Causes and consequences of the gender difference in age at onset of schizophrenia

Schizophrenia Bulletin

Volumn 24, Issue 1, 1998, Pages 99-113

  Häfner, Heinz ^a   An Der Heiden, Wolfram ^a   Behrens, Stephan ^d   Gattaz, Wagner F ^e   Hambrecht, Martin ^c   Löffler, Walter ^a   Maurer, Kurt ^a   Munk Jørgensen, Povl ^b   Nowotny, Birgit ^a   Riecher Rössler, Anita ^a   Stein, Astrid ^a  

^a CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e University of Heidelberg ^*

Author keywords

Age at onset; Early course; Gender differences

Indexed keywords

ESTRADIOL; ESTROGEN;

AGE DISTRIBUTION; DISEASE COURSE; GENDER; HOSPITAL ADMISSION; HUMAN; ILLNESS BEHAVIOR; ONSET AGE; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SEX DIFFERENCE; SOCIAL BEHAVIOR; WORLD HEALTH ORGANIZATION;

EID: 0344109573     PISSN: 05867614     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.schbul.a033317     Document Type: Review

References (65)

1. Albus, M., and Maier, W. Lack of gender differences in age at onset in familial schizophrenia. Schizophrenia Research, 18:51-57, 1995.
2. Andreasen, N.C. The Scale for the Assessment of Negative Symptoms (SANS): Conceptual and theoretical foundations. British Journal of Psychiatry, 155:49-52, 1989.
3. Angermeyer, M.C., and Kühn, L. Gender differences in age at onset of schizophrenia. European Archives of Psychiatry and Neurological Sciences, 237:351-364, 1988.
4. Asamow, R.F., and Asarnow, J.R. Childhood-onset schizophrenia: Editors' introduction. Schizophrenia Bulletin, 20(4):591-598, 1995.
5. Biehl, H.; Maurer, K.; Jablensky, A.; Cooper, J.E.; and Tomov, T. The WHO Psychological Impairments Rating Schedule (WHO/PIRS): I. Introducing a new instrument for rating observed behaviour and the rationale of the psy- chological impairment concept. British Journal of Psychiatry, 155:68-70, 1989.
6. Biehl, H.; Maurer, K.; Schubart, C.; Krumm, B.; and Jung, E. Prediction of outcome and utilization of medical services in a prospective study of first onset schizophrenics - Results of a prospective 5-year follow-up study. European Archives of Psychiatry and Neurological Sciences, 236:139-147, 1986.
7. Castle, D.J.; Abel, K.; Takei, N.; and Murray, R.M. Gender differences in schizophrenia: Hormonal effect or subtypes? Schizophrenia Bulletin, 21(1):1-12, 1995.
8. Castle, D.J., and Murray, R.M. The epidemiology of lateonset schizophrenia. Schizophrenia Bulletin, 19(4):691-700, 1993.
9. Cutting, J., and Dunne, F. Subjective experience of schizophrenia. Schizophrenia Bulletin, 15(2):217-231, 1989.
10. DeLisi, L.E.; Bass, N.; Boccio, A.; Shields, G.; Morganti, C.; and Vita, A. Age of onset in familial schizophrenia. Archives of General Psychiatry, 51:334-335, 1994.
11. DiPaolo, T., and Falardeau, P. Modulation of brain and pituitary dopamine receptors by estrogens and prolactin. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 9:473-480, 1985.
12. Dohrenwend, B.P.; Levav, I.; Shrout, P.E.; Schwartz, S.; Naveh, G.; Link, B.G.; Skodol, A.E.; and Stueve, A. Socioeconomic status and psychiatric disorders: The causation-selection issue. Science, 255:946-952, 1992.
13. Endicott, J., and Spitzer, R.L. A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry, 35:837-844, 1978.
