메뉴 건너뛰기




Volumn , Issue , 2015, Pages 110-130

L-Dopa dyskinesias

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84953407847     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9781107588738.012     Document Type: Chapter
Times cited : (1)

References (182)
  • 2
    • 1542269162 scopus 로고    scopus 로고
    • The scientific basis for the current treatment of Parkinson’s disease
    • Olanow CW. The scientific basis for the current treatment of Parkinson’s disease. Annual review of medicine 2004;55:41-60.
    • (2004) Annual Review of medicine , vol.55 , pp. 41-60
    • Olanow, C.W.1
  • 3
    • 72149094883 scopus 로고    scopus 로고
    • Chronic dopaminergic stimulation in Parkinson’s disease: From dyskinesias to impulse control disorders
    • Voon V, Fernagut PO, Wickens J, et al. Chronic dopaminergic stimulation in Parkinson’s disease: from dyskinesias to impulse control disorders. Lancet neurology 2009;8:1140-1149.
    • (2009) Lancet neurology , vol.8 , pp. 1140-1149
    • Voon, V.1    Fernagut, P.O.2    Wickens, J.3
  • 4
    • 77950937729 scopus 로고    scopus 로고
    • Dyskinesia and the antiparkinsonian response always temporally coincide: A retrospective study
    • Nutt JG, Chung KA, Holford NH. Dyskinesia and the antiparkinsonian response always temporally coincide: a retrospective study. Neurology 2010;74:1191-1197.
    • (2010) Neurology , vol.74 , pp. 1191-1197
    • Nutt, J.G.1    Chung, K.A.2    Holford, N.H.3
  • 6
    • 0033995552 scopus 로고    scopus 로고
    • A home diary to assess functional status in patients with Parkinson’s disease with motor fluctuations and dyskinesia
    • Hauser RA, Friedlander J, Zesiewicz TA, et al. A home diary to assess functional status in patients with Parkinson’s disease with motor fluctuations and dyskinesia. Clinical neuropharmacology 2000;23:75-81.
    • (2000) Clinical Neuropharmacology , vol.23 , pp. 75-81
    • Hauser, R.A.1    Friedlander, J.2    Zesiewicz, T.A.3
  • 11
    • 41449108899 scopus 로고    scopus 로고
    • The sensitivity and specificity of the 9-item Wearing-off Questionnaire
    • Stacy MA, Murphy JM, Greeley DR, et al. The sensitivity and specificity of the 9-item Wearing-off Questionnaire. Parkinsonism & related disorders2008;14:205-212.
    • (2008) Parkinsonism & Related Disorders , vol.14 , pp. 205-212
    • Stacy, M.A.1    Murphy, J.M.2    Greeley, D.R.3
  • 12
    • 34548427887 scopus 로고    scopus 로고
    • Quantifying the impact of dyskinesias in PD: The PDYS-26: A patient-based outcome measure
    • Katzenschlager R, Schrag A, Evans A, et al. Quantifying the impact of dyskinesias in PD: the PDYS-26: a patient-based outcome measure. Neurology 2007;69:555-563.
    • (2007) Neurology , vol.69 , pp. 555-563
    • Katzenschlager, R.1    Schrag, A.2    Evans, A.3
  • 19
    • 0028040917 scopus 로고
    • Do parkinsonian symptoms and levodopa-induced dyskinesias start in the foot?
    • Vidailhet M, Bonnet AM, Marconi R, Gouider-Khouja N, Agid Y. Do parkinsonian symptoms and levodopa-induced dyskinesias start in the foot? Neurology1994;44:1613-1616.
    • (1994) Neurology , vol.44 , pp. 1613-1616
    • Vidailhet, M.1    Bonnet, A.M.2    Marconi, R.3    Gouider-Khouja, N.4    Agid, Y.5
  • 20
    • 0038662544 scopus 로고    scopus 로고
    • Parkin disease: A phenotypic study of a large case series
    • Khan NL, Graham E, Critchley P, et al. Parkin disease: a phenotypic study of a large case series. Brain: a journal of neurology 2003;126:1279-1292.
    • (2003) Brain: A journal of Neurology , vol.126 , pp. 1279-1292
    • Khan, N.L.1    Graham, E.2    Critchley, P.3
  • 21
    • 2942534518 scopus 로고    scopus 로고
    • Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism
    • Scherfler C, Khan NL, Pavese N, et al. Striatal and cortical pre- and postsynaptic dopaminergic dysfunction in sporadic parkin-linked parkinsonism. Brain: a journal of neurology 2004;127:1332-1342.
    • (2004) Brain: A Journal of Neurology , vol.127 , pp. 1332-1342
    • Scherfler, C.1    Khan, N.L.2    Pavese, N.3
  • 25
    • 1842728438 scopus 로고    scopus 로고
    • Pharmacological and PET studies in patients with Parkinson’s disease and a short duration-motor response: Implications in the pathophysiology of motor complications
    • Linazasoro G, Antonini A, Maguire RP, Leenders KL. Pharmacological and PET studies in patients with Parkinson’s disease and a short duration-motor response: implications in the pathophysiology of motor complications. Journal ofneural transmission2004;111:497-509.
    • (2004) Journal Ofneural Transmission , vol.111 , pp. 497-509
    • Linazasoro, G.1    Antonini, A.2    Maguire, R.P.3    Leenders, K.L.4
  • 26
    • 65249107128 scopus 로고    scopus 로고
    • PET demonstrates reduced dopamine transporter expression in PD with dyskinesias
    • Troiano AR, dela Fuente-Fernandez R, Sossi V, et al. PET demonstrates reduced dopamine transporter expression in PD with dyskinesias. Neurology2009;72:1211-1216.
    • (2009) Neurology , vol.72 , pp. 1211-1216
    • Troiano, A.R.1    Dela Fuente-Fernandez, R.2    Sossi, V.3
  • 27
    • 84902149096 scopus 로고    scopus 로고
    • Presynaptic dopamine depletion predicts levodopa-induced dyskinesia in de novo Parkinson disease
    • Hong JY, Oh JS, Lee I, et al. Presynaptic dopamine depletion predicts levodopa-induced dyskinesia in de novo Parkinson disease. Neurology2014;82:1597-1604.
    • (2014) Neurology , vol.82 , pp. 1597-1604
    • Hong, J.Y.1    Oh, J.S.2    Lee, I.3
  • 28
    • 74249120624 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias in Parkinson disease are independent of the extent of striatal dopaminergic denervation: A pharmacological and SPECT study
    • Linazasoro G, Van Blercom N, Bergaretxe A, Inaki FM, Laborda E, Ruiz Ortega JA. Levodopa-induced dyskinesias in Parkinson disease are independent of the extent of striatal dopaminergic denervation: a pharmacological and SPECT study. Clinical neuropharmacology 2009;32:326-329.
