Impact of ligand density on the optimization of ion-exchange membrane chromatography for viral vector purification

Biotechnology and Bioengineering

Volumn 108, Issue 6, 2011, Pages 1347-1359

  Vicente, Tiago ^a,b   Fáber, René ^c   Alves, Paula M ^a,b   Carrondo, Manuel J T ^a,b,d   Mota, José P B ^d  

^a IBET   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c SARTORIUS STEDIM BIOTECH GMBH   (Germany)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Anion exchange membrane chromatography; Ligand density; Surface plasmon resonance; Viral vector

Indexed keywords

ANION EXCHANGE MEMBRANE; CLINICAL APPLICATION; DIETHYLAMINES; DOWNSTREAM PROCESS; EXPERIMENTAL EVIDENCE; GRADIENT ELUTION; HOST CELL PROTEIN; HYDRODYNAMIC PARTICLES; LIGAND DENSITY; MODEL-BASED; OPERATING CONDITION; OVER CURRENT; PROCESS IMPROVEMENT; RATIONAL DESIGN; RESIDUAL CONCENTRATIONS; STANDARD VALUES; STERIC MASS ACTION MODEL; SURFACE PLASMONS; VIRAL VECTOR; VIRAL VECTORS;

CHROMATOGRAPHY; EXPERIMENTS; IONS; LIGANDS; MEMBRANES; PARTICLE SIZE ANALYSIS; PLASMONS; PURIFICATION; SURFACE PLASMON RESONANCE; VECTORS;

ION EXCHANGE;

BACULOVIRUS VECTOR; BOVINE SERUM ALBUMIN; CAPSID PROTEIN; CELL PROTEIN; DIETHYLAMINE; DIETHYLAMINOETHYL CELLULOSE; DNA; DOUBLE STRANDED DNA; GREEN FLUORESCENT PROTEIN; LIGAND;

ADENOVIRUS 5; ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ANION EXCHANGE MEMBRANE CHROMATOGRAPHY; ARTICLE; BACULOVIRUS; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DENSITY; FILTERS AND MEMBRANES; HYDRODYNAMICS; LIGAND BINDING; LIGAND DENSITY; LIGHT SCATTERING; NONHUMAN; PARTICLE SIZE; PROCESS MODEL; PROCESS OPTIMIZATION; SARTOBIND D MEMBRANE; SURFACE PLASMON RESONANCE; VIRUS ATTACHMENT; VIRUS PURIFICATION; VIRUS RECOMBINANT;

ADSORPTION; ANIMALS; ANIONS; BACULOVIRIDAE; CELL LINE; CHROMATOGRAPHY, ION EXCHANGE; COMPUTER SIMULATION; DEAE-CELLULOSE; LIGANDS; MODELS, CHEMICAL; SURFACE PLASMON RESONANCE; SURFACE PROPERTIES;

EID: 79954488461     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.23058     Document Type: Article

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