Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 1, 2016, Pages 74-79

  Schwarz, Flavio ^a,b,c,d   Springer, Stevan A ^a,b,d   Altheide, Tasha K ^a,b,c,d   Varki, Nissi M ^a,b,e   Gagneux, Pascal ^a,b,e   Varki, Ajit ^a,b,c,d  

^a San Diego   (United States)

^b University of California San Diego   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; CD33; Cognitive capacity; Postreproductive lifespan; Siglec

Indexed keywords

APOLIPOPROTEIN E; CD33 ANTIGEN; CD33 PROTEIN, HUMAN;

ALLELE; ALTERNATIVE RNA SPLICING; ALZHEIMER DISEASE; ANIMAL; BRAIN; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; EVOLUTION; FERTILITY; GENE LOCUS; GENETIC SELECTION; GENETICS; HUMAN; PAN TROGLODYTES; PATHOPHYSIOLOGY; PHYSIOLOGY; REPRODUCTIVE FITNESS;

ALLELES; ALTERNATIVE SPLICING; ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEINS E; BIOLOGICAL EVOLUTION; BRAIN; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; FERTILITY; GENETIC FITNESS; GENETIC LOCI; HUMANS; PAN TROGLODYTES; SELECTION, GENETIC; SIALIC ACID BINDING IG-LIKE LECTIN 3;

EID: 84953294939     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1517951112     Document Type: Article

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