    • (2009) Clinical neuropharmacology , vol.32 , pp. 326-329
    • Linazasoro, G.1    Van Blercom, N.2    Bergaretxe, A.3    Inaki, F.M.4    Laborda, E.5    Ruiz Ortega, J.A.6
  • 29
    • 0141987877 scopus 로고    scopus 로고
    • Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and/or duration of symptoms
    • Schneider JS, Gonczi H, Decamp E. Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and/or duration of symptoms. Brain research2003;990:38-44.
    • (2003) Brain Research , vol.990 , pp. 38-44
    • Schneider, J.S.1    Gonczi, H.2    Decamp, E.3
  • 31
    • 19744378296 scopus 로고    scopus 로고
    • Levodopa and the progression of Parkinson’s disease. The
    • Fahn S, Oakes D, Shoulson I, et al. Levodopa and the progression of Parkinson’s disease. The New England journal of medicine 2004;351:2498-2508.
    • (2004) New England journal of Medicine , vol.351 , pp. 2498-2508
    • Fahn, S.1    Oakes, D.2    Shoulson, I.3
  • 32
    • 0036895554 scopus 로고    scopus 로고
    • Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: An 18F-dopa PET study
    • Khan NL, Valente EM, Bentivoglio AR, et al. Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study. Annals of neurology 2002;52:849-853.
    • (2002) Annals of Neurology , vol.52 , pp. 849-853
    • Khan, N.L.1    Valente, E.M.2    Bentivoglio, A.R.3
  • 34
    • 0034682308 scopus 로고    scopus 로고
    • A five-year study of the incidence of dyskinesia in patients with early Parkinson’s disease who were treated with ropinirole or levodopa. 056 Study Group
    • Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE. A five-year study of the incidence of dyskinesia in patients with early Parkinson’s disease who were treated with ropinirole or levodopa. 056 Study Group. The New England journal of medicine2000;342:1484-1491.
    • (2000) The New England Journal of Medicine , vol.342 , pp. 1484-1491
    • Rascol, O.1    Brooks, D.J.2    Korczyn, A.D.3    De Deyn, P.P.4    Clarke, C.E.5    Lang, A.E.6
  • 37
    • 20144388439 scopus 로고    scopus 로고
    • Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: An exploratory study
    • Zappia M, Annesi G, Nicoletti G, et al. Sex differences in clinical and genetic determinants of levodopa peak-dose dyskinesias in Parkinson disease: an exploratory study. Archives of neurology2005;62:601-605.
    • (2005) Archives of Neurology , vol.62 , pp. 601-605
    • Zappia, M.1    Annesi, G.2    Nicoletti, G.3
  • 38
    • 0035954334 scopus 로고    scopus 로고
    • Association study ofdopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD
    • Wang J, Liu ZL, Chen B. Association study ofdopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD. Neurology 2001;56:1757-1759.
    • (2001) Neurology , vol.56 , pp. 1757-1759
    • Wang, J.1    Liu, Z.L.2    Chen, B.3
  • 41
    • 0028337689 scopus 로고
    • The role of pulsatile versus continuous dopamine receptor stimulation for functional recovery in Parkinson’s disease. The
    • Obeso JA, Grandas F, Herrero MT, Horowski R. The role of pulsatile versus continuous dopamine receptor stimulation for functional recovery in Parkinson’s disease. The European journal ofneuroscience1994;6:889-897.
    • (1994) European Journal Ofneuroscience , vol.6 , pp. 889-897
    • Obeso, J.A.1    Grandas, F.2    Herrero, M.T.3    Horowski, R.4
  • 43
    • 0026059697 scopus 로고
    • Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
    • Grace AA. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 1991;41:1-24.
    • (1991) Neuroscience , vol.41 , pp. 1-24
    • Grace, A.A.1
  • 46
    • 84902168489 scopus 로고    scopus 로고
    • Predicting the development of levodopa-induced dyskinesias: A presynaptic mechanism?
    • Lewitt PA, Mouradian MM. Predicting the development of levodopa-induced dyskinesias: A presynaptic mechanism? Neurology 2014;82:1574-1575.
    • (2014) Neurology , vol.82 , pp. 1574-1575
    • Lewitt, P.A.1    Mouradian, M.M.2
  • 47
    • 0035434121 scopus 로고    scopus 로고
    • Pathophysiology of levodopa-induced dyskinesia: Potential for new therapies
    • Bezard E, Brotchie JM, Gross CE. Pathophysiology of levodopa-induced dyskinesia: potential for new therapies. Nature reviews Neuroscience 2001;2:577-588.
    • (2001) Nature Reviews Neuroscience , vol.2 , pp. 577-588
    • Bezard, E.1    Brotchie, J.M.2    Gross, C.E.3
  • 48
    • 50049087567 scopus 로고    scopus 로고
    • Molecular mechanisms of L-DOPA-induced dyskinesia
    • Jenner P. Molecular mechanisms of L-DOPA-induced dyskinesia. Nature reviews Neuroscience2008;9:665-677.
    • (2008) Nature Reviews Neuroscience , vol.9 , pp. 665-677
    • Jenner, P.1
  • 49
    • 72649085036 scopus 로고    scopus 로고
    • Dopamine receptors and L-dopa-induced dyskinesia
    • Berthet A, Bezard E. Dopamine receptors and L-dopa-induced dyskinesia. Parkinsonism & related disorders 2009; 15 Suppl 4:S8-12.
    • (2009) Parkinsonism & Related Disorders , vol.15 , pp. 8-12
    • Berthet, A.1    Bezard, E.2
  • 51
    • 0029002052 scopus 로고
    • D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum
    • Le Moine C, Bloch B. D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. The Journal of comparative neurology 1995;355:418-426.
    • (1995) The Journal of comparative neurology , vol.355 , pp. 418-426
    • Le Moine, C.1    Bloch, B.2
  • 52
    • 0027447142 scopus 로고
    • Differential visualization of dopamine D2 and D3 receptor sites in rat brain. A comparative study using in situ hybridization histochemistry and ligand binding autoradiography
    • Landwehrmeyer B, Mengod G, Palacios JM. Differential visualization of dopamine D2 and D3 receptor sites in rat brain. A comparative study using in situ hybridization histochemistry and ligand binding autoradiography. The European journal of neuroscience 1993;5:145-153.
    • (1993) The European Journal of neuroscience , vol.5 , pp. 145-153
    • Landwehrmeyer, B.1    Mengod, G.2    Palacios, J.M.3
  • 53
    • 0038579160 scopus 로고    scopus 로고
    • Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
    • Bezard E, Ferry S, Mach U, et al. Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nature medicine2003;9:762-767.
    • (2003) Nature Medicine , vol.9 , pp. 762-767
    • Bezard, E.1    Ferry, S.2    Mach, U.3
  • 54
    • 0025572196 scopus 로고
    • D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    • Gerfen CR, Engber TM, Mahan LC, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science1990;250:1429-1432.
