Schizophrenia: A Neural Diathesis-Stress Model

Psychological Review

Volumn 104, Issue 4, 1997, Pages 667-685

  Walker, Elaine F ^a   Diforio, Donald ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MODEL; DISEASE PREDISPOSITION; FEMALE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MALE; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT; REVIEW; SCHIZOPHRENIA; STRESS;

DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MODELS, BIOLOGICAL; PITUITARY-ADRENAL SYSTEM; SCHIZOPHRENIA; STRESS;

EID: 0031255540     PISSN: 0033295X     EISSN: None     Source Type: Journal    
DOI: 10.1037/0033-295X.104.4.667     Document Type: Article

References (202)

1. Akiyama, K., Kanzaki, A., Tsuchida, K., & Ujike, H. (1994). Methamphetamine-induced behavioral sensitization and its implications for relapse of schizophrenia. Schizophrenia Research, 12, 251-257.
2. Aleem, A., Kulkarni, A., & Yeragani, V. K. (1988). Dexamethasone suppression test, schizophrenia and movement disorder. Acta Psychiatrica Scandinavica, 78, 689-694.
3. Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990). Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Progress in Brain Research, 85, 119-145.
4. Altamura, C., Guercetti, G., & Percudani, M. (1989). Dexamethasone suppression test in positive and negative schizophrenia. Psychiatry Research, 30, 69-75.
5. Altmann, L., Gutowski, M., & Wiegand, H. (1994). Effects of maternal lead exposure on functional plasticity in the visual cortex and hippocampus of immature rats. Developmental Brain Research, 81, 50-56.
6. Antelman, S. M., & Chiodo, L. A. (1984). Stress: Its effects on interactions among biogenic amines and role in the induction and treatment of disease. In L. L. Iverson & S. H. Snyder (Eds.), Handbook of psychopharmacology (pp. 279-334). New York: Plenum Press.
7. Baron, R., & Kenny, D. (1986). The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. Journal of Personality and Social Psychology, 6, 1173-1182.
8. Barrelet, L., Ferrero, F., Szigethy, L., Giddey, C., & Pellizzer, G. (1990). Expressed emotion and first-admission schizophrenia: Nine-month follow up in a French cultural environment. British Journal of Psychiatry, 156, 357-362.
9. Bell, I. R., Martino, G. M., Meredith, K. E., Schwartz, G. E., Siani, M. M., & Morrow, F. D. (1993). Vascular disease risk factors, urinary free cortisol, and health histories in older adults: Shyness and gender interactions. Biological Psychology, 35, 37-49.
10. Benes, F. M. (1994). Developmental changes in stress adaptation in relation to psychopathology. Development and Psychopathology, 6, 723-739.
11. Besedorsky, H. (1989). Mechanism of virus-induced stimulation of the hypothalamic-pituitary-adrenal axis. Journal of Steroid Biochemistry, 34, 235-239.
12. Birley, J., & Brown, G. W. (1970). Crisis and life changes preceding the onset or relapse of acute schizophrenia: Clinical aspects. British Journal of Psychiatry, 16, 327-333.
13. Biron, D., Dauphin, C., & DiPaolo, T. (1992). Effects of adrenalectomy and glucocorticoids on rat brain dopamine receptors. Neuroendocrinology, 55, 468-476.
14. Bogerts, B. (1989). Limbic and paralimbic pathology in schizophrenia: Interaction with age and stress related factors. In S. C. Schultz & C. A. Tamminga (Eds.), Schizophrenia: Scientific Progress (pp. 216-227). Oxford, United Kingdom: Oxford University Press.
15. Bogerts, B., & Falkai, P. (1995). Postmortem brain abnormalities in schizophrenia. In C. L. Shriqui & H. A. Nasrallah (Eds.), Contemporary Issues in the Treatment of Schizophrenia (pp. 43-59). Washington, DC: American Psychiatric Press.
16. Bogerts, B., Meertz, E., & Schonfeldt-Bausch, R. (1985). Basal ganglia and limbic system pathology in schizophrenia. Archives of General Psychiatry, 42, 784-791.
17. Bracha, H. S., Torrey, E. F., Bigelow, L. B., Lohr, J. B., & Linington, B. B. (1991). Subtle signs of prenatal maldevelopment of the hand ectoderm in schizophrenia: A preliminary monozygotic twin study. Biological Psychiatry, 30, 719-725.
18. Breier, A., & Buchanan, R. W. (1992). The effects of metabolic stress on plasma progesterone in healthy volunteers and schizophrenic patients. Life Sciences, 51, 1527-1534.
19. Breier, A., Buchanan, R. W., Elkashef, A., Munson, R. C., Kirkpatrick, B., & Gellad, F. (1992). Brain morphology and schizophrenia: A magnetic resonance imaging study of limbic, prefrontal cortex, and caudate structures. Archives of General Psychiatry, 49, 921-926.
20. Breier, A., Davis, O. R., Buchanan, R. W., Moricle, L. A., & Munson, R. C. (1993). Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia: Relationship to prefrontal cortex volume. Archives of General Psychiatry, 50, 541-550.
21. Breier, A., Kirkpatrick, B., & Buchanan, R. W. (1993). Clozapine attenuates meta-chlorophenylpiperazine (m CPP)-induced plasma cortisol increases in schizophrenia. Biological Psychiatry, 34, 492-494.
22. Breier, A., Wolkowitz, O. M., Doran, A. R., Bellar, S., & Pickar, D. (1988). Neurobiological effects of lumbar puncture stress in psychiatric patients and healthy volunteers. Psychiatry Research, 25, 187-194.
23. Breier, A., Wolkowitz, O. M., & Pickar, D. (1991). Stress and schizophrenia. In C. A. Tamminga & S. C. Schulz (Eds.), Advances in Neuropsychiatry and Psychopharmacology: Volume 1. Schizophrenia Research (pp. 141-152). New York: Raven Press.
