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Volumn 11, Issue 3, 2015, Pages 157-165

White matter hyperintensities, cognitive impairment and dementia: An update

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; MEMANTINE;

EID: 84924650926     PISSN: 17594758     EISSN: 17594766     Source Type: Journal    
DOI: 10.1038/nrneurol.2015.10     Document Type: Review
Times cited : (864)

References (127)
  • 1
    • 9444268676 scopus 로고    scopus 로고
    • Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people
    • The Cardiovascular Health Study
    • Longstreth, W. T. Jr, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 27, 1274-1282 (1996
    • (1996) Stroke , vol.27 , pp. 1274-1282
    • Longstreth, W.T.1
  • 3
    • 0035960290 scopus 로고    scopus 로고
    • Cerebral white matter lesions in the elderly: Vascular risk factors and cognitive consequences [dutch
    • de Leeuw, F. E., de Groot, J. C. & van Gijn, J. Cerebral white matter lesions in the elderly: vascular risk factors and cognitive consequences [Dutch]. Ned. Tijdschr. Geneeskd. 145, 2067-2071 (2001
    • (2001) Ned. Tijdschr. Geneeskd , vol.145 , pp. 2067-2071
    • De Leeuw, F.E.1    De Groot, J.C.2    Van Gijn, J.3
  • 4
    • 0030937940 scopus 로고    scopus 로고
    • Pathogenesis of leukoaraiosis: A review
    • Pantoni, L. & Garcia, J. H. Pathogenesis of leukoaraiosis: a review. Stroke 28, 652-659 (1997
    • (1997) Stroke , vol.28 , pp. 652-659
    • Pantoni, L.1    Garcia, J.H.2
  • 5
    • 84920406414 scopus 로고    scopus 로고
    • Reconsidering harbingers of dementia: Progression of parietal lobe white matter hyperintensities predicts alzheimer's disease incidence
    • Brickman, A. M., et al. Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer's disease incidence. Neurobiol. Aging 36, 27-32 (2015
    • (2015) Neurobiol. Aging , vol.36 , pp. 27-32
    • Brickman, A.M.1
  • 6
    • 77955360281 scopus 로고    scopus 로고
    • The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-Analysis
    • Debette, S. & Markus, H. S. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-Analysis. BMJ 341, c3666 (2010
    • (2010) BMJ , vol.341 , pp. c3666
    • Debette, S.1    Markus, H.S.2
  • 7
    • 24344482925 scopus 로고    scopus 로고
    • Cerebral small-vessel disease and decline in information processing speed, executive function and memory
    • Prins, N. D., et al. Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain 128, 2034-2041 (2005
    • (2005) Brain , vol.128 , pp. 2034-2041
    • Prins, N.D.1
  • 8
    • 0037468674 scopus 로고    scopus 로고
    • Silent brain infarcts and the risk of dementia and cognitive decline
    • Vermeer, S. E., et al. Silent brain infarcts and the risk of dementia and cognitive decline. N. Engl. J. Med. 348, 1215-1222 (2003
    • (2003) N. Engl. J. Med , vol.348 , pp. 1215-1222
    • Vermeer, S.E.1
  • 9
    • 80052400687 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the american heart association/american stroke association
    • Gorelick, P. B., et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 42, 2672-2713 (2011
    • (2011) Stroke , vol.42 , pp. 2672-2713
    • Gorelick, P.B.1
  • 10
    • 77953533246 scopus 로고    scopus 로고
    • Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges
    • Pantoni, L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 9, 689-701 (2010
    • (2010) Lancet Neurol , vol.9 , pp. 689-701
    • Pantoni, L.1
  • 11
    • 34447325381 scopus 로고    scopus 로고
    • Subcortical ischemic vascular dementia
    • Chui, H. C. Subcortical ischemic vascular dementia. Neurol. Clin. 25, 717-740 (2007
    • (2007) Neurol. Clin , vol.25 , pp. 717-740
    • Chui, H.C.1
  • 12
    • 84924243730 scopus 로고    scopus 로고
    • Vascular disease and risk factors are associated with cognitive decline in the alzheimer disease spectrum
    • Lorius, N., et al. Vascular disease and risk factors are associated with cognitive decline in the Alzheimer disease spectrum. Alzheimer Dis. Assoc. Disord. http://dx.doi.org/10.1097/WAD.0000000000000043
    • Alzheimer Dis. Assoc. Disord
    • Lorius, N.1
  • 13
    • 84920843761 scopus 로고    scopus 로고
    • Vascular risk factors and alzheimer's disease
    • O'Brien, J. T. & Markus, H. S. Vascular risk factors and Alzheimer's disease. BMC Med. 12, 218 (2014
    • (2014) BMC Med , vol.12 , pp. 218
    • O'brien, J.T.1    Markus, H.S.2
  • 14
    • 84883741074 scopus 로고    scopus 로고
    • Dementia: Vascular and neurodegenerative pathways-will they meet?
    • Kalaria, R. N. & Ihara, M. Dementia: vascular and neurodegenerative pathways-will they meet?. Nat. Rev. Neurol. 9, 487-488 (2013
    • (2013) Nat. Rev. Neurol , vol.9 , pp. 487-488
    • Kalaria, R.N.1    Ihara, M.2
  • 15
    • 84882801362 scopus 로고    scopus 로고
    • Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia
    • Akinyemi, R. O., Mukaetova-Ladinska, E. B., Attems, J., Ihara, M. & Kalaria, R. N. Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia. Curr. Alzheimer Res. 10, 642-653 (2013
    • (2013) Curr. Alzheimer Res , vol.10 , pp. 642-653
    • Akinyemi, R.O.1    Mukaetova-Ladinska, E.B.2    Attems, J.3    Ihara, M.4    Kalaria, R.N.5
  • 16
    • 84876003577 scopus 로고    scopus 로고
    • Association between subcortical vascular lesion location and cognition: A voxel-based and tract-based lesion-symptom mapping study
    • The SMART-MR study
    • Biesbroek, J. M., et al. Association between subcortical vascular lesion location and cognition: a voxel-based and tract-based lesion-symptom mapping study. The SMART-MR study. PLoS ONE 8, e60541 (2013
    • (2013) PLoS ONE , vol.8 , pp. e60541
    • Biesbroek, J.M.1
  • 17
    • 33845946376 scopus 로고    scopus 로고
    • Extent and distribution of white matter hyperintensities in normal aging mci, and ad
    • Yoshita, M., et al. Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 67, 2192-2198 (2006
    • (2006) Neurology , vol.67 , pp. 2192-2198
    • Yoshita, M.1
  • 18
    • 0037219650 scopus 로고    scopus 로고
    • Strategic involvement of cholinergic pathways and executive dysfunction: Does location of white matter signal hyperintensities matter?