    • (1990) Science , vol.250 , pp. 1429-1432
    • Gerfen, C.R.1    Engber, T.M.2    Mahan, L.C.3
  • 55
    • 0025321039 scopus 로고
    • Functional architecture of basal ganglia circuits: Neural substrates of parallel processing
    • Alexander GE, Crutcher MD. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends in neurosciences 1990;13:266-271.
    • (1990) Trends in Neurosciences , vol.13 , pp. 266-271
    • Alexander, G.E.1    Crutcher, M.D.2
  • 58
    • 0024566826 scopus 로고
    • Time and dose dependence of the ‘priming of the expression of dopamine receptor supersensitivity
    • Morelli M, Fenu S, Garau L, Di Chiara G. Time and dose dependence of the ‘priming of the expression of dopamine receptor supersensitivity. European journal of pharmacology 1989;162:329-335.
    • (1989) European journal of Pharmacology , vol.162 , pp. 329-335
    • Morelli, M.1    Fenu, S.2    Garau, L.3    Di Chiara, G.4
  • 59
    • 0031925945 scopus 로고    scopus 로고
    • L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    • Cenci MA, Lee CS, Bjorklund A. L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA. The European journal of neuroscience 1998;10:2694-2706.
    • (1998) The European Journal of neuroscience , vol.10 , pp. 2694-2706
    • Cenci, M.A.1    Lee, C.S.2    Bjorklund, A.3
  • 60
    • 0036459952 scopus 로고    scopus 로고
    • Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model ofParkinson's disease
    • Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, Cenci MA. Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model ofParkinson's disease. The European journal of neuroscience 2002;15:120-132.
    • (2002) The European journal of Neuroscience , vol.15 , pp. 120-132
    • Lundblad, M.1    Ersson, M.2    Winkler, C.3    Kirik, D.4    Wierup, N.5    Cenci, M.A.6
  • 61
    • 3142619404 scopus 로고    scopus 로고
    • Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism
    • Picconi B, Centonze D, Rossi S, Bernardi G, Calabresi P. Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism. Brain: a journal of neurology 2004;127:1661-1669.
    • (2004) Brain: A journal of Neurology , vol.127 , pp. 1661-1669
    • Picconi, B.1    Centonze, D.2    Rossi, S.3    Bernardi, G.4    Calabresi, P.5
  • 63
    • 3242741195 scopus 로고    scopus 로고
    • Receptor compartmentalization and trafficking at glutamate synapses: A developmental proposal
    • van Zundert B, Yoshii A, Constantine-Paton M. Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal. Trends in neurosciences 2004;27:428-437.
    • (2004) Trends in Neurosciences , vol.27 , pp. 428-437
    • Van Zundert, B.1    Yoshii, A.2    Constantine-Paton, M.3
  • 64
    • 21844449693 scopus 로고    scopus 로고
    • Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosets
    • Hurley MJ, Jackson MJ, Smith LA, Rose S, Jenner P. Immunoautoradiographic analysis of NMDA receptor subunits and associated postsynaptic density proteins in the brain of dyskinetic MPTP-treated common marmosets. The European journal ofneuroscience2005;21:3240-3250.
    • (2005) The European Journal Ofneuroscience , vol.21 , pp. 3240-3250
    • Hurley, M.J.1    Jackson, M.J.2    Smith, L.A.3    Rose, S.4    Jenner, P.5
  • 65
    • 27744571228 scopus 로고    scopus 로고
    • Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD
    • Bibbiani F, Oh JD, Kielaite A, Collins MA, Smith C, Chase TN. Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Experimental neurology 2005;196:422-429.
    • (2005) Experimental neurology , vol.196 , pp. 422-429
    • Bibbiani, F.1    Oh, J.D.2    Kielaite, A.3    Collins, M.A.4    Smith, C.5    Chase, T.N.6
  • 73
    • 0037013695 scopus 로고    scopus 로고
    • Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats
    • Carta AR, Pinna A, Cauli O, Morelli M. Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats. Synapse 2002;44:166-174.
    • (2002) Synapse , vol.44 , pp. 166-174
    • Carta, A.R.1    Pinna, A.2    Cauli, O.3    Morelli, M.4
  • 74
    • 22844435191 scopus 로고    scopus 로고
    • New ideas on the origin of L-dopa-induced dyskinesias: Age, genes and neural plasticity
    • Linazasoro G. New ideas on the origin of L-dopa-induced dyskinesias: age, genes and neural plasticity. Trends in pharmacological sciences2005;26:391-397.
    • (2005) Trends in Pharmacological Sciences , vol.26 , pp. 391-397
    • Linazasoro, G.1
  • 75
    • 0024471981 scopus 로고
    • D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour
    • Robertson HA, Peterson MR, Murphy K, Robertson GS. D1-dopamine receptor agonists selectively activate striatal c-fos independent of rotational behaviour. Brain research 1989;503:346-349.
    • (1989) Brain Research , vol.503 , pp. 346-349
    • Robertson, H.A.1    Peterson, M.R.2    Murphy, K.3    Robertson, G.S.4
  • 76
    • 0025191503 scopus 로고
    • D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons
    • Dragunow M, Robertson GS, Faull RL, Robertson HA, Jansen K. D2 dopamine receptor antagonists induce fos and related proteins in rat striatal neurons. Neuroscience 1990;37:287-294.
    • (1990) Neuroscience , vol.37 , pp. 287-294
    • Dragunow, M.1    Robertson, G.S.2    Faull, R.L.3    Robertson, H.A.4    Jansen, K.5
  • 78
    • 10644250114 scopus 로고    scopus 로고
    • Dopamine-receptor stimulation: Biobehavioral and biochemical consequences
    • Calon F, Hadj Tahar A, Blanchet PJ, et al. Dopamine-receptor stimulation: biobehavioral and biochemical consequences. Trends in neurosciences2000;23:S92-100.
    • (2000) Trends in Neurosciences , vol.23 , pp. 92-100
    • Calon, F.1    Hadj Tahar, A.2    Blanchet, P.J.3
  • 79
    • 0037407662 scopus 로고    scopus 로고
    • L-DOPA, dyskinesia and striatal plasticity
    • Dunnett S. L-DOPA, dyskinesia and striatal plasticity. Nature neuroscience 2003;6:437-438.
    • (2003) Nature Neuroscience , vol.6 , pp. 437-438
    • Dunnett, S.1
  • 80
    • 0037407907 scopus 로고    scopus 로고
    • Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
    • Picconi B, Centonze D, Hakansson K, et al. Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia. Nature neuroscience 2003;6:501-506.
    • (2003) Nature Neuroscience , vol.6 , pp. 501-506
    • Picconi, B.1    Centonze, D.2    Hakansson, K.3
  • 81
    • 0033166545 scopus 로고    scopus 로고
    • Beyond the dopamine receptor: The DARPP-32/protein phosphatase-1 cascade
    • Greengard P, Allen PB, Nairn AC. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 1999;23:435-447.
