Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Haller, Gabe ^a   Li, Ping ^a   Esch, Caroline ^a   Hsu, Simon ^a   Goate, Alison M ^a   Steinbach, Joe Henry ^a  

^a WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NICOTINIC RECEPTOR; ACETYLCHOLINE; CHRNB4 PROTEIN, HUMAN; NERVE PROTEIN; NICOTINE;

ARTICLE; CHRNA3 GENE; CHRNA5 GENE; CHRNA6 GENE; CHRNB3 GENE; CHRNB4 GENE; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; GLYCOSYLATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; RISK REDUCTION; SMOKING; TOBACCO DEPENDENCE; DOSE RESPONSE; DRUG EFFECTS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HEK293 CELL LINE; KIDNEY;

ACETYLCHOLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HEK293 CELLS; HUMANS; KIDNEY; NERVE TISSUE PROTEINS; NICOTINE; RECEPTORS, NICOTINIC; SMOKING; TOBACCO USE DISORDER;

EID: 84900540871     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096753     Document Type: Article

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