14. Fields, J.Z., and Gordon, J.H. Estrogen inhibits the dopaminergic supersensitivity induced by neuroleptics. Life Sciences, 30:229-234, 1982.
15. Galdos, P., and van Os, J. Gender, psychopathology, and development: From puberty to early adulthood. Schizophrenia Research, 14:105-112, 1995.
16. Gattaz, W.F.; Behrens, S.; De Vry, J.; and Häfner, H. Östradiol hemmt Dopamin-vermittelte Verhaltensweisen bei Ratten - ein Tiermodell zur Untersuchung der geschlechtsspezifischen Unterschiede bei der Schizophrenie. Fortschritte der Neurologie Psychiatrie, 60:8-16, 1992.
17. Häfner, H.; Behrens, S.; De Vry, J.; and Gattaz, W.F. An animal model for the effects of estradiol on dopamine-mediated behavior: Implications for sex differences in schizophrenia. Psychiatry Research, 38:125-134, 1991a.
18. Häfner, H.; Behrens, S.; De Vry, J.; Gattaz, W.F.; Löffler, W.; Maurer, K.; and Riecher-Rössler, A. Warum erkranken Frauen später an Schizophrenie? Nervenheilkunde, 10:154-163, 1991b.
19. Häfner, H.; Hambrecht, M.; Löffler, W.; Munk-Jørgensen, R; and Riecher-Rössler, A. Is schizophrenia a disorder of all ages? A comparison of first episodes and early course over the life-cycle. Psychological Medicine, in press.
20. Häfner, H.; Maurer, K.; Löffler, W.; Bustamante, S.; an der Heiden, W.; Riecher-Rössler, A.; and Nowotny, B. Onset and early course of schizophrenia. In: Häfner, H., and Gattaz, W.F., eds. Search for the Causes of Schizophrenia. Vol. III. Berlin, Germany: Springer-Verlag, 1995a. pp. 43-66.
21. Häfner, H.; Maurer, K.; Löffler, W.; and Riecher-Rössler, A. The influence of age and sex on the onset and early course of schizophrenia. British Journal of Psychiatry, 162:80-86, 1993a.
22. Häfner, H., and Nowotny, B. Epidemiology of early-onset schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 245:80-92, 1995.
23. Häfner, H.; Nowotny, B.; Löffler, W.; an der Heiden, W.; and Maurer, K. When and how does schizophrenia produce social deficits? European Archives of Psychiatry and Clinical Neuroscience, 246:17-28, 1995b.
24. Häfner, H.; Riecher, A.; Maurer, K.; Fätkenheuer, B.; Löffler, W.; an der Heiden, W.; Munk-Jørgensen, P.; and Strömgren, E. Geschlechts-unterschiede bei schizophrenen Erkrankungen. Fortschritte der Neurologie Psychiatrie, 59:343-396, 1991c.
25. Häfner, H.; Riecher, A.; Maurer, K.; Löffler, W.; and Munk-Jørgensen, P. How does gender influence age at first hospitalization for schizophrenia? A transnational case register study. Psychological Medicine, 19:903-918, 1989.
26. Häfner, H.; Riecher-Rössler, A.; an der Heiden, W.; Maurer, K.; Fätkenheuer, B.; and Löffler, W. Generating and testing a causal explanation of the gender difference in age at first onset of schizophrenia. Psychological Medicine, 23:925-940, 1993b.
27. Häfner, H.; Riecher-Rössler, A.; Hambrecht, M.; Maurer, K.; Meissner, S.; Schmidtke, A.; Fätkenheuer, B.; Löffler, W.; and an der Heiden, W. IRAOS: An instrument for the assessment of onset and early course of schizophrenia. Schizophrenia Research, 6:209-223, 1992.
28. Hambrecht, M.; Maurer, K.; Sartorius, N.; and Häfner, H. Transnational stability of gender differences in schizophrenia? An analysis based on the WHO Study on Determinants of Outcome of Severe Mental Disorders. European Archives of Psychiatry and Clinical Neuroscience, 242:6-12, 1992.