    • (1999) Neuron , vol.23 , pp. 435-447
    • Greengard, P.1    Allen, P.B.2    Nairn, A.C.3
  • 82
    • 84862640021 scopus 로고    scopus 로고
    • Beyond the dopamine receptor: Regulation and roles of serine/threonine protein phosphatases
    • Walaas SI, Hemmings HC, Jr., Greengard P, Nairn AC Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases. Frontiers in neuroanatomy 2011;5:50.
    • (2011) Frontiers in neuroanatomy , vol.5 , pp. 50
    • Walaas, S.I.1    Hemmings, H.C.2    Greengard, P.3    Nairn, A.C.4
  • 83
    • 0027234405 scopus 로고
    • L-dopa stimulates c-fos expression in dopamine denervated striatum by combined activation of D-1 and D-2 receptors
    • Morelli M, Cozzolino A, Pinna A, Fenu S, Carta A, Di Chiara G. L-dopa stimulates c-fos expression in dopamine denervated striatum by combined activation of D-1 and D-2 receptors. Brain research1993;623:334-336.
    • (1993) Brain Research , vol.623 , pp. 334-336
    • Morelli, M.1    Cozzolino, A.2    Pinna, A.3    Fenu, S.4    Carta, A.5    Di Chiara, G.6
  • 84
    • 0028859611 scopus 로고
    • Dynorphin opioid inhibition of cocaine-induced, D1 dopamine receptor-mediated immediate-early gene expression in the striatum
    • Steiner H, Gerfen CR. Dynorphin opioid inhibition of cocaine-induced, D1 dopamine receptor-mediated immediate-early gene expression in the striatum. The Journal ofcomparative neurology 1995;353:200-212.
    • (1995) The Journal Ofcomparative Neurology , vol.353 , pp. 200-212
    • Steiner, H.1
  • 85
    • 0029620358 scopus 로고
    • D1 and D2 dopamine receptor function in the striatum: Coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons
    • Gerfen CR, Keefe KA, Gauda EB. D1 and D2 dopamine receptor function in the striatum: coactivation of D1- and D2-dopamine receptors on separate populations of neurons results in potentiated immediate early gene response in D1-containing neurons. The Journal of neuroscience: the official journal of the Society for Neuroscience 1995;15:8167-8176.
    • (1995) The Journal of Neuroscience: The Official journal of the Society for Neuroscience , vol.15 , pp. 8167-8176
    • Gerfen, C.R.1    Keefe, K.A.2    Gauda, E.B.3
  • 86
    • 0025333492 scopus 로고
    • Striatonigral projection neurons contain D1 dopamine receptor-activated c-fos
    • Robertson GS, Vincent SR, Fibiger HC. Striatonigral projection neurons contain D1 dopamine receptor-activated c-fos. Brain research 1990;523:288-290.
    • (1990) Brain Research , vol.523 , pp. 288-290
    • Robertson, G.S.1    Vincent, S.R.2    Fibiger, H.C.3
  • 87
    • 0029919162 scopus 로고    scopus 로고
    • D1 dopamine receptor-mediated induction of zif268 and c-fos in the dopamine-depleted striatum: Differential regulation and independence from NMDA receptors
    • Keefe KA, Gerfen CR. D1 dopamine receptor-mediated induction of zif268 and c-fos in the dopamine-depleted striatum: differential regulation and independence from NMDA receptors. The Journal of comparative neurology 1996;367:165-176.
    • (1996) The Journal of Comparative Neurology , vol.367 , pp. 165-176
    • Keefe, K.A.1    Gerfen, C.R.2
  • 90
    • 0024405531 scopus 로고
    • Continuous and intermittent levodopa differentially affect basal ganglia function
    • Juncos JL, Engber TM, Raisman R, et al. Continuous and intermittent levodopa differentially affect basal ganglia function. Annals of neurology1989;25:473-478.
    • (1989) Annals of Neurology , vol.25 , pp. 473-478
    • Juncos, J.L.1    Engber, T.M.2    Raisman, R.3
  • 91
    • 0028988221 scopus 로고
    • Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding protein
    • Konradi C, Heckers S. Haloperidol-induced Fos expression in striatum is dependent upon transcription factor cyclic AMP response element binding protein. Neuroscience 1995;65:1051-1061.
    • (1995) Neuroscience , vol.65 , pp. 1051-1061
    • Konradi, C.1    Heckers, S.2
  • 92
    • 0030561396 scopus 로고    scopus 로고
    • Dopaminergic regulation of AP-1 transcription factor DNA binding activity in rat striatum
    • Huang KX, Walters JR. Dopaminergic regulation of AP-1 transcription factor DNA binding activity in rat striatum. Neuroscience 1996;75:757-775.
    • (1996) Neuroscience , vol.75 , pp. 757-775
    • Huang, K.X.1    Walters, J.R.2
  • 93
    • 19944427055 scopus 로고    scopus 로고
    • Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia
    • Aubert I, Guigoni C, Hakansson K, et al. Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. Annals of neurology 2005;57:17-26.
    • (2005) Annals of Neurology , vol.57 , pp. 17-26
    • Aubert, I.1    Guigoni, C.2    Hakansson, K.3
  • 94
    • 34147170029 scopus 로고    scopus 로고
    • Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates
    • Guigoni C, Doudnikoff E, Li Q, Bloch B, Bezard E. Altered D(1) dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates. Neurobiology of disease 2007;26:452-463.
    • (2007) Neurobiology of Disease , vol.26 , pp. 452-463
    • Guigoni, C.1    Doudnikoff, E.2    Li, Q.3    Bloch, B.4    Bezard, E.5
  • 95
    • 65549129089 scopus 로고    scopus 로고
    • Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia
    • Berthet A, Porras G, Doudnikoff E, et al. Pharmacological analysis demonstrates dramatic alteration of D1 dopamine receptor neuronal distribution in the rat analog of L-DOPA-induced dyskinesia. The Journal ofneuroscience: the official journal of the Society for Neuroscience2009;29:4829-4835.
    • (2009) The Journal Ofneuroscience: The Official Journal of the Society for Neuroscience , vol.29 , pp. 4829-4835
    • Berthet, A.1    Porras, G.2    Doudnikoff, E.3
  • 96
    • 15944407993 scopus 로고    scopus 로고
    • L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain
    • Bezard E, Gross CE, Qin L, Gurevich VV, Benovic JL, Gurevich EV. L-DOPA reverses the MPTP-induced elevation of the arrestin2 and GRK6 expression and enhanced ERK activation in monkey brain. Neurobiology of disease 2005;18:323-335.
