Comparison of systemic absorption between ofloxacin ophthalmic in situ gels and ofloxacin conventional ophthalmic solutions administration to rabbit eyes by HPLC-MS/MS

International Journal of Pharmaceutics

Volumn 450, Issue 1-2, 2013, Pages 104-113

  Li, Jiawei ^a,b   Zhao, Hainan ^a,b   Okeke, Chukwunweike Ikechukwu ^a,b   Li, Lin ^a,b   Liu, Zhidong ^a,b   Yin, Zhongpeng ^a,b   Zhuang, Pengwei ^a   Sun, Jingtong ^a,b   Wu, Tao ^c   Wang, Meng ^a,b   Li, Nan ^a,b   Pi, Jiaxin ^a,b   Zhang, Qian ^a,b   Zhang, Rui ^a,b   Ma, Li ^a,b   Pang, Xiaochen ^a,b   Liu, Zhanbiao ^a,b   Zhang, Li ^a,b   Fan, Lili ^a,b  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c Institute of Double Crane   (China)

Author keywords

HPLC MS MS; Ofloxacin; Ophthalmic in situ gel; Systemic absorption

Indexed keywords

EYE DROPS; OFLOXACIN;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG INSTILLATION; DRUG SOLUTION; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OPHTHALMIC DRUG DELIVERY DEVICE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ADMINISTRATION, OPHTHALMIC; ANIMALS; ANTI-BACTERIAL AGENTS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GELS; INJECTIONS, INTRAVENOUS; OFLOXACIN; OPHTHALMIC SOLUTIONS; RABBITS; TANDEM MASS SPECTROMETRY;

EID: 84877647927     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.04.018     Document Type: Article

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