24. Brixey, S. N., Gallagher, B. J., McFalls, J. A., & Parmelee, L. F. (1993). Gestational and neonatal factors in the etiology of schizophrenia. Journal of Clinical Psychology, 49, 447-456.
25. Brooks, A. N., & Challis, J. R. (1992). Adrenocorticotrophin responses to hypoxaemia in fetal sheep are sustained in the presence of naloxone. Journal of Developmental Physiology, 17, 221-225.
26. Brophy, M. H., Rush, A. J., & Crowley, G. (1983). Cortisol, estradiol, and androgens in accutely ill paranoid schizophrenics. Biological Psychiatry, 18, 583-590.
27. Butler, P. D., Susser, E. S., Brown, A. S., Kaufmann, C. A., & Gorman, J. M. (1994). Prenatal nutritional deprivation as a risk factor in schizophrenia: Preclinical evidence. Neuropsychopharmacology, 11, 227-235.
28. Cabib, S., & Puglisi-Allegra, S. (1991). Genotype-dependent effects of chronic stress on apomorphine-induced alterations of striatal and mesolimbic dopamine metabolism. Brain Research, 542, 91-96.
29. Cador, M., Cole, B. J., Koob, G. F., & Stinus, L. (1993). Central administration of corticotropin releasing factor induces long-term sensitization to D-amphetamine. Brain Research, 606, 181-186.
30. Cantor-Graae, E., McNeil, T. F., Sjostrom, K., Nordstrom, L. G., & Rosenlund, T. (1995). Obstetric complications and their relationship to other etiological risk factors in schizophrenia: A case-control study. Journal of Nervous and Mental Disease, 182, 645-650.
31. Casolini, P., Kabbaj, M., Leprat, F., Piazza, P. V., Rouge-Pont, F., Angelucci, L., Simon, H., Le Moal, M., & Maccari, S. (1993). Basal and stress-induced corticosterone secretion is decreased by lesion of mesenchephalic dopaminergic neurons. Brain Research, 622, 311-314.
32. Chrousos, G. P., & Gold, P. W. (1992). The concepts of stress and stress system disorders: Overview of physical and behavioral homeostasis. Journal of the American Medical Association, 267, 1244-1252.
33. Cohen, J. (1988). Statistical power analyses for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum.
34. Copolov, D. L., Rubin, R. T., Stuart, G. W., Poland, R. E., Mander, A. J., Sashidharan, S. P., Whitehouse, A. M., Blackburn, I. M., Freeman, C. P., & Blackwood, D. H. R. (1989). Specificity of the salivary cortisol dexamethasone suppression test across psychiatric diagnoses. Biological Psychiatry, 25, 879-893.
35. Csernansky, J. G., Murphy, G. M., & Faustman, W. O. (1991). Limbic/ mesolimbic connections and the pathogenesis of schizophrenia. Society of Biological Psychiatry, 30, 383-400.
36. Cullinan, W. E., Herman, J. P., Helmreich, D. L., & Watson, S. J., Jr. (1995). A neuroanatomy of stress. In M. J. Friedman, D. S. Charney, & A. Y. Deutch (Eds.), Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD (pp. 3-25). Philadelphia: Lippincott.
37. Dabbs, J. M., & Hopper, C. H. (1990). Cortisol, arousal, and personality in two groups of normal men. Personality and Individual Differences, 11, 931-935.
38. Dahl, R. E., Kaufman, J., Ryan, N. D., Perel, J. M., Al-Shabbout, M., Birmaher, B., Nelson, B., & Puig-Antich, J. (1992). The dexamethasone suppression test in children and adolescents: A review and a controlled study. Biological Psychiatry, 32, 109-126.
39. Dallman, M. F., Akana, S. F., Levin, N., Walker, C. D., Bradbury, M. J., Suemaru, S., & Scribner, K. S. (1994). Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis. In R. de Kloet, E. C. Azmitia, & P. W. Landfield (Eds.), Annals of the New York Academy of Sciences: Vol. 746. Brain corticosteroid receptors (pp. 22-31). New York: New York Academy of Sciences.
40. Davis, K. L., Khan, R. S., Ko, G., & Davidson, M. (1991). Dopamine in schizophrenia: A review and reconceptualization. American Journal of Psychiatry, 148, 1474-1486.
41. Davis, M., & Emory E. (1995). Sex differences in neonatal stress responsivity. Child Development, 66, 14-27.
42. Deroche, V., Marinelli, M., Piazza, P. V., Maccari, S., Kharouby, M., Le Moal, M., & Simon, H. (1993). Corticosterone and sensitivity to drugs of abuse: Modulation of psychomotor effects. Society for Neuroscience Abstracts, 19, 1860.
43. Deroche, V., Piazza, P. V., Maccari, S., LeMoal, M., & Simon, H. (1992). Repeated corticosterone administration sensitizes the locomotor response to amphetamine. Brain Research, 584, 309-313.
44. Eyler-Zorrilla, L. T., & Cannon, T. D. (1995). Structural brain abnormalities in schizophrenia: Distribution, etiology, and implications. In S. A. Mednick & J. M. Hollister (Eds.), Neural Development and Schizophrenia (pp. 57-69). New York: Plenum Press.
45. Fameli, M., Kitraki, E., & Stylianopoulou, F. (1994). Effects of hyperactivity of the maternal hypothalamic-pituitary-adrenal (HPA) axis during pregnancy on the development of the HPA axis and brain monoamines of the offspring. International Journal of Developmental Neuroscience, 12, 651-659.
46. Fontana, D., Post, R. M., Weiss, S. R. B., & Pert, A. (1993). The role of D1 and D2 dopamine receptors in the acquisition and expression of cocaine-induced conditioned increase in locomotor behavior. Behavioral Pharmacology, 4, 375-387.
