Preparation and in vitro-in vivo evaluation of ofloxacin loaded ophthalmic nano structured lipid carriers modified with chitosan oligosaccharide lactate for the treatment of bacterial keratitis

European Journal of Pharmaceutical Sciences

Volumn 63, Issue , 2014, Pages 204-215

  Üstündaǧ Okur, Neslihan ^a   Gökçe, Evren Homan ^a   Bozbiyik, Duygu Inci ^b   Eǧrilmez, Sait ^a   Özer, Özgen ^a   Ertan, Gökhan ^a  

^a EGE UNIVERSITY   (Turkey)

^b Department of Cardiology   (Turkey)

Author keywords

Bacterial keratitis; Nanostructured lipid carriers; Ocular delivery; Ofloxacin; Topical application

Indexed keywords

ALCOHOL; CHITOSAN DERIVATIVE; CHITOSAN OLIGOSACCHARIDE LACTATE; COSURFACTANT; EYE DROPS; GLYCEROL BEHENATE; LIPID; NANOCARRIER; NANOSTRUCTURED LIPID CARRIER; OFLOXACIN; OLEIC ACID; POLYSORBATE 80; SURFACTANT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CHITOSAN; DRUG CARRIER; LACTIC ACID DERIVATIVE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; AQUEOUS HUMOR; ARTICLE; BACTERIAL KERATITIS; CONTROLLED STUDY; CORNEA; CORNEA OPACITY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG INSTILLATION; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG STABILITY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; EVALUATION STUDY; EX VIVO STUDY; EXPERIMENTAL RABBIT; EYE REDNESS; HIGH SHEAR HOMOGENIZATION METHOD; IN VITRO STUDY; IN VIVO STUDY; LIQUID; MALE; MEAN RESIDENCE TIME; METHODOLOGY; MICROEMULSION; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL; TOPICAL TREATMENT; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; KERATITIS; MICROBIAL SENSITIVITY TEST; RABBIT; STAPHYLOCOCCUS AUREUS; SURFACE PROPERTY;

ANIMALS; ANTI-BACTERIAL AGENTS; CHITOSAN; DRUG CARRIERS; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; KERATITIS; LACTATES; LIPIDS; MALE; MICROBIAL SENSITIVITY TESTS; NANOPARTICLES; OFLOXACIN; PARTICLE SIZE; RABBITS; STAPHYLOCOCCUS AUREUS; SURFACE PROPERTIES; VISCOSITY;

EID: 84907329910     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.07.013     Document Type: Article

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