    • (2005) Neurobiology of Disease , vol.18 , pp. 323-335
    • Bezard, E.1    Gross, C.E.2    Qin, L.3    Gurevich, V.V.4    Benovic, J.L.5    Gurevich, E.V.6
  • 97
    • 39849085956 scopus 로고    scopus 로고
    • Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment
    • Ahmed MR, Bychkov E, Gurevich VV, Benovic JL, Gurevich EV. Altered expression and subcellular distribution of GRK subtypes in the dopamine-depleted rat basal ganglia is not normalized by l-DOPA treatment. Journal of neurochemistry2008;104:1622-1636.
    • (2008) Journal of Neurochemistry , vol.104 , pp. 1622-1636
    • Ahmed, M.R.1    Bychkov, E.2    Gurevich, V.V.3    Benovic, J.L.4    Gurevich, E.V.5
  • 98
    • 14744290753 scopus 로고    scopus 로고
    • Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease
    • Hallett PJ, Dunah AW, Ravenscroft P, et al. Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease. Neuropharmacology 2005;48:503-516.
    • (2005) Neuropharmacology , vol.48 , pp. 503-516
    • Hallett, P.J.1    Dunah, A.W.2    Ravenscroft, P.3
  • 99
    • 72449160194 scopus 로고    scopus 로고
    • Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate
    • Silverdale MA, Kobylecki C, Hallett PJ, et al. Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate. Synapse 2010;64:177-180.
    • (2010) Synapse , vol.64 , pp. 177-180
    • Silverdale, M.A.1    Kobylecki, C.2    Hallett, P.J.3
  • 102
    • 45649085857 scopus 로고    scopus 로고
    • Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization
    • Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, Missale C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Molecular pharmacology2008;74:59-69.
    • (2008) Molecular Pharmacology , vol.74 , pp. 59-69
    • Fiorentini, C.1    Busi, C.2    Gorruso, E.3    Gotti, C.4    Spano, P.5    Missale, C.6
  • 103
    • 54449099573 scopus 로고    scopus 로고
    • Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum
    • Marcellino D, Ferre S, Casado V, et al. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. The Journal ofbiological chemistry2008;283:26016-26025.
    • (2008) The Journal Ofbiological Chemistry , vol.283 , pp. 26016-26025
    • Marcellino, D.1    Ferre, S.2    Casado, V.3
  • 104
    • 0038290734 scopus 로고    scopus 로고
    • Targeting Ras/ERK signaling in the striatum: Will it help?
    • Brambilla R. Targeting Ras/ERK signaling in the striatum: will it help? Molecular psychiatry2003;8:366-368.
    • (2003) Molecular Psychiatry , vol.8 , pp. 366-368
    • Brambilla, R.1
  • 106
    • 34047178328 scopus 로고    scopus 로고
    • Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors
    • Westin JE, Vercammen L, Strome EM, Konradi C, Cenci MA. Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors. Biological psychiatry 2007;62:800-810.
    • (2007) Biological Psychiatry , vol.62 , pp. 800-810
    • Westin, J.E.1    Vercammen, L.2    Strome, E.M.3    Konradi, C.4    Cenci, M.A.5
  • 107
    • 0023205239 scopus 로고
    • Agonist-induced homologous and heterologous sensitization to D-1-and D-2-dependent contraversive turning
    • Morelli M, Di Chiara G. Agonist-induced homologous and heterologous sensitization to D-1-and D-2-dependent contraversive turning. European journal of pharmacology 1987;141:101-107.
    • (1987) European journal of Pharmacology , vol.141 , pp. 101-107
    • Morelli, M.1    Di Chiara, G.2
  • 108
    • 0034668949 scopus 로고    scopus 로고
    • Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
    • Calabresi P, Gubellini P, Centonze D, et al. Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity. The Journal ofneuroscience: the official journal of the Society for Neuroscience2000;20:8443-8451.
    • (2000) The Journal Ofneuroscience: The official Journal of the Society for Neuroscience , vol.20 , pp. 8443-8451
    • Calabresi, P.1    Gubellini, P.2    Centonze, D.3
  • 109
    • 33749672231 scopus 로고    scopus 로고
    • A convergent model for cognitive dysfunctions in Parkinson’s disease: The critical dopamine-acetylcholine synaptic balance
    • Calabresi P, Picconi B, Parnetti L, Di Filippo M. A convergent model for cognitive dysfunctions in Parkinson’s disease: the critical dopamine-acetylcholine synaptic balance. Lancet neurology2006;5:974-983.
    • (2006) Lancet Neurology , vol.5 , pp. 974-983
    • Calabresi, P.1    Picconi, B.2    Parnetti, L.3    Di Filippo, M.4
  • 113
    • 0033540728 scopus 로고    scopus 로고
    • D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys
    • Grondin R, Doan VD, Gregoire L, Bedard PJ. D1 receptor blockade improves L-dopa-induced dyskinesia but worsens parkinsonism in MPTP monkeys. Neurology 1999;52:771-776.
    • (1999) Neurology , vol.52 , pp. 771-776
    • Grondin, R.1    Doan, V.D.2    Gregoire, L.3    Bedard, P.J.4
  • 114
    • 33744811731 scopus 로고    scopus 로고
    • Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine
    • Meissner W, Ravenscroft P, Reese R, et al. Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine. Neurobiology of disease 2006;22:586-598.
    • (2006) Neurobiology of Disease , vol.22 , pp. 586-598
    • Meissner, W.1    Ravenscroft, P.2    Reese, R.3
  • 116
    • 10344236071 scopus 로고    scopus 로고
    • Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson’s disease: Implications for dyskinesias
    • dela Fuente-Fernandez R, Sossi V, Huang Z, et al. Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson’s disease: implications for dyskinesias. Brain: a journal of neurology 2004;127:2747-2754.
    • (2004) Brain: A journal of Neurology , vol.127 , pp. 2747-2754
    • Dela Fuente-Fernandez, R.1    Sossi, V.2    Huang, Z.3
  • 117
    • 33748677017 scopus 로고    scopus 로고
    • Post- versus presynaptic plasticity in L-DOPA-induced dyskinesia
    • Cenci MA, Lundblad M. Post- versus presynaptic plasticity in L-DOPA-induced dyskinesia. Journal of neurochemistry 2006;99:381-392.
    • (2006) Journal of neurochemistry , vol.99 , pp. 381-392
    • Cenci, M.A.1    Lundblad, M.2
  • 120
    • 58749101356 scopus 로고    scopus 로고
    • The thalamostriatal systems: Anatomical and functional organization in normal and parkinsonian states
    • Smith Y, Raju D, Nanda B, Pare JF, Galvan A, Wichmann T. The thalamostriatal systems: anatomical and functional organization in normal and parkinsonian states. Brain research bulletin2009;78:60-68.
