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Volumn 9, Issue 3, 2014, Pages 380-387

Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway

Author keywords

Alpha synuclein; autophagy; Corynoxine; mTOR; Parkinson's disease

Indexed keywords

ALKALOID DERIVATIVE; ALPHA SYNUCLEIN; C 13002; CATHEPSIN D; CORYNOXINE; LYSOSOME ENZYME; MAMMALIAN TARGET OF RAPAMYCIN; OXINDOLE; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; ALKALOID; CORYNOXEINE; MTOR PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE;

EID: 84901263861     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-014-9528-2     Document Type: Article
Times cited : (81)

References (38)
  • 1
    • 84870871828 scopus 로고    scopus 로고
    • Expression of human E46K-mutated alpha-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment
    • Cannon JR, Geghman KD, Tapias V, Sew T, DailMK, Li C, Greenamyre JT (2013) Expression of human E46K-mutated alpha-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Exp Neurol 240:44-56
    • (2013) Exp Neurol , vol.240 , pp. 44-56
    • Cannon, J.R.1    Geghman, K.D.2    Tapias, V.3    Sew, T.4    Dail, M.K.5    Li, C.6    Greenamyre, J.T.7
  • 3
    • 33745919520 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • DOI 10.1016/S1474-4422(06)70471-9, PII S1474442206704719
    • de Lau LM, Breteler MM (2006) Epidemiology of Parkinson's disease. Lancet Neurol 5:525-535 (Pubitemid 44262284)
    • (2006) Lancet Neurology , vol.5 , Issue.6 , pp. 525-535
    • De Lau, L.M.1    Breteler, M.M.2
  • 4
    • 84877352565 scopus 로고    scopus 로고
    • Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
    • Febbraro F, Sahin G, Farran A, Soares S, Jensen PH, Kirik D, Romero-Ramos M (2013) Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease. Neurobiol Dis 56C:47-58
    • (2013) Neurobiol Dis , vol.56 C , pp. 47-58
    • Febbraro, F.1    Sahin, G.2    Farran, A.3    Soares, S.4    Jensen, P.H.5    Kirik, D.6    Romero-Ramos, M.7
  • 5
    • 35848965721 scopus 로고    scopus 로고
    • Erratum: Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages (Autophagy)
    • Floto RA, Sarkar S, Perlstein EO, Kampmann B, Schreiber SL, Rubinsztein DC (2007) Small molecule enhancers of rapamycininduced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages. Autophagy 3:620-622 (Pubitemid 350060063)
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 620-622
    • Floto, R.A.1    Sarkar, S.2    Perlstein, E.O.3    Kampmann, B.4    Schreiber, S.L.5    Rubinsztein, D.C.6
  • 9
    • 84871414210 scopus 로고    scopus 로고
    • The many faces of alpha-synuclein: From structure and toxicity to therapeutic target
    • Lashuel HA, Overk CR, Oueslati A,Masliah E (2013) The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14:38-48
    • (2013) Nat Rev Neurosci , vol.14 , pp. 38-48
    • Lashuel, H.A.1    Overk, C.R.2    Oueslati, A.3    Masliah, E.4
  • 10
    • 77955447356 scopus 로고    scopus 로고
    • Clearance of mutant huntingtin
    • Li XJ, Li H, Li S (2010) Clearance of mutant huntingtin. Autophagy 6
    • (2010) Autophagy , vol.6
    • Li, X.J.1    Li, H.2    Li, S.3
  • 11
    • 0036679197 scopus 로고    scopus 로고
    • alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
    • Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P (2002) alpha-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci 99:10813-10818
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 10813-10818
    • Lo Bianco, C.1    Ridet, J.L.2    Schneider, B.L.3    Deglon, N.4    Aebischer, P.5
  • 13
    • 84863012020 scopus 로고    scopus 로고
    • Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy
    • Lu JH, Tan JQ, Durairajan SS, Liu LF, Zhang ZH, Ma L, ShenHM, Chan HY, Li M (2012) Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy. Autophagy 8:98-108
    • (2012) Autophagy , vol.8 , pp. 98-108
    • Lu, J.H.1    Tan, J.Q.2    Durairajan, S.S.3    Liu, L.F.4    Zhang, Z.H.5    Ma, L.6    Shen, H.M.7    Chan, H.Y.8    Li, M.9
  • 15
    • 75749127850 scopus 로고    scopus 로고
    • Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
    • Malagelada C, Jin ZH, Jackson-Lewis V, Przedborski S, Greene LA (2010) Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 30:1166-1175
    • (2010) J Neurosci , vol.30 , pp. 1166-1175
    • Malagelada, C.1    Jin, Z.H.2    Jackson-Lewis, V.3    Przedborski, S.4    Greene, L.A.5
  • 16
    • 79251551356 scopus 로고    scopus 로고
    • alpha-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies
    • Mizuno H, Fujikake N, Wada K, Nagai Y (2010) alpha-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Parkinsons Dis 2011:212706.
    • (2010) Parkinsons Dis , vol.2011 , pp. 212706
    • Mizuno, H.1    Fujikake, N.2    Wada, K.3    Nagai, Y.4
  • 20
  • 22
    • 37849042536 scopus 로고    scopus 로고
    • A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
    • Sarkar S, Krishna G, Imarisio S, Saiki S, O'Kane CJ, Rubinsztein DC (2008) A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet 17:170-178