    • Swartz, R. H., Sahlas, D. J. & Black, S. E. Strategic involvement of cholinergic pathways and executive dysfunction: does location of white matter signal hyperintensities matter?. J. Stroke Cerebrovasc. Dis. 12, 29-36 (2003
    • (2003) J. Stroke Cerebrovasc. Dis , vol.12 , pp. 29-36
    • Swartz, R.H.1    Sahlas, D.J.2    Black, S.E.3
  • 20
    • 0027339590 scopus 로고
    • A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging
    • Scheltens, P., et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J. Neurol. Sci. 114, 7-12 (1993
    • (1993) J. Neurol. Sci , vol.114 , pp. 7-12
    • Scheltens, P.1
  • 21
    • 33749449793 scopus 로고    scopus 로고
    • Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: The ladis study
    • Gouw, A. A., et al. Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study. J. Neurol. 253, 1189-1196 (2006
    • (2006) J. Neurol , vol.253 , pp. 1189-1196
    • Gouw, A.A.1
  • 22
    • 37549046722 scopus 로고    scopus 로고
    • An automated procedure for the assessment of white matter hyperintensities by multispectral (t1, t2, pd) mri and an evaluation of its between-centre reproducibility based on two large community databases
    • Maillard, P., et al. An automated procedure for the assessment of white matter hyperintensities by multispectral (T1, T2, PD) MRI and an evaluation of its between-centre reproducibility based on two large community databases. Neuroradiology 50, 31-42 (2008
    • (2008) Neuroradiology , vol.50 , pp. 31-42
    • Maillard, P.1
  • 23
    • 84890491465 scopus 로고    scopus 로고
    • Automated white matter total lesion volume segmentation in diabetes
    • Maldjian, J. A., et al. Automated white matter total lesion volume segmentation in diabetes. AJNR Am. J. Neuroradiol. 34, 2265-2270 (2013
    • (2013) AJNR Am. J. Neuroradiol , vol.34 , pp. 2265-2270
    • Maldjian, J.A.1
  • 24
    • 84878791771 scopus 로고    scopus 로고
    • Mri markers for mild cognitive impairment: Comparisons between white matter integrity and gray matter volume measurements
    • Zhang, Y., et al. MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS ONE 8, e66367 (2013
    • (2013) PLoS ONE , vol.8 , pp. e66367
    • Zhang, Y.1
  • 25
    • 84859063821 scopus 로고    scopus 로고
    • Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging
    • Lockhart, S. N., et al. Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging. Front. Hum. Neurosci. 6, 56 (2012
    • (2012) Front. Hum. Neurosci , vol.6 , pp. 56
    • Lockhart, S.N.1
  • 26
    • 84878939757 scopus 로고    scopus 로고
    • High blood pressure and cerebral white matter lesion progression in the general population
    • Verhaaren, B. F., et al. High blood pressure and cerebral white matter lesion progression in the general population. Hypertension 61, 1354-1359 (2013
    • (2013) Hypertension , vol.61 , pp. 1354-1359
    • Verhaaren, B.F.1
  • 27
    • 84866743847 scopus 로고    scopus 로고
    • White matter lesion progression in ladis: Frequency, clinical effects, and sample size calculations
    • Schmidt, R., et al. White matter lesion progression in LADIS: frequency, clinical effects, and sample size calculations. Stroke 43, 2643-2647 (2012
    • (2012) Stroke , vol.43 , pp. 2643-2647
    • Schmidt, R.1
  • 28
    • 54049142899 scopus 로고    scopus 로고
    • Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam scan study
    • van Dijk, E. J., et al. Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences: Rotterdam Scan study. Stroke 39, 2712-2719 (2008
    • (2008) Stroke , vol.39 , pp. 2712-2719
    • Van Dijk, E.J.1
  • 29
    • 0141596878 scopus 로고    scopus 로고
    • Pathophysiology of cerebral small vessels in vascular cognitive impairment
    • Pantoni, L. & Simoni, M. Pathophysiology of cerebral small vessels in vascular cognitive impairment. Int. Psychogeriatr. 15 (Suppl 1), 59-65 (2003
    • (2003) Int. Psychogeriatr , vol.15 , Issue.SUPPL. 1 , pp. 59-65
    • Pantoni, L.1    Simoni, M.2
  • 31
    • 0036713743 scopus 로고    scopus 로고
    • Periventricular cerebral white matter lesions predict rate of cognitive decline
    • De Groot, J. C., et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann. Neurol. 52, 335-341 (2002
    • (2002) Ann. Neurol , vol.52 , pp. 335-341
    • De Groot, J.C.1
  • 32
    • 23944483142 scopus 로고    scopus 로고
    • Decline in intelligence is associated with progression in white matter hyperintensity volume
    • Garde, E., Lykke Mortensen, E., Rostrup, E. & Paulson, O. B. Decline in intelligence is associated with progression in white matter hyperintensity volume. J. Neurol. Neurosurg. Psychiatry 76, 1289-1291 (2005
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 1289-1291
    • Garde, E.1    Lykke Mortensen, E.2    Rostrup, E.3    Paulson, O.B.4
  • 33
    • 0034643822 scopus 로고    scopus 로고
    • Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy
    • Swan, G. E., et al. Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. Neurology 54, 2108-2114 (2000
    • (2000) Neurology , vol.54 , pp. 2108-2114
    • Swan, G.E.1
  • 34
    • 0031054674 scopus 로고    scopus 로고
    • Brain infarction and the clinical expression of alzheimer disease
    • The Nun Study
