메뉴 건너뛰기




Volumn 53, Issue 1, 2016, Pages 83-94

Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway

Author keywords

Autophagy; Beclin 1; JNK; Neuroprotection; Parkinson s disease; asarone

Indexed keywords

3 METHYLADENINE; 3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; ALPHA SYNUCLEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BECLIN 1; BETA ASARONE; HOMOVANILLIC ACID; NEUROTRANSMITTER; OXIDOPAMINE; PROTEIN BCL 2; PROTEIN P62; RAPAMYCIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TYROSINE 3 MONOOXYGENASE; ANISOLE DERIVATIVE; APOPTOSIS REGULATORY PROTEIN; ASARONE; BECN1 PROTEIN, RAT; DOPAMINE; NEUROPROTECTIVE AGENT;

EID: 84953367411     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8950-z     Document Type: Article
Times cited : (62)

References (52)
  • 1
    • 0142125350 scopus 로고    scopus 로고
    • New insights into Parkinson’s disease
    • Chung KK, Dawson VL, Dawson TM (2003) New insights into Parkinson’s disease. J Neurol 250:15–24
    • (2003) J Neurol , vol.250 , pp. 15-24
    • Chung, K.K.1    Dawson, V.L.2    Dawson, T.M.3
  • 2
    • 78650824020 scopus 로고    scopus 로고
    • Parkinson’s disease involves autophagy and abnormal distribution of cathepsin L
    • Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z (2011) Parkinson’s disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett 489:62–67
    • (2011) Neurosci Lett , vol.489 , pp. 62-67
    • Li, L.1    Wang, X.2    Fei, X.3    Xia, L.4    Qin, Z.5    Liang, Z.6
  • 3
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305:1292–1295
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 4
    • 84899437700 scopus 로고    scopus 로고
    • Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2
    • Trenti A, Grumati P, Cusinato F, Orso G, Bonaldo P, Trevisi L (2014) Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2. Biochem Pharmacol 89:197–209
    • (2014) Biochem Pharmacol , vol.89 , pp. 197-209
    • Trenti, A.1    Grumati, P.2    Cusinato, F.3    Orso, G.4    Bonaldo, P.5    Trevisi, L.6
  • 6
    • 84867475229 scopus 로고    scopus 로고
    • Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway
    • Castro-Caldas M, Carvalho AN, Rodrigues E, Henderson C, Wolf CR, Gama MJ (2012) Glutathione S-transferase pi mediates MPTP-induced c-Jun N-terminal kinase activation in the nigrostriatal pathway. Mol Neurobiol 45:466–477
    • (2012) Mol Neurobiol , vol.45 , pp. 466-477
    • Castro-Caldas, M.1    Carvalho, A.N.2    Rodrigues, E.3    Henderson, C.4    Wolf, C.R.5    Gama, M.J.6
  • 7
    • 84872356254 scopus 로고    scopus 로고
    • Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo
    • Chambers JW, Howard S, LoGrasso PV (2013) Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo. J Biol Chem 288:1079–1087
    • (2013) J Biol Chem , vol.288 , pp. 1079-1087
    • Chambers, J.W.1    Howard, S.2    LoGrasso, P.V.3
  • 9
    • 75949126311 scopus 로고    scopus 로고
    • Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway
    • Pan J, Qian J, Zhang Y, Ma J, Wang G, Xiao Q, Chen S, Ding J (2010) Small peptide inhibitor of JNKs protects against MPTP-induced nigral dopaminergic injury via inhibiting the JNK-signaling pathway. Lab Invest 90:156–167
    • (2010) Lab Invest , vol.90 , pp. 156-167
    • Pan, J.1    Qian, J.2    Zhang, Y.3    Ma, J.4    Wang, G.5    Xiao, Q.6    Chen, S.7    Ding, J.8
  • 10
    • 79955080679 scopus 로고    scopus 로고
    • JNK inhibition protects dopamine neurons and provides behavioral improvement in a rat 6-hydroxydopamine model of Parkinson’s disease
    • Crocker CE, Khan S, Cameron MD, Robertson HA, Robertson GS, Lograsso P (2011) JNK inhibition protects dopamine neurons and provides behavioral improvement in a rat 6-hydroxydopamine model of Parkinson’s disease. ACS Chem Neurosci 2:207–212
    • (2011) ACS Chem Neurosci , vol.2 , pp. 207-212
    • Crocker, C.E.1    Khan, S.2    Cameron, M.D.3    Robertson, H.A.4    Robertson, G.S.5    Lograsso, P.6
