Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism

Molecular Neurobiology

Volumn 53, Issue 1, 2016, Pages 472-484

  Wen, Li ^a   Jiang, Keran ^a   Yuan, Wenji ^a   Cui, Wenyan ^a   Li, Ming D ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

CHRNA5 A3 B4; Functional variants; Lung cancer; Nicotine dependence; Nicotinic receptors; SNPs

Indexed keywords

AMFEBUTAMONE; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA5; NICOTINIC RECEPTOR BETA4; UNCLASSIFIED DRUG; VARENICLINE; CHRNA5 PROTEIN, HUMAN; CHRNB4 PROTEIN, HUMAN; NERVE PROTEIN; NICOTINIC RECEPTOR SUBUNIT ALPHA3;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHRNA3 GENE; CHRNA5 GENE; CHRNB4 GENE; CHROMOSOME 15; EXON; GENE CLUSTER; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HABENULA; HUMAN; INTERPEDUNCULAR NUCLEUS; LUNG CANCER; MOLECULAR PATHOLOGY; MUTATION RATE; NICOTINE REPLACEMENT THERAPY; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; SMOKING CESSATION; TOBACCO DEPENDENCE; ANIMAL; EPIDEMIOLOGY; GENETIC ASSOCIATION STUDY; GENETIC VARIATION; GENETICS; MULTIGENE FAMILY; PROCEDURES;

ANIMALS; CHROMOSOMES, HUMAN, PAIR 15; GENETIC ASSOCIATION STUDIES; GENETIC VARIATION; HUMANS; MULTIGENE FAMILY; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; SMOKING;

EID: 84953358326     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8997-x     Document Type: Review

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