    • (2009) Brain Research Bulletin , vol.78 , pp. 60-68
    • Smith, Y.1    Raju, D.2    Nanda, B.3    Pare, J.F.4    Galvan, A.5    Wichmann, T.6
  • 121
    • 77957664714 scopus 로고    scopus 로고
    • An update on the potential role of excitotoxicity in the pathogenesis of Parkinson’s disease
    • Blandini F. An update on the potential role of excitotoxicity in the pathogenesis of Parkinson’s disease. Functional neurology 2010;25:65-71.
    • (2010) Functional Neurology , vol.25 , pp. 65-71
    • Blandini, F.1
  • 122
    • 84886020232 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias in Parkinson’s disease: Emerging treatments
    • Bargiotas P, Konitsiotis S. Levodopa-induced dyskinesias in Parkinson’s disease: emerging treatments. Neuropsychiatric disease and treatment2013;9:1605-1617.
    • (2013) Neuropsychiatric Disease and Treatment , vol.9 , pp. 1605-1617
    • Bargiotas, P.1    Konitsiotis, S.2
  • 125
    • 27344444293 scopus 로고    scopus 로고
    • Amantadine reduces the duration of levodopa-induced dyskinesia: A randomized, doubleblind, placebo-controlled study
    • da Silva-Junior FP, Braga-Neto P, Sueli Monte F, de Bruin VM. Amantadine reduces the duration of levodopa-induced dyskinesia: a randomized, doubleblind, placebo-controlled study. Parkinsonism & related disorders 2005;11:449-452.
    • (2005) Parkinsonism & related Disorders , vol.11 , pp. 449-452
    • Da Silva-Junior, F.P.1    Braga-Neto, P.2    Sueli Monte, F.3    De Bruin, V.M.4
  • 129
    • 84886054678 scopus 로고    scopus 로고
    • Early use of amantadine to prevent or delay onset of levodopa-induced dyskinesia in Parkinson’s disease
    • Jahangirvand AR, A. Early use of amantadine to prevent or delay onset of levodopa-induced dyskinesia in Parkinson’s disease. Movement disorders: official journal of the Movement Disorder Society 2013;28:207.
    • (2013) Movement disorders: Official Journal of the Movement Disorder Society , vol.28 , pp. 207
    • Jahangirvand, A.R.1
  • 132
    • 0034793204 scopus 로고    scopus 로고
    • Evaluation of dyskinesias in a pilot, randomized, placebo-controlled trial of remacemide in advanced Parkinson disease
    • Parkinson Study G. Evaluation of dyskinesias in a pilot, randomized, placebo-controlled trial of remacemide in advanced Parkinson disease. Archives of neurology 2001;58:1660-1668.
    • (2001) Archives of Neurology , vol.58 , pp. 1660-1668
    • Parkinson Study, G.1
  • 136
    • 0032730121 scopus 로고    scopus 로고
    • Effect of memantine (NMDA antagonist) on Parkinson’s disease: A double-blind crossover randomized study
    • Merello M, Nouzeilles MI, Cammarota A, Leiguarda R. Effect of memantine (NMDA antagonist) on Parkinson’s disease: a double-blind crossover randomized study. Clinical neuropharmacology1999;22:273-276.
    • (1999) Clinical Neuropharmacology , vol.22 , pp. 273-276
    • Merello, M.1    Nouzeilles, M.I.2    Cammarota, A.3    Leiguarda, R.4
  • 137
    • 84876100906 scopus 로고    scopus 로고
    • Memantine for axial signs in Parkinson’s disease: A randomised, double-blind, placebo-controlled pilot study
    • Moreau C, Delval A, Tiffreau V, et al. Memantine for axial signs in Parkinson’s disease: a randomised, double-blind, placebo-controlled pilot study. Journal ofneurology, neurosurgery, and psychiatry2013;84:552-555.
    • (2013) Journal ofneurology, Neurosurgery, and Psychiatry , vol.84 , pp. 552-555
    • Moreau, C.1    Delval, A.2    Tiffreau, V.3
  • 138
    • 84872253989 scopus 로고    scopus 로고
    • Unexpected improvement in levodopa-induced dyskinesia and on-off phenomena after introduction of memantine for treatment of Parkinson’s disease dementia
    • Vidal EI, Fukushima FB, Valle AP, Villas Boas PJ. Unexpected improvement in levodopa-induced dyskinesia and on-off phenomena after introduction of memantine for treatment of Parkinson’s disease dementia. Journal of the American Geriatrics Society2013;61:170-172.
    • (2013) Journal of the American Geriatrics Society , vol.61 , pp. 170-172
    • Vidal, E.I.1    Fukushima, F.B.2    Valle, A.P.3    Villas Boas, P.J.4
  • 139
    • 3042833166 scopus 로고    scopus 로고
    • The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson’s disease
    • Nash JE, Ravenscroft P, McGuire S, Crossman AR, Menniti FS, Brotchie JM. The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson’s disease. Experimental neurology 2004;188:471-479.
    • (2004) Experimental Neurology , vol.188 , pp. 471-479
    • Nash, J.E.1    Ravenscroft, P.2    Mc Guire, S.3    Crossman, A.R.4    Menniti, F.S.5    Brotchie, J.M.6
  • 141
    • 84953407434 scopus 로고    scopus 로고
    • Pharmacokinetic and Pharmacodynamic Study of Neu-120 in Patients With Advanced Phase Idiopathic Parkinson’s Disease With Levodopa Induced Dyskinesia [online]Available at:, Accessed April 30
    • Ltd. NP. A Double-blind, Placebo Controlled, Crossover, Ascending Single Dose Safety Tolerability, Pharmacokinetic and Pharmacodynamic Study of Neu-120 in Patients With Advanced Phase Idiopathic Parkinson’s Disease With Levodopa Induced Dyskinesia [online]. Available at: http://www.clinicaltrials.gov/ct2/show/NCT00607451?term=NC T00607451%26rank=1. Accessed April 30, 2014.
    • (2014) A Double-Blind, Placebo Controlled, Crossover, Ascending Single Dose Safety Tolerability
  • 142
    • 84899939104 scopus 로고    scopus 로고
    • Targeting metabotropic glutamate receptors as a new strategy against levodopa-induced dyskinesia in Parkinson’s disease?
    • Picconi B, Calabresi P. Targeting metabotropic glutamate receptors as a new strategy against levodopa-induced dyskinesia in Parkinson’s disease?Movement disorders: official journal of the Movement Disorder Society 2014;29:715-719.
    • (2014) Movement Disorders: Official Journal of the Movement Disorder Society , vol.29 , pp. 715-719
    • Picconi, B.1    Calabresi, P.2
  • 143
    • 33645050113 scopus 로고    scopus 로고
    • Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson’s disease
    • Dekundy A, Pietraszek M, Schaefer D, Cenci MA, Danysz W. Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson’s disease. Brain research bulletin2006;69:318-326.
