Design, formulation and optimization of valsartan transdermal gel containing iso-eucalyptol as novel permeation enhancer: Preclinical assessment of pharmacokinetics in Wistar albino rats

Expert Opinion on Drug Delivery

Volumn 11, Issue 8, 2014, Pages 1149-1162

  Ahad, Abdul ^a   Aqil, Mohd ^b   Kohli, Kanchan ^b   Sultana, Yasmin ^b   Mujeeb, Mohd ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Box Behnken design; Iso eucalyptol; Pharmacokinetic; Transdermal and valsartan

Indexed keywords

ALCOHOL; CARBOPOL 940; CINEOLE; ISOEUCALYPTOL; MACROGOL 400; PENETRATION ENHANCING AGENT; POLYMER; UNCLASSIFIED DRUG; VALSARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CADAVER; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG PENETRATION; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PH; PLASMA CONCENTRATION-TIME CURVE; RAT; SKIN PERMEABILITY; SKIN SURFACE; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSDERMAL DRUG ADMINISTRATION; VISCOMETRY; VISCOSITY;

BOX-BEHNKEN DESIGN; ISO-EUCALYPTOL; PHARMACOKINETIC; TRANSDERMAL AND VALSARTAN;

ADMINISTRATION, CUTANEOUS; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CYCLOHEXANOLS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; GELS; HUMANS; MONOTERPENES; RATS; RATS, WISTAR; SKIN; SKIN ABSORPTION; SOLVENTS; TETRAZOLES; VALINE; VISCOSITY;

EID: 84904631044     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.914027     Document Type: Article

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