29. Hambrecht, M.; Riecher-Rössler, A.; Fätkenheuer, B.; Louza, M.R.; and Häfner, H. Higher morbidity risk for schizophrenia in males: Fact or fiction? Comparative Psychiatry. 35:39-49, 1994.
30. Hamilton, M. Hamilton Depression Scale. In: Guy, W., ed. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: National Institute of Mental Health, DHEW Publication No. (ADM)76-338, 1976. pp. 179-192.
31. Harris, M.J., and Jeste, D.V. Late-onset schizophrenia: An overview. Schizophrenia Bulletin, 14(1):39-55, 1988.
32. Honigfeld, G.; Gillis, R.; and Klett, C.J. NOSIE: Nurses' Observation Scale for Inpatient Evaluation. In: Guy, W., ed. ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: National Institute of Mental Health, DHEW Publication No. (ADM)76-338, 1976. pp. 265-273.
33. Hruska, R.E. Elevation of striatal dopamine receptors by estrogen: Dose and time studies. Journal of Neurochemistry, 47:1908-1915, 1986.
34. Jablensky, A.; Sartorius, N.; Ernberg, G.; Anker, M.; Korten, A.; Cooper, J.E.; Day, R.; and Bertelsen, A. Schizophrenia: Manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychological Medicine Monograph Supplement, 20:1-97, 1992.
35. Javitt, D.C., and Zukin, S.R. Recent advancement in the phencyclidine model of schizophrenia. American Journal of Psychiatry, 148:1301-1308, 1991.
36. Jenkins, C.D.; Hurst, M.W.; and Rose, R.M. Life changes: Do people really remember? Archives of General Psychiatry, 36:379-384, 1979.
37. Jenkins, G.M., and Watts, D.G. Spectral Analysis and Its Applications. Oakland, CA: Holden Day, 1968.
38. Jung, E.; Krumm, B.; Biehl, H.; Maurer, K.; and BauerSchubart, C. DAS - Mannheimer Skala zur Einschätzung sozialer Behinderung. Weinheim, Germany: Beltz, 1989.
39. Klosterkötter, J. Entwicklung der schizophrenen Symptome ersten Ranges. Fundamenta Psychiatrica, 6:81-93, 1992.
40. Kraepelin, E. Psychiatrie, 8th ed., Vol. 1-4. Leipzig, Germany: Barth, 1909-1915.
41. Lewine, R.R.J. Gender and schizophrenia. In: Nasrallah, H.A., ed. Handbook of Schizophrenia. Vol. 3. Amsterdam, The Netherlands: Eisevier Science Publishers, 1988. pp. 389-397.
42. Loebel, A.D.; Lieberman, J.A.; Alvir, J.M.J.; Mayerhoff, D.I.; Geister, S.H.; and Szymanski, S.R. Duration of psychosis and outcome in first-episode schizophrenia. American Journal of Psychiatry, 149:1183-1188, 1992.
43. Loranger, A.W. Sex differences in age of onset of schizophrenia. Archives of General Psychiatry, 41:157-161, 1984.
44. Maurer, K., and Häfner, H. Methodological aspects of onset assessment in schizophrenia. Schizophrenia Research, 15:265-276, 1995.
45. McGuffin, P.; Katz, R.; and Aldrich, J. Past and Present State Examination: The assessment of "lifetime ever" psychopathology. Psychological Medicine, 16:461-465, 1986.
46. Mendelson, W.B.; Gillin, J.C.; and Wyatt, R.J. Sexual physiology and schizophrenia. Acta Scientifica Venezolana, 28:417-425, 1977.
47. Monroe, S.M. Assessment of life events - Retrospective vs. concurrent strategies. Archives of General Psychiatry, 39:606-610, 1982.
48. Overall, J.E., and Gorham, D.R. The Brief Psychiatric Rating Scale. Psychological Reports, 10:799-812, 1962.
49. Riecher-Rössler, A.; Häfner, H.; Dütsch-Strobel, A.; Oster, M.; Stumbanm, M.; van Gülick-Bailer, M.; and Löffler, W. Further evidence for a specific role of estradiol in schizophrenia? Biological Psychiatry, 36:492-495, 1994a.
