Injury induced c-Jun expression and phosphorylation in the dopaminergic nigral neurons of the rat: Correlation with neuronal death and modulation by glial-cell-line-derived neurotrophic factor

European Journal of Neuroscience

Volumn 13, Issue 1, 2001, Pages 1-14

  Vaudano, Elisabetta ^a,b   Rosenblad, Carl ^a   Björklund, Anders ^a  

^a LUND UNIVERSITY   (Sweden)

^b H LUNDBECK A S   (Denmark)

Author keywords

6 OHDA; c Jun; Excitotoxic lesion; GDNF; Neuronal cell death; Parkinson's disease

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; OXIDOPAMINE; PROTEIN C JUN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; CORRELATION FUNCTION; DOPAMINERGIC NERVE CELL; FEMALE; MALE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; SUBSTANTIA NIGRA;

AGING; ANIMALS; ANIMALS, NEWBORN; BRAIN DISEASES; CELL DEATH; DOPAMINE; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MALE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROTOXINS; OXIDOPAMINE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 0035187383     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2001.01356.x     Document Type: Article

References (59)

1. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay
2. Oncogene jun encodes a sequence-specific transactivator similar to AP-1
3. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor
4. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro
5. Mesencephalic dopaminergic neurones protected by GDNF from axotomy-induced degeneration in the adult brain
6. Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
7. Programmed cell death: Does it play a role in Parkinson's disease?
8. Overexpression of c-jun, junB, or junD affects cell growth differently
9. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurones
10. Evidence of a novel event during neuronal death: Development of competence-to-die in response to cytoplasmic cytochrome C
11. Genetic and metabolic status of NGF-deprived sympathetic neurones saved by an inhibitor of ICE family proteases
12. Transcription factors interactions: Selectors of positive or negative regulation from a single DNA element
13. The role of inducible transcription factors in apoptotic nerve cell death
14. Altered gene expression in neurones during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
15. Ionizing radiation-induced apoptosis is associated with c-Jun expression and c-Jun/AP-1 activation in the developing cerebellum of the rat
16. Radiation-induced apoptosis in developing rats and kainic acid-induced excitotoxicity in adult rats are associated with distinctive morphological and biochemical c-Jun/AP-1 (N) expression
17. A c-Jun dominant negative mutant protects sympathetic neurones against programmed cell death
18. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury
19. The c-jun transcription factor-bipotential mediator of neuronal death, survival and regeneration
20. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
21. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurones in vivo
22. Long term increase in the levels of c-jun mRNA and Jun protein-like immunoreactivity in motor and sensory neurones following axon damage
23. Expression of c-Jun as a response to dorsal root and peripheral nerve section in damaged and adjacent intact primary sensory neurones in the rat
24. Defective induction of Jun and Fos-related proteins in phorbol ester resistant EL4 mouse thymoma cells
25. A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture
26. Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and jun D in adult rat dorsal root ganglia in vivo
27. Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
28. Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurones
29. Dopaminergic neuronal degeneration and motor impairments following lesion by intrastriatal 6-hydroxydopamine in the rat
30. Retrograde degenerative changes in the substantia nigra pars compacta following an excitotoxic lesion of the striatum
31. Effect of striatal lesion with quinolinate on the development of substantia nigra dopaminergic neurones: A quantitative morphological analysis
32. Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurones of the substantia nigra
33. Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation
34. Jun expression is found in neurones located in the vicinity of subacute plaques in patients with multiple sclerosis
35. Glial-derived neurotrophic factor (GDNF) prevents ethanol induced apoptosis and Jun-kinase phosphorylation
36. Cytoarchitectural distribution of calcium binding proteins in midbrain dopaminergic regions of rats and humans
37. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
38. Expression of c-fos, c-jun and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurones of the substantia nigra
39. Intrastriatal glial cell line derived neurotrophic factor promotes sprouting of spared nigrostriatal dopaminergic aferents and induces recovery of function in a rat model of Parkinson's disease
40. Delayed transneuronal death of substantia nigra neurones prevented by gamma-aminobutyric acid agonist
41. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurones in vivo
42. Progressive degeneration of nigrostriatal dopamine neurones following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
43. Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurones following striatal 6-hydroxydopamine lesion
44. Cross-coupling of signal transduction pathways: Zinc finger meets leucine zipper
45. Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurones
46. Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurones
47. Transneuronal degeneration in substantia nigra pars reticulata following striatal excitotoxic injury in adult rat: Time-course, distribution, and morphology of cell death
48. Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function
49. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
50. Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells
51. The effects of a lesion or a peripheral nerve graft on GAP-43 upregulation in the adult rat brain: An in situ hybridization and immunocytochemical study
52. Axonal injury and peripheral nerve grafting in the thalamus and cerebellum of the adult rat: Upregulation of c-Jun and correlation with regenerative potential
53. CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurones
54. Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones
55. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons
56. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurones in a rat model of Parkinson's disease
57. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
58. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the JNK3 gene