    • (2006) Brain Research Bulletin , vol.69 , pp. 318-326
    • Dekundy, A.1    Pietraszek, M.2    Schaefer, D.3    Cenci, M.A.4    Danysz, W.5
  • 144
    • 77952382801 scopus 로고    scopus 로고
    • Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson’s disease
    • Johnston TH, Fox SH, McIldowie MJ, Piggott MJ, Brotchie JM. Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson’s disease. The Journal of pharmacology and experimental therapeutics2010;333:865-873.
    • (2010) The Journal of pharmacology and Experimental Therapeutics , vol.333 , pp. 865-873
    • Johnston, T.H.1    Fox, S.H.2    Mc Ildowie, M.J.3    Piggott, M.J.4    Brotchie, J.M.5
  • 145
    • 36549085132 scopus 로고    scopus 로고
    • Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson’s disease
    • Levandis G, Bazzini E, Armentero MT, Nappi G, Blandini F. Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson’s disease. Neurobiology of disease2008;29:161-168.
    • (2008) Neurobiology of Disease , vol.29 , pp. 161-168
    • Levandis, G.1    Bazzini, E.2    Armentero, M.T.3    Nappi, G.4    Blandini, F.5
  • 146
    • 79954995144 scopus 로고    scopus 로고
    • The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in L-Dopa-treated parkinsonian monkeys
    • Gregoire L, Morin N, Ouattara B, et al. The acute antiparkinsonian and antidyskinetic effect of AFQ056, a novel metabotropic glutamate receptor type 5 antagonist, in L-Dopa-treated parkinsonian monkeys. Parkinsonism & related disorders2011;17:270-276.
    • (2011) Parkinsonism & Related Disorders , vol.17 , pp. 270-276
    • Gregoire, L.1    Morin, N.2    Ouattara, B.3
  • 148
    • 84953400692 scopus 로고    scopus 로고
    • Tolerability and Efficacy of AFQ056 in Parkinson’s Patients With L-dopa Induced DyskinesiasAvailable at, Accessed April 30
    • Pharmaceuticals N. An Open-label Treatment Study to Evaluate the Safety, Tolerability and Efficacy of AFQ056 in Parkinson’s Patients With L-dopa Induced Dyskinesias [online]. Available at: http://www.clinicaltrials.gov/ct2/show/NCT01173731?term=NCT01173731%26rank= 1. Accessed April 30, 2014.
    • (2014) An Open-Label Treatment Study to Evaluate the Safety
    • Pharmaceuticals, N.1
  • 149
    • 84893117990 scopus 로고    scopus 로고
    • Safety, tolerability and anti-dyskinetic efficacy of dipraglurant, a novel mGluR5 negative allosteric modulator (NAM) in Parkinson’s disease (PD) patients with levodopa-induced dyskinesia (LID)
    • Tison FD, Corvol J, Eggert K, Trenkwalder C, Lew, M, Isaacson S, Keywood C, Rascol O. Safety, tolerability and anti-dyskinetic efficacy of dipraglurant, a novel mGluR5 negative allosteric modulator (NAM) in Parkinson’s disease (PD) patients with levodopa-induced dyskinesia (LID). Neurology 2013;80:004.
    • (2013) Neurology , vol.80 , pp. 004
    • Tison, F.D.1    Corvol, J.2    Eggert, K.3    Trenkwalder, C.4    Lew, M.5    Isaacson, S.6    Keywood, C.7    Rascol, O.8
  • 150
    • 0034090891 scopus 로고    scopus 로고
    • AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys
    • Konitsiotis S, Blanchet PJ, Verhagen L, Lamers E, Chase TN. AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys. Neurology 2000;54:1589-1595.
    • (2000) Neurology , vol.54 , pp. 1589-1595
    • Konitsiotis, S.1    Blanchet, P.J.2    Verhagen, L.3    Lamers, E.4    Chase, T.N.5
  • 153
    • 84855825060 scopus 로고    scopus 로고
    • Perampanel in Parkinson disease fluctuations: A double-blind randomized trial with placebo and entacapone
    • Rascol O, Barone P, Behari M, et al. Perampanel in Parkinson disease fluctuations: a double-blind randomized trial with placebo and entacapone. Clinical neuropharmacology 2012;35:15-20.
    • (2012) Clinical Neuropharmacology , vol.35 , pp. 15-20
    • Rascol, O.1    Barone, P.2    Behari, M.3
  • 154
    • 0042474326 scopus 로고    scopus 로고
    • Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease
    • Savola JM, Hill M, Engstrom M, et al. Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson’s disease. Movement disorders: official journal of the Movement Disorder Society2003;18:872-883.
    • (2003) Movement Disorders: Official journal of the Movement Disorder Society , vol.18 , pp. 872-883
    • Savola, J.M.1    Hill, M.2    Engstrom, M.3
  • 155
    • 84866249555 scopus 로고    scopus 로고
    • Randomized clinical trial of fipamezole for dyskinesia in Parkinson disease (FJORD study)
    • Lewitt PA, Hauser RA, Lu M, et al. Randomized clinical trial of fipamezole for dyskinesia in Parkinson disease (FJORD study). Neurology2012;79:163-169.
    • (2012) Neurology , vol.79 , pp. 163-169
    • Lewitt, P.A.1    Hauser, R.A.2    Lu, M.3
  • 159
    • 72849153132 scopus 로고    scopus 로고
    • The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: An in vivo microdialysis study in 6-hydroxydopamine-lesioned rats
    • Buck K, Voehringer P, Ferger B. The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats. Journal of neurochemistry 2010;112:444-452.
    • (2010) Journal of neurochemistry , vol.112 , pp. 444-452
    • Buck, K.1    Voehringer, P.2    Ferger, B.3
  • 160
    • 77956424883 scopus 로고    scopus 로고
    • Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders
    • Hodgson RA, Bedard PJ, Varty GB, et al. Preladenant, a selective A(2A) receptor antagonist, is active in primate models of movement disorders. Experimental neurology 2010;225:384-390.
    • (2010) Experimental Neurology , vol.225 , pp. 384-390
    • Hodgson, R.A.1    Bedard, P.J.2    Varty, G.B.3
  • 161
    • 79951720949 scopus 로고    scopus 로고
    • Preladenant in patients with Parkinson’s disease and motor fluctuations: A phase 2, double-blind, randomised trial
    • Hauser RA, Cantillon M, Pourcher E, et al. Preladenant in patients with Parkinson’s disease and motor fluctuations: a phase 2, double-blind, randomised trial. Lancet neurology 2011;10:221-229.
    • (2011) Lancet Neurology , vol.10 , pp. 221-229
    • Hauser, R.A.1    Cantillon, M.2    Pourcher, E.3
  • 163
    • 0035888262 scopus 로고    scopus 로고
    • Presynaptic localisation of the nicotinic acetylcholine receptor beta2 subunit immunoreactivity in rat nigrostriatal dopaminergic neurones
    • Jones IW, Bolam JP, Wonnacott S. Presynaptic localisation of the nicotinic acetylcholine receptor beta2 subunit immunoreactivity in rat nigrostriatal dopaminergic neurones. The Journal ofcomparative neurology 2001;439:235-247.
