Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

Cell Reports

Volumn 14, Issue 3, 2016, Pages 572-585

  Saini, Vikram ^a,b   Cumming, Bridgette M ^e   Guidry, Loni ^a   Lamprecht, Dirk A ^e   Adamson, John H ^e   Reddy, Vineel P ^a   Chinta, Krishna C ^a   Mazorodze, James H ^e   Glasgow, Joel N ^a   Richard Greenblatt, Melissa ^c   Gomez Velasco, Anaximandro ^c   Bach, Horacio ^c   Av Gay, Yossef ^c   Eoh, Hyungjin ^d   Rhee, Kyu ^d   Steyn, Adrie J C ^a,b,e,f  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e AFRICA HEALTH RESEARCH INSTITUTE   (South Africa)

^f UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BEDAQUILINE; CLOFAZIMINE; ISONIAZID; MYCOTHIOL; RIFAMPICIN; THIOL DERIVATIVE; THIONEINE; UNCLASSIFIED DRUG; ANTIOXIDANT; BACTERIAL PROTEIN; CARBON; CYSTEINE; GLYCOPEPTIDE; INOSITOL; TRANSCRIPTION FACTOR; TUBERCULOSTATIC AGENT;

ANIMAL TISSUE; ARTICLE; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; BIOENERGY; CARBON METABOLISM; CONTROLLED STUDY; DRUG SENSITIVITY; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOLECULAR DYNAMICS; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; TRANSCRIPTOMICS; ANIMAL; CELL LINE; DISEASE PREDISPOSITION; DRUG EFFECTS; ENERGY METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG; METABOLISM; MICROBIOLOGY; OXIDATION REDUCTION REACTION; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; TANDEM MASS SPECTROMETRY; VIRULENCE;

ANIMALS; ANTIOXIDANTS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CARBON; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; DISEASE SUSCEPTIBILITY; ENERGY METABOLISM; ERGOTHIONEINE; GLYCOPEPTIDES; INOSITOL; LUNG; MACROPHAGES; MICE; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; PRINCIPAL COMPONENT ANALYSIS; TANDEM MASS SPECTROMETRY; TRANSCRIPTION FACTORS; VIRULENCE;

EID: 84953311283     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.12.056     Document Type: Article

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