    • Snowdon, D. A., et al. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277, 813-817 (1997
    • (1997) JAMA , vol.277 , pp. 813-817
    • Snowdon, D.A.1
  • 35
    • 0035915621 scopus 로고    scopus 로고
    • Neuropathology Group Medical Research Council Cognitive Function Aging Study Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS
    • Neuropathology Group. Medical Research Council Cognitive Function and Aging Study. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet 357, 169-175 (2001
    • (2001) Lancet , vol.357 , pp. 169-175
  • 37
    • 0034986196 scopus 로고    scopus 로고
    • A new rating scale for age-related white matter changes applicable to mri and ct
    • Wahlund, L. O., et al. A new rating scale for age-related white matter changes applicable to MRI and CT. Stroke 32, 1318-1322 (2001
    • (2001) Stroke , vol.32 , pp. 1318-1322
    • Wahlund, L.O.1
  • 38
    • 0028800386 scopus 로고
    • Brain mri findings and cognitive impairment in patients undergoing chronic hemodialysis treatment
    • Fazekas, G., et al. Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment. J. Neurol. Sci. 134, 83-38 (1995
    • (1995) J. Neurol. Sci , vol.134 , pp. 83-38
    • Fazekas, G.1
  • 39
    • 0037322688 scopus 로고    scopus 로고
    • Visual rating of age-related white matter changes on magnetic resonance imaging: Scale comparison, interrater agreement, and correlations with quantitative measurements
    • Kapeller, P., et al. Visual rating of age-related white matter changes on magnetic resonance imaging: scale comparison, interrater agreement, and correlations with quantitative measurements. Stroke 34, 441-445 (2003
    • (2003) Stroke , vol.34 , pp. 441-445
    • Kapeller, P.1
  • 40
    • 2342608440 scopus 로고    scopus 로고
    • Measuring progression of cerebral white matter lesions on mri: Visual rating and volumetrics
    • Prins, N. D., et al. Measuring progression of cerebral white matter lesions on MRI: visual rating and volumetrics. Neurology 62, 1533-1539 (2004
    • (2004) Neurology , vol.62 , pp. 1533-1539
    • Prins, N.D.1
  • 41
    • 33750966471 scopus 로고    scopus 로고
    • A fully automated method for quantifying and localizing white matter hyperintensities on mr images
    • Wu, M., et al. A fully automated method for quantifying and localizing white matter hyperintensities on MR images. Psychiatry Res. 148, 133-142 (2006
    • (2006) Psychiatry Res , vol.148 , pp. 133-142
    • Wu, M.1
  • 42
    • 41349097700 scopus 로고    scopus 로고
    • Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    • Gouw, A. A., et al. Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression. Cerebrovasc. Dis. 25, 247-253 (2008
    • (2008) Cerebrovasc. Dis , vol.25 , pp. 247-253
    • Gouw, A.A.1
  • 43
    • 70349315265 scopus 로고    scopus 로고
    • Fully-Automated white matter hyperintensity detection with anatomical prior knowledge and without flair
    • Schwarz, C., Fletcher, E., DeCarli, C. & Carmichael, O. Fully-Automated white matter hyperintensity detection with anatomical prior knowledge and without FLAIR. Inf. Process. Med. Imaging 21, 239-251 (2009
    • (2009) Inf. Process. Med. Imaging , vol.21 , pp. 239-251
    • Schwarz, C.1    Fletcher, E.2    Decarli, C.3    Carmichael, O.4
  • 44
    • 84873629627 scopus 로고    scopus 로고
    • Flair and diffusion mri signals are independent predictors of white matter hyperintensities
    • Maillard, P., et al. FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities. AJNR Am. J. Neuroradiol. 34, 54-61 (2013
    • (2013) AJNR Am. J. Neuroradiol , vol.34 , pp. 54-61
    • Maillard, P.1
  • 45
    • 84899102572 scopus 로고    scopus 로고
    • Cerebral small vessel disease affects white matter microstructure in mild cognitive impairment
    • Papma, J. M., et al. Cerebral small vessel disease affects white matter microstructure in mild cognitive impairment. Hum. Brain Mapp. 35, 2836-2851 (2014
    • (2014) Hum. Brain Mapp , vol.35 , pp. 2836-2851
    • Papma, J.M.1
  • 46
    • 84893456095 scopus 로고    scopus 로고
    • Cerebral microbleeds: A review of clinical, genetic, and neuroimaging associations
    • Yates, P. A., et al. Cerebral microbleeds: a review of clinical, genetic, and neuroimaging associations. Front. Neurol. 4, 205 (2014
    • (2014) Front. Neurol , vol.4 , Issue.205
    • Yates, P.A.1
  • 47
    • 80053966811 scopus 로고    scopus 로고
    • Dynamic temporal change of cerebral microbleeds: Long-Term follow-up mri study
    • Lee, S. H., et al. Dynamic temporal change of cerebral microbleeds: long-Term follow-up MRI study. PLoS ONE 6, e25930 (2011
    • (2011) PLoS ONE , vol.6 , pp. e25930
    • Lee, S.H.1
  • 48
    • 84902167026 scopus 로고    scopus 로고
    • Incidence of cerebral microbleeds in preclinical alzheimer disease
    • Yates, P. A., et al. Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology 82, 1266-1273 (2014
    • (2014) Neurology , vol.82 , pp. 1266-1273
    • Yates, P.A.1
  • 50
    • 33644909914 scopus 로고    scopus 로고
    • Cerebral microbleeds on mri: Prevalence, associations, and potential clinical implications
    • Koennecke, H. C. Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications. Neurology 66, 165-171 (2006
    • (2006) Neurology , vol.66 , pp. 165-171
    • Koennecke, H.C.1