47. Forman, S. D., Bissette, G., Yao, J., Nemeroff, C. B., & van Kammen, D. P. (1994). Cerebrospinal fluid corticotropin-releasing factor increases following haloperidol withdrawal in chronic schizophrenia. Schizophrenia Research, 12, 43-51.
48. Fossom, L. H., Sterling, C. R., & Tank, A. W. (1992). Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid. Molecular Pharmacology, 42, 898-908.
49. Fowles, D. C. (1992). Schizophrenia: Diathesis-stress revisited. Annual Review of Psychology, 43, 303-336.
50. Frankenhaeuser, M., Rauste-vonWright, M., Collins, A., von Wright, J., Sedvall, G., & Swahn, C. (1978). Sex differences in psychoneuroendocrine response to examination stress. Psychosomatic Medicine, 40, 334-343.
51. Franzen, G. (1971). Serum cortisol in chronic schizophrenia: Changes in the diurnal rhythm and psychiatric mental status on withdrawal of drugs. Psychiatria Clinica, 4, 237-246.
52. Friedman, M. J., Charney, D. S., & Deutch, A. Y. (Eds.). (1995). Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder. Philadelphia: Lippincott.
53. Garcia-Ruiz, M., Diaz-Cintra, S., Cintra, L., & Corkidi, G. (1993). Effect of protein malnutrition on CA3 hippocampal pyramidal cells in rats of three ages. Brain Research, 625, 203-212.
54. Gerfen, C. R. (1992). The neostriatal mosaic: Multiple levels of compartmental organization in the basal ganglia. Annual Review of Neuroscience, 15, 285-320.
55. Gil-Ad, A. I., Dickerman, Z., Amdursky, A., & Laron, Z. (1986). Diurnal rhythm of plasma beta endorphin, cortisol and growth hormone in schizophrenia as compared to control subjects. Psychopharmacology, 88, 496-499.
56. Granger, D. A., Stansbury, K., & Henker, B. (1994). Preschoolers' behavioral and neuroendocrine responses to social challenge. Merrill-Palmer Quarterly, 40, 190-211.
57. Granger, D. A., Weisz, J. R., & Kauneckis, D. (1994). Neuroendocrine reactivity, internalizing behavior problems, and control-related cognitions in clinic-referred children and adolescents. Journal of Abnormal Psychology, 103, 259-266.
58. Grossman, R. G. (1993). The relationship between hormonal mediators and systemic hypermetabolism after severe head injury. Journal of Trauma, 34, 806-816.
59. Gunnar, M. R., Hertsgaard, L., Larson, M. C., & Rigatuso, J. (1991). Cortisol and behavioral responses to repeated stressors in the human newborn. Developmental Psychobiology, 24, 487-505.
60. Henry, D. J., & White, F. J. (1991). Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. Journal of Pharmacological and Experimental Therapeutics, 258, 882-890.
61. Henry, S. C., Guegant, G., Cador, M., Arnauld, E., Arsaut, J., Le Moal, M., & Demotes-Mainard, J. (1995). Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens. Brain Research, 685, 179-186.
62. Hermans, R. H., McGivern, R. F., Chen, W., & Longo, L. D. (1993). Altered adult sexual behavior in the male rat following chronic prenatal hypoxia. Neurotoxicology & Teratology, 15, 353-363.
63. Heuser, I., Yassouridis, A., & Holsboer, F. (1994). The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders. Journal of Psychiatric Research, 28, 341-356.
64. Hogarty, G. E., Anderson, C. M., Reiss, D. J., Kornblith, S. J., Greenwald, D. P., Jauna, C. D., & Madonia, M. J. (1986). Family psychoeducation, social skills, and maintenance chemotherapy in the aftercare of schizophrenia. Archives of General Psychiatry, 53, 19-24.
65. Hollister, J. M., Laing, P., & Mednick, S. A. (1996). Rhesus incompatibility as a risk factor for schizophrenia in male adults. Archives of General Psychiatry, 53, 19-24.
66. Horger, B. A., & Roth, R. H. (1995). Stress and central amino acid systems. In M. J. Friedman, D. S. Charney, & A. Y. Deutch (Eds.), Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. Philadelphia: Lippincott.
67. Hubain, P. P., Simonnet, M. P., & Mendlewicz, J. (1986). The dexamethasone suppression test in affective illnesses and schizophrenia: Relationship with psychotic symptoms. Neuropsychobiology, 16, 57-60.
68. Huttunen, M. O. (1989). Maternal stress during pregnancy and the behavior of the offspring. In S. Doxiadis (Ed.), Early influences shaping the individual (pp. 175-182). New York: Plenum Press.
69. Huttunen, M. O., Machon, R. A., & Mednick, S. A. (1994). Prenatal factors in the pathogenesis of schizophrenia. British Journal of Psychiatry, 164, 15-19.
70. Iqbal, N., Asnis, G. M., Wetzler, S., Kahn, R. S., Kay, S. R., & van Pragg, H. M. (1991). The mCPP challenge test in schizophrenia: Hormonal and behavioral responses. Biological Psychiatry, 30, 770-778.
71. Iuvone, P. M., Morasco, J., & Dunn, A. J. (1977). Effect of corticosterone on the synthesis of [3H] catecholamines in the brains of CD-1 mice. Brain Research, 120, 571-576.
72. Jeste, D. V., & Lohr, J. B. (1989). Hippocampal pathologic findings in schizophrenia. Archives of General Psychiatry, 46, 1019-1024.
73. Kalachinik, J. E., Young, R. C., & Offerman, O. (1984). A tardive dyskinesia evaluation and diagnosis form for applied facilities. Psychopharmacology Bulletin, 20, 303-309.
74. Kaneko, M., Yokoyama, F., Hoshino, Y., Takahagi, K., Murata, S., Watanabe, M., & Kumashiro, H. (1992). Hypothalamic-pituitary-adrenal axis function in chronic schizophrenia: Association with clinical features. Neuropsychobiology, 25, 1-7.
