메뉴 건너뛰기




Volumn 69, Issue 4, 2011, Pages 618-627

Genetic Vulnerability and Susceptibility to Substance Dependence

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ASPARAGINE; ASPARTIC ACID; CYTOCHROME P450 2A6; DOPAMINE 2 RECEPTOR; MU OPIATE RECEPTOR; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA5; NICOTINIC RECEPTOR ALPHA6; NICOTINIC RECEPTOR BETA3; NICOTINIC RECEPTOR BETA4; UNCLASSIFIED DRUG;

EID: 79951694140     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2011.02.015     Document Type: Review
Times cited : (123)

References (74)
  • 1
    • 0004235298 scopus 로고
    • American Psychiatric Association (APA), American Psychiatric Association, Washington, DC
    • Diagnostic and Statistical Manual of Mental Disorders 1994, American Psychiatric Association (APA), American Psychiatric Association, Washington, DC. Fourth Edition.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 4
    • 33745205621 scopus 로고    scopus 로고
    • Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: A meta-analysis
    • Arias A., Feinn R., Kranzler H.R. Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: A meta-analysis. Drug Alcohol Depend. 2006, 83:262-268.
    • (2006) Drug Alcohol Depend. , vol.83 , pp. 262-268
    • Arias, A.1    Feinn, R.2    Kranzler, H.R.3
  • 6
    • 0031791365 scopus 로고    scopus 로고
    • Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism
    • Bierut L.J., Dinwiddie S.H., Begleiter H., Crowe R.R., Hesselbrock V., Nurnberger J.I., Porjesz B., Schuckit M.A., Reich T. Familial transmission of substance dependence: Alcohol, marijuana, cocaine, and habitual smoking: A report from the Collaborative Study on the Genetics of Alcoholism. Arch. Gen. Psychiatry 1998, 55:982-988.
    • (1998) Arch. Gen. Psychiatry , vol.55 , pp. 982-988
    • Bierut, L.J.1    Dinwiddie, S.H.2    Begleiter, H.3    Crowe, R.R.4    Hesselbrock, V.5    Nurnberger, J.I.6    Porjesz, B.7    Schuckit, M.A.8    Reich, T.9
  • 9
    • 44349132708 scopus 로고    scopus 로고
    • Common and rare variants in multifactorial susceptibility to common diseases
    • Bodmer W., Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat. Genet. 2008, 40:695-701.
    • (2008) Nat. Genet. , vol.40 , pp. 695-701
    • Bodmer, W.1    Bonilla, C.2
  • 10
    • 13144261678 scopus 로고    scopus 로고
    • Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction
    • Bond C., LaForge K.S., Tian M., Melia D., Zhang S., Borg L., Gong J., Schluger J., Strong J.A., Leal S.M., et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc. Natl. Acad. Sci. USA 1998, 95:9608-9613.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9608-9613
    • Bond, C.1    LaForge, K.S.2    Tian, M.3    Melia, D.4    Zhang, S.5    Borg, L.6    Gong, J.7    Schluger, J.8    Strong, J.A.9    Leal, S.M.10
  • 11
    • 0031671199 scopus 로고    scopus 로고
    • Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination
    • Bowen C.A., Grant K.A. Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination. Psychopharmacology (Berl.) 1998, 139:86-94.
    • (1998) Psychopharmacology (Berl.) , vol.139 , pp. 86-94
    • Bowen, C.A.1    Grant, K.A.2
  • 13
    • 77956640415 scopus 로고    scopus 로고
    • Current cigarette smoking among adults aged >18 years-United States, 2009
    • Centers for Disease Control (CDC)
    • Current cigarette smoking among adults aged >18 years-United States, 2009. MMWR Morb. Mortal. Wkly. Rep. 2010, 59:1135-1140. Centers for Disease Control (CDC).
    • (2010) MMWR Morb. Mortal. Wkly. Rep. , vol.59 , pp. 1135-1140
  • 15
    • 34547433163 scopus 로고    scopus 로고
    • The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants
    • Edenberg H.J. The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health 2007, 30:5-13.
    • (2007) Alcohol Res. Health , vol.30 , pp. 5-13
    • Edenberg, H.J.1
  • 17
    • 44649088160 scopus 로고    scopus 로고
    • The role of GABA(A) receptors in the development of alcoholism
    • Enoch M.A. The role of GABA(A) receptors in the development of alcoholism. Pharmacol. Biochem. Behav. 2008, 90:95-104.
