Glutathione disulfide and S-nitrosoglutathione detoxification by Mycobacterium tuberculosis thioredoxin system

FEBS Letters

Volumn 583, Issue 19, 2009, Pages 3215-3220

  Attarian, Rodgoun ^a   Bennie, Chelsea ^a   Bach, Horacio ^a   Av Gay, Yossef ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Glutathione; Mycobacteria; Mycothiol; S nitrosoglutathione; Thioredoxin; Tuberculosis

Indexed keywords

GLUTATHIONE DISULFIDE; S NITROSOGLUTATHIONE; THIOREDOXIN; THIOREDOXIN C; THIOREDOXIN REDUCTASE B2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ARTICLE; BACTERICIDAL ACTIVITY; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; DRUG DETOXIFICATION; DRUG IDENTIFICATION; HOST; IN VITRO STUDY; INTRACELLULAR SPACE; MICROBIAL METABOLISM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

GLUTATHIONE DISULFIDE; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; S-NITROSOGLUTATHIONE; THIOREDOXIN-DISULFIDE REDUCTASE; THIOREDOXINS;

CORYNEBACTERINEAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 70349470951     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.09.007     Document Type: Article

References (33)

1. WHO. (2007) Tuberculosis Fact Sheet No. 104. In http://www.who.int/mediacentre/factsheets/fs104/en/index.html ed.^eds.
2. Manca C., Paul S., Barry III C.E., Freedman V.H., and Kaplan G. Mycobacterium tuberculosis catalase and peroxidase activities and resistance to oxidative killing in human monocytes in vitro. Infect. Immun. 67 (1999) 74-79
3. Zhang Y., Lathigra R., Garbe T., Catty D., and Young D. Genetic analysis of superoxide dismutase, the 23 kDa antigen of Mycobacterium tuberculosis. Mol. Microbiol. 5 (1991) 381-391
4. Ung K.S., and Av-Gay Y. Mycothiol-dependent mycobacterial response to oxidative stress. FEBS Lett. 580 (2006) 2712-2716
5. Jaeger T., Budde H., Flohe L., Menge U., Singh M., Trujillo M., and Radi R. Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch. Biochem. Biophys. 423 (2004) 182-191
6. Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid. Redox Signal. 2 (2000) 811-820
7. Holmgren A. Thioredoxin. Annu. Rev. Biochem. 54 (1985) 237-271
8. Cole S.T., et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393 (1998) 537-544
9. Zhang Z., Hillas P.J., and Ortiz de Montellano P.R. Reduction of peroxides and dinitrobenzenes by Mycobacterium tuberculosis thioredoxin and thioredoxin reductase. Arch. Biochem. Biophys. 363 (1999) 19-26
10. Chan J., Xing Y., Magliozzo R.S., and Bloom B.R. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 175 (1992) 1111-1122
11. Miller C.C., Rawat M., Johnson T., and Av-Gay Y. Innate protection of Mycobacterium smegmatis against the antimicrobial activity of nitric oxide is provided by mycothiol. Antimicrob. Agents Chemother. 51 (2007) 3364-3366
12. Zahrt T.C., and Deretic V. Reactive nitrogen and oxygen intermediates and bacterial defenses: unusual adaptations in Mycobacterium tuberculosis. Antioxid. Redox Signal. 4 (2002) 141-159
13. Venketaraman V., Dayaram Y.K., Talaue M.T., and Connell N.D. Glutathione and nitrosoglutathione in macrophage defense against Mycobacterium tuberculosis. Infect. Immun. 73 (2005) 1886-1889
14. Dayaram Y.K., Talaue M.T., Connell N.D., and Venketaraman V. Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J. Bacteriol. 188 (2006) 1364-1372
15. Cowley S.C., Babakaiff R., and Av-Gay Y. Expression and localization of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Res. Microbiol. 153 (2002) 233-241
16. Bach, H., Wong, D. and Av-Gay, Y. (2009) Mycobacterium tuberculosis PtkA is a novel protein tyrosine kinase whose substrate is PtpA. Biochem. J.
17. Bach H., Sun J., Hmama Z., and Av-Gay Y. Mycobacterium avium subsp. Paratuberculosis PtpA is an endogenous tyrosine phosphatase secreted during infection. Infect. Immun. 74 (2006) 6540-6546
18. Newton G.L., Av-Gay Y., and Fahey R.C. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry 39 (2000) 10739-10746
19. Holmgren A. Thioredoxin catalyzes the reduction of insulin disulfides by dithiothreitol and dihydrolipoamide. J. Biol. Chem. 254 (1979) 9627-9632
20. Holmgren A. Bovine thioredoxin system. Purification of thioredoxin reductase from calf liver and thymus and studies of its function in disulfide reduction. J. Biol. Chem. 252 (1977) 4600-4606
21. Luthman M., and Holmgren A. Rat liver thioredoxin and thioredoxin reductase: purification and characterization. Biochemistry 21 (1982) 6628-6633
22. Anderberg S.J., Newton G.L., and Fahey R.C. Mycothiol biosynthesis and metabolism. Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol in mycobacterium smegmatis. J. Biol. Chem. 273 (1998) 30391-30397
23. Fisher C.L., and Pei G.K. Modification of a PCR-based site-directed mutagenesis method. Biotechniques 23 (1997) 570-574
24. Holmgren A., and Bjornstedt M. Thioredoxin and thioredoxin reductase. Methods Enzymol. 252 (1995) 199-208
25. Trujillo M., et al. The mycobacterial thioredoxin peroxidase can act as a one-cysteine peroxiredoxin. J. Biol. Chem. 281 (2006) 20555-20566
26. Vogt R.N., Steenkamp D.J., Zheng R., and Blanchard J.S. The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase. Biochem. J. 374 (2003) 657-666
27. Nikitovic D., and Holmgren A. S-nitrosoglutathione is cleaved by the thioredoxin system with liberation of glutathione and redox regulating nitric oxide. J. Biol. Chem. 271 (1996) 19180-19185
28. Stoyanovsky D.A., et al. Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols. J. Am. Chem. Soc. 127 (2005) 15815-15823
29. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu. Rev. Immunol. 15 (1997) 323-350
30. Green R.M., Seth A., and Connell N.D. A peptide permease mutant of Mycobacterium bovis BCG resistant to the toxic peptides glutathione and S-nitrosoglutathione. Infect. Immun. 68 (2000) 429-436
31. Rawat M., and Av-Gay Y. Mycothiol-dependent proteins in actinomycetes. FEMS Microbiol. Rev. 31 (2007) 278-292
32. Kanzok S.M., Schirmer R.H., Turbachova I., Iozef R., and Becker K. The thioredoxin system of the malaria parasite Plasmodium falciparum. Glutathione reduction revisited. J. Biol. Chem. 275 (2000) 40180-40186
33. Patel M.P., and Blanchard J.S. Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase. Biochemistry 38 (1999) 11827-11833