  • 51
    • 84867501408 scopus 로고    scopus 로고
    • Age- and sex-specific rates of leukoaraiosis in tia and stroke patients: Population-based study
    • Simoni, M., et al. Age- And sex-specific rates of leukoaraiosis in TIA and stroke patients: population-based study. Neurology 79, 1215-1222 (2012
    • (2012) Neurology , vol.79 , pp. 1215-1222
    • Simoni, M.1
  • 53
    • 10744226082 scopus 로고    scopus 로고
    • Magnetic resonance imaging of the brain in diabetes: The cardiovascular determinants of dementia (cascade) study
    • Schmidt, R., et al. Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes 53, 687-692 (2004
    • (2004) Diabetes , vol.53 , pp. 687-692
    • Schmidt, R.1
  • 54
    • 0035132684 scopus 로고    scopus 로고
    • Prevalence of cerebral white matter lesions in elderly people: A population based magnetic resonance imaging study
    • The Rotterdam Scan Study
    • de Leeuw, F. E., et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J. Neurol. Neurosurg. Psychiatry 70, 9-14 (2001
    • (2001) J. Neurol. Neurosurg. Psychiatry , vol.70 , pp. 9-14
    • De Leeuw, F.E.1
  • 55
    • 0033031974 scopus 로고    scopus 로고
    • White matter lesions on magnetic resonance imaging in dementia with lewy bodies, alzheimer's disease, vascular dementia, and normal aging
    • Barber, R., et al. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging. J. Neurol. Neurosurg. Psychiatry 67, 66-72 (1999
    • (1999) J. Neurol. Neurosurg. Psychiatry , vol.67 , pp. 66-72
    • Barber, R.1
  • 56
    • 51649119598 scopus 로고    scopus 로고
    • The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among korean patients with ischemic stroke
    • Lee, S. J., et al. The leukoaraiosis is more prevalent in the large artery atherosclerosis stroke subtype among Korean patients with ischemic stroke. BMC Neurol. 8, 31 (2008
    • (2008) BMC Neurol , vol.8 , pp. 31
    • Lee, S.J.1
  • 57
    • 10844278989 scopus 로고    scopus 로고
    • Impact of age-related cerebral white matter changes on the transition to disability-The ladis study: Rationale, design and methodology
    • Pantoni, L., et al. Impact of age-related cerebral white matter changes on the transition to disability-The LADIS study: rationale, design and methodology. Neuroepidemiology 24, 51-62 (2005
    • (2005) Neuroepidemiology , vol.24 , pp. 51-62
    • Pantoni, L.1
  • 58
    • 25444467168 scopus 로고    scopus 로고
    • White matter lesion progression, brain atrophy, and cognitive decline: The austrian stroke prevention study
    • Schmidt, R., et al. White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study. Ann. Neurol. 58, 610-616 (2005
    • (2005) Ann. Neurol , vol.58 , pp. 610-616
    • Schmidt, R.1
  • 59
    • 0029018417 scopus 로고
    • The significance of cerebral white matter abnormalities 100 years after binswanger's report
    • Pantoni, L. & Garcia, J. H. The significance of cerebral white matter abnormalities 100 years after Binswanger's report. A review. Stroke 26, 1293-1301 (1995
    • (1995) A Review. Stroke , vol.26 , pp. 1293-1301
    • Pantoni, L.1    Garcia, J.H.2
  • 60
    • 78751574080 scopus 로고    scopus 로고
    • Heterogeneity of small vessel disease: A systematic review of mri and histopathology correlations
    • Gouw, A. A., et al. Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations. J. Neurol. Neurosurg. Psychiatry 82, 126-135 (2011
    • (2011) J. Neurol. Neurosurg. Psychiatry , vol.82 , pp. 126-135
    • Gouw, A.A.1
  • 61
    • 0033966134 scopus 로고    scopus 로고
    • Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly
    • de Leeuw, F. E., et al. Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly. Stroke 31, 425-429 (2000
    • (2000) Stroke , vol.31 , pp. 425-429
    • De Leeuw, F.E.1
  • 62
    • 0036208828 scopus 로고    scopus 로고
    • Hypertension and cerebral white matter lesions in a prospective cohort study
    • de Leeuw, F. E., et al. Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 125, 765-772 (2002
    • (2002) Brain , vol.125 , pp. 765-772
    • De Leeuw, F.E.1
  • 63
    • 20444364445 scopus 로고    scopus 로고
    • Ambulatory blood pressure and the brain: A 5 year follow-up
    • Goldstein, I. B., Bartzokis, G., Guthrie, D. & Shapiro, D. Ambulatory blood pressure and the brain: a 5 year follow-up. Neurology 64, 1846-1852 (2005
    • (2005) Neurology , vol.64 , pp. 1846-1852
    • Goldstein, I.B.1    Bartzokis, G.2    Guthrie, D.3    Shapiro, D.4
  • 64
    • 74049088608 scopus 로고    scopus 로고
    • Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis risk in communities (aric) study
    • Gottesman, R. F., et al. Blood pressure and white-matter disease progression in a biethnic cohort: Atherosclerosis Risk in Communities (ARIC) study. Stroke 41, 3-8 (2010
    • (2010) Stroke , vol.41 , pp. 3-8
    • Gottesman, R.F.1
  • 66
    • 84906701270 scopus 로고    scopus 로고
    • Metabolic syndrome, prediabetes, and brain abnormalities on mri in patients with manifest arterial disease: The smart-mr study
    • Tiehuis, A. M., et al. Metabolic syndrome, prediabetes, and brain abnormalities on MRI in patients with manifest arterial disease: the SMART-MR study. Diabetes Care 37, 2515-2521 (2014
    • (2014) Diabetes Care , vol.37 , pp. 2515-2521