50. Riecher-Rössler, A.; Häfner, H.; Stumbaum, M.; Maurer, K.; and Schmidt, R. Can estradiol modulate schizophrenic symptomatology? Schizophrenia Bulletin, 20(2):203-214, 1994b.
51. Salokangas, R.K.R.; Stengard, E.; Räkköläinen, V.; and Kaljonen, I.H.A. New schizophrenic patients and their families. (English summary) In: Reports of Psychiatria Fennica, No. 78. Helsinki, Finland: Foundation for Psychiatric Research in Finland, 1987. pp. 119-216.
52. Schneider, K. Klinische Psychopathologie. 3rd ed. Stuttgart, Germany: Thieme-Verlag, 1950.
53. Seeman, M. Interaction of sex, age and neuroleptic dose. Comprehensive Psychiatry, 24:125-128, 1983.
54. Seeman, M.V., and Lang, M. The role of estrogens in schizophrenia gender differences. Schizophrenia Bulletin, 16(2):185-194, 1990.
55. Shepherd, M.; Watt, D.; Falloon, I.; and Smeeton, N. The natural history of schizophrenia: A five-year follow-up study of outcome and prediction in a representative sample of schizophrenics. London, England: Cambridge University Press, 1989.
56. Sumner, B.E.H., and Fink, G. Oestradiol-17β in its positive feedback mode significantly increases 5-HT2a recep- tor density in the frontal, cingulate and piriform cortex of the female rat. Journal of Physiology, 483:52, 1995.
57. Tsuang, M.T., and Fleming, J.A. Long-term outcome of schizophrenia and other psychoses. In: Hafner, H.; Gattaz, W.F.; and Janzarik, W., eds. Search for the Causes of Schizophrenia. Berlin, Germany: Springer-Verlag, 1987. pp. 88-97.
58. von Zerssen, D., and Koeller, D.M. Klinische Selbstbeurteilungs-Skalen (KSb-Si) aus dem Münchener Psychiatrischen Informations-System (PSYCHIS München). Manuale: (a) Allgemeiner Teil, (b) Paranoid-Depressivitäts-Skala, (c) Befindlichkeits-Skala, (d) Beschwerden-Liste. Weinheim, Germany: Beltz, 1976.
59. Wing, J.K. Epidemiological research using psychiatric case registers. In: ten Horn, G.H.M.M.; Giel, R.; Gulbinat, W.H.; and Henderson, J.H., eds. Psychiatric Case Registers in Public Health: A Worldwide Inventory 1960-1985. Amsterdam, The Netherlands: Elsevier Science Publishers, 1986. pp. 14-25.
60. Wing, J.K.; Cooper, J.E.; and Sartorius, N. Measurement and Classification of Psychiatric Symptoms: An Instruction Manual for the PSE and CATEGO Program. London, England: Cambridge University Press, 1974.
61. Wittchen, H.-U.; Burke, J.D.J.; Semler, G.; Pfister, H.; von Cranach, M.; and Zaudig, M. Recall and dating of psychiatric symptoms - Test-retest reliability of time-related symptom questions in a standardized psychiatric interview (CIDI/DIS). Archives of General Psychiatry, 46:437-443, 1989.
62. Woolley, C.S., and McEwen, B.S. Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism. Journal of Neuroscience, 14:7680-7687, 1994.
63. World Health Organization. Glossary of Mental Disorders and Guide to Their Classification for Use in Conjunction With the International Classification of Diseases. 8th rev. Geneva, Switzerland: The Organization, 1967.
64. World Health Organization. Mental Disorders: Glossary and Guide to Their Classification in Accordance With the Ninth Revision of the International Classification of Diseases. Geneva, Switzerland: The Organization, 1978.
65. World Health Organization. Psychiatric Disability Assessment Schedule (WHO/DAS). Geneva, Switzerland: The Organization, 1988.