    • (2008) Pharmacol. Biochem. Behav. , vol.90 , pp. 95-104
    • Enoch, M.A.1
  • 19
    • 79953246461 scopus 로고    scopus 로고
    • Habenular α5 nicotinic receptor subunit signalling controls nicotine intake
    • in press
    • Fowler C.D., Lu Q., Johnson P.M., Marks M.J., Kenny P.J. Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature 2011, in press.
    • (2011) Nature
    • Fowler, C.D.1    Lu, Q.2    Johnson, P.M.3    Marks, M.J.4    Kenny, P.J.5
  • 20
    • 62549085618 scopus 로고    scopus 로고
    • Human genetic variation and its contribution to complex traits
    • Frazer K.A., Murray S.S., Schork N.J., Topol E.J. Human genetic variation and its contribution to complex traits. Nat. Rev. Genet. 2009, 10:241-251.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 241-251
    • Frazer, K.A.1    Murray, S.S.2    Schork, N.J.3    Topol, E.J.4
  • 22
    • 0019181813 scopus 로고
    • Genetic studies on alcohol-metabolizing enzymes: Detection of isozymes in human hair roots
    • Goedde H.W., Agarwal D.P., Harada S. Genetic studies on alcohol-metabolizing enzymes: Detection of isozymes in human hair roots. Enzyme 1980, 25:281-286.
    • (1980) Enzyme , vol.25 , pp. 281-286
    • Goedde, H.W.1    Agarwal, D.P.2    Harada, S.3
  • 24
    • 1342267138 scopus 로고
    • Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan
    • Harada S., Agarwal D.P., Goedde H.W., Tagaki S., Ishikawa B. Possible protective role against alcoholism for aldehyde dehydrogenase isozyme deficiency in Japan. Lancet 1982, 2:827.
    • (1982) Lancet , vol.2 , pp. 827
    • Harada, S.1    Agarwal, D.P.2    Goedde, H.W.3    Tagaki, S.4    Ishikawa, B.5
  • 26
    • 34347394132 scopus 로고    scopus 로고
    • Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions
    • Hasin D.S., Stinson F.S., Ogburn E., Grant B.F. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry 2007, 64:830-842.
    • (2007) Arch. Gen. Psychiatry , vol.64 , pp. 830-842
    • Hasin, D.S.1    Stinson, F.S.2    Ogburn, E.3    Grant, B.F.4
  • 28
    • 79951692985 scopus 로고    scopus 로고
    • A catalog of published genome-wide association studies.
    • Hindorff, L.A., Junkins, H.A., Hall, P.N., Mehta, J.P., and Manolio, T.A. (2010). A catalog of published genome-wide association studies. http://www.genome.gov/gwastudies.
    • (2010)
    • Hindorff, L.A.1    Junkins, H.A.2    Hall, P.N.3    Mehta, J.P.4    Manolio, T.A.5
  • 32
    • 0141567810 scopus 로고    scopus 로고
    • The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women
    • Kendler K.S., Prescott C.A., Myers J., Neale M.C. The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Arch. Gen. Psychiatry 2003, 60:929-937.
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 929-937
    • Kendler, K.S.1    Prescott, C.A.2    Myers, J.3    Neale, M.C.4
  • 34
    • 78651336831 scopus 로고    scopus 로고
    • Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)2α5 AChR function
    • Kuryatov A., Berrettini W., Lindstrom J. Acetylcholine receptor (AChR) α5 subunit variant associated with risk for nicotine dependence and lung cancer reduces (α4β2)2α5 AChR function. Mol. Pharmacol. 2011, 79:119-125.
    • (2011) Mol. Pharmacol. , vol.79 , pp. 119-125
    • Kuryatov, A.1    Berrettini, W.2    Lindstrom, J.3
  • 35
    • 61449155496 scopus 로고    scopus 로고
    • Genetics of dopamine receptors and drug addiction: A comprehensive review
    • Le Foll B., Gallo A., Le Strat Y., Lu L., Gorwood P. Genetics of dopamine receptors and drug addiction: A comprehensive review. Behav. Pharmacol. 2009, 20:1-17.