    • Tiehuis, A.M.1
  • 68
    • 79958103460 scopus 로고    scopus 로고
    • Vascular risk factors and longitudinal changes on brain mri: The aric study
    • Knopman, D. S., et al. Vascular risk factors and longitudinal changes on brain MRI: the ARIC study. Neurology 76, 1879-1885 (2011
    • (2011) Neurology , vol.76 , pp. 1879-1885
    • Knopman, D.S.1
  • 69
    • 1642390437 scopus 로고    scopus 로고
    • Plasma amyloid β, apolipoprotein e, lacunar infarcts, and white matter lesions
    • van Dijk, E. J., et al. Plasma amyloid β, apolipoprotein E, lacunar infarcts, and white matter lesions. Ann. Neurol. 55, 570-575 (2004
    • (2004) Ann. Neurol , vol.55 , pp. 570-575
    • Van Dijk, E.J.1
  • 70
    • 0025337383 scopus 로고
    • Immunohistochemical study of cerebral amyloid angiopathy iii widespread alzheimer a4 peptide in cerebral microvessel walls colocalizes with gamma trace in patients with leukoencephalopathy
    • Vinters, H. V., Secor, D. L., Pardridge, W. M. & Gray, F. Immunohistochemical study of cerebral amyloid angiopathy. III. Widespread Alzheimer A4 peptide in cerebral microvessel walls colocalizes with gamma trace in patients with leukoencephalopathy. Ann. Neurol. 28, 34-42 (1990
    • (1990) Ann. Neurol , vol.28 , pp. 34-42
    • Vinters, H.V.1    Secor, D.L.2    Pardridge, W.M.3    Gray, F.4
  • 71
    • 0028877552 scopus 로고
    • Periventricular venous collagenosis: Association with leukoaraiosis
    • Moody, D. M., Brown, W. R., Challa, V. R. & Anderson, R. L. Periventricular venous collagenosis: association with leukoaraiosis. Radiology 194, 469-476 (1995
    • (1995) Radiology , vol.194 , pp. 469-476
    • Moody, D.M.1    Brown, W.R.2    Challa, V.R.3    Anderson, R.L.4
  • 72
    • 0031866395 scopus 로고    scopus 로고
    • Neuropathology of white matter changes in alzheimer's disease and vascular dementia
    • Englund, E. Neuropathology of white matter changes in Alzheimer's disease and vascular dementia. Dement. Geriatr. Cogn. Disord. 9 (Suppl 1), 6-12 (1998
    • (1998) Dement. Geriatr. Cogn. Disord , vol.9 , Issue.SUPPL. 1 , pp. 6-12
    • Englund, E.1
  • 73
    • 84863554633 scopus 로고    scopus 로고
    • The neuropathology of vascular disease in the medical research council cognitive function and ageing study (mrc cfas
    • Richardson, K., et al. The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Curr. Alzheimer Res. 9, 687-696 (2012
    • (2012) Curr. Alzheimer Res , vol.9 , pp. 687-696
    • Richardson, K.1
  • 74
    • 79951775520 scopus 로고    scopus 로고
    • Association between apoe genotype, neuropathology and dementia in the older population of england and wales
    • Nicoll, J. A., et al. Association between APOE genotype, neuropathology and dementia in the older population of England and Wales. Neuropathol. Appl. Neurobiol. 37, 285-294 (2011
    • (2011) Neuropathol. Appl. Neurobiol , vol.37 , pp. 285-294
    • Nicoll, J.A.1
  • 75
    • 84901798537 scopus 로고    scopus 로고
    • White matter hyperintensities are associated with amyloid burden in apoe4 non-carriers
    • Noh, Y., et al. White matter hyperintensities are associated with amyloid burden in APOE4 non-carriers. J. Alzheimers Dis. 40, 877-886 (2014
    • (2014) J. Alzheimers Dis , vol.40 , pp. 877-886
    • Noh, Y.1
  • 76
    • 84878782202 scopus 로고    scopus 로고
    • Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor mri
    • Chao, L. L., et al. Associations between white matter hyperintensities and β amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS ONE 8, e65175 (2013
    • (2013) PLoS ONE , vol.8 , pp. e65175
    • Chao, L.L.1
  • 77
    • 84875841467 scopus 로고    scopus 로고
    • The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: A study among patients with subcortical vascular cognitive impairments
    • Kim, H. J., et al. The effects of small vessel disease and amyloid burden on neuropsychiatric symptoms: a study among patients with subcortical vascular cognitive impairments. Neurobiol. Aging 34, 1913-1920 (2013
    • (2013) Neurobiol. Aging , vol.34 , pp. 1913-1920
    • Kim, H.J.1
  • 78
    • 84877593391 scopus 로고    scopus 로고
    • Vascular and alzheimer's disease markers independently predict brain atrophy rate in alzheimer's disease neuroimaging initiative controls
    • Barnes, J., et al. Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls. Neurobiol. Aging 34, 1996-2002 (2013
    • (2013) Neurobiol. Aging , vol.34 , pp. 1996-2002
    • Barnes, J.1
  • 79
    • 84885619924 scopus 로고    scopus 로고
    • White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment
    • 5 Suppl
    • Guzman, V. A., et al. White matter hyperintensities and amyloid are independently associated with entorhinal cortex volume among individuals with mild cognitive impairment. Alzheimers Dement. 9 (5 Suppl.), S124-S131 (2013
    • (2013) Alzheimers Dement , vol.9 , pp. S124-S131
    • Guzman, V.A.1
  • 80
    • 0031784085 scopus 로고    scopus 로고
    • Patterns of mri lesions in cadasil
    • Chabriat, H., et al. Patterns of MRI lesions in CADASIL. Neurology 51, 452-457 (1998
    • (1998) Neurology , vol.51 , pp. 452-457
    • Chabriat, H.1
  • 81
    • 84924730009 scopus 로고    scopus 로고
    • Cadasil and carasil