75. Kathol, R. G., Gehris, T. L., Carroll, B. T., Samuelson, S. D., Pitts, A. F., Meiler, W. H., & Carter, J. L. (1992). Blunted ACTH response to hypoglycemic stress in depressed patients but not in patients with schizophrenia. Journal of Psychiatry Research, 26, 103-116.
76. Keshavan, M. S., Brar, J., Ganguli, R., & Jarrett, D. B. (1989). DST and schizophrenic symptomatology. Biological Psychiatry, 26, 856-858.
77. Kiess, W., Meidert, A., Dressendorfer, R. A., Schriever, K., Kessler, U., Konig, A., Schwarz, H. D., & Strasburger, C. J. (1995). Salivary cortisol levels throughout childhood and adolescence: Relation with age, pubertal stage and weight. Pediatric Research, 37, 502-506.
78. Kirschbaum, C., Prussner, J. C., Stone, A. A., Federenko, I., Gaab, J., Lintz, D., Schommer, N., & Hellhammer, D. H. (1995). Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men. Psychosomatic Medicine, 57, 468-474.
79. Kirschbaum, C., Wust, S., & Hellhammer, D. (1992). Consistent sex differences in cortisol response to psychological stress. Psychosomatic Medicines, 54, 648-657.
80. Kraus, R., Grof, P., & Brown, G. M. (1988). Drugs and the DST: Need for a reappraisal. American Journal of Psychiatry, 145, 666-674.
81. Krystal, J. H., Karper, L. P., Seibyl, J. P., Freeman, G. K., Delaney, R., Bremner, J. D., Heninger, G. R., Bowers, M. B., & Charney, D. S. (1994). Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Archives of General Psychiatry, 51, 199-214.
82. Kuhs, H., & Folkerts, H. (1995). Suspension therapy in acute schizophrenia. Clinical and neuroendocrine/biochemical effects of abrupt discontinuation of neuroleptic medication. Neuropsychology, 31, 135-145.
83. Lamb, E. J., Noonan, K. A., & Burrin, J. M. (1994). Urine-free cortisol excretion of sex-dependence. Annals of Clinical Biochemistry, 31, 455-458.
84. Larson, M. C., Gunnar, M., & Hertsgaard, L. (1991). The effects of morning naps, car trips, and maternal separation on adrenocortical activity in human infants. Child Development, 62, 362-372.
85. Lerer, B., Ran, A., Blacker, M., Silver, H., Weller, M. P., Drummer, D., Ebstein, B., & Calev, A. (1988). Neuroendocrine responses in chronic schizophrenia: Evidence for serotonergic dysfunction. Schizophrenia Research, 1, 405-410.
86. Levine, S. (1993). Psychosocial factors in the regulation of the stress response during infancy. Biological Psychiatry, 33, 38-39.
87. Lipska, B. K., Jaskiw, G. E., & Weinberger, D. R. (1993). Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia. Neuropsychopharmacology, 9, 67-75.
88. Lipska, B. K., Jaskiw, G. E., & Weinberger, D. R. (1994). The effects of combined prefrontal cortical and hippocampal damage on dopamine-related behaviors in rats. Pharmacology, Biochemistry, & Behavior, 48, 1053-1057.
89. Lucas, P. B., Pickar, D., Kelsoe, J., Rapaport, M., Pato, C., & Hommer, D. (1990). Effects of the acute administration of caffeine in patients with schizophrenia. Biological Psychiatry, 28, 35-40.
90. Lundberg, U., Westermark, O., & Rasch, B. (1987). Type A behavior and physiological stress response in preschool children: Sex differences at the ages of three and four (Tech. Rep. No. 664). Stockholm, Sweden: University of Stockholm, Department of Psychology.
91. Lundberg, U., Westermark, O., & Rasch, B. (1993). Cardiovascular and neuroendocrine activity in preschool children: Comparison between day-care and home levels. Scandinavian Journal of Psychology, 34, 371-378.
92. Maccari, S., Piazza, P. V., Kabbaj, M., Barbazanges, A., Simon, H., & Le Moal, M. (1995). Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. The Journal of Neuroscience, 15, 110-116.
93. McEwen, B. S. (1995). Stressful experience, brain, and emotion: Developmental, genetic and hormonal influences. In M. S. Gazzaniga (Ed.), The Cognitive Neurosciences (pp. 1117-1136). Cambridge, MA: MIT Press.
94. McGauley, G. A., Aldridge, C. R., Fahy, T. A., & Eastment, C. (1989). The dexamethasone suppression test and negative symptoms of schizophrenia. Acta Psychiatrica Scandinavica, 80, 548-553.
95. McGuffin, P., Asherson, P., Owen, M., & Farmer, A. (1994). The strength of the genetic effect: Is there room for an environmental influence in the aetiology of schizophrenia? British Journal of Psychiatry, 164, 593-599.
96. McMurray, R. G., Newbould, E., Bouloux, G. M., Besser, G. M., & Grossman, A. (1991). High-dose naloxone modifies cardiovascular and neuroendocrine function in ambulant subjects. Psychoneuroendocrineology, 16, 447-455.
97. Meaney, M. J., Sapolsky, R. M., & McEwen, B. S. (1985). The development of the glucocorticoid receptor system in the rat limbic brain: I. Ontogeny and autoregulation. Developmental Brain Research, 18, 159-164.
98. Mednick, S. A. (1970). Breakdown in individuals at high risk for schizophrenia: Possible predispositional perinatal factors. Mental Hygiene, 54, 50-63.
99. Mednick, S. A., & Hollister, J. M. (1995). Neural development and schizophrenia: Theory and research. New York: Plenum Press.
100. Mendoza, S. P., Hennessey, M. B., & Lyons, D. M. (1992). Distinct immediate and prolonged effects of separation on plasma cortisol in adult female squirrel monkeys. Psychobiology, 20, 300-306.