  • 11
    • 84860647087 scopus 로고    scopus 로고
    • Pharmacokinetics of beta-asarone in rabbit blood, hippocampus, cortex, brain stem, thalamus and cerebellum
    • Fang YQ, Shi C, Liu L, Fang RM (2012) Pharmacokinetics of beta-asarone in rabbit blood, hippocampus, cortex, brain stem, thalamus and cerebellum. Pharmazie 67:120–123
    • (2012) Pharmazie , vol.67 , pp. 120-123
    • Fang, Y.Q.1    Shi, C.2    Liu, L.3    Fang, R.M.4
  • 13
    • 77952322271 scopus 로고    scopus 로고
    • Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins
    • Chengchong L, Guihua X, Miaoxian D, Li Z, Jiaming L, Gang W, Dejia Z, Rui W, Jicheng L, Yingcai N (2010) Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins. Eur J Pharmacol 635:96–102
    • (2010) Eur J Pharmacol , vol.635 , pp. 96-102
    • Chengchong, L.1    Guihua, X.2    Miaoxian, D.3    Li, Z.4    Jiaming, L.5    Gang, W.6    Dejia, Z.7    Rui, W.8    Jicheng, L.9    Yingcai, N.10
  • 14
    • 77952409566 scopus 로고    scopus 로고
    • Beta-Asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection Rats
    • Yutao G, Chengchong L, Jicheng L, Guihua X, Li Z, Miaoxian D, Xueyan L, Yingcai N (2010) Beta-Asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection Rats. Biol Pharm Bull 33:836–843
    • (2010) Biol Pharm Bull , vol.33 , pp. 836-843
    • Yutao, G.1    Chengchong, L.2    Jicheng, L.3    Guihua, X.4    Li, Z.5    Miaoxian, D.6    Xueyan, L.7    Yingcai, N.8
  • 15
    • 79953304340 scopus 로고    scopus 로고
    • Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells
    • De-Jia Z, Gang W, Ji-Cheng L, Miao-Xian D, Xiao-Ming L, Chun Z, Li Z, Rui W, Ying-Cai N (2011) Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells. Pharmazie 66:45–51
    • (2011) Pharmazie , vol.66 , pp. 45-51
    • De-Jia, Z.1    Gang, W.2    Ji-Cheng, L.3    Miao-Xian, D.4    Xiao-Ming, L.5    Chun, Z.6    Li, Z.7    Rui, W.8    Ying-Cai, N.9
  • 16
    • 84868203556 scopus 로고    scopus 로고
    • Cerebrovascular protection of β-asarone in Alzheimer’s disease rats: a behavioral, cerebral blood flow, biochemical and genic study
    • Zhiqiang L, Guoping Z, Sanqi Q, Zijun Y, Xiaoyin C, Jia C, Chuan C, Xue bing L, Jun G (2012) Cerebrovascular protection of β-asarone in Alzheimer’s disease rats: a behavioral, cerebral blood flow, biochemical and genic study. J Ethnopharmacol 144:305–312
    • (2012) J Ethnopharmacol , vol.144 , pp. 305-312
    • Zhiqiang, L.1    Guoping, Z.2    Sanqi, Q.3    Zijun, Y.4    Xiaoyin, C.5    Jia, C.6    Chuan, C.7    Xue bing, L.8    Jun, G.9
  • 20
    • 84893547450 scopus 로고    scopus 로고
    • Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and Superoxide Dismutase
    • Hennis MR, Seamans KW, Marvin MA, Casey BH, Goldberg MS (2013) Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and Superoxide Dismutase. Plos One 8:e84894
    • (2013) Plos One , vol.8 , pp. 84894
    • Hennis, M.R.1    Seamans, K.W.2    Marvin, M.A.3    Casey, B.H.4    Goldberg, M.S.5
  • 21
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson M, Nikkhah G, Bentlage C, Björklund A (1995) Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15:3863–3875
    • (1995) J Neurosci , vol.15 , pp. 3863-3875
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Björklund, A.4
  • 22
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator
    • West MJ, Slomianka L, Gundersen HJ (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482–497
    • (1991) Anat Rec , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.3
  • 23
    • 4344712684 scopus 로고    scopus 로고
    • Methods for monitoring autophagy
    • Mizushima N (2004) Methods for monitoring autophagy. Int J Biochem Cell Biol 36:2491–2502
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2491-2502
    • Mizushima, N.1
  • 24
    • 84881137863 scopus 로고    scopus 로고
    • Establish a flow cytometric method for quantitative detection of Beclin-1 expression