    • Tikka, S., et al. CADASIL and CARASIL. Brain Pathol. 24, 525-544 (2014
    • (2014) Brain Pathol , vol.24 , pp. 525-544
    • Tikka, S.1
  • 82
    • 84898751519 scopus 로고    scopus 로고
    • Two novel htra1 mutations in a european carasil patient
    • Bianchi, S., et al. Two novel HTRA1 mutations in a European CARASIL patient. Neurology 82, 898-900 (2014
    • (2014) Neurology , vol.82 , pp. 898-900
    • Bianchi, S.1
  • 83
    • 84866640874 scopus 로고    scopus 로고
    • The genetics of small-vessel disease
    • Bersano, A., et al. The genetics of small-vessel diseasE curr. Med. Chem. 19, 4124-4141 (2012
    • (2012) Curr. Med. Chem , vol.19 , pp. 4124-4141
    • Bersano, A.1
  • 84
    • 79959397958 scopus 로고    scopus 로고
    • Genome-wide association studies of cerebral white matter lesion burden: The charge consortium
    • Fornage, M., et al. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann. Neurol. 69, 928-939 (2011
    • (2011) Ann. Neurol , vol.69 , pp. 928-939
    • Fornage, M.1
  • 85
    • 84880180775 scopus 로고    scopus 로고
    • 17q25 locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status
    • Adib-Samii, P., et al. 17q25 locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status. Stroke 44, 1609-1615 (2013
    • (2013) Stroke , vol.44 , pp. 1609-1615
    • Adib-Samii, P.1
  • 86
    • 84876325430 scopus 로고    scopus 로고
    • Association of chr17q25 with cerebral white matter hyperintensities and cognitive impairment the j shipp study
    • Tabara, Y., et al. Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J SHIPP study. Eur. J. Neurol. 20, 860-862 (2013
    • (2013) Eur. J. Neurol , vol.20 , pp. 860-862
    • Tabara, Y.1
  • 87
    • 81555196710 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy in the elderly
    • Viswanathan, A. & Greenberg, S. M. Cerebral amyloid angiopathy in the elderly. Ann. Neurol. 70, 871-880 (2011
    • (2011) Ann. Neurol , vol.70 , pp. 871-880
    • Viswanathan, A.1    Greenberg, S.M.2
  • 88
    • 0031887307 scopus 로고    scopus 로고
    • Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis dutch type (hchwad
    • Vinters, H. V., et al. Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA D). Acta Neuropathol. 95, 235-244 (1998
    • (1998) Acta Neuropathol , vol.95 , pp. 235-244
    • Vinters, H.V.1
  • 89
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
    • McDonald, W. I., et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50, 121-127 (2001
    • (2001) Ann. Neurol , vol.50 , pp. 121-127
    • McDonald, W.I.1
  • 90
    • 0032886533 scopus 로고    scopus 로고
    • Defining and categorizing leukoencephalopathies of unknown origin: Mr imaging approach
    • van der Knaap, M. S., Breiter, S. N., Naidu, S., Hart, A. A. & Valk, J. Defining and categorizing leukoencephalopathies of unknown origin: MR imaging approach. Radiology 213, 121-133 (1999
    • (1999) Radiology , vol.213 , pp. 121-133
    • Van Der Knaap, M.S.1    Breiter, S.N.2    Naidu, S.3    Hart, A.A.4    Valk, J.5
  • 91
    • 84878987706 scopus 로고    scopus 로고
    • Melas and reversible vasoconstriction of the major cerebral arteries
    • Yoshida, T., et al. MELAS and reversible vasoconstriction of the major cerebral arteries. Intern. Med. 52, 1389-1392 (2013
    • (2013) Intern. Med , vol.52 , pp. 1389-1392
    • Yoshida, T.1
  • 92
    • 0033950216 scopus 로고    scopus 로고
    • Cerebral white matter lesions and cognitive function: The rotterdam scan study
    • de Groot, J. C., et al. Cerebral white matter lesions and cognitive function: the Rotterdam Scan Study. Ann. Neurol. 47, 145-151 (2000
    • (2000) Ann. Neurol , vol.47 , pp. 145-151
    • De Groot, J.C.1
  • 94
    • 0035956485 scopus 로고    scopus 로고
    • Mri predictors of cognition in subcortical ischemic vascular disease and alzheimer's disease
    • Mungas, D., et al. MRI predictors of cognition in subcortical ischemic vascular disease and Alzheimer's disease. Neurology 57, 2229-2235 (2001
    • (2001) Neurology , vol.57 , pp. 2229-2235
    • Mungas, D.1
  • 95
    • 77956845047 scopus 로고    scopus 로고
    • Longitudinal changes in white matter disease and cognition in the first year of the alzheimer disease neuroimaging initiative
    • Carmichael, O., et al. Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative. Arch. Neurol. 67, 1370-1378 (2010
    • (2010) Arch. Neurol , vol.67 , pp. 1370-1378
    • Carmichael, O.1
  • 96
    • 84911955552 scopus 로고    scopus 로고
    • Brain imaging findings in elderly adults and years of life, healthy life, and able life over the ensuing 16 years: The cardiovascular health study
    • Longstreth, W. T., Diehr, P. H., Yee, L. M., Newman, A. B. & Beauchamp, N. J. Brain imaging findings in elderly adults and years of life, healthy life, and able life over the ensuing 16 years: the Cardiovascular Health Study. J. Am. Geriatr. Soc. 62, 1838-1843 (2014
    • (2014) J. Am. Geriatr. Soc , vol.62 , pp. 1838-1843
    • Longstreth, W.T.1    Diehr, P.H.2    Yee, L.M.3    Newman, A.B.4    Beauchamp, N.J.5
  • 97
    • 84055200066 scopus 로고    scopus 로고
    • 2001 -2011: A decade of the LADIS (Leukoaraiosis and disability) Study: What have we learned about white matter changes and small-vessel disease?
