Memantine for axial signs in Parkinson's disease: A randomised, double-blind, placebo-controlled pilot study

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 84, Issue 5, 2013, Pages 552-555

  Moreau, Caroline ^a   Delval, Arnaud ^a   Tiffreau, Vincent ^a   Defebvre, Luc ^a   Dujardin, Kathy ^a   Duhamel, Alain ^a   Petyt, Gregory ^a   Hossein Foucher, Claude ^a   Blum, David ^a   Sablonnière, Bernard ^a   Schraen, Susanna ^a   Allorge, Delphine ^a   Destée, Alain ^a   Bordet, Régis ^a   Devos, David ^a  

^a UNIV LILLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

LEVODOPA; MEMANTINE; PLACEBO;

ADULT; AGED; ALOPECIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DYNAMOMETRY; DYSKINESIA; DYSKINESIA RATING SCALE; GAIT; GAIT DISORDER; HUMAN; MORNING DOSAGE; MUSCLE HYPERTONIA; MUSCLE STRENGTH; PARKINSON DISEASE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCORING SYSTEM; STRIDE LENGTH; UNIFIED PARKINSON DISEASE RATING SCALE;

EID: 84876100906     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2012-303182     Document Type: Article

References (15)

1. Bloem BR, Grimbergen YA, Cramer M, et al. Prospective assessment of falls in Parkinson's disease. J Neurol 2001;248:950-8. (Pubitemid 36124720)
2. Rodriguez MC, Obeso JA, Olanow CW. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Ann Neurol 1998;44(3 Suppl 1):S175-88. (Pubitemid 28423846)
3. Carroll CB, Holloway V, Brotchie JM, et al. Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms. Psychopharmacology (Berl) 1995;119:55-65.
4. Pahapill PA, Lozano AM. The pedunculopontine nucleus and Parkinson's disease. Brain 2000;123:1767-83. (Pubitemid 30664282)
5. Steiniger B, Kretschmer BD. Effects of ibotenate pedunculopontine tegmental nucleus lesions on exploratory behaviour in the open field. Behav Brain Res 2004;151:17-23. (Pubitemid 38501424)
6. Johnson JW, Kotermanski SE. Mechanism of action of memantine. Curr Opin Pharmacol 2006;6:61-7. (Pubitemid 43103820)
7. Kucheryanu VG, Kryzhanovskii GN. Effect of glutamate and antagonists of N-methyl-D-aspartate receptors on experimental parkinsonian syndrome in rats. Bull Exp Biol Med 2000;130:629-32. (Pubitemid 32000370)
8. Skuza G, Rogoz Z, Quack G, et al. Memantine, amantadine, and L-deprenyl potentiate the action of L-dopa in monoamine-depleted rats. J Neural Transm Gen Sect 1994;98:57-67.
9. Gibb WR, Lees AJ. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J Neurol Neurosurg Psychiatry 1988;51:745-52.
10. Pang MY, Mak MK. Trunk muscle strength, but not trunk rigidity, is independently associated with bone mineral density of the lumbar spine in patients with Parkinson's disease. Mov Disord 2009;24:1176-82.
11. Devos D, Krystkowiak P, Clement F, et al. Improvement of gait by chronic, high doses of methylphenidate in patients with advanced Parkinson's disease. J Neurol Neurosurg Psychiatry 2007;78:470-5. (Pubitemid 46662893)
12. Fischer PA, Jacobi P, Schneider E, et al. Effects of intravenous administration of memantine in parkinsonian patients (author's transl). Arzneimittelforschung 1977;27:1487-9. (Pubitemid 8128463)
13. Schneider E, Fischer PA, Clemens R, et al. Effects of oral memantine administration on Parkinson symptoms. Results of a placebo-controlled multicenter study. Dtsch Med Wochenschr 1984;109:987-90.
14. Rabey JM, Nissipeanu P, Korczyn AD. Efficacy of memantine, an NMDA receptor antagonist, in the treatment of Parkinson's disease. J Neural Transm Park Dis Dement Sect 1992;4:277-82.
15. Merello M, Nouzeilles MI, Cammarota A, et al. Effect of memantine (NMDA antagonist) on Parkinson's disease: a double-blind crossover randomized study. Clin Neuropharmacol 1999;22:273-6. (Pubitemid 29506396)