l-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases

Neuroscience Letters

Volumn 398, Issue 3, 2006, Pages 211-214

  Napolitano, Maddalena ^a   Picconi, Barbara ^b   Centonze, Diego ^b,c   Bernardi, Giorgio ^b,c   Calabresi, Paolo ^b,d   Gulino, Alberto ^a,e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d UNIVERSITY OF PERUGIA   (Italy)

^e IRCCS NEUROMED   (Italy)

Author keywords

6 Hydroxydopamine; Dopamine; Glutamate; Lyn and Src kinases; Protein kinase C

Indexed keywords

DOPAMINE; GLUTAMIC ACID; LEVODOPA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; OXIDOPAMINE; PROTEIN KINASE C; PROTEIN KINASE LYN; RECEPTOR SUBUNIT; STEROID RECEPTOR COACTIVATOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCLING BEHAVIOR; CONTROLLED STUDY; DENERVATION; DRUG EFFECT; GENE EXPRESSION; MALE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPTIC TRANSMISSION;

ANIMALS; ANTIPARKINSON AGENTS; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; LEVODOPA; MALE; OXIDOPAMINE; PARKINSON DISEASE, SECONDARY; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SRC-FAMILY KINASES; TIME FACTORS;

EID: 33646375464     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.12.077     Document Type: Article

References (18)

1. Ali D.W., and Salter M.W. NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr. Opin. Neurobiol. 11 (2001) 336-342
2. Calabresi P., Centonze D., and Bernardi G. Electrophysiology of dopamine in normal and denervated striatal neurons. Trends Neurosci. 23 (2000) S57-S63
3. Centonze D., Gubellini P., Picconi B., Calabresi P., Giacomini P., and Bernardi G. Unilateral dopamine denervation blocks corticostriatal LTP. J. Neurophysiol. 8 (1999) 3575-3579
4. Dunah A.W., Wang Y., Yasuda R.P., Kameyama K., Huganir R.L., Wolfe B.B., and Standaert D.G. Alterations in subunit expression, composition, and phosphorylation of striatal N-methyl-d-aspartate glutamate receptors in a rat 6-hydroxydopamine model of Parkinson's disease. Mol. Pharmacol. 57 (2000) 342-352
5. Ferrario J.E., Tavarini I.R.E., Mourlevat S., Steafno A., Delfino M.A., raisman-Vozari R., Murer M.G., Ruberg M., and Gershanik O. Differential gene expression induced by chronic levodopa treatment in the striatum of rats with lesions of the nigrostriatal system. J. Neurochem. 90 (2004) 1348-1358
6. Grunblatt E., Mandel S., Jacob-Hirsh J., Zeligson S., Amariglo N., Rechavi G., Li J., Ravid R., Roggendorf W., Riederer P., and Youdim M.B. Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes. J. Neural. Transm. 111 (2004) 1543-1573
7. Hayashi T., Umemori H., Mishina M., and Yamamoto T. The AMPA receptor interacts with the signals through the protein tyrosine kinase Lyn. Nature 397 (1999) 72-76
8. Konradi C., Westin E.J., Carta M., Eaton E.M., Kuter K., Dekundy A., Lunblad M., and Cenci M.A. Transcriptome analysis in a rat model of l-DOPA-induced dyskinesia. Neurobiol. Dis. 17 (2004) 219-236
9. Kuo W.L., Chung K.C., and Rosner M.R. Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src. Mol. Cell. Biol. 17 (1997) 4633-4643
10. Lang A.P., and Lozano A.E. Parkinson's disease. N. Engl. J. Med. 339 (1998) 1044-1053
11. Napolitano M., Centonze D., Calce A., Picconi B., Spiezia S., Gulino A., Bernardi G., and Calabresi P. Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum. Neurobiol. Dis. (2002) 387-395
12. Obeso J.A., Olanow C.W., and Nutt J.G. Levodopa motor complications in Parkinson's disease. Trends Neurosci. (2000) S2-S7
13. Oh J.D., Russel D., Vaughan C.L., and Chase T.N. Enhanced tyrosine phosphorylation of striatal NMDA receptor subunits: Effect of dopaminergic denervation and l-DOPA administration. Brain Res. 812 (1998) 150-159
14. Picconi B., Centonze D., Hakansson K., Bernardi G., Greengard P., Fisone G., Cenci M.A., and Calabresi P. Loss of bidirectional striatal synaptic plasticity in l-DOPA-induced dyskinesia. Nat. Neurosci. 6 (2003) 501-506
15. Schmidt R.H., Ingvar M., Lindvall O., Stenevi U., and Bjorklund A. Functional activity of substantia nigra grafts reinnervating the striatum: neurotransmitter metabolism and [14C]2-deoxy-d-glucose autoradiography. J. Neurochem. 38 (1982) 737-748
16. Tingley W.G., Ehlers M.D., Kameyama K., Doherty C., Ptak J.B., Riley C.T., and Huganir R.L. Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-d-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J. Biol. Chem. 272 (1997) 5157-5166
17. Umemori H., Ogura H., Tozawa N., Mikoshiba K., Nishizumi H., and Yamamoto T. Impairment of N-methyl-d-aspartate receptor-controlled motor activity in LYN-deficient mice. Neuroscience 118 (2003) 709-713
18. Wang Y.T., and Salter M.W. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369 (1994) 233-235