101. Mittleman, G., Blaha, C., & Phillips, A. (1992). Pituitary-adrenal and dopaminergic modulation of schedule-induced polydipsia: Behavioral and neurochemical evidence. Behavioral Neuroscience, 106, 408-420.
102. Mokrani, M., Duval, F., Crocq, M. A., Bailey, P. E., & Macher, J. P. (1995). Multihormonal responses to apomorphine in mental illness. Psychoneuroendocrinology, 20, 365-375.
103. Monteleone, P., Maj, M., Fusco, M., Kemali, D., & Reiter, R. J. (1992). Depressed nocturnal plasma melatonin levels in drug free paranoid schizophrenics. Schizophrenia Research, 7, 77-84.
104. Morphy, A. M., Fava, G. A., Carson, S. W., Perini, G. I., Molnar, G., & Jusko, W. J. (1985). The metyrapone test in schizophrenia patients and healthy subjects. Neuropsychobiology, 14, 35-38.
105. Mossman, D., & Somoza, E. (1989). Maximizing diagnostic information from the dexamethasone suppression test. Archives of General Psychiatry, 46, 653-660.
106. Nasrallah, H. A., & Olson, S. C. (1996). Hippocampal and entorhinal hypoplasia in schizophrenia is associated with early onset. Biological Psychiatry, 39, 597.
107. Nerozzi, D., Magnani, A., Sforza, V., Scaramucci, E., Cerilli, M., Moretti, C., Antonozzi, I., & Frajese, G. (1990). Prolactin and growth hormone responses to growth hormone-releasing hormone in acute schizophrenia. Neuropsychobiology, 23, 15-17.
108. Neumann, C. S., Grimes, K., Walker, E. F., & Baum, K. (1995). Developmental pathways to schizophrenia: Behavioral subtypes. Journal of Abnormal Psychology, 104, 558-566.
109. Newcomer, J. W., Faustman, W. O., Whiteford, H. A., Moses, J. A., & Csernansky, J. G. (1991). Symptomatology and cognitive impairment associate independently with post-dexamethasone cortisol concentrations in unmedicated schizophrenic patients. Biological Psychiatry, 29, 855-864.
110. Newell-Morris, L. L., Fahrenbruch, C. E., & Sackett, G. P. (1989). Prenatal psychological stress, dermatoglyphic asymmetry and pregnancy outcome in the pigtailed macaque (macaca nemestina). Biology of the Neonate, 56, 61-75.
111. Norman, R. M., & Malla, A. K. (1993a). Stressful life events and schizophrenia: I. A review of the research. British Journal of Psychiatry, 162, 161-166.
112. Norman, R. M., & Malla, A. K. (1993b). Stressful life events and schizophrenia: II. Conceptual and methodological issues. British Journal of Psychiatry, 162, 166-174.
113. Norman, R. M., & Malla, A. K. (1994). A prospective study of daily stressors and symptomatology in schizophrenic patients. Social Psychiatry and Psychiatric Epidemiology, 29, 244-259.
114. Nuechterlein, K. H., Dawson, M. E., Ventura, J., Gitlin, M., Subotnik, K. L., Snyder, K. S., Mintz, J., & Bartzokis, G. (1994). The vulnerability/stress model of schizophrenic relapse: A longitudinal study. Acta Psychiatrica Scandinavica, 89, 58-64.
115. Nuechterlein, K. H., Snyder, K. S., & Mintz, J. (1992). Paths to relapse: Possible transactional processes connecting patient illness onset, expressed emotion, and psychotic relapse. British Journal of Psychiatry, 161, 88-96.
116. Nyakas, C., Buwalda, B., Kramers, R. J., Traber, J., & Luiten, P. G. (1994). Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: Effects of nitrite-induced prenatal hypoxia and nimodipine treatment. Neuroscience, 59, 541-559.
117. Olney, J. W., & Farber, N. B. (1995). Glutamate receptor dysfunction and schizophrenia. Archives of General Psychiatry, 52, 998-1007.
118. Oritz, J., DeCaprio, J. L., Kosten, T. A., & Nestler, E. J. (1995). Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegemental area. Neuroscience, 67, 383-397.
119. Pearce, B. D., Steffensen, S. C., Paoletti, A. D., Henriksen, S. J., & Buchmeier, M. J. (1996). Persistent dentate granule cell hyperexcitability after neonatal infection with lymphocytic choriomeningitis virus. Journal of Neuroscience, 16, 220-228.
120. Peris, J., Boyson, S. J., Cass, W. A., Curella, P., Dwoskin, L. P., Larson, G., Lin, L. H., Yasuda, R. P., & Zahniser, N. R. (1990). Persistence of neurochemical changes in dopamine systems after repeated cocaine administration. Journal of Pharmacology and Experimental Therapeutics, 253, 38-44.
121. Piazza, P. V., Deminiere, J. M., LeMoal, M., & Simon, H. (1990). Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration. Brain Research, 514, 22-26.
122. Pitman, D. L., Ottenweller, J. E., & Natelson, B. H. (1990). Effect of stressor intensity on habituation and sensitization of glucocorticoid responses in rats. Behavioral Neuroscience, 104, 28-36.
123. Plocka, M., Matkowski, K., Lehmann, W., Kanarkowski, R., & Rybakowski, J. (1992). Dexamethasone suppression test in endogenous depression and schizophrenia in male and female patients. Psychiatrica Polska, 26, 373-380.
124. Plotsky, P. M., & Meaney, M. J. (1993). Early postnatal experience alters hypothalamic cortitropin releasing factor (CRF) mRNA, median eminence CRF content, and stress-induced release in adult rats. Molecular Brain Research, 18, 195-200.
125. Post, R. M., Weiss, S. R. B., & Leverich, G. S. (1994). Recurrent affective disorder: Roots in developmental neurobiology and illness progression based on changes in gene expression. Development & Psychopathology, 6, 781-813.
