5) (2004), 273–280.
215. Takayanagi, Y., Takahashi, T., Orikabe, L., et al. Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness. PLoS ONE, 6(6), 2011, e21047.
216. Takei, N., Sham, P., O'Callaghan, E., Murray, G.K., Glover, G., Murray, R.M., Prenatal exposure to influenza and the development of schizophrenia: is the effect confined to females?. Am. J. Psychiatry 151:1 (1994), 117–119.
217. Tamminga, C.A., Gender and schizophrenia. J. Clin. Psychiatry 58:Suppl. 15 (1997), 33–37.
218. Tandon, R., Keshavan, M.S., Nasrallah, H.A., Schizophrenia, “Just the Facts”: what we know in 2008. Part 1: Overview. Schizophr. Res. 100:1–3 (2008), 4–19.
219. Tandon, R., Nasrallah, H.A., Keshavan, M.S., Schizophrenia, “just the facts” 4. Clinical features and conceptualization. Schizophr. Res. 110:May (1–3) (2009), 1–23.
220. Thompson, P.M., Giedd, J.N., Woods, R.P., MacDonald, D., Evans, A.C., Toga, A.W., Growth patterns in the developing brain detected by using continuum mechanical tensor maps. Nature 404:Mar (6774) (2000), 190–193.
221. Torniainen, M., Suvisaari, J., Partonen, T., et al. Sex differences in cognition among persons with schizophrenia and healthy first-degree relatives. Psychiatry Res. 188:Jun (1) (2011), 7–12.
222. van der Werf, M., Hanssen, M., Kohler, S., Verkaaik, M., Verhey, F.R., van Winkel, R., van Os, J., Allardyce, J., Systematic review and collaborative recalculation of 133,693 incident cases of schizophrenia. Psychol. Med. 44:1 (2014), 9–16.
223. van Rijn, S., Aleman, A., Swaab, H., Kahn, R., Klinefelter's syndrome (karyotype 47, XXY) and schizophrenia-spectrum pathology. Br. J. Psychiatry: J. Ment. Sci. 189:Nov (2006), 459–460.
224. Vaskinn, A., Sundet, K., Simonsen, C., Hellvin, T., Melle, I., Andreassen, O.A., Sex differences in neuropsychological performance and social functioning in schizophrenia and bipolar disorder. Neuropsychology 25:Jul (4) (2011), 499–510.
225. Vazquez-Barquero, J.L., Cuesta Nunez, M.J., Quintana Pando, F., de la Varga, M., Herrera Castanedo, S., Dunn, G., Structural abnormalities of the brain in schizophrenia: sex differences in the Cantabria First Episode of Schizophrenia Study. Psychol. Med. 25:Nov (6) (1995), 1247–1257.
226. Venkatasubramanian, G., Arasappa, R., Rao, N.P., Gangadhar, B.N., Digit ratio (2D:4D) asymmetry and Schneiderian first rank symptoms: implications for cerebral lateralisation theories of schizophrenia. Laterality 16:Jul (4) (2011), 499–512.
227. Vogeley, K., Schneider-Axmann, T., Pfeiffer, U., Tepest, R., Bayer, T.A., Bogerts, B., Honer, W.G., Falkai, P., Disturbed gyrification of the prefrontal region in male schizophrenic patients: a morphometric postmortem study. Am. J. Psychiatry 157:1 (2000), 34–39.
228. Voronkov, B.V., Relationship between sex and the clinical picture of schizophrenia in adolescents. Zhurnal nevropatologii i psikhiatrii imeni SS Korsakova 78:10 (1978), 1528–1531.
229. Walder, D.J., Andersson, T.L., McMillan, A.L., Breedlove, S.M., Walker, E.F., Sex differences in digit ratio (2D:4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor. Schizophr. Res. 86:Sep (1–3) (2006), 118–122.
230. Walker, E.F., Diforio, D., Schizophrenia: a neural diathesis–stress model. Psychol. Rev. 104:Oct (4) (1997), 667–685.
231. Walker, E.F., Brennan, P.A., Esterberg, M., Brasfield, J., Pearce, B., Compton, M.T., Longitudinal changes in cortisol secretion and conversion to psychosis in at-risk youth. J. Abnormal Psychol. 119:May (2) (2010), 401–408.
232. Weinberger, D.R., From neuropathology to neurodevelopment. Lancet 346:Aug (8974) (1995), 552–557.
233. Weis, S., Hausmann, M., Stoffers, B., Vohn, R., Kellermann, T., Sturm, W., Estradiol modulates functional brain organization during the menstrual cycle: an analysis of interhemispheric inhibition. J. Neurosci. 28:Dec (50) (2008), 13401–13410.
234. Weiss, E., Siedentopf, C.M., Hofer, A., et al. Sex differences in brain activation pattern during a visuospatial cognitive task: a functional magnetic resonance imaging study in healthy volunteers. Neurosci. Lett. 344:Jul (3) (2003), 169–172.
235. Wieselgren, I.M., Lindstrom, L.H., A prospective 1–5 year outcome study in first-admitted and readmitted schizophrenic patients; relationship to heredity, premorbid adjustment, duration of disease and education level at index admission and neuroleptic treatment. Acta Psychiatr. Scand. 93:1 (1996), 9–19.
236. Wood, J.L., Heitmiller, D., Andreasen, N.C., Nopoulos, P., Morphology of the ventral frontal cortex: relationship to femininity and social cognition. Cereb. Cortex 18:3 (2008), 534–540.
237. Xiu, D., Geiger, M.J., Klaver, P., Emotional face expression modulates occipital–frontal effective connectivity during memory formation in a bottom-up fashion. Front. Behav. Neurosci., 9, 2015, 90.
238. Yotsutsuji, T., Saitoh, O., Suzuki, M., et al. Quantification of lateral ventricular subdivisions in schizophrenia by high-resolution three-dimensional magnetic resonance imaging. Psychiatry Res. 122:1 (2003), 1–12.
239. Zanelli, J., Morgan, K., Dazzan, P., et al. Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. PLoS ONE, 8(10), 2013, e77318.
240. Zhu, Y.K., Li, C.B., Jin, J., Wang, J.J., Lachmann, B., Sariyska, R., Montag, C., The 2D:4D ratio of the hand and schizotypal personality traits in schizophrenia patients and healthy control persons. Asian J. Psychiatr. 9:Jun (2014), 67–72.