    • (2009) Behav. Pharmacol. , vol.20 , pp. 1-17
    • Le Foll, B.1    Gallo, A.2    Le Strat, Y.3    Lu, L.4    Gorwood, P.5
  • 36
    • 56449101208 scopus 로고    scopus 로고
    • Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine
    • Le Marchand L., Derby K.S., Murphy S.E., Hecht S.S., Hatsukami D., Carmella S.G., Tiirikainen M., Wang H. Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. Cancer Res. 2008, 68:9137-9140.
    • (2008) Cancer Res. , vol.68 , pp. 9137-9140
    • Le Marchand, L.1    Derby, K.S.2    Murphy, S.E.3    Hecht, S.S.4    Hatsukami, D.5    Carmella, S.G.6    Tiirikainen, M.7    Wang, H.8
  • 37
    • 33645559825 scopus 로고    scopus 로고
    • The genetics of nicotine dependence
    • Li M.D. The genetics of nicotine dependence. Curr. Psychiatry Rep. 2006, 8:158-164.
    • (2006) Curr. Psychiatry Rep. , vol.8 , pp. 158-164
    • Li, M.D.1
  • 42
    • 33750531834 scopus 로고    scopus 로고
    • CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking
    • Malaiyandi V., Goodz S.D., Sellers E.M., Tyndale R.F. CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiol. Biomarkers Prev. 2006, 15:1812-1819.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 1812-1819
    • Malaiyandi, V.1    Goodz, S.D.2    Sellers, E.M.3    Tyndale, R.F.4
  • 45
    • 1542347858 scopus 로고    scopus 로고
    • Actual causes of death in the United States, 2000
    • Mokdad A.H., Marks J.S., Stroup D.F., Gerberding J.L. Actual causes of death in the United States, 2000. JAMA 2004, 291:1238-1245.
    • (2004) JAMA , vol.291 , pp. 1238-1245
    • Mokdad, A.H.1    Marks, J.S.2    Stroup, D.F.3    Gerberding, J.L.4
  • 49
    • 63449101907 scopus 로고    scopus 로고
    • A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci
    • Pillai S.G., Ge D., Zhu G., Kong X., Shianna K.V., Need A.C., Feng S., Hersh C.P., Bakke P., Gulsvik A., et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci. PLoS Genet. 2009, 5:e1000421.
    • (2009) PLoS Genet. , vol.5
    • Pillai, S.G.1    Ge, D.2    Zhu, G.3    Kong, X.4    Shianna, K.V.5    Need, A.C.6    Feng, S.7    Hersh, C.P.8    Bakke, P.9    Gulsvik, A.10
  • 50
    • 70149090145 scopus 로고    scopus 로고
    • The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    • Saccone N.L., Wang J.C., Breslau N., Johnson E.O., Hatsukami D., Saccone S.F., Grucza R.A., Sun L., Duan W., Budde J., et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Res. 2009, 69:6848-6856.
    • (2009) Cancer Res. , vol.69 , pp. 6848-6856
    • Saccone, N.L.1    Wang, J.C.2    Breslau, N.3    Johnson, E.O.4    Hatsukami, D.5    Saccone, S.F.6    Grucza, R.A.7    Sun, L.8    Duan, W.9    Budde, J.10
  • 54
    • 4644255903 scopus 로고    scopus 로고
    • Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
    • Schoedel K.A., Hoffmann E.B., Rao Y., Sellers E.M., Tyndale R.F. Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians. Pharmacogenetics 2004, 14:615-626.
    • (2004) Pharmacogenetics , vol.14 , pp. 615-626
    • Schoedel, K.A.1    Hoffmann, E.B.2    Rao, Y.3    Sellers, E.M.4    Tyndale, R.F.5
  • 55
    • 64549151693 scopus 로고    scopus 로고
    • Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans
    • Sherva R., Rice J.P., Neuman R.J., Rochberg N., Saccone N.L., Bierut L.J. Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans. Alcohol. Clin. Exp. Res. 2009, 33:848-857.
    • (2009) Alcohol. Clin. Exp. Res. , vol.33 , pp. 848-857
    • Sherva, R.1    Rice, J.P.2    Neuman, R.J.3    Rochberg, N.4    Saccone, N.L.5    Bierut, L.J.6
  • 58
    • 77953774727 scopus 로고    scopus 로고
    • Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies
    • Siontis K.C., Patsopoulos N.A., Ioannidis J.P. Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. Eur. J. Hum. Genet. 2010, 18:832-837.