    • He Y, Mo Z, Xue Z, Fang Y (2013) Establish a flow cytometric method for quantitative detection of Beclin-1 expression. Cytotechnology 65:481–489
    • (2013) Cytotechnology , vol.65 , pp. 481-489
    • He, Y.1    Mo, Z.2    Xue, Z.3    Fang, Y.4
  • 25
    • 84862776587 scopus 로고    scopus 로고
    • Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1
    • Liu L, Fang Y-Q, Xue Z-F, He Y-P, Fang R-M, Li L (2012) Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1. European J Pharmacol 680:34–40
    • (2012) European J Pharmacol , vol.680 , pp. 34-40
    • Liu, L.1    Fang, Y.-Q.2    Xue, Z.-F.3    He, Y.-P.4    Fang, R.-M.5    Li, L.6
  • 26
    • 64149107612 scopus 로고    scopus 로고
    • Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson’s disease
    • Anastasia A, Torre L, de Erausquin GA, Masco DH (2009) Enriched environment protects the nigrostriatal dopaminergic system and induces astroglial reaction in the 6-OHDA rat model of Parkinson’s disease. J Neurochem 109:755–765
    • (2009) J Neurochem , vol.109 , pp. 755-765
    • Anastasia, A.1    Torre, L.2    de Erausquin, G.A.3    Masco, D.H.4
  • 28
    • 0034287012 scopus 로고    scopus 로고
    • Functional changes of the basal ganglia circuitry in Parkinson’s disease
    • Blandini F, Nappi G, Tassorelli C, Martignoni E (2000) Functional changes of the basal ganglia circuitry in Parkinson’s disease. Prog Neurobiol 62:63–88
    • (2000) Prog Neurobiol , vol.62 , pp. 63-88
    • Blandini, F.1    Nappi, G.2    Tassorelli, C.3    Martignoni, E.4
  • 29
    • 33644813224 scopus 로고    scopus 로고
    • Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats
    • Carta M, Lindgren HS, Lundblad M, Stancampiano R, Fadda F, Cenci MA (2006) Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats. J Neurochem 96:1718–1727
    • (2006) J Neurochem , vol.96 , pp. 1718-1727
    • Carta, M.1    Lindgren, H.S.2    Lundblad, M.3    Stancampiano, R.4    Fadda, F.5    Cenci, M.A.6
  • 30
    • 35348938494 scopus 로고    scopus 로고
    • Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB(1) and TRPV1 receptors
    • Morgese MG, Cassano T, Cuomo V, Giuffrida A (2007) Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson’s disease: role of CB(1) and TRPV1 receptors. Exp Neurol 208:110–119
    • (2007) Exp Neurol , vol.208 , pp. 110-119
    • Morgese, M.G.1    Cassano, T.2    Cuomo, V.3    Giuffrida, A.4
  • 31
  • 33
    • 41549114279 scopus 로고    scopus 로고
    • The role of autophagy- lysosome pathway in neurodegeneration associated with Parkinson’s disease
    • Pan T, Kondo S, Le W, Jankovic J (2008) The role of autophagy- lysosome pathway in neurodegeneration associated with Parkinson’s disease. Brain 131:1969–1978
    • (2008) Brain , vol.131 , pp. 1969-1978
    • Pan, T.1    Kondo, S.2    Le, W.3    Jankovic, J.4
  • 34
    • 53049098471 scopus 로고    scopus 로고
    • Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells
    • Vogiatzi T, Xilouri M, Vekrellis K, Stefanis L (2008) Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem 283:23542–23556
    • (2008) J Biol Chem , vol.283 , pp. 23542-23556
    • Vogiatzi, T.1    Xilouri, M.2    Vekrellis, K.3    Stefanis, L.4
  • 35
    • 67649399288 scopus 로고    scopus 로고
    • Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
    • Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT (2009) Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 284:13843–13855
    • (2009) J Biol Chem , vol.284 , pp. 13843-13855
    • Dagda, R.K.1    Cherra, S.J.2    Kulich, S.M.3    Tandon, A.4    Park, D.5    Chu, C.T.6
  • 38
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar S, Davies JE, Huang Z, Tunnacliffe A, Rubinsztein DC (2007) Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J Biol Chem 282:5641–5652
    • (2007) J Biol Chem , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 39
    • 33750292972 scopus 로고    scopus 로고
    • Cell death in the nervous system
