Modeling and simulation of anion-exchange membrane chromatography for purification of Sf9 insect cell-derived virus-like particles

Journal of Chromatography A

Volumn 1429, Issue , 2016, Pages 142-154

  Ladd Effio, Christopher ^a   Hahn, Tobias ^a   Seiler, Julia ^a   Oelmeier, Stefan A ^a,b   Asen, Iris ^c   Silberer, Christine ^c   Villain, Louis ^d   Hubbuch, Jürgen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c DIARECT AG   (Germany)

^d SARTORIUS STEDIM BIOTECH GMBH   (Germany)

Author keywords

Downstream processing; High throughput process development; Membrane chromatography; Predictive modeling; Quality by design; Virus like particle vaccine

Indexed keywords

BINS; CHROMATOGRAPHY; DESIGN; DISEASES; ION EXCHANGE; ION EXCHANGE MEMBRANES; IONS; MEMBRANES; PORE SIZE; PROCESS DESIGN; PROCESS ENGINEERING; PROTEINS; RECOMBINANT PROTEINS; THROUGHPUT; VACCINES; VIRUSES;

DOWNSTREAM-PROCESSING; HIGH THROUGHPUT PROCESS DEVELOPMENT; MEMBRANE CHROMATOGRAPHY; PREDICTIVE MODELING; QUALITY BY DESIGNS; VIRUS-LIKE PARTICLES;

PURIFICATION;

INSECT PROTEIN; RECOMBINANT PROTEIN; VIRUS LIKE PARTICLE VACCINE;

ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ANION EXCHANGE MEMBRANE CHROMATOGRAPHY; ARTICLE; DNA DETERMINATION; DOWNSTREAM PROCESSING; HUMAN PARVOVIRUS B19; HYDRODYNAMICS; INSECT CELL; NONHUMAN; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; PRODUCT RECOVERY; PURIFICATION; SPODOPTERA FRUGIPERDA; STOICHIOMETRY; THERMODYNAMICS; VIRUS LIKE AGENT; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETICS; ION EXCHANGE CHROMATOGRAPHY; ISOLATION AND PURIFICATION; PROCEDURES; SF9 CELL LINE; VIROLOGY;

ANIMALS; CHROMATOGRAPHY, ION EXCHANGE; COMPUTER SIMULATION; MODELS, BIOLOGICAL; RECOMBINANT PROTEINS; SF9 CELLS; VACCINES, VIRUS-LIKE PARTICLE; VIROLOGY;

EID: 84953352458     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2015.12.006     Document Type: Article

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