126. Prince, C. R., & Anisman, H. (1990). Situation specific effects of stressor controllability on plasma corticosterone changes in mice. Pharmacology, Biochemistry & Behavior, 37, 613-621.
127. Ramsay, D. S., & Lewis, M. (1994). Developmental change in infant cortisol and behavioral response to inoculation. Child Development, 65, 1491-1502.
128. Rao, M. L., Strebel, B., Halaris, A., Gross, G., Braunig, P., Huber, G., & Marier, M. (1995). Circadian rhythm of vital signs, norepinephrine, epinephrine, thyroid hormones, and cortisol in schizophrenia. Psychiatry Research, 57, 21-39.
129. Regestein, Q. R., Jackson, W. J., & Peterson, H. F. (1986). Effects of various hippocampal lesions on monkey plasma cortisol levels in two experimental conditions. Behavioral & Neural Biology, 45, 329-341.
130. Risch, S. C., Lewine, R. J., Kalin, N. H., Jewart, R. D., Risby, E. D., Caudle, J. M., Stipetic, M., Turner, J., Eccard, M. B., & Pollard, W. E. (1992). Limbic-hypothalamic-pituitary-adrenal axis activity and ventricular-to-brain ratio studies in affective illness and schizophrenia. Neuropsychopharmocology, 6, 95-100.
131. Rosenthal, D. (1970). Genetic Theory and Abnormal Behavior. New York: McGraw-Hill.
132. Rosenthal, P. A., Doherty, M. B., & Rosenthal, S. (1988). Depressive symptomatology and dexamethasone suppression test in preschoolage children. Hillside Journal of Clinical Psychiatry, 10, 3-15.
133. Rostene, W., Sarrieau, A., Nicot, A., Scarceriaux, V., Betancur, C., Gully, D., Meaney, M., Rowe, W., De Kloet, R., Pelaprat, D., & Berod, A. (1995). Steroid effects on brain functions: An example of the action of glucocorticoids on central dopaminergic and neurotensinergic systems. Journal of Psychiatry and Neuroscience, 20, 349-356.
134. Rothschild, A. J., Langlais, P. J., Schatzberg, A. F., Miller, M. M., Salomon, M. S., Lerbinger, J. E., Cole, J. O., & Bird, E. D. (1985). The effects of a single dose of dexamethasone on monoamine and metabolite levels in rat brain. Life Sciences, 36, 2491.
135. Rothschild, A. J., Langlais, P. J., Schatzberg, A. F., Walsh, F. X., Cole, J. O., & Bird, E. D. (1984). Dexamethasone increases plasma-free dopamine in man. Journal of Psychiatry Research, 18, 217-223.
136. Rothschild, A. J., Schatzberg, A. F., Langlais, P. J., Lerbinger, J. E., Miller, M. M., & Cole, J. O. (1987). Psychotic and nonpsychotic depressions: I. Comparison of plasma catecholimines and cortisol measures. Psychiatry Research, 20, 143-153.
137. Roy, A., Pickar, D., Doran, A., Wolkowitz, O., Gallucci, W., Chrousos, G., & Gold, P. (1986). The corticotropin-releasing hormone stimulation test in chronic schizophrenia. American Journal of Psychiatry, 143, 1393-1397.
138. Rubin, R. T., Poland, R. E., Lesser, I. M., Winston, R. A., & Blodgett, A. L. N. (1987). Neuroendocrine aspects of primary endogenous depression: I. Cortisol secretory dynamics inpatients and matched controls. Archives of General Psychiatry, 44, 328-336.
139. Rybakowski, J., & Linka, M. (1991). Effect of neuroleptic treatment on positive and negative symptoms of schizophrenia and the results of the dexamethasone test. Psychiatria Polska, 25, 1-6.
140. Rybakowski, J., Linka, M., Matkowski, K., & Kanarkowski, R. (1991). Dexamethasone suppression test and the positive and negative symptoms of schizophrenia. Psychiatria Polska, 25, 9-15.
141. Sachar, E. J., Kanter, S. S., Buie, D., Engle, R., & Mehlman, R. (1970). Psychoendocrinology of ego disintegration. American Journal of Psychiatry, 126, 1067-1078.
142. Sapolsky, R. (1992). Stress, The Aging Brain, and the Mechanisms of Neuron Death. Cambridge, MA: MIT Press.
143. Sapolsky, R. M., Armanini, M. P., Packan, D. R., Sutton, W. S., & Plotsky, P. M. (1990). Glucocorticoid feedback inhibition of adrenocorticotropic hormone secretagogue release. Neuroendocrinology, 51, 328-336.
144. Sapolsky, R., Krey, L., & McEwen, B. (1985). Prolonged glucocorticoid exposure reduces hippocampal neural number: Implications for aging. Journal of Neuroscience, 5, 1221-1224.
145. Sapolsky, R., & Plotsky, P. M. (1990). Hypercortisolism and its possible neural bases. Biological Psychiatry, 27, 937-952.
146. Scerbo, A. S., & Kolko, D. J. (1994). Salivary testosterone and cortisol in disruptive children: Relationship to aggressive, hyperactive, and internalizing behaviors. Journal of the American Academy of Child & Adolescent Psychiatry, 33, 1174-1184.
147. Schaeffer, M., & Baum, A. (1984). Adrenal cortical response to stress at Three Mile Island. Psychosomatic Medicine, 46, 227-237.
148. Schatzberg, A. F., Posener, J. A., & Rothschild, A. J. (1995). The role of dopamine in psychotic depression: Symposium. Dopamine receptor subtypes in neurological and psychiatric diseases. Clinical Neuropharmacology, 18, S66-S73.
149. Schatzberg, A. F., & Rothschild, A. J. (1988). The role of glucocorticoid and dopaminergic systems in delusional (psychotic) depression. In P. W. Kalivas & C. B. Nemoroff (Eds.), Annals of the New York Academy of Sciences: Vol. 537. The mesocorticolimbic dopamine system (pp. 462-471). New York: New York Academy of Sciences.