    • LADIS Study Group
    • LADIS Study Group. 2001-2011: a decade of the LADIS (Leukoaraiosis And DISability) Study: what have we learned about white matter changes and small-vessel disease?. Cerebrovasc. Dis. 32, 577-588 (2011
    • (2011) Cerebrovasc Dis , vol.32 , pp. 577-588
  • 98
    • 5344253243 scopus 로고    scopus 로고
    • Cerebral white matter lesions and the risk of dementia
    • Prins, N. D., et al. Cerebral white matter lesions and the risk of dementia. Arch. Neurol. 61, 1531-1534 (2004
    • (2004) Arch. Neurol , vol.61 , pp. 1531-1534
    • Prins, N.D.1
  • 99
    • 33750022878 scopus 로고    scopus 로고
    • Vascular determinants of cholinergic deficits in alzheimer disease and vascular dementia
    • Román, G. C. & Kalaria, R. N. Vascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia. Neurobiol. Aging 27, 1769-1785 (2006
    • (2006) Neurobiol. Aging , vol.27 , pp. 1769-1785
    • Román, G.C.1    Kalaria, R.N.2
  • 100
    • 0034676511 scopus 로고    scopus 로고
    • Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats
    • Kimura, S., et al. Pathogenesis of vascular dementia in stroke-prone spontaneously hypertensive rats. Toxicology 153, 167-178 (2000
    • (2000) Toxicology , vol.153 , pp. 167-178
    • Kimura, S.1
  • 101
    • 79251635233 scopus 로고    scopus 로고
    • Cognitive function, dementia and type 2 diabetes mellitus in the elderly
    • Strachan, M. W., Reynolds, R. M., Marioni, R. E. & Price, J. F. Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nat. Rev. Endocrinol. 7, 108-114 (2011
    • (2011) Nat. Rev. Endocrinol , vol.7 , pp. 108-114
    • Strachan, M.W.1    Reynolds, R.M.2    Marioni, R.E.3    Price, J.F.4
  • 102
    • 12244287634 scopus 로고    scopus 로고
    • Homocysteine as a risk factor for cognitive impairment in stroke patients
    • Sachdev, P. S., et al. Homocysteine as a risk factor for cognitive impairment in stroke patients. Dement. Geriatr. Cogn. Disord. 15, 155-162 (2003
    • (2003) Dement. Geriatr. Cogn. Disord , vol.15 , pp. 155-162
    • Sachdev, P.S.1
  • 103
    • 0034603520 scopus 로고    scopus 로고
    • Vascular risk factors for alzheimer's disease: An epidemiologic perspective
    • Breteler, M. M. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol. Aging 21, 153-160 (2000
    • (2000) Neurobiol. Aging , vol.21 , pp. 153-160
    • Breteler, M.M.1
  • 104
    • 0036130159 scopus 로고    scopus 로고
    • Small vessel disease and alzheimer's dementia: Pathological considerations
    • Kalaria, R. N. Small vessel disease and Alzheimer's dementia: pathological considerations. Cerebrovasc. Dis. 13 (Suppl 2), 48-52 (2002
    • (2002) Cerebrovasc. Dis , vol.13 , Issue.SUPPL. 2 , pp. 48-52
    • Kalaria, R.N.1
  • 105
    • 84867578043 scopus 로고    scopus 로고
    • Pre-clinical models of human cerebral small vessel disease: Utility for clinical application
    • Hainsworth, A. H., Brittain, J. F. & Khatun, H. Pre-clinical models of human cerebral small vessel disease: utility for clinical application. J. Neurol. Sci. 322, 237-240 (2012
    • (2012) J. Neurol. Sci , vol.322 , pp. 237-240
    • Hainsworth, A.H.1    Brittain, J.F.2    Khatun, H.3
  • 106
    • 84887083328 scopus 로고    scopus 로고
    • Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition
    • Bink, D. I., Ritz, K., Aronica, E., van der Weerd, L. & Daemen, M. J. Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J. Cereb. Blood Flow Metab. 33, 1666-1684 (2013
    • (2013) J. Cereb. Blood Flow Metab , vol.33 , pp. 1666-1684
    • Bink, D.I.1    Ritz, K.2    Aronica, E.3    Van Der Weerd, L.4    Daemen, M.J.5
  • 107
    • 27444445761 scopus 로고    scopus 로고
    • Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: The ladis study
    • van der Flier, W. M., et al. Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study. J. Neurol. Neurosurg. Psychiatry 76, 1497-1500 (2005
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 1497-1500
    • Van Der Flier, W.M.1
  • 108
    • 84872768081 scopus 로고    scopus 로고
    • Effect of white matter hyperintensity on medial temporal lobe atrophy in alzheimer's disease
    • Jang, J. W., et al. Effect of white matter hyperintensity on medial temporal lobe atrophy in Alzheimer's disease. Eur. Neurol. 69, 229-235 (2013
    • (2013) Eur. Neurol , vol.69 , pp. 229-235
    • Jang, J.W.1
  • 109
    • 0023232439 scopus 로고
    • Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?
    • Erkinjuntti, T., et al. Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease?. J. Neurol. Neurosurg. Psychiatry 50, 37-42 (1987
    • (1987) J. Neurol. Neurosurg. Psychiatry , vol.50 , pp. 37-42
    • Erkinjuntti, T.1
  • 110
    • 23244462426 scopus 로고    scopus 로고
    • Subcortical vascular dementia: Integrating neuropsychological and neuroradiologic data
    • Price, C. C., Jefferson, A. L., Merino, J. G., Heilman, K. M. & Libon, D. J. Subcortical vascular dementia: integrating neuropsychological and neuroradiologic data. Neurology 65, 376-382 (2005
    • (2005) Neurology , vol.65 , pp. 376-382
    • Price, C.C.1    Jefferson, A.L.2    Merino, J.G.3    Heilman, K.M.4    Libon, D.J.5
  • 111
    • 0029398499 scopus 로고
    • The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults
    • DeCarli, C., et al. The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology 45, 2077-2084 (1995
    • (1995) Neurology , vol.45 , pp. 2077-2084
    • Decarli, C.1
  • 112
    • 79960121999 scopus 로고    scopus 로고
    • White matter hyperintensities and cognition: Testing the reserve hypothesis
    • Brickman, A. M., et al. White matter hyperintensities and cognition: testing the reserve hypothesis. Neurobiol. Aging 32, 1588-1598 (2011
    • (2011) Neurobiol. Aging , vol.32 , pp. 1588-1598
    • Brickman, A.M.1
  • 113
    • 83755182724 scopus 로고    scopus 로고
    • The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and alzheimer's diseases