    • (2010) Eur. J. Hum. Genet. , vol.18 , pp. 832-837
    • Siontis, K.C.1    Patsopoulos, N.A.2    Ioannidis, J.P.3
  • 60
    • 0034665139 scopus 로고    scopus 로고
    • Human cytochrome P450 CYP2A13: Predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    • Su T., Bao Z., Zhang Q.Y., Smith T.J., Hong J.Y., Ding X. Human cytochrome P450 CYP2A13: Predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 2000, 60:5074-5079.
    • (2000) Cancer Res. , vol.60 , pp. 5074-5079
    • Su, T.1    Bao, Z.2    Zhang, Q.Y.3    Smith, T.J.4    Hong, J.Y.5    Ding, X.6
  • 61
    • 0005208313 scopus 로고
    • Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes
    • Suzdak P.D., Schwartz R.D., Skolnick P., Paul S.M. Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc. Natl. Acad. Sci. USA 1986, 83:4071-4075.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 4071-4075
    • Suzdak, P.D.1    Schwartz, R.D.2    Skolnick, P.3    Paul, S.M.4
  • 62
    • 78049499923 scopus 로고    scopus 로고
    • Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles
    • Tanaka F., Yamamoto K., Suzuki S., Inoue H., Tsurumaru M., Kajiyama Y., Kato H., Igaki H., Furuta K., Fujita H., et al. Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. Gut 2010, 59:1457-1464.
    • (2010) Gut , vol.59 , pp. 1457-1464
    • Tanaka, F.1    Yamamoto, K.2    Suzuki, S.3    Inoue, H.4    Tsurumaru, M.5    Kajiyama, Y.6    Kato, H.7    Igaki, H.8    Furuta, K.9    Fujita, H.10
  • 63
    • 84855804147 scopus 로고    scopus 로고
    • The National Center on Addiction and Substance Abuse at Columbia University, National Center on Addiction and Substance Abuse at Columbia University, New York
    • Shoveling Up II: The Impact of Substance Abuse on Federal, State and Local Budgets 2009, The National Center on Addiction and Substance Abuse at Columbia University, National Center on Addiction and Substance Abuse at Columbia University, New York.
    • (2009) Shoveling Up II: The Impact of Substance Abuse on Federal, State and Local Budgets
  • 66
    • 77951711343 scopus 로고    scopus 로고
    • Genome-wide meta-analyses identify multiple loci associated with smoking behavior
    • Tobacco and Genetics (TAG) Consortium
    • Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat. Genet. 2010, 42:441-447. Tobacco and Genetics (TAG) Consortium.
    • (2010) Nat. Genet. , vol.42 , pp. 441-447
  • 69
    • 20544452286 scopus 로고    scopus 로고
    • Heritability of smoking initiation and nicotine dependence
    • Vink J.M., Willemsen G., Boomsma D.I. Heritability of smoking initiation and nicotine dependence. Behav. Genet. 2005, 35:397-406.
    • (2005) Behav. Genet. , vol.35 , pp. 397-406
    • Vink, J.M.1    Willemsen, G.2    Boomsma, D.I.3
  • 71
    • 0015526413 scopus 로고
    • Ethnic differences in alcohol sensitivity
    • Wolff P.H. Ethnic differences in alcohol sensitivity. Science 1972, 175:449-450.
    • (1972) Science , vol.175 , pp. 449-450
    • Wolff, P.H.1
  • 72
    • 0003396452 scopus 로고    scopus 로고
    • World Health Organization (WHO), World Health Organization, Geneva
    • Global Status Report on Alcohol 2004 2004, World Health Organization (WHO), World Health Organization, Geneva.
    • (2004) Global Status Report on Alcohol 2004
  • 73
    • 77249123257 scopus 로고    scopus 로고
    • Tobacco Key Facts.
    • World Health Organization (WHO). (2010). Tobacco Key Facts. http://www.who.int/topics/tobacco/facts/en/index.html.
    • (2010) World Health Organization (WHO)
  • 74
    • 0032931833 scopus 로고    scopus 로고
    • Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
    • Yamazaki H., Inoue K., Hashimoto M., Shimada T. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch. Toxicol. 1999, 73:65-70.
    • (1999) Arch. Toxicol. , vol.73 , pp. 65-70
    • Yamazaki, H.1    Inoue, K.2    Hashimoto, M.3    Shimada, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.