150. Schatzberg, A. F., Rothschild, A. J., Langlais, P. J., Bird, E. D., & Cole, J. O. (1985). A corticosteroid/dopamine hypothesis for psychotic depression and related states. Journal of Psychiatric Research, 19, 57-64.
151. Schatzberg, A. F., Rothschild, A. J., Langlais, P. J., Lerbinger, J. E., Schildkraut, J. J., & Cole, J. O. (1987). Psychotic and nonpsychotic depressions: II. Platelet MAO activity, plasma catecholamines, cortisol, and specific symptoms. Psychiatry Research, 20, 155-164.
152. Schilling, J. C., Adamus, W. S., & Pulluk, R. (1992). Neuroendocrine and side effect profile of pramipexole, a new dopamine receptor agonist, in humans. Clinical Pharmacology & Therapeutics, 51, 541-548.
153. Schneider, M. L. (1992a). The effect of mild stress during pregnancy on birth weight and neuromotor maturation in Rhesus monkey infants (Macaca mulatta). Infant Behavior and Development, 15, 389-403.
154. Schneider, M. L. (1992b). Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants. Developmental Psychobiology, 25, 529-540.
155. Scott, S. M., & Watterberg, K. L. (1995). Effects of gestational age, postnatal age, and illness on plasma cortisol concentrations in premature infants. Pediatric Research, 37, 112-116.
156. Seeman, P., Hong-Chang, G., & Van Tol, H. M. (1993). Dopamine D4 receptors elevated in schizophrenia. Nature, 365, 441-445.
157. Shanks, N., Griffiths, J., & Anisman, H. (1994). Norepinephrine and serotonin alterations following chronic stressor exposure: Mouse strain differences. Pharmacology, Biochemistry, & Behavior, 49, 57-65.
158. Sharma, R. P., Pandey, G. N., Janicak, P. G., Peterson, J., Comaty, J. E., & Davis, J. M. (1988). The effect of diagnosis and age on the DST: A meta-analytic approach. Biological Psychiatry, 24, 555-568.
159. Sora, I., Nishimon, K., & Otsuki, S. (1986). Dexamethasone suppression test and noradrenergic function in affective and schizophrenic disorders. Biological Psychiatry, 21, 621-631.
160. Sorg, B. A., & Kalivas, P. W. (1995). Stress and neuronal sensitization. In M. J. Friedman, D. S. Charney, & A. Y. Deutch (Eds.), Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to PTSD. Philadelphia: Lippincott.
161. Spangler, G., & Grossmann, K. E. (1993). Biobehavioral organization in securely and insecurely attached infants. Child Development, 64, 1439-1450.
162. Stansbury, K., & Gunnar, M. R. (1994). Adrenocortical activity and emotion regulation. Monographs of the Society for Research in Child Development, 59, 108-134.
163. Stanton, M. E., Gutierrez, Y. R., & Levine, S. (1988). Maternal deprivation potentiates pituitary-adrenal stress responses in infant rats. Behavioral Neuroscience, 102, 692-700.
164. Starkman, M. N., Gebarski, S. S., Berent, S., & Schteingart, D. E. (1992). Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome. Biological Psychiatry, 32, 756-765.
165. Stein-Behrens, B., Mattson, M. P., Chang, I., Yeh, M., & Sapolsky, R. (1994). Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus. Journal of Neuroscience, 14, 5373-5380.
166. Suddath, R. L., Christison, G. W., Torrey, E. F., Casanova, M. F., & Weinberger, D. R. (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine, 322, 789-794.
167. Susser, E., Neugebauer, R., Hoek, H. W., Brown, A. S., Lin, S., Labovitz, D., & Gorman, J. M. (1996). Schizophrenia after prenatal famine. Archives of General Psychiatry, 53, 25-31.
168. Swaab, D. F., Raadsheer, F. C., Endert, E., Hofman, M. A., Kamphorst, W., & Ravid, R. (1994). Increased cortisol levels in aging and Alzheimer's disease in postmortem cerebral spinal fluid. Journal of Neuroendocrinology, 6, 681-687.
169. Szuran, T., Zimmerman, E., & Welzl, H. (1994). Water maze performance and hippocampal weight of prenatally stressed rats. Behavioral Brain Research, 65, 153-155.
170. Tandon, R., Mazzara, C., DeQuardo, J., Craig, K. A., Meador-Woodruff, J. H., Goldman, R., & Greden, J. F. (1991). Dexamethasone suppression test in schizophrenia: Relationship to symptomatology, ventricular enlargement, and outcome. Biological Psychiatry, 29, 953-964.
171. Tank, A. W., Ham, L., & Curella, P. (1986). Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: Effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase. Molecular Pharmacology, 30, 486-496.
172. Tarrier, N., Barrowclough, C., Vaughn, C., Bamrah, J. S., Porceddu, K., Watts, S., & Freeman, H. (1988). The community management of schizophrenia: A controlled trial of a behavioural intervention with families to reduce relapse. British Journal of Psychiatry, 153, 532-542.
173. Tennes, K., & Kreye, M. (1985). Children's adrenocortical responses to classroom activities and tests in elementary school. Psychosomatic Medicine, 47, 451-460.
174. Tennes, K., Kreye, M., Avitable, N., & Wells, R. (1986). Behavioral correlates of excreted catecholamines and cortisol in second-grade children. Journal of the American Academy of Child Psychiatry, 25, 764-770.
175. Tienari, P. (1991). Interaction between genetic vulnerability and family environment. Acta Psychiatrica Scandanavica, 84, 460-465.
176. 11C-N-methylspiperone. Psychiatry Research, 49, 219-237.