    • Bredesen DE, Rao RV, Mehlen P (2006) Cell death in the nervous system. Nature 443:796–802
    • (2006) Nature , vol.443 , pp. 796-802
    • Bredesen, D.E.1    Rao, R.V.2    Mehlen, P.3
  • 40
    • 65849127844 scopus 로고    scopus 로고
    • Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    • Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L (2009) Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. Plos One 4:e5515
    • (2009) Plos One , vol.4 , pp. 5515
    • Xilouri, M.1    Vogiatzi, T.2    Vekrellis, K.3    Park, D.4    Stefanis, L.5
  • 41
    • 70349637955 scopus 로고    scopus 로고
    • The complexity in regulation of MEF2D by chaperone-mediated autophagy
    • Yang Q, Mao Z (2009) The complexity in regulation of MEF2D by chaperone-mediated autophagy. Autophagy 5:1073–1074
    • (2009) Autophagy , vol.5 , pp. 1073-1074
    • Yang, Q.1    Mao, Z.2
  • 43
    • 0035964358 scopus 로고    scopus 로고
    • Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson’s disease
    • Xia XG, Harding T, Weller M, Bieneman A, Uney JB, Schulz JB (2001) Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson’s disease. Proc Natl Acad Sci U S A 98:10433–10438
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10433-10438
    • Xia, X.G.1    Harding, T.2    Weller, M.3    Bieneman, A.4    Uney, J.B.5    Schulz, J.B.6
  • 45
    • 0035187383 scopus 로고    scopus 로고
    • Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor
    • Vaudano E, Rosenblad C, Bjorklund A (2001) Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor. Eur J Neurosci 113:1–14
    • (2001) Eur J Neurosci , vol.113 , pp. 1-14
    • Vaudano, E.1    Rosenblad, C.2    Bjorklund, A.3
  • 46
    • 35748946322 scopus 로고    scopus 로고
    • Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase pathway in 6-OHDA-induced rat model of Parkinson disease
    • Pan J, Zhao YX, Wang ZQ, Jin L, Sun ZK, Chen SD (2007) Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase pathway in 6-OHDA-induced rat model of Parkinson disease. Neurosci Lett 428:82–87
    • (2007) Neurosci Lett , vol.428 , pp. 82-87
    • Pan, J.1    Zhao, Y.X.2    Wang, Z.Q.3    Jin, L.4    Sun, Z.K.5    Chen, S.D.6
  • 47
    • 0347717690 scopus 로고    scopus 로고
    • CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine
    • Ganguly A, Oo TF, Rzhetskaya M, Pratt R, Yarygina O, Momoi T, Kholodilov N, Burke RE (2004) CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine. J Neurochem 88:469–480
    • (2004) J Neurochem , vol.88 , pp. 469-480
    • Ganguly, A.1    Oo, T.F.2    Rzhetskaya, M.3    Pratt, R.4    Yarygina, O.5    Momoi, T.6    Kholodilov, N.7    Burke, R.E.8
  • 48
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo Y, Kanzawa T, Sawaya R, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5:726–734
    • (2005) Nat Rev Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 49
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: crosstalk between autophagy and apoptosis
    • Maiuri MC, Zalckvar E, Kimchi A, Kroemer G (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8:741–752
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 50
    • 44949237240 scopus 로고    scopus 로고
    • JNK1 -mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B (2008) JNK1 -mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30:678–688
    • (2008) Mol Cell , vol.30 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 52
    • 64549084052 scopus 로고    scopus 로고
    • Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death
    • Park K-J, Lee S-H, Lee C-H, Jang J-Y, Chung J, Kwon M-H, Kim Y-S (2009) Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death. Biochem Biophys Res Commun 382:726–729
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 726-729
    • Park, K.-J.1    Lee, S.-H.2    Lee, C.-H.3    Jang, J.-Y.4    Chung, J.5    Kwon, M.-H.6    Kim, Y.-S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.