    • Murray, A. D., et al. The balance between cognitive reserve and brain imaging biomarkers of cerebrovascular and Alzheimer's diseases. Brain 134, 3687-3696 (2011
    • (2011) Brain , vol.134 , pp. 3687-3696
    • Murray, A.D.1
  • 115
    • 0032564132 scopus 로고    scopus 로고
    • Prevention of dementia in randomised double-blind placebo-controlled systolic hypertension in europe (syst-eur) trial
    • Forette, F., et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 352, 1347-1351 (1998
    • (1998) Lancet , vol.352 , pp. 1347-1351
    • Forette, F.1
  • 116
    • 84895726481 scopus 로고    scopus 로고
    • Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: A randomized clinical trial
    • Williamson, J. D., et al. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern. Med. 174, 324-333 (2014
    • (2014) JAMA Intern. Med , vol.174 , pp. 324-333
    • Williamson, J.D.1
  • 117
    • 18844415380 scopus 로고    scopus 로고
    • Effect of pravastatin on cerebral infarcts and white matter lesions
    • ten Dam, V. H., et al. Effect of pravastatin on cerebral infarcts and white matter lesions. Neurology 64, 1807-1809 (2005
    • (2005) Neurology , vol.64 , pp. 1807-1809
    • Ten Dam, V.H.1
  • 118
    • 77649155203 scopus 로고    scopus 로고
    • Vascular care in patients with alzheimer disease with cerebrovascular lesions slows progression of white matter lesions on mri: The evaluation of vascular care in alzheimer's disease (eva) study
    • Richard, E., Gouw, A. A., Scheltens, P. & van Gool, W. A. Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of white matter lesions on MRI: the evaluation of vascular care in Alzheimer's disease (EVA) study. Stroke 41, 554-556 (2010
    • (2010) Stroke , vol.41 , pp. 554-556
    • Richard, E.1    Gouw, A.A.2    Scheltens, P.3    Van Gool, W.A.4
  • 119
    • 65449169183 scopus 로고    scopus 로고
    • Evaluation of vascular care in alzheimer's disease vascular care in patients with alzheimer's disease with cerebrovascular lesions-A randomized clinical trial
    • Richard, E., Kuiper, R., Dijkgraaf, M. G., Van Gool, W. A. & Evaluation of Vascular care in Alzheimer's disease. Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-A randomized clinical trial. J. Am. Geriatr. Soc. 57, 797-805 (2009
    • (2009) J. Am. Geriatr. Soc , vol.57 , pp. 797-805
    • Richard, E.1    Kuiper, R.2    Dijkgraaf, M.G.3    Van Gool, W.A.4
  • 120
    • 70349095579 scopus 로고    scopus 로고
    • Prevention of dementia by intensive vascular care (prediva): A cluster-randomized trial in progress
    • Richard, E., et al. Prevention of dementia by intensive vascular care (PreDIVA): a cluster-randomized trial in progress. Alzheimer Dis. Assoc. Disord. 23, 198-204 (2009
    • (2009) Alzheimer Dis. Assoc. Disord , vol.23 , pp. 198-204
    • Richard, E.1
  • 121
    • 84867237403 scopus 로고    scopus 로고
    • Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on mri in older adults with memory complaints and mild cognitive impairment: The aibl active trial
    • Cyarto, E. V., et al. Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial. BMC Psychiatry 12, 167 (2012
    • (2012) BMC Psychiatry , vol.12 , pp. 167
    • Cyarto, E.V.1
  • 122
    • 27844606984 scopus 로고    scopus 로고
    • Donepezil in vascular dementia: Combined analysis of two large-scale clinical trials
    • Román, G. C., et al. Donepezil in vascular dementia: combined analysis of two large-scale clinical trials. Dement. Geriatr. Cogn. Disord. 20, 338-344 (2005
    • (2005) Dement. Geriatr. Cogn. Disord , vol.20 , pp. 338-344
    • Román, G.C.1
  • 123
    • 76649086048 scopus 로고    scopus 로고
    • The long-Term efficacy and tolerability of donepezil in patients with vascular dementia
    • Wilkinson, D., et al. The long-Term efficacy and tolerability of donepezil in patients with vascular dementia. Int. J. Geriatr. Psychiatry 25, 305-313 (2010
    • (2010) Int. J. Geriatr. Psychiatry , vol.25 , pp. 305-313
    • Wilkinson, D.1
  • 124
    • 0037070773 scopus 로고    scopus 로고
    • Efficacy of galantamine in probable vascular dementia and alzheimer's disease combined with cerebrovascular disease: A randomised trial
    • Erkinjuntti, T., et al. Efficacy of galantamine in probable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial. Lancet 359, 1283-1290 (2002
    • (2002) Lancet , vol.359 , pp. 1283-1290
    • Erkinjuntti, T.1
  • 125
    • 0036314492 scopus 로고    scopus 로고
    • Efficacy and safety of memantine in patients with mild to moderate vascular dementia: A randomized, placebo-controlled trial (mmm 300)
    • Orgogozo, J. M., Rigaud, A. S., Stöffler, A., Möbius, H. J. & Forette, F. Efficacy and safety of memantine in patients with mild to moderate vascular dementia: a randomized, placebo-controlled trial (MMM 300). Stroke 33, 1834-1839 (2002
    • (2002) Stroke , vol.33 , pp. 1834-1839
    • Orgogozo, J.M.1    Rigaud, A.S.2    Stöffler, A.3    Möbius, H.J.4    Forette, F.5
  • 126
    • 68149108650 scopus 로고    scopus 로고
    • Changes in white matter as determinant of global functional decline in older independent outpatients: Three year follow-up of ladis (leukoaraiosis and disability) study cohort
    • Inzitari, D., et al. Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. BMJ 339, b2477 (2009
    • (2009) BMJ , vol.339 , pp. b2477
    • Inzitari, D.1
  • 127
    • 23944473801 scopus 로고    scopus 로고
    • Progression of cerebral white matter lesions in Alzheimer's disease: A new window for therapy?
    • de Leeuw, F. E., Barkhof, F. & Scheltens, P. Progression of cerebral white matter lesions in Alzheimer's disease: a new window for therapy?. J. Neurol. Neurosurg. Psychiatry 76, 1286-1288 (2005
    • (2005) J. Neurol. Neurosurg. Psychiatry , vol.76 , pp. 1286-1288
    • De Leeuw, F.E.1    Barkhof, F.2    Scheltens, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.