177. Uno, H., Eisele, S., Sakai, A., & DeJesus, O. (1994). Neurotoxicity of glucocorticoids in the primate brain. Hormones and Behavior, 28, 336-348.
178. Valone, K., Norton, J. P., Goldstein, M. J., & Doane, J. A. (1983). Parental expressed emotion and affective style in an adolescent sample at risk for schizophrenia spectrum disorders. Journal of Abnormal Psychology, 92, 399-407.
179. Van Cauter, E., Linkowski, P., Kerkhofs, M., Hubain, P., L'Hermite-Baleriaux, M., Leclereq, R., Brasseur, M., Copinschi, G., & Mendlewicz, J. (1991). Circadian and sleep-related endocrine rhythms in schizophrenia. Archives of General Psychiatry, 48, 348-356.
180. Vaughn, C. E., Snyder, K., Jones, S., Freeman, W. B., & Falloon, I. R. H. (1984). Family factors in schizophrenic relapse. Archives of General Psychiatry, 41, 1169-1177.
181. Ventura, J., Nuechterlein, K. H., Hardesty, J. P., & Gitlin, M. (1992). Life events and schizophrenic relapse after withdrawal of medication. British Journal of Psychiatry, 161, 615-620.
182. Ventura, J., Nuechterlein, K. H., Lukoff, D., & Hardesty, J. P. (1989). A prospective study of stressful life events and schizophrenic relapse. Journal of Abnormal Psychology, 98, 407-411.
183. Waldo, M. C., Cawthra, E., Adler, L. E., Dubester, S., Staunton, M., Nagamoto, H., Baker, N., Madison, A., Simon, J., Scherzinger, A., Drebing, C., Gerhardt, G., & Freedman, R. (1994). Auditory sensory gaiting, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings. Schizophrenia Research, 12, 93-106.
184. Walker, E. F. (1994). The developmentally moderated expression of the neuropathology underlying schizophrenia. Schizophrenia Bulletin, 20, 453-480.
185. Walker, E. F., Cudeck, R., Mednick, S. A., & Schulsinger, F. (1981). The effects of parental absence and institutionalization on the development of clinical symptoms in high-risk children. Acta Psychiatrica Scandinavica, 63, 95-109.
186. Walker, E. F., Downey, G., & Bergman, A. (1989). The effects of parental psychopathology and maltreatment on child behavior: A test of the diathesis-stress model. Child Development, 60, 15-24.
187. Walker, E. F., Grimes, K. E., Davis, D. M., & Smith, A. J. (1993). Childhood precursors of schizophrenia: Facial expressions of emotion. American Journal of Psychiatry, 150, 1654-1660.
188. Walker, E. F., & Lewine, R. J. (1988). The positive/negative symptom distinction in schizophrenia: Validity and etiological relevance. Schizophrenia Research, 1, 315-328.
189. Walker, E. F., & Lewine, R. J. (1993). The impact of sampling bias on findings in gender research in schizophrenia. Schizophrenia Bulletin, 19, 1-7.
190. Walker, E. F., Neumann, C., Baum, K. M., Davis, D., Diforio, D., & Bergman, A. (1996). Developmental pathways to schizophrenia: Moderating effects of stress. Development and Psychopathology 8, 647-665.
191. Walker, E. F., Savoie, T., & Davis, D. (1994). Neuromotor precursors of schizophrenia. Schizophrenia Bulletin, 20, 453-480.
192. Weinberger, D. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660-669.
193. Weiner, W. J., & Sanchez-Ramos, J. (1992). Movement disorders and dopaminomimetic stimulant drugs. In A. E. Lang, & W. J. Weiner (Eds.), Drug-Induced Movement Disorders. Mount Kisco, NY: Futura.
194. Whalley, L. J., Christie, J. E., Blackwood, D. H. R., Bennie, J., Dick, H., Blackburn, I. M., & Fink, G. (1989). Disturbed endocrine function in the psychoses: I. Disordered homeostasis of disease process? British Journal of Psychiatry, 155, 455-461.
195. Wik, G. (1995). Effects of neuroleptic treatment on cortisol and 3-methoxy-4-hydroxyphenylethyl glycol levels in blood. Journal of Endocrinology, 144, 425-429.
196. Wolkowitz, O. M. (1994). Prospective controlled studies of the behavioral and biological effects of exogenous corticosteroids: Review. Psychoneuroendocrinology, 19, 233-255.
197. Wolkowitz, O. M., Doran, A. R., Breier, A., Cohen, M. R., & Pickar, D. (1986). Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia. Biological Psychiatry, 21, 366-373.
198. Wolkowitz, O. M., Doran, A., Breier, A., Roy, A., & Pickar D. (1989). Specificity of plasma HVA response to dexamethasone in psychotic depression. Psychiatry Research, 29, 177-186.
199. Wong, D. F., Wagner, H. N. Jr., Tune, L. E., Dannals, R. F., Pearlson, G. D., Links, J. M., Tamminga, C. A., Broussolle, E. P., Ravert, H. T., Wilson, A. A., Toung, J. K. T., Malat, J., Williams, J. A., O'Tuama, L. A., Snyder, S. H., Kuhar, M. J., & Gjedde, A. (1986, December 9). Positron emission tomagrophy reveals elevated D2 dopamine receptors in neuroleptic-naive schizophrenics. Science, 234, 1558-1563.
200. Wyatt, R. J. (1995). Antipsychotic medication and the long-term course of schizophrenia. In C. L. Shriqui & H. A. Nasrallah (Eds.), Contemporary Issues in the Treatment of Schizophrenia (pp. 385-410). Washington, DC: American Psychiatric Press.
201. Yehuda, R., Boisoneau, D., Mason, J. W., & Giller, E. L. (1993). Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biological Psychiatry, 34, 18-25.
202. Young, E. A. (1995). The role of gonadal steroids in hypothalamic-pituitary-adrenal axis regulation. Critical Reviews in Neurobiology, 9, 371-380.