    • (2001) The Journal ofcomparative neurology , vol.439 , pp. 235-247
    • Jones, I.W.1    Bolam, J.P.2    Wonnacott, S.3
  • 164
    • 1042299831 scopus 로고    scopus 로고
    • Clozapine improves dyskinesias in Parkinson disease: A doubleblind, placebo-controlled study
    • Durif F, Debilly B, Galitzky M, et al. Clozapine improves dyskinesias in Parkinson disease: a doubleblind, placebo-controlled study. Neurology2004;62:381-388.
    • (2004) Neurology , vol.62 , pp. 381-388
    • Durif, F.1    Debilly, B.2    Galitzky, M.3
  • 167
    • 67651149481 scopus 로고    scopus 로고
    • Aripiprazole in L-dopa-induced dyskinesias: A one-year open-label pilot study
    • Meco G, Stirpe P, Edito F, et al. Aripiprazole in L-dopa-induced dyskinesias: a one-year open-label pilot study. Journal of neural transmission2009;116:881-884.
    • (2009) Journal of Neural Transmission , vol.116 , pp. 881-884
    • Meco, G.1    Stirpe, P.2    Edito, F.3
  • 168
    • 84860377625 scopus 로고    scopus 로고
    • Pardoprunox as adjunct therapy to levodopa in patients with Parkinson’s disease experiencing motor fluctuations: Results of a double-blind, randomized, placebocontrolled, trial
    • Rascol O, Bronzova J, Hauser RA, et al. Pardoprunox as adjunct therapy to levodopa in patients with Parkinson’s disease experiencing motor fluctuations: results of a double-blind, randomized, placebocontrolled, trial. Parkinsonism & related disorders2012;18:370-376.
    • (2012) Parkinsonism & Related Disorders , vol.18 , pp. 370-376
    • Rascol, O.1    Bronzova, J.2    Hauser, R.A.3
  • 169
    • 65449137170 scopus 로고    scopus 로고
    • Safety and tolerability of pardoprunox, a new partial dopamine agonist, in a randomized, controlled study of patients with advanced Parkinson’s disease
    • Hauser RA, Bronzova J, Sampaio C, et al. Safety and tolerability of pardoprunox, a new partial dopamine agonist, in a randomized, controlled study of patients with advanced Parkinson’s disease. European neurology 2009;62:40-48.
    • (2009) European neurology , vol.62 , pp. 40-48
    • Hauser, R.A.1    Bronzova, J.2    Sampaio, C.3
  • 171
    • 15844386001 scopus 로고    scopus 로고
    • Rasagiline as an adjunct to levodopa in patients with Parkinson’s disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): A randomised, double-blind, parallelgroup trial
    • Rascol O, Brooks DJ, Melamed E, et al. Rasagiline as an adjunct to levodopa in patients with Parkinson’s disease and motor fluctuations (LARGO, Lasting effect in Adjunct therapy with Rasagiline Given Once daily, study): a randomised, double-blind, parallelgroup trial. Lancet 2005;365:947-954.
    • (2005) Lancet , vol.365 , pp. 947-954
    • Rascol, O.1    Brooks, D.J.2    Melamed, E.3
  • 172
    • 84855957418 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson’s disease patients
    • Stocchi F, Borgohain R, Onofrj M, et al. A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson’s disease patients. Movement disorders: official journal of the Movement Disorder Society2012;27:106-112.
    • (2012) Movement disorders: Official Journal of the Movement Disorder Society , vol.27 , pp. 106-112
    • Stocchi, F.1    Borgohain, R.2    Onofrj, M.3
  • 173
    • 20844441058 scopus 로고    scopus 로고
    • Cannabis for dyskinesia in Parkinson disease: A randomized double-blind crossover study
    • Carroll CB, Bain PG, Teare L, et al. Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study. Neurology2004;63:1245-1250.
    • (2004) Neurology , vol.63 , pp. 1245-1250
    • Carroll, C.B.1    Bain, P.G.2    Teare, L.3
  • 174
  • 175
    • 84901014445 scopus 로고    scopus 로고
    • Surgical treatment of dyskinesia in Parkinson’s disease
    • Munhoz RP, Cerasa A, Okun MS. Surgical treatment of dyskinesia in Parkinson’s disease. Frontiers in neurology 2014;5:65.
    • (2014) Frontiers in neurology , vol.5 , pp. 65
    • Munhoz, R.P.1    Cerasa, A.2    Okun, M.S.3
  • 176
    • 0035960120 scopus 로고    scopus 로고
    • Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s disease
    • Deep-Brain Stimulation for Parkinson’s Disease Study G. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson’s disease. The New England journal of medicine 2001;345:956-963.
    • (2001) The New England Journal of medicine , vol.345 , pp. 956-963
  • 177
    • 26044468127 scopus 로고    scopus 로고
    • Bilateral deep brain stimulation in Parkinson’s disease: A multicentre study with 4 years follow-up
    • Rodriguez-Oroz MC, Obeso JA, Lang AE, et al. Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain: a journal of neurology 2005;128:2240-2249.
    • (2005) Brain: A Journal of Neurology , vol.128 , pp. 2240-2249
    • Rodriguez-Oroz, M.C.1    Obeso, J.A.2    Lang, A.E.3
  • 178
    • 2542571133 scopus 로고    scopus 로고
    • Schnitzler A, Freund HJ. Long-term results of bilateral pallidal stimulation in Parkinson’s disease
    • Volkmann J, Allert N, Voges J, Sturm V, Schnitzler A, Freund HJ. Long-term results of bilateral pallidal stimulation in Parkinson’s disease. Annals of neurology 2004;55:871-875.
    • (2004) Annals of neurology , vol.55 , pp. 871-875
    • Volkmann, J.1    Allert, N.2    Voges, J.3    Sturm, V.4
  • 179
    • 0242658923 scopus 로고    scopus 로고
    • Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. The
    • Krack P, Batir A, Van Blercom N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. The New England journal of medicine2003;349:1925-1934.
    • (2003) New England Journal of Medicine , vol.349 , pp. 1925-1934
    • Krack, P.1    Batir, A.2    Van Blercom, N.3
  • 182
    • 84870831762 scopus 로고    scopus 로고
    • Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): A randomised controlled trial
    • Odekerken VJ, van Laar T, Staal MJ, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease (NSTAPS study): a randomised controlled trial. Lancet neurology 2013;12:37-44.
    • (2013) Lancet Neurology , vol.12 , pp. 37-44
    • Odekerken, V.J.1    Van Laar, T.2    Staal, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.