Application of Box-Behnken design for preparation of levofloxacin-loaded stearic acid solid lipid nanoparticles for ocular delivery: Optimization, in vitro release, ocular tolerance, and antibacterial activity

International Journal of Biological Macromolecules

Volumn 85, Issue , 2016, Pages 258-270

  Baig, Mirza Salman ^a   Ahad, Abdul ^b   Aslam, Mohammed ^a   Imam, Syed Sarim ^c   Aqil, Mohd ^a   Ali, Asgar ^a  

^a HAMDARD UNIVERSITY   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c The Glocbal University   (India)

Author keywords

Antibacterial activity; Box Behnken design; HET CAM; Levofloxacin; Ocular drug delivery; Optimization; SLN; Solid lipid nanoparticles

Indexed keywords

LEVOFLOXACIN; SOLID LIPID NANOPARTICLE; STEARIC ACID; ANTIINFECTIVE AGENT; DRUG CARRIER; EYE DROPS; LIPID; NANOPARTICLE; STEARIC ACID DERIVATIVE;

ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RETENTION; DRUG TOLERABILITY; ESCHERICHIA COLI; EXPERIMENTAL DESIGN; GOAT; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; PROCESS OPTIMIZATION; RISK ASSESSMENT; STAPHYLOCOCCUS AUREUS; X RAY DIFFRACTION; ANIMAL; CHEMISTRY; CHICKEN; DISK DIFFUSION; DRUG EFFECTS; DRUG RELEASE; EYE; METABOLISM; PERMEABILITY; SOLUBILITY; ULTRASTRUCTURE;

ANIMALS; ANTI-BACTERIAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHICKENS; DISK DIFFUSION ANTIMICROBIAL TESTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; DRUG LIBERATION; EYE; LEVOFLOXACIN; LIPIDS; NANOPARTICLES; OPHTHALMIC SOLUTIONS; PARTICLE SIZE; PERMEABILITY; SOLUBILITY; STEARIC ACIDS; X-RAY DIFFRACTION;

EID: 84953312653     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2015.12.077     Document Type: Article

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