    • (2008) Hum Mol Genet , vol.17 , pp. 170-178
    • Sarkar, S.1    Krishna, G.2    Imarisio, S.3    Saiki, S.4    O'Kane, C.J.5    Rubinsztein, D.C.6
  • 23
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • DOI 10.1016/j.devcel.2004.07.009, PII S153458070400245X
    • Scott RC, Schuldiner O, Neufeld TP (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7:167-178 (Pubitemid 39145023)
    • (2004) Developmental Cell , vol.7 , Issue.2 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 25
    • 0037066396 scopus 로고    scopus 로고
    • Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats
    • DOI 10.1016/S0024-3205(02)01534-5, PII S0024320502015345
    • Suk K, Kim SY, Leem K, Kim YO, Park SY, Hur J, Baek J, Lee KJ, Zheng HZ, Kim H (2002) Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats. Life Sci 70:2467-2480 (Pubitemid 34267036)
    • (2002) Life Sciences , vol.70 , Issue.21 , pp. 2467-2480
    • Suk, K.1    Kim, S.Y.2    Leem, K.3    Kim, Y.O.4    Park, S.Y.5    Hur, J.6    Baek, J.7    Lee, K.J.8    Zheng, H.Z.9    Kim, H.10
  • 28
    • 78049231804 scopus 로고    scopus 로고
    • A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
    • Tsvetkov AS, Miller J, Arrasate M, Wong JS, Pleiss MA, Finkbeiner S (2010) A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model. Proc Natl Acad Sci 107:16982-16987
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 16982-16987
    • Tsvetkov, A.S.1    Miller, J.2    Arrasate, M.3    Wong, J.S.4    Pleiss, M.A.5    Finkbeiner, S.6
  • 30
    • 84879232282 scopus 로고    scopus 로고
    • Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
    • Wolfe DM, Lee JH, Kumar A, Lee S, Orenstein SJ, Nixon RA (2013) Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci 37:1949-1961
    • (2013) Eur J Neurosci , vol.37 , pp. 1949-1961
    • Wolfe, D.M.1    Lee, J.H.2    Kumar, A.3    Lee, S.4    Orenstein, S.J.5    Nixon, R.A.6
  • 31
    • 33745845126 scopus 로고    scopus 로고
    • Autophagy contributes to caspase-independent macrophage cell death
    • DOI 10.1074/jbc.M513377200
    • Xu Y, Kim SO, Li Y, Han J (2006) Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 281:19179-19187 (Pubitemid 44035422)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.28 , pp. 19179-19187
    • Xu, Y.1    Sung, O.K.2    Li, Y.3    Han, J.4
  • 32
    • 5444249974 scopus 로고    scopus 로고
    • Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: Resemblance to pathogenetic changes in Parkinson's disease
    • DOI 10.1111/j.1471-4159.2004.02728.x
    • Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H (2004) Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease. J Neurochem 91:451-461 (Pubitemid 39363444)
    • (2004) Journal of Neurochemistry , vol.91 , Issue.2 , pp. 451-461
    • Yamada, M.1    Iwatsubo, T.2    Mizuno, Y.3    Mochizuki, H.4
  • 33
    • 34247211775 scopus 로고    scopus 로고
    • Identification of a Small-Molecule Inhibitor of Class Ia PI3Ks with Cell-Based Screening
    • DOI 10.1016/j.chembiol.2007.02.004, PII S1074552107000713
    • Yang J, Shamji A, Matchacheep S, Schreiber SL (2007) Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening. Chem Biol 14:371-377 (Pubitemid 46617312)
    • (2007) Chemistry and Biology , vol.14 , Issue.4 , pp. 371-377
    • Yang, J.1    Shamji, A.2    Matchacheep, S.3    Schreiber, S.L.4
  • 34
    • 79960566099 scopus 로고    scopus 로고
    • Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism
    • Yelamanchili SV, Chaudhuri AD, Flynn CT, Fox HS (2011) Upregulation of cathepsin D in the caudate nucleus of primates with experimental parkinsonism. Mol Neurodegener 6:52
    • (2011) Mol Neurodegener , vol.6 , pp. 52
    • Yelamanchili, S.V.1    Chaudhuri, A.D.2    Flynn, C.T.3    Fox, H.S.4
  • 36
    • 84865000133 scopus 로고    scopus 로고
    • Pramipexole-related chronic lower limb oedema in a patient with Parkinson's disease
    • Zavala JA, Munhoz RP, Teive HA (2012) Pramipexole-related chronic lower limb oedema in a patient with Parkinson's disease. J Clin Neurosci 19:1298-1299
    • (2012) J Clin Neurosci , vol.19 , pp. 1298-1299
    • Zavala, J.A.1    Munhoz, R.P.2    Teive, H.A.3
  • 37
    • 79953709986 scopus 로고    scopus 로고
    • Targeting the mTOR kinase domain: The second generation of mTOR inhibitors
    • Zhang YJ, Duan Y, Zheng XF (2011) Targeting the mTOR kinase domain: the second generation of mTOR inhibitors. Drug Discov Today 16:325-331
    • (2011) Drug Discov Today , vol.16 , pp. 325-331
    • Zhang, Y.J.1    Duan, Y.2    Zheng, X.F.3
  • 38
    • 48449091227 scopus 로고    scopus 로고
    • Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha
    • Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM (2008) Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell 14:180-192
    • (2008) Cancer Cell , vol.14 , pp. 180-192
    • Zunder, E.R.1    Knight, Z.A.2    Houseman, B.T.3    